宫颈高危型人乳头瘤病毒持续性感染相关危险因素研究进展
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摘要
宫颈癌是一种复杂的多因素疾病,高危型人乳头瘤病毒(high risk Human papillomavirus,HR-HPV)持续性感染是导致宫颈癌的最主要原因。此外存在多种因素共同作用于HPV感染的发生与清除过程,影响宫颈病变的发生与发展。早期针对HR-HPV持续性感染相关危险因素进行预防,对降低宫颈癌的发病率具有重要意义。本文就宫颈HR-HPV持续性感染相关危险因素研究进展进行综述,以期对宫颈癌的防治进行指导。
Cervical cancer is a complex multifactorial disease. High risk human papillomavirus( HR-HPV) persistent infection is the most common cause of cervical cancer. In addition,a variety of factors play a role in the occurrence and elimination of HPV infection and affect Cervical lesions occurrence and development. Early prevention of risk factors related to HR-HPV persistent infection is of great significance in reducing the incidence of cervical cancer. This article reviews the research progress of risk factors related to the persistent HR-HPV infection in cervix,in order to guide the prevention and treatment of cervical cancer.
Cervical cancer is a complex multifactorial disease. High risk human papillomavirus( HR-HPV) persistent infection is the most common cause of cervical cancer. In addition,a variety of factors play a role in the occurrence and elimination of HPV infection and affect Cervical lesions occurrence and development. Early prevention of risk factors related to HR-HPV persistent infection is of great significance in reducing the incidence of cervical cancer. This article reviews the research progress of risk factors related to the persistent HR-HPV infection in cervix,in order to guide the prevention and treatment of cervical cancer.
引文
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[2] Bosch F X,Robles C,Díaz M,et al. HPV-FASTER:broadening the scope for prevention of HPV-related cancer[J]. Nat Rev Clin Oncol,2016,13(2):119-132.
[3] Forman D,De M C,Lacey C J,et al. Global burden of human papillomavirus and related diseases[J]. Vaccine,2012,30 Suppl 5:F12-23.
[4]陈娇梅,魏传珍.1 524例妇女HPV感染与宫颈病变相关性分析[J].赣南医学院学报,2015,35(3):439-440.
[5]罗仲秋,冷平,刘祥琴,等.成都地区妇女HPV感染的流行病学特征及与宫颈病变的关系[J].国际生殖健康/计划生育杂志,2018(1):49-53.
[6] Wang R,Guo X L,Wisman G B,et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China[J]. Bmc Infec Dis,2015,15(1):257.
[7]胥莎莎,何鑫,刘英俏,等.高危型人乳头瘤病毒感染患者病毒清除及持续感染的随访性研究[J].首都医科大学学报,2015,36(2):212-218.
[8] Houlihan C F,Baisley K,Bravo I G,et al. Rapid acquisition of HPV around the time of sexual debut in adolescent girls in Tanzania[J]. Int J Epidemiol,2016,45(3):762-773.
[9] Lopezdiez E,Perez S,Carballo M,et al. Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population[J]. Plos One,2017,12(9):e0184492.
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[11] Aung E T,Fairley C K,Tabrizi S N,et al. Detection of human papillomavirus in urine among heterosexual men in relation to location of genital warts and circumcision status[J]. Sex Transm Infect,2018,94(3):222-225.
[12] Manga M M,Fowotade A,Abdullahi Y M,et al. Epidemiological patterns of cervical human papillomavirus infection among women presenting for cervical cancer screening in North-Eastern Nigeria[J]. Infect Agent Cancer,2015,10(1):39.
[13] Jensen K E,Schmiedel S,Norrild B,et al. Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection:a 13-year follow-up[J]. Br J Cancer,2013,108(1):234-239.
[14]彭雪,胡丽娜. HPV感染及危险因素的研究[J].实用妇产科杂志,2010,26(3):168-170.
[15] Volpato L K,Siqueira I R,Nunes R D,et al. Association between Hormonal Contraception and Injuries Induced by Human Papillomavirus in the Uterine Cervix[J]. Rev Bras Ginecol Obstet,2018,40(4):196-202.
[16] Marks M,Gravitt P E,Gupta S B,et al. Combined Oral Contraceptive Use Increases HPV Persistence but Not New HPV Detection in a Cohort of Women From Thailand[J]. J Infect Dis,2011,204(10):1505-13.
[17] Roura E,Noémie Travier,Waterboer T,et al. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer:Results from the EPIC Cohort[J]. Plos One,2016,11(1):e0147029.
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[19] Lekovich J P,Amrane S,Pangasa M,et al. Comparison of human papillomavirus infection and cervical cytology in women using copper-containing and levonorgestrel-containing intrauterine devices[J]. Obstet Gynecol,2015,125(5):1101-1105.
[20] Roura E,Travier N,Waterboer T,et al. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer:Results from the EPIC Cohort[J]. Plos One,2016,11(1):e0147029.
[21] Winer R L,Hughes J P,Feng Q,et al. Condom use and the risk of genital human papillomavirus infection in young women[J]. N Engl J Med,2006,354(25):2645.
[22] Hogewoning CJ,Bleeker MC,van den Brule AJ,et al.Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus:a randomized clinical trial[J]. Int J Cancer,2003,107(5):811-6.
[23] Pierce Campbell C M,Lin H Y,Fulp W,et al. Consistent condom use reduces the genital human papillomavirus burden among high-risk men:the HPV infection in men study[J]. J Infect Dis,2013,208(3):373-384.
[24] Blakely T,Barendregt J J,Foster R H,et al. The association of active smoking with multiple cancers:national census-cancer registry cohorts with quantitative bias analysis[J]. Cancer Causes Control,2013,24(6):1243-1255.
[25] Tarney CM,Beltran TA,Klaric J,et al. Tobacco Use and Prevalence of Human Papillomavirus in Self-Collected Cervicovaginal Swabs Between 2009 and 2014[J]. Obstet Gynecol,2018,132(1):45-51.
[26] Feng R M,Hu S Y,Zhao F H,et al. Role of active and passive smoking in high-risk human papillomavirus infection and cervical intraepithelial neoplasia grade 2 or worse[J]. J Gynecol Oncol,2017,28(5):e47.
[27] Massad L S,Xie X,Burk R,et al. Long-term cumulative detection of human papillomavirus among HIV seropositive women[J]. AIDS,2014,28(17):2601-8.
[28] Looker K J,Rnn M M,Brock P M,et al. Evidence of synergistic relationships between HIV and Human Papillomavirus(HPV):systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status,and of HIV acquisition by HPV status[J]. J Int Aids Society,2018,21(6):e25110.
[29] de Abreu A L,Malaguti N,Souza R P,et al. Association of human papillomavirus,Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of highgrade squamous intraepithelial cervical lesion[J]. Am J Cancer Res,2016,6(6):1371-1383.
[30] Panatto D,Amicizia D,Bianchi S,et al. Chlamydia trachomatis prevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology[J]. Hum Vaccin Immunother,2015,11(1):270-6.
[31]谈红英,马建婷.阴道微生态变化与宫颈人乳头瘤病毒感染的相关性研究进展[J].中华生殖与避孕杂志,2017,37(5):418-422.
[32] Tamarelle J,Thiébaut A,De B B,et al. The vaginal microbiota and its association with Human Papillomavirus,Chlamydia trachomatis, Neisseria gonorrhea and Mycoplasma genitalium infections:a systematic review and meta-analysis[J]. Clin Microbiol Infect,2019,25(1):35-47.
[33] Mitra A,Macintyre D A,Marchesi J R,et al. The vaginal microbiota,human papillomavirus infection and cervical intraepithelial neoplasia:what do we know and where are we going next?[J]. Microbiome,2016,4(1):58.
[34] Gao W,Weng J,Gao Y,et al. Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection:a cross-sectional study[J]. Bmc Infect Dis,2013,13(1):271-271.
[35] Huang X,Li C,Li F,et al. Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types[J]. Int J Cancer,2018,143(3):621-634.
[36] Shannon B,Yi T J,Perusini S,et al. Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota[J]. Mucosal Immunol,2017,10(5):1310-1319.
[37] Chen D,Cui T,Ek W E,et al. Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability[J]. Carcinogenesis,2015,36(9):992-998.
[38] Leo P J,Madeleine M M,Wang S,et al. Defining the genetic susceptibility to cervical neoplasia:A genome-wide association study[J]. Plos Genet,2017,13(8):e1006866.
[39] Safaeian M,Johnson L G,Yu K,et al. Human Leukocyte Antigen ClassⅠandⅡAlleles and Cervical Adenocarcinoma[J]. Front Oncol,2014,4:119.
[40] Wu Y,Liu B,Lin W,et al. Human leukocyte antigen classⅡalleles and risk of cervical cancer in China[J].Hum Immunol,2007,68(3):192-200.
[41]曹蓉蓉,刘云春.宫颈癌遗传易感性的研究进展[J].生命科学仪器,2017(6):24-30.
[42] Habbous S,Pang V,Eng L,et al. p53 Arg72Pro polymorphism,HPV status and initiation,progression,and development of cervical cancer:a systematic review and meta-analysis[J]. Clin Cancer Res,2012,18(23):6407-6415.
[43] De S J,Imahorn E,Itin P,et al. Epidermodysplasia Verruciformis:Inborn Errors of Immunity to Human BetaPapillomaviruses[J]. Front Microbiol,2018,9:1222.
[44] Mcdermott D H,Gao J L,Murphy P M. Chromothriptic cure of WHIM syndrome[J]. Cell,2015,3(1):686-699.
[2] Bosch F X,Robles C,Díaz M,et al. HPV-FASTER:broadening the scope for prevention of HPV-related cancer[J]. Nat Rev Clin Oncol,2016,13(2):119-132.
[3] Forman D,De M C,Lacey C J,et al. Global burden of human papillomavirus and related diseases[J]. Vaccine,2012,30 Suppl 5:F12-23.
[4]陈娇梅,魏传珍.1 524例妇女HPV感染与宫颈病变相关性分析[J].赣南医学院学报,2015,35(3):439-440.
[5]罗仲秋,冷平,刘祥琴,等.成都地区妇女HPV感染的流行病学特征及与宫颈病变的关系[J].国际生殖健康/计划生育杂志,2018(1):49-53.
[6] Wang R,Guo X L,Wisman G B,et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China[J]. Bmc Infec Dis,2015,15(1):257.
[7]胥莎莎,何鑫,刘英俏,等.高危型人乳头瘤病毒感染患者病毒清除及持续感染的随访性研究[J].首都医科大学学报,2015,36(2):212-218.
[8] Houlihan C F,Baisley K,Bravo I G,et al. Rapid acquisition of HPV around the time of sexual debut in adolescent girls in Tanzania[J]. Int J Epidemiol,2016,45(3):762-773.
[9] Lopezdiez E,Perez S,Carballo M,et al. Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population[J]. Plos One,2017,12(9):e0184492.
[10] Spiess P E,Dhillon J,Baumgarten A S,et al. Pathophysiological basis of human papillomavirus in penile cancer:Key to prevention and delivery of more effective therapies[J]. Ca A Cancer Journal for Clinicians,2016,66(6):481-495.
[11] Aung E T,Fairley C K,Tabrizi S N,et al. Detection of human papillomavirus in urine among heterosexual men in relation to location of genital warts and circumcision status[J]. Sex Transm Infect,2018,94(3):222-225.
[12] Manga M M,Fowotade A,Abdullahi Y M,et al. Epidemiological patterns of cervical human papillomavirus infection among women presenting for cervical cancer screening in North-Eastern Nigeria[J]. Infect Agent Cancer,2015,10(1):39.
[13] Jensen K E,Schmiedel S,Norrild B,et al. Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection:a 13-year follow-up[J]. Br J Cancer,2013,108(1):234-239.
[14]彭雪,胡丽娜. HPV感染及危险因素的研究[J].实用妇产科杂志,2010,26(3):168-170.
[15] Volpato L K,Siqueira I R,Nunes R D,et al. Association between Hormonal Contraception and Injuries Induced by Human Papillomavirus in the Uterine Cervix[J]. Rev Bras Ginecol Obstet,2018,40(4):196-202.
[16] Marks M,Gravitt P E,Gupta S B,et al. Combined Oral Contraceptive Use Increases HPV Persistence but Not New HPV Detection in a Cohort of Women From Thailand[J]. J Infect Dis,2011,204(10):1505-13.
[17] Roura E,Noémie Travier,Waterboer T,et al. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer:Results from the EPIC Cohort[J]. Plos One,2016,11(1):e0147029.
[18] CastellsaguéX,Díaz M,Vaccarella S,et al. Intrauterine device use,cervical infection with human papillomavirus,and risk of cervical cancer:a pooled analysis of26 epidemiological studies[J]. Lancet Oncology,2011,12(11):1023-1031.
[19] Lekovich J P,Amrane S,Pangasa M,et al. Comparison of human papillomavirus infection and cervical cytology in women using copper-containing and levonorgestrel-containing intrauterine devices[J]. Obstet Gynecol,2015,125(5):1101-1105.
[20] Roura E,Travier N,Waterboer T,et al. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer:Results from the EPIC Cohort[J]. Plos One,2016,11(1):e0147029.
[21] Winer R L,Hughes J P,Feng Q,et al. Condom use and the risk of genital human papillomavirus infection in young women[J]. N Engl J Med,2006,354(25):2645.
[22] Hogewoning CJ,Bleeker MC,van den Brule AJ,et al.Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus:a randomized clinical trial[J]. Int J Cancer,2003,107(5):811-6.
[23] Pierce Campbell C M,Lin H Y,Fulp W,et al. Consistent condom use reduces the genital human papillomavirus burden among high-risk men:the HPV infection in men study[J]. J Infect Dis,2013,208(3):373-384.
[24] Blakely T,Barendregt J J,Foster R H,et al. The association of active smoking with multiple cancers:national census-cancer registry cohorts with quantitative bias analysis[J]. Cancer Causes Control,2013,24(6):1243-1255.
[25] Tarney CM,Beltran TA,Klaric J,et al. Tobacco Use and Prevalence of Human Papillomavirus in Self-Collected Cervicovaginal Swabs Between 2009 and 2014[J]. Obstet Gynecol,2018,132(1):45-51.
[26] Feng R M,Hu S Y,Zhao F H,et al. Role of active and passive smoking in high-risk human papillomavirus infection and cervical intraepithelial neoplasia grade 2 or worse[J]. J Gynecol Oncol,2017,28(5):e47.
[27] Massad L S,Xie X,Burk R,et al. Long-term cumulative detection of human papillomavirus among HIV seropositive women[J]. AIDS,2014,28(17):2601-8.
[28] Looker K J,Rnn M M,Brock P M,et al. Evidence of synergistic relationships between HIV and Human Papillomavirus(HPV):systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status,and of HIV acquisition by HPV status[J]. J Int Aids Society,2018,21(6):e25110.
[29] de Abreu A L,Malaguti N,Souza R P,et al. Association of human papillomavirus,Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of highgrade squamous intraepithelial cervical lesion[J]. Am J Cancer Res,2016,6(6):1371-1383.
[30] Panatto D,Amicizia D,Bianchi S,et al. Chlamydia trachomatis prevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology[J]. Hum Vaccin Immunother,2015,11(1):270-6.
[31]谈红英,马建婷.阴道微生态变化与宫颈人乳头瘤病毒感染的相关性研究进展[J].中华生殖与避孕杂志,2017,37(5):418-422.
[32] Tamarelle J,Thiébaut A,De B B,et al. The vaginal microbiota and its association with Human Papillomavirus,Chlamydia trachomatis, Neisseria gonorrhea and Mycoplasma genitalium infections:a systematic review and meta-analysis[J]. Clin Microbiol Infect,2019,25(1):35-47.
[33] Mitra A,Macintyre D A,Marchesi J R,et al. The vaginal microbiota,human papillomavirus infection and cervical intraepithelial neoplasia:what do we know and where are we going next?[J]. Microbiome,2016,4(1):58.
[34] Gao W,Weng J,Gao Y,et al. Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection:a cross-sectional study[J]. Bmc Infect Dis,2013,13(1):271-271.
[35] Huang X,Li C,Li F,et al. Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types[J]. Int J Cancer,2018,143(3):621-634.
[36] Shannon B,Yi T J,Perusini S,et al. Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota[J]. Mucosal Immunol,2017,10(5):1310-1319.
[37] Chen D,Cui T,Ek W E,et al. Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability[J]. Carcinogenesis,2015,36(9):992-998.
[38] Leo P J,Madeleine M M,Wang S,et al. Defining the genetic susceptibility to cervical neoplasia:A genome-wide association study[J]. Plos Genet,2017,13(8):e1006866.
[39] Safaeian M,Johnson L G,Yu K,et al. Human Leukocyte Antigen ClassⅠandⅡAlleles and Cervical Adenocarcinoma[J]. Front Oncol,2014,4:119.
[40] Wu Y,Liu B,Lin W,et al. Human leukocyte antigen classⅡalleles and risk of cervical cancer in China[J].Hum Immunol,2007,68(3):192-200.
[41]曹蓉蓉,刘云春.宫颈癌遗传易感性的研究进展[J].生命科学仪器,2017(6):24-30.
[42] Habbous S,Pang V,Eng L,et al. p53 Arg72Pro polymorphism,HPV status and initiation,progression,and development of cervical cancer:a systematic review and meta-analysis[J]. Clin Cancer Res,2012,18(23):6407-6415.
[43] De S J,Imahorn E,Itin P,et al. Epidermodysplasia Verruciformis:Inborn Errors of Immunity to Human BetaPapillomaviruses[J]. Front Microbiol,2018,9:1222.
[44] Mcdermott D H,Gao J L,Murphy P M. Chromothriptic cure of WHIM syndrome[J]. Cell,2015,3(1):686-699.