白虎加人参汤治疗糖尿病(肺胃热盛)随机平行对照研究
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摘要
[目的]观察白虎加人参汤治疗糖尿病(肺胃热盛)疗效。[方法]使用随机平行对照方法,将80例门诊患者按随机数字表法随机分为两组。对照组40例二甲双胍,0.5g/次,2次/d,或0.85g/次,1次/d,根据病情调整剂量,最大不超过2.55g/d。治疗组40例白虎加参汤(生石膏75g,知母、玉竹各20g,人参、麦冬、生地黄各25g,花粉、粳米各15g,甘草10g),水煎400mL,1剂/d,早晚温服;二甲双胍治疗同对照组。连续治疗2个月为1疗程。观测临床表现、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血糖蛋白(HbA1C)、不良反应。治疗1疗程(2个月),判定疗效。[结果]治疗组显效28例,有效10例,无效2例,总有效率95.00%;对照组显效20例,有效11例,无效9例,总有效率77.50%;治疗组疗效优于对照组(P<0.05)。FPG、2hPG、HbA1C两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]白虎加人参汤治疗糖尿病(肺胃热盛),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Baihu Jiashen decoction on diabetes mellitus(Feiwei Resheng). [Method] 80 outpatients were randomly divided into two groups by random number table method.The control group consisted of 40 cases of metformin, 0.5 g/time, 2 times/day, or 0.85 g/time, 1 time/day. The dosage was adjusted according to the condition, and the maximum dosage was not more than 2550 mg/day.In the treatment group, 40 cases of Baihu Jiashen decoction(Shengshigao 75 g, Zhimu, Yuzhu each 20 g,Renshen, Maidong, Shengdihuang each 25 g, Tianhuafen, Jingmi each 15 g, Gancao 10 g) were decocted in water, 400 mL, 1 dose/d, warm in the morning and evening; metformin treatment was the same as the control group. Continuous treatment for 2 months is a course of treatment. Clinical manifestations, fasting blood glucose(FPG), postprandial blood glucose(2 hPG), glycated glycoprotein(HbA1 C) and adverse reactions were observed. One course of treatment(2 months) was used to determine the curative effect. [Result] 28 cases were markedly effective in the treatment group, 10 cases were effective, 2 cases were ineffective, and the total effective rate was 95.00%. 10 cases were markedly effective in the control group, 11 cases were effective, 9 cases were ineffective, the total effective rate was 77.50%. The curative effect of the treatment group was better than that of the control group(P<0.05). FPG, 2 hPG and HbA1 C were improved in both groups(P<0.01),and the improvement in treatment group was better than that in control group(P<0.01). [Conclusion] Baihu Jiashen decoction has satisfactory curative effect in treating diabetes mellitus(hyperthermia of lung and stomach), and has no serious adverse reactions. It is worth popularizing.
[Objective] To observe the curative effect of Baihu Jiashen decoction on diabetes mellitus(Feiwei Resheng). [Method] 80 outpatients were randomly divided into two groups by random number table method.The control group consisted of 40 cases of metformin, 0.5 g/time, 2 times/day, or 0.85 g/time, 1 time/day. The dosage was adjusted according to the condition, and the maximum dosage was not more than 2550 mg/day.In the treatment group, 40 cases of Baihu Jiashen decoction(Shengshigao 75 g, Zhimu, Yuzhu each 20 g,Renshen, Maidong, Shengdihuang each 25 g, Tianhuafen, Jingmi each 15 g, Gancao 10 g) were decocted in water, 400 mL, 1 dose/d, warm in the morning and evening; metformin treatment was the same as the control group. Continuous treatment for 2 months is a course of treatment. Clinical manifestations, fasting blood glucose(FPG), postprandial blood glucose(2 hPG), glycated glycoprotein(HbA1 C) and adverse reactions were observed. One course of treatment(2 months) was used to determine the curative effect. [Result] 28 cases were markedly effective in the treatment group, 10 cases were effective, 2 cases were ineffective, and the total effective rate was 95.00%. 10 cases were markedly effective in the control group, 11 cases were effective, 9 cases were ineffective, the total effective rate was 77.50%. The curative effect of the treatment group was better than that of the control group(P<0.05). FPG, 2 hPG and HbA1 C were improved in both groups(P<0.01),and the improvement in treatment group was better than that in control group(P<0.01). [Conclusion] Baihu Jiashen decoction has satisfactory curative effect in treating diabetes mellitus(hyperthermia of lung and stomach), and has no serious adverse reactions. It is worth popularizing.
引文
[1]张培毅,刘新民.糖尿病用药与饮食[M].沈阳:辽宁科学技术出版社,2010:25.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2018-02-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,30(8):893-942.
[4]中华中医药学会.糖尿病肾病中医防治指南[J].中国中医药现代远程教育,2011,9(4):151-153.
[5]国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:236.
[6]温国平,李丽华.糖尿病患者的社区护理[J].中国医药导报,2008,5(1):146.
[7]苗述楷,蔡惠文.糖尿病并发症防治学[M].2版.北京:中国医药科技出版社,2005:75-77.
[8]薛仕坤.药物联合饮食控制、运动疗法治疗社区糖尿病的临床价值及可行性研究[J].中国社区医师,2015(9):152.
[9]王茜.二甲双胍治疗2型糖尿病的临床疗效及药理分析[J].中国社区医师,2017,33(30):32-33.
[10]何银舟.二甲双胍的临床应用和评价[J].内蒙古中医药,2011,30(5):31-32.
[11]周翔海,纪立农.空腹血糖和糖化血红蛋白用于筛查糖尿病的研究[J].中国糖尿病杂志,2005,13(3):203-205.
[12]廖远泉,朱大武,王玲玲.空腹血糖及餐后2小时血糖测定诊断糖尿病临床价值的研究[J].国际检验医学杂志,2010,31(9):1021-1022.
[13]徐珂.空腹血糖、餐后2h血糖、糖化血红蛋白检测在糖尿病诊断中的临床价值分析[J].中国当代医药,2014,21(13):75-77.
[14]周仲瑛.中医内科学[M].北京:中国中医药出版社,2004:427.
[15]赵昱,周丽波,董柳,等.《黄帝内经》消渴相关病名考辨[J].中国中医基础医学杂志,2007,13(8):574-576.
[16]程国彭.医学心悟[M].天津:天津科学技术出版社,2011:95.
[17]张仲景.伤寒论[M].北京:人民卫生出版社,2012:29.
[18]高学敏.中药学[M].北京:中国中医药出版社,2007.
[19]姚杰良,吴素蓉,黎忠民.粳米药用刍议[J].内蒙古中医药,2008,27(17):85-86.
[20]祝建华,周霞玲.白虎加人参汤治疗糖尿病疗效观察[J].按摩与康复医学,2014,19(5):120-121.
[21]侯亚莉,张雨,林梅.白虎加人参汤对2型糖尿病患者氧化应激水平与胰岛素敏感性的影响[J].中药药理与临床,2017,33(5):194-196.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2018-02-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,30(8):893-942.
[4]中华中医药学会.糖尿病肾病中医防治指南[J].中国中医药现代远程教育,2011,9(4):151-153.
[5]国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:236.
[6]温国平,李丽华.糖尿病患者的社区护理[J].中国医药导报,2008,5(1):146.
[7]苗述楷,蔡惠文.糖尿病并发症防治学[M].2版.北京:中国医药科技出版社,2005:75-77.
[8]薛仕坤.药物联合饮食控制、运动疗法治疗社区糖尿病的临床价值及可行性研究[J].中国社区医师,2015(9):152.
[9]王茜.二甲双胍治疗2型糖尿病的临床疗效及药理分析[J].中国社区医师,2017,33(30):32-33.
[10]何银舟.二甲双胍的临床应用和评价[J].内蒙古中医药,2011,30(5):31-32.
[11]周翔海,纪立农.空腹血糖和糖化血红蛋白用于筛查糖尿病的研究[J].中国糖尿病杂志,2005,13(3):203-205.
[12]廖远泉,朱大武,王玲玲.空腹血糖及餐后2小时血糖测定诊断糖尿病临床价值的研究[J].国际检验医学杂志,2010,31(9):1021-1022.
[13]徐珂.空腹血糖、餐后2h血糖、糖化血红蛋白检测在糖尿病诊断中的临床价值分析[J].中国当代医药,2014,21(13):75-77.
[14]周仲瑛.中医内科学[M].北京:中国中医药出版社,2004:427.
[15]赵昱,周丽波,董柳,等.《黄帝内经》消渴相关病名考辨[J].中国中医基础医学杂志,2007,13(8):574-576.
[16]程国彭.医学心悟[M].天津:天津科学技术出版社,2011:95.
[17]张仲景.伤寒论[M].北京:人民卫生出版社,2012:29.
[18]高学敏.中药学[M].北京:中国中医药出版社,2007.
[19]姚杰良,吴素蓉,黎忠民.粳米药用刍议[J].内蒙古中医药,2008,27(17):85-86.
[20]祝建华,周霞玲.白虎加人参汤治疗糖尿病疗效观察[J].按摩与康复医学,2014,19(5):120-121.
[21]侯亚莉,张雨,林梅.白虎加人参汤对2型糖尿病患者氧化应激水平与胰岛素敏感性的影响[J].中药药理与临床,2017,33(5):194-196.