中胚层给药治疗雄激素性脱发的临床观察
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摘要
目的观察和分析中胚层给药技术治疗雄激素性脱发的临床疗效。方法将60例雄激素性脱发患者随机分为观察组(30例)和对照组(30例),其中观察组采用中胚层给药疗法,治疗7周;对照组外用米诺地尔酊。疗程结束时和3个月后随访收集观察数据,并进行统计学分析。结果治疗结束时,观察组有效率为73.3%,对照组有效率为76.7%,两组比较差异无统计学意义。观察组患者的油腻程度、瘙痒程度、鳞屑程度、脱发情况有所改善。治疗结束3个月后,观察组有效率为66.7%,对照组有效率为53.3%,观察组优于对照组。结论中胚层给药治疗雄激素性脱发疗效明显,具有良好的临床应用前景。
Objective To observe and analyze the clinical effect of mesoderm injection in the treatment of androgenic alopecia. Methods Sixty patients with androgenic alopecia were randomly divided into observation group(30 cases) and control group(30 cases). The observation group was treated with mesodermal injection for 7 weeks, while the control group was treated with minoxidil tincture. At the end of the course and 3 months later, the observation data were collected and analyzed statistically. Results At the end of treatment, the total effective rate was 73.3% in the observation group and 76.7% in the control group, and there was no significant difference between the two groups. In the observation group, the degree of greasy, pruritus, scales and hair loss were improved. Three months after the end of treatment, the total effective rate of the observation group and the control group was 66.7% and 53.3% respectively, and the observation group was superior to the control group. Conclusion Mesoderm administration is effective in the treatment of androgenic alopecia, which has good clinical application prospects.
Objective To observe and analyze the clinical effect of mesoderm injection in the treatment of androgenic alopecia. Methods Sixty patients with androgenic alopecia were randomly divided into observation group(30 cases) and control group(30 cases). The observation group was treated with mesodermal injection for 7 weeks, while the control group was treated with minoxidil tincture. At the end of the course and 3 months later, the observation data were collected and analyzed statistically. Results At the end of treatment, the total effective rate was 73.3% in the observation group and 76.7% in the control group, and there was no significant difference between the two groups. In the observation group, the degree of greasy, pruritus, scales and hair loss were improved. Three months after the end of treatment, the total effective rate of the observation group and the control group was 66.7% and 53.3% respectively, and the observation group was superior to the control group. Conclusion Mesoderm administration is effective in the treatment of androgenic alopecia, which has good clinical application prospects.
引文
[1]王端,徐巧瑜,雷霞,等.三种常见脱发性疾病与睡眠质量和情绪因素的相关性调查[J].实用皮肤病学杂志,2013,6(6):339-342.
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[10]El-Komy M,Hassan A,Tawdy A,et al.Hair loss at injection sites of mesotherapy for alopecia[J].J Cosmet Dermatol,2017,16(4):e28-e30.
[11]Orasan MS,Roman II,Coneac A,et al.Hair loss and regeneration performed on animal models[J].Clujul Med,2016,89(3):327-334.
[2]张建中.中国雄激素性秃发诊疗指南[J].临床皮肤科杂志,2014(3):182-186.
[3]国家药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:342-345.
[4]叶萌,辛李宁,程宝文,等.雄激素性脱发相关研究进展[J].国际遗传学杂志,2015,38(3):174-178.
[5]王任,袁婷,吴承艳,等.脱发的中西医病因机制研究进展[J].世界中西医结合杂志,2016,11(7):1028-1030.
[6]郭金竹,李邻峰.雄激素性秃发治疗进展[J].实用皮肤病学杂志,2012,5(6):347-350.
[7]Stachowski J,Botts K,Rine L,et al.Pollock J.Mesotherapy:cosmetic applications[J].Int J Pharm Compd,2006,10(5):331-334.
[8]Pyo HK,Yoo HG,Won CH,et al.The effect of tripeptide-copper complex on human hair growth in vitro[J].Arch Pharm Res,2007,30(7):834-839.
[9]Stamatiadis D,Bulteau-Portois MC,Mowszowicz I.Inhibition of 5alpha-reductase activity in human skin by zinc and azelaic acid[J].Br J Dermatol,1988,119(5):627-632.
[10]El-Komy M,Hassan A,Tawdy A,et al.Hair loss at injection sites of mesotherapy for alopecia[J].J Cosmet Dermatol,2017,16(4):e28-e30.
[11]Orasan MS,Roman II,Coneac A,et al.Hair loss and regeneration performed on animal models[J].Clujul Med,2016,89(3):327-334.