调控毛囊发育的Wnt信号通路研究进展
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摘要
毛囊周期性发育过程受多种分子及信号通路调控,Wnt信号通路就是其中之一。Wnt信号通路调控动物发育过程中的多个重要环节,包括细胞增殖、细胞迁移及细胞分化等,且在毛囊发育过程中发挥着重要的调控作用,这对动物毛皮质量的提高、人皮肤损伤的治疗及日益严重的脱发问题等提供更多的研究思路和实际应用价值。近年来,Wnt信号通路已成为信号通路研究中的热点之一。因此,论文就Wnt信号通路、毛囊发育及Wnt信号通路对毛囊发育的调控作用进行了综述,为广大科研人员的后续研究提供参考。
Follicle development process is regulated periodically by a variety of molecules and the signaling pathways,Wnt signaling pathway is one of them.Wnt signaling pathway regulates many important aspects of animal development,including cell proliferation,cell migration and cell differentiation,etc.,and plays an important regulatory role in the development of hair follicles,which would provide more research ideas and practical application value for improving the quality of animal skins,treating the damage of human skin and solving increasingly serious hair loss problems.Therefore,in recent years,Wnt signaling pathway has been one of the hot spots in the study of signaling pathways.Therefore,this article reviewed Wnt signaling pathways,the development of hair follicles,and the regulation of Wnt signaling pathways on the development of hair follicles,so as to provide a theoretical basis for the follow-up research of researchers.
Follicle development process is regulated periodically by a variety of molecules and the signaling pathways,Wnt signaling pathway is one of them.Wnt signaling pathway regulates many important aspects of animal development,including cell proliferation,cell migration and cell differentiation,etc.,and plays an important regulatory role in the development of hair follicles,which would provide more research ideas and practical application value for improving the quality of animal skins,treating the damage of human skin and solving increasingly serious hair loss problems.Therefore,in recent years,Wnt signaling pathway has been one of the hot spots in the study of signaling pathways.Therefore,this article reviewed Wnt signaling pathways,the development of hair follicles,and the regulation of Wnt signaling pathways on the development of hair follicles,so as to provide a theoretical basis for the follow-up research of researchers.
引文
[1]Kim Y E,Choi H C,Lee I C,et al.3-Deoxysappanchalcone promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 Mice by modulating Wnt/β-catenin and STAT signaling[J].Biomol Ther(Seoul),2016,24(6):572-580.
[2]张桂山.辽宁绒山羊与乾华肉用美利奴羊皮肤毛囊miRNA筛选及靶基因验证[D].吉林长春:吉林农业大学,2016.
[3]Grainger S,Willert K.Mechanisms of wnt signaling and control[J].Wiley Interdiscip Rev Syst Biol Med,2018:e1422.
[4]Foulquier S,Daskalopoulos E P,Lluri G,et al.Wnt signaling in cardiac and vascular disease[J].Pharmacol Rev,2018,70(1):68-141.
[5]Yi R.Concise review:Mechanisms of quiescent hair follicle stem cell regulation[J].Stem Cells,2017,35(12):2323-2330.
[6]程晓印.Wnt10b基因在乾华肉用美利奴羊毛囊发育周期中表达规律的研究[D].吉林长春:吉林农业大学,2017.
[7]Zhou L,Yang K,Xu M,et al.Activatingβ-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity[J].FEBS J,2016,283(15):2823-2835.
[8]Yu N,Song Z,Zhang K,et al.MAD2Bacts as a negative regulatory partner of TCF4on proliferation in human dermal papilla cells[J].Sci Rep,2017,15;7(1):11687.
[9]Tsai S Y,Sennett R,Rezza A,et al.Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation[J].Dev Biol,2014,385(2):179-188.
[10]Lin C M,Yuan Y P,Chen X C,et al.Expression of Wnt/β-catenin signaling,stem-cell markers and proliferating cell markers in rat whisker hair follicles[J].J Mol Histol,2015,46(3):233-240.
[11]Kim D,Garza L A.The negative regulator CXXC5:making wnt look a little less dishevelled[J].J Invest Dermatol,2017,137(11):2248-2250.
[12]Qiu W,Lei M,Zhou L,et al.Hair follicle stem proliferation,Akt and Wnt signaling activation in TPA-induced hair regeneration[J].Histochem Cell Biol,2017,147(6):749-758.
[13]Liu B,Chen X,Yi H,et al.β-catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an vitro culture mode[J].Fitoterapia,2017,121:136-140.
[14]Leirós G J,Ceruti J M,Castellanos M L,et al.Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia[J].Mol Cell Endocrinol,2017,439:26-34.
[15]张铁佳,吴静,王岩,等.Wnt10b的生理功能及其在绒毛生长中的作用[J].畜牧与兽医,2016,48(7):115-118.
[16]Zhang Y,Xing Y,Guo H,et al.Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced Wnt10b[J].Int J Med Sci,2016,13(10):765-771.
[17]Zhang T,Liu L,Fan J,et al.Low-level laser treatment stimulates hair growth via upregulating Wnt10bandβ-catenin expression in C3H/HeJ mice[J].Lasers Med Sci,2017,32(5):1189-1195.
[18]Zhou Y,Kipps T J,Zhang S.Wnt5asignaling in normal and cancer stem cells[J].Stem Cells Int,2017,5295286.doi:10.1155/2017/5295286.
[19]He L,Lei M,Xing Y,et al.Gsdma3regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway[J].Oncotarget,2017,59(8):100269-100279.
[20]李瑶.Wnt5a和FGF4基因对鹅毛囊及羽毛发育影响的研究[D].吉林长春:吉林农业大学,2014.
[21]Xing Y,Ma X,Guo H,et al.Wnt5asuppressesβ-catenin signaling during hair follicle regeneration[J].Int J Med Sci,2016,13(8):603-610.
[22]Guo H,Yang K,Deng F,et al.Wnt3apromotes melanin synthesis of mouse hair follicle melanocytes[J].Biochem Biophys Res Commun,2012,420(4):799-804.
[23]Carre A L,Hu M S,James A W,et al.β-catenin-dependent Wnt signaling:A pathway in acute cutaneous wounding[J].Plast Reconstr Surg,2018,141(3):669-678.
[24]Nguyen H,Rendl M,Fuchs E.Tcf3governs stem cell features and represses cell fate determination in skin[J].Cell,2006,127:171-183.
[25]Ito M,Yang Z,Andl T,et al.Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding[J].Nature,2007,447(7142):316-320.
[26]Howard J M,Nuguid J M,Ngole D.Tcf3expression marks both stem and progenitor cells in multiple epithelia[J].Development,2014,141(16):3143-3152.
[27]向萌娟.Wnt信号通路介导的基因调控毛囊干细胞定向分化的研究[D].广州医学院,2012.
[28]Brunner M A T,Jagannathan V,Waluk D P,et al.Novel insights into the pathways regulating the canine cycle and their deregulation in alopecia X[J].PLoS One,2017,12(10):e0186469.
[2]张桂山.辽宁绒山羊与乾华肉用美利奴羊皮肤毛囊miRNA筛选及靶基因验证[D].吉林长春:吉林农业大学,2016.
[3]Grainger S,Willert K.Mechanisms of wnt signaling and control[J].Wiley Interdiscip Rev Syst Biol Med,2018:e1422.
[4]Foulquier S,Daskalopoulos E P,Lluri G,et al.Wnt signaling in cardiac and vascular disease[J].Pharmacol Rev,2018,70(1):68-141.
[5]Yi R.Concise review:Mechanisms of quiescent hair follicle stem cell regulation[J].Stem Cells,2017,35(12):2323-2330.
[6]程晓印.Wnt10b基因在乾华肉用美利奴羊毛囊发育周期中表达规律的研究[D].吉林长春:吉林农业大学,2017.
[7]Zhou L,Yang K,Xu M,et al.Activatingβ-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity[J].FEBS J,2016,283(15):2823-2835.
[8]Yu N,Song Z,Zhang K,et al.MAD2Bacts as a negative regulatory partner of TCF4on proliferation in human dermal papilla cells[J].Sci Rep,2017,15;7(1):11687.
[9]Tsai S Y,Sennett R,Rezza A,et al.Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation[J].Dev Biol,2014,385(2):179-188.
[10]Lin C M,Yuan Y P,Chen X C,et al.Expression of Wnt/β-catenin signaling,stem-cell markers and proliferating cell markers in rat whisker hair follicles[J].J Mol Histol,2015,46(3):233-240.
[11]Kim D,Garza L A.The negative regulator CXXC5:making wnt look a little less dishevelled[J].J Invest Dermatol,2017,137(11):2248-2250.
[12]Qiu W,Lei M,Zhou L,et al.Hair follicle stem proliferation,Akt and Wnt signaling activation in TPA-induced hair regeneration[J].Histochem Cell Biol,2017,147(6):749-758.
[13]Liu B,Chen X,Yi H,et al.β-catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an vitro culture mode[J].Fitoterapia,2017,121:136-140.
[14]Leirós G J,Ceruti J M,Castellanos M L,et al.Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia[J].Mol Cell Endocrinol,2017,439:26-34.
[15]张铁佳,吴静,王岩,等.Wnt10b的生理功能及其在绒毛生长中的作用[J].畜牧与兽医,2016,48(7):115-118.
[16]Zhang Y,Xing Y,Guo H,et al.Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced Wnt10b[J].Int J Med Sci,2016,13(10):765-771.
[17]Zhang T,Liu L,Fan J,et al.Low-level laser treatment stimulates hair growth via upregulating Wnt10bandβ-catenin expression in C3H/HeJ mice[J].Lasers Med Sci,2017,32(5):1189-1195.
[18]Zhou Y,Kipps T J,Zhang S.Wnt5asignaling in normal and cancer stem cells[J].Stem Cells Int,2017,5295286.doi:10.1155/2017/5295286.
[19]He L,Lei M,Xing Y,et al.Gsdma3regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway[J].Oncotarget,2017,59(8):100269-100279.
[20]李瑶.Wnt5a和FGF4基因对鹅毛囊及羽毛发育影响的研究[D].吉林长春:吉林农业大学,2014.
[21]Xing Y,Ma X,Guo H,et al.Wnt5asuppressesβ-catenin signaling during hair follicle regeneration[J].Int J Med Sci,2016,13(8):603-610.
[22]Guo H,Yang K,Deng F,et al.Wnt3apromotes melanin synthesis of mouse hair follicle melanocytes[J].Biochem Biophys Res Commun,2012,420(4):799-804.
[23]Carre A L,Hu M S,James A W,et al.β-catenin-dependent Wnt signaling:A pathway in acute cutaneous wounding[J].Plast Reconstr Surg,2018,141(3):669-678.
[24]Nguyen H,Rendl M,Fuchs E.Tcf3governs stem cell features and represses cell fate determination in skin[J].Cell,2006,127:171-183.
[25]Ito M,Yang Z,Andl T,et al.Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding[J].Nature,2007,447(7142):316-320.
[26]Howard J M,Nuguid J M,Ngole D.Tcf3expression marks both stem and progenitor cells in multiple epithelia[J].Development,2014,141(16):3143-3152.
[27]向萌娟.Wnt信号通路介导的基因调控毛囊干细胞定向分化的研究[D].广州医学院,2012.
[28]Brunner M A T,Jagannathan V,Waluk D P,et al.Novel insights into the pathways regulating the canine cycle and their deregulation in alopecia X[J].PLoS One,2017,12(10):e0186469.