壳聚糖基复合水凝胶在创伤修复中的应用
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摘要
综述了近年来壳聚糖与温敏材料、生长因子、多肽及多种其他材料通过物理或化学方法复合制备的壳聚糖基水凝胶及其在创伤修复领域中研究和应用的新进展,并对其发展前景进行了展望,期望为后续壳聚糖基水凝胶的进一步研究提供参考。
The recent advances in chitosan-based hydrogels prepared by combination chitosan with thermosensitive materials,growth factors,peptides and various other materials through physical or chemical methods and their new research and applications in the field of wound repair are reviewed. Furthermore,the development prospects of chitosan-based hydrogels are also forecasted. It is expected to provide reference for further research of chitosan-based hydrogels in the future.
The recent advances in chitosan-based hydrogels prepared by combination chitosan with thermosensitive materials,growth factors,peptides and various other materials through physical or chemical methods and their new research and applications in the field of wound repair are reviewed. Furthermore,the development prospects of chitosan-based hydrogels are also forecasted. It is expected to provide reference for further research of chitosan-based hydrogels in the future.
引文
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[25] Chen S,Zhang M,Shao X,et al. A laminin mimetic peptide SIKVAV-conjugated chitosan hydrogel promoting wound healing by enhancing angiogenesis,re-epithelialization and collagen deposition[J]. Journal of Materials Chemistry B,2015,3(33):6798-6804.
[26] Chen X,Zhang M,Chen S,et al. Peptide-modified chitosan hydrogels accelerate skin wound healing by promoting fibroblast proliferation,migration,and secretion[J].Cell Transplantation,2017,26(8):1331-1340.
[27] Chen X,Cao X,Jiang H,et al. SIKVAV-modified chitosan hydrogel as a skin substitutes for wound closure in mice[J]. Molecules,2018,23(10):2611.
[28] Liu L,Wen H,Rao Z,et al. Preparation and characterization of chitosan-collagen peptide/oxidized konjac glucomannan hydrogel[J]. Int J Biol Macromol,2018,108:376-382.
[29] Xiao Y,Reis L A,Feric N,et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization[J]. Proceedings of the National Academy of Sciences of the United States of America,2016,113(40):E5792-E5801.
[30] Chen H,Xing X,Tan H,et al. Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing[J]. Mater Sci Eng C Mater Biol Appl,2017,70(Pt 1):287-295.
[31] Zhao X,Wu H,Guo B,et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing[J]. Biomaterials,2017,122:34-47.
[32] Noori S,Kokabi M,Hassan Z M. Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing[J]. Journal of Applied Polymer Science,2018,135(21):46311.
[33] Carpenter A W,Schoenfisch M H. Nitric oxide release:Part II. Therapeutic applications[J]. Chemical Society Reviews,2012,41(10):3742-3752.
[34] Pelegrino M,de Araujo Lima B,do Nascimento M,et al.Biocompatible and antibacterial nitric oxide-releasing pluronic F-127/chitosan hydrogel for topical applications[J]. Polymers,2018,10(4):452.
[35] Tsai C Y,Woung L C,Yen J C,et al. Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing[J]. Carbohydr Polym,2016,135:308-315.
[2] Boateng J S,Matthews K H,Stevens H N E,et al. Wound healing dressings and drug delivery systems:A review[J]. Journal of Pharmaceutical Sciences,2008,97(8):2892-2923.
[3]崔福德.药剂学[M]. 7版.北京:人民卫生出版社,2011:296-298.
[4] Rao S B,Sharma C P. Use of chitosan as a biomaterial:studies on its safety and hemostatic potential[J]. Journal of Biomedical Materials Research,1997,34(1):21-28.
[5]康肸,邓爱鹏,杨树林.壳聚糖基温敏水凝胶的研究进展[J].中国生物工程杂志,2018,38(5):79-84.
[6] Chenite A,Chaput C,Wang D,et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ[J]. Biomaterials,2000,21(21):2155-2161.
[7] Huang C L,Chen Y B,Lo Y L,et al. Development of chitosan/beta-glycerophosphate/glycerol hydrogel as a thermosensitive coupling agent[J]. Carbohydr Polym,2016,147:409-414.
[8] Liu X,Chen Y,Huang Q,et al. A novel thermo-sensitive hydrogel based on thiolated chitosan/hydroxyapatite/betaglycerophosphate[J]. Carbohydrate Polymers,2014,110:62-69.
[9] Raymond M A,Désormeaux A,Laplante P,et al. Apoptosis of endothelial cells triggers a caspase-dependent antiapoptotic paracrine loop active on VSMC[J]. FASEB J,2004,18(6):705-707.
[10] Charbonneau C,Liberelle B,Hebert M J,et al. Stimulation of cell growth and resistance to apoptosis in vascular smooth muscle cells on a chondroitin sulfate/epidermal growth factor coating[J]. Biomaterials,2011,32(6):1591-1600.
[11] Taylor K R,Gallo R L. Glycosaminoglycans and their proteoglycans:host-associated molecular patterns for initiation and modulation of inflammation[J]. FASEB J,2006,20(1):9-22.
[12] Alinejad Y,Adoungotchodo A,Hui E,et al. An injectable chitosan/chondroitin sulfate hydrogel with tunable mechanical properties for cell therapy/tissue engineering[J]. Int J Biol Macromol,2018,113:132-141.
[13] Nguyen T H M,Abueva C,Ho H V,et al. In vitro and in vivo acute response towards injectable thermosensitive chitosan/TEMPO-oxidized cellulose nanofiber hydrogel[J].Carbohydr Polym,2018,180:246-255.
[14] Sun G,Zhang X,Bao Z,et al. Reinforcement of thermoplastic chitosan hydrogel using chitin whiskers optimized with response surface methodology[J]. Carbohydr Polym,2018,189:280-288.
[15] Xia G,Liu Y,Tian M,et al. Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds[J]. Journal of Materials Chemistry B,2017,5(17):3172-3185.
[16] Ngadaonye J I,Geever L M,McEvoy K E,et al. Evaluation of novel antibiotic-eluting thermoresponsive chitosanPDEAAm based wound dressings[J]. International Journal of Polymeric Materials and Polymeric Biomaterials,2014,63(17):873-883.
[17] Zhao Y,Liu J G,Chen W M,et al. Efficacy of thermosensitive chitosan/beta-glycerophosphate hydrogel loaded with beta-cyclodextrin-curcumin for the treatment of cutaneous wound infection in rats[J]. Exp Ther Med,2018,15(2):1304-1313.
[18] Wang T,Chen L,Shen T,et al. Preparation and properties of a novel thermo-sensitive hydrogel based on chitosan/hydroxypropyl methylcellulose/glycerol[J]. Int J Biol Macromol,2016,93(Pt A):775-782.
[19] Hu Y,Zhang Z,Li Y,et al. Dual-crosslinked amorphous polysaccharide hydrogels based on chitosan/alginate for wound healing applications[J]. Macromol Rapid Commun,2018,39(20):e1800069.
[20] Cheng N C,Lin W J,Ling T Y,et al. Sustained release of adipose-derived stem cells by thermosensitive chitosan/gelatin hydrogel for therapeutic angiogenesis[J]. Acta Biomater,2017,51:258-267.
[21] Chen S,Shi J,Zhang M,et al. Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing[J]. Sci Rep,2015(5):18104.
[22] Hastings C L,Kelly H M,Murphy M J,et al. Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia[J]. J Control Release,2012,161(1):73-80.
[23] Zhu C,Lei H,Fan D,et al. Novel enzymatic crosslinked hydrogels that mimic extracellular matrix for skin wound healing[J]. Journal of Materials Science,2018,53(8):5909-5928.
[24] Lin X,Takahashi K,Liu Y,et al. Enhancement of cell attachment and tissue integration by a IKVAV containing multi-domain peptide[J]. Biochimica Et Biophysica ActaGeneral Subjects,2006,1760(9):1403-1410.
[25] Chen S,Zhang M,Shao X,et al. A laminin mimetic peptide SIKVAV-conjugated chitosan hydrogel promoting wound healing by enhancing angiogenesis,re-epithelialization and collagen deposition[J]. Journal of Materials Chemistry B,2015,3(33):6798-6804.
[26] Chen X,Zhang M,Chen S,et al. Peptide-modified chitosan hydrogels accelerate skin wound healing by promoting fibroblast proliferation,migration,and secretion[J].Cell Transplantation,2017,26(8):1331-1340.
[27] Chen X,Cao X,Jiang H,et al. SIKVAV-modified chitosan hydrogel as a skin substitutes for wound closure in mice[J]. Molecules,2018,23(10):2611.
[28] Liu L,Wen H,Rao Z,et al. Preparation and characterization of chitosan-collagen peptide/oxidized konjac glucomannan hydrogel[J]. Int J Biol Macromol,2018,108:376-382.
[29] Xiao Y,Reis L A,Feric N,et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization[J]. Proceedings of the National Academy of Sciences of the United States of America,2016,113(40):E5792-E5801.
[30] Chen H,Xing X,Tan H,et al. Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing[J]. Mater Sci Eng C Mater Biol Appl,2017,70(Pt 1):287-295.
[31] Zhao X,Wu H,Guo B,et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing[J]. Biomaterials,2017,122:34-47.
[32] Noori S,Kokabi M,Hassan Z M. Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing[J]. Journal of Applied Polymer Science,2018,135(21):46311.
[33] Carpenter A W,Schoenfisch M H. Nitric oxide release:Part II. Therapeutic applications[J]. Chemical Society Reviews,2012,41(10):3742-3752.
[34] Pelegrino M,de Araujo Lima B,do Nascimento M,et al.Biocompatible and antibacterial nitric oxide-releasing pluronic F-127/chitosan hydrogel for topical applications[J]. Polymers,2018,10(4):452.
[35] Tsai C Y,Woung L C,Yen J C,et al. Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing[J]. Carbohydr Polym,2016,135:308-315.