我国常见海洋神经毒素的毒性脱除消减方法研究进展
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摘要
旨在探讨我国常见的海洋生物神经毒素的脱除方法,有效提高海洋水产品食用的安全性。本文从物理、化学和生物这三大方法综述海洋生物中含有的神经毒素在水产品中的脱除方法及消减率研究进展;分别对温度处理,暂养脱毒,臭氧、氯气、微生物降解,酶解转化等的研究成果进行了分析与总结,以期为海洋神经毒素毒性的脱除及消减研究提供参考。
In order to explore the removal of marine neurotoxin in our country and improve the safety of marine aquatic food consumption,it was reviewed the research progress of removal methods and abatement rates of neurotoxins contained in marine organisms in aquatic products from the three major methods of physics,chemistry and biology.The methods of temperature treatment,detoxification,ozone,chlorine,microbial degradation,solution and transformation of the research results were analyzed and summarized,to provide reference for the study of marine neurotoxin toxicity removal and reduction.
In order to explore the removal of marine neurotoxin in our country and improve the safety of marine aquatic food consumption,it was reviewed the research progress of removal methods and abatement rates of neurotoxins contained in marine organisms in aquatic products from the three major methods of physics,chemistry and biology.The methods of temperature treatment,detoxification,ozone,chlorine,microbial degradation,solution and transformation of the research results were analyzed and summarized,to provide reference for the study of marine neurotoxin toxicity removal and reduction.
引文
[1]陈曦,陈秀霞,陈强,等.海洋生物活性物质研究简述[J].福建农林科技,2012(2):83-85.
[2]炳辉,高炳淼,于海鹏,等.海洋生物毒素研究新进展[J].海南大学学报,2011(1):78-88.
[3]Kvitek R G,Degange A R,Beitler M K.Paralytic shellfish poisoning toxins mediate feeding behavior of sea otters[J]1991,33:393-404.
[4]Romana R B,Ivana U.PSP toxins profile in ascidian Microcosmus vulgaris(Heller,187)after human poisoning in Croatia(Adriatic Sea)[J].Toxicon,2014,79(2):28-36.
[5]李美慧,李爱峰,曹际娟,等.我国常见的几种脂溶性贝毒的研究进展[J]生命科学,2016,28(1):33-43.
[6]Per A,Tore A,Daniel G B.et al.Report of the joint FAO/WHO/IOC ad hoc expert consultation on biotoxins in bicalve molluscs[R].Norway,2004.
[7]Jan Alwxander,Diane Benford,Alan Boobis,et al.Marine biotoxins in shellfish-Summary on regulated marine biotoxins scientific opinion of the Panel on contaminants in the food China[J].EFSA,2009,1306(8):1-23.
[8]Etheride S M.Paralytic shellfish poisoning:Seafood safety and human health perspectives[J].Toxicon,2010,56(2):108-122.
[9]Hungerford J M,Wekell M M.Algal toxin in seafood and drinking water:Control measures in shellfish and finfish industries in the USA[M].New York:Academic press,1993:117-128.
[10]Kao C Y.Algal Toxin in Seafood and Drinking Water:Paralytic shellfish poisoning[M].New York:Academic Press,1993:75-86.
[11]Gessner B D,Moddaugh J P.Paralytic Shellfish Poisoning in Alaska:A 20-year retrospective analysis[J].Am J Epidemiol1995,141(4):766-770.
[12]Cesar Mattei,Christian Legros.The voltage-gated sodium channel:A major target of marine Neurotoxins[J].Toxicon,2014,91:84-95.
[13]Noguchi T,Jeon J-K,Arakawa O,et al.Occurrence of tetrodotoxin and anhydrote-trodotoxin in Vibrio sp.isolated from the intestines of a xanthid crab,Atergatis floridus[J].J Biochem,1986,99:311-314.
[14]Sheumack D D,Howden M E,Spence I,et al.Maculotoxin:a neurotoxin from the venom glands of the octopus Hapalochlaena maculosa identied as tetrodotoxin[J].Science,1978,199:188-189.
[15]Yasumoto,T,Yasumura,D,Yotsu,M,et al.Bacterial production of tetrodotoxin and anhydro tetrodotoxin[J].Agrice Biol Chem,1978,50:793-795.
[16]Do HK,Kogure K,Imada C,et al.Tetrodotoxin production of actinomycetes isolated from marine sediment[J].Journal of Applied Microbiology,1991,70(6):464-468.
[17]岳田芳.海藻希瓦氏菌发酵产生河豚毒素的提取与检测[D].青岛:中国海洋大学,2008.
[18]Daly J W,Gusovsky F,Myers CW,et al.First occurrence of tetrodotoxin in a dendrobatid frog(Colos-tethus inguinalis),with further reports for the bufonid genus Atelopus[J].Toxicon,1994,32:279-285.
[19]Cesar M,Christian L.The voltage-gated sodium channel:Amajor target of marineneurotoxins[J].Toxicon,2014,84:85-94.
[20]Reboreda A,Lago J,Chapela M J,et al.Decrease of marine toxin content in bivalves by industrial processes[J].Toxicon,2014,55(2):235-243.
[21]Jing Liu,Fen Wei,Ying Lu,et al.Production level of tetrodotoxin in Aeromonas is associated with the copy number of a plasmid[J].toxicon,2015,101:27-34.
[22]Medcof J C,Leim A H,Needler A B,et al.Paralytic shellfish poisoning on the Canadian Atlantic coast[J].Bull Fish,1947,75:1-32.
[23]Moore R E,Scheuer P J.Palytoxin:a new marine toxin from a coelenterate[J].Science,1971,172:495-498.
[24]Ciminiello P,Aversano C,Fattorusso E,et al.Putative palytoxin and its new analogue,ovatoxin-a,in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak.[J]Mass Spectrom,2008,19,111-120.
[25]EFSA(European Food Safety Authority).Scientific opinion on marine bio-toxins in shell fish palytoxin group[J].EFSA J2009,7:1-38.
[26]Dai QY.Conus snail species in China[M]//Liang SP,Zhang Y.Animal Peptide Toxins of China.Beijing:Science Press,2016:385-390.
[27]Aligizaki K,Katikou P,Milandri A,et al.Occurrence of palytoxin group toxins in seafood and future strategies to complement the present state of the art[J],Toxicon.2011,57,390-399.
[28]戴秋云.芋螺毒素的毒理学和药理学研究[J].中国药理学与毒理学杂志,2016,30(12):1397-1404.
[29]Reboreda A,Lago J,Chapela M J,et al.Decrease of marine toxin content in bivalves by industrial processes[J].Toxicon,2010,55(2):235-243.
[30]毛丹卉,解万翠,杨锡红,等.贝类中PSP毒素的脱出方法研究进展[J]食品工业科技,2015,36(4):391-396.
[31]王广和,华元渝,朱永祥,等.暗纹东方去毒技术研究[J].动物医学防治,2004,20(11):662-664.
[32]Bricelj V M,Shumway S E.Paralytic shellfish toxins in bivalve molluscs:occurrence,transfer kinetics,and Biotrans formation[J].Reviews in Fisheries Science,1998,6(4):315-383.
[33]位正鹏,步营,于玲,等.电离辐射对腹泻性贝毒和麻痹性贝毒降解的研究[J].水产科技情报,2010,37(3):139-143.
[34]Jiangbing Qiu,Hua Fan,Ting Liu,et al.Application of activated carbon to accelerate detoxification of paralytic shell fish toxins from mussels Mytilus galloprovincialis and scallops Chlamys farreri.[J].Ecotoxicology and Environmental Safety,2018(148):402-409.
[35]Ali Fakhri,Mahsa Naji.Degradation photocatalysis of tetrodotoxin as a poison by gold doped Pd O nanoparticles supported on reduced graphene oxide nanocomposites and evaluation of its antibacterial activity[J].Photochemistry and Photobiology 2017:167:58-63.
[36]Yin Kuo Chao,MinHsiao Hung.Preparation of iodine doped titanium dioxide to photodegrade aqueous bisphenol A under visible light[J].Process Safety and Environmental Protection,2015,95:265-270.
[37]Cheng Wang,Jiaxiang Zhu,Xiangyang Wu,et al.Photocatalytic degradation of bisphenol A and dye by grapheneoxide/Ag3PO4 composite under visible light irradiation[J].Ceramics International,2013,40:8061-8070.
[38]毛羽扬,蒋云升,周忠民,等.河豚鱼的去毒方法与去毒后风味调整的研究[J].食品科学,2006,23(10):121-123.
[39]张松山,哈益明.麻痹性贝类毒素控制与降解技术研究[D].北京:中国农业科学院,2015.
[40]Ciminiello P,Aversano C,Fattorusso E,et al.Putative palytoxin and its new analogue,ovatoxin-a,in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak[J].Mass Spectrom,2008,19,111-120.
[41]96/77/EC:Commission Decision of 18 January 1996establishing the conditions for the harvesting and processing of certain bivalve molluscs coming from areas where the paralytic shellfish poison level exceeds the limit laid down by Council Directive 91/492/EEC[J].Official Journal of European Communities,1996,15(1):46-47.
[42]Newcombe G,Nicholson B.Treatment options for the saxitoxin class of cyanotoxins[J].Water Science and Technology:Water supply,2002,5(2):271-275.
[43]贾晋斌,舒静,彭锐,等.酒曲生物转化降解河豚毒素的初步研究[J]中国医药生物技术,2013,8(4):269-273.
[44]藤井建夫,森真由美.水産加工品のいろいろ「ふぐ肉·卵巣糠漬け」[OL].http://nrifs.fra.affrc.go.jp/kakou/souran/ransounukaduke/.
[45]Sugawara A,Imamura T,Aso S,et al.Change of paralyticshellfish poison by the marinebacteria living in the intestine of the Japanesesurf clam,Pseudocardium sybillae,and the brown sole,Pleuronectes herensteini[J].Scientific Reports of the Hokkaido Fisheries Experimental Station,1997,50(3):35-42.
[46]Donovan C J,Ku J C,Quilliam M A,et al.Bacterial degradation of paralytic shellfish toxins[J].Toxicon,2008,52(1):91-100.
[47]Mari Vasama,Himanshu Kumar,Seppo Salminen.Removal of paralytic shellfish toxins by probiotic lactic acid bacteria[J].Toxins 2014,6,2127-2136.
[48]Zou Z Y,He Z F,Li H J,et al.In vitro removal of deoxynivalenol and t-2 toxin by lactic acid bacteria[J].Food Sci Biotechnol,2012,21,1677-1683.
[49]Elsanhoty R M,Ramadan M F,El-Goherym S S,et al.Ability of selected microorganisms for removing aflatoxins in vitro and fate of aflatoxins in dontaminated wheat during baladi bread baking[J].Food Control,2013,33,287-292.
[50]Andrinolo D,Gomes P,Fraga S,et al.Transport of the organic cations gonyautoxin 2/3 epimers,a paralytic shellfish poison toxin,through the human and rat intestinal epitheliums[J].Toxicon,2002,40,1389-1397.
[51]Sullivan J J,Iwaoka W T,Liston J.Enzymatic transformation of PSP toxins in the littleneck clam(Protothaca staminea)[J].Biochem Biophys,1983,114:465-472.
[52]Oshima Y.Harmful Marine Algal Blooms:Chemical and enzymatic transformation of paralytic shell fish toxins in marine organisms[M].Paris:Lavoisier Intercept,1995:475-480.
[53]Yuko Cho,Noriyuki Ogawa,Miyako Takahashi,et al.Purification and characterization of paralytic shell fish toxintransforming enzyme,sulfocarbamoylase I,from the Japanese bivalve Peronidia venulosa[J].Biochimicaet Biophysica Acta2008,1784(9):1277-1285.
[2]炳辉,高炳淼,于海鹏,等.海洋生物毒素研究新进展[J].海南大学学报,2011(1):78-88.
[3]Kvitek R G,Degange A R,Beitler M K.Paralytic shellfish poisoning toxins mediate feeding behavior of sea otters[J]1991,33:393-404.
[4]Romana R B,Ivana U.PSP toxins profile in ascidian Microcosmus vulgaris(Heller,187)after human poisoning in Croatia(Adriatic Sea)[J].Toxicon,2014,79(2):28-36.
[5]李美慧,李爱峰,曹际娟,等.我国常见的几种脂溶性贝毒的研究进展[J]生命科学,2016,28(1):33-43.
[6]Per A,Tore A,Daniel G B.et al.Report of the joint FAO/WHO/IOC ad hoc expert consultation on biotoxins in bicalve molluscs[R].Norway,2004.
[7]Jan Alwxander,Diane Benford,Alan Boobis,et al.Marine biotoxins in shellfish-Summary on regulated marine biotoxins scientific opinion of the Panel on contaminants in the food China[J].EFSA,2009,1306(8):1-23.
[8]Etheride S M.Paralytic shellfish poisoning:Seafood safety and human health perspectives[J].Toxicon,2010,56(2):108-122.
[9]Hungerford J M,Wekell M M.Algal toxin in seafood and drinking water:Control measures in shellfish and finfish industries in the USA[M].New York:Academic press,1993:117-128.
[10]Kao C Y.Algal Toxin in Seafood and Drinking Water:Paralytic shellfish poisoning[M].New York:Academic Press,1993:75-86.
[11]Gessner B D,Moddaugh J P.Paralytic Shellfish Poisoning in Alaska:A 20-year retrospective analysis[J].Am J Epidemiol1995,141(4):766-770.
[12]Cesar Mattei,Christian Legros.The voltage-gated sodium channel:A major target of marine Neurotoxins[J].Toxicon,2014,91:84-95.
[13]Noguchi T,Jeon J-K,Arakawa O,et al.Occurrence of tetrodotoxin and anhydrote-trodotoxin in Vibrio sp.isolated from the intestines of a xanthid crab,Atergatis floridus[J].J Biochem,1986,99:311-314.
[14]Sheumack D D,Howden M E,Spence I,et al.Maculotoxin:a neurotoxin from the venom glands of the octopus Hapalochlaena maculosa identied as tetrodotoxin[J].Science,1978,199:188-189.
[15]Yasumoto,T,Yasumura,D,Yotsu,M,et al.Bacterial production of tetrodotoxin and anhydro tetrodotoxin[J].Agrice Biol Chem,1978,50:793-795.
[16]Do HK,Kogure K,Imada C,et al.Tetrodotoxin production of actinomycetes isolated from marine sediment[J].Journal of Applied Microbiology,1991,70(6):464-468.
[17]岳田芳.海藻希瓦氏菌发酵产生河豚毒素的提取与检测[D].青岛:中国海洋大学,2008.
[18]Daly J W,Gusovsky F,Myers CW,et al.First occurrence of tetrodotoxin in a dendrobatid frog(Colos-tethus inguinalis),with further reports for the bufonid genus Atelopus[J].Toxicon,1994,32:279-285.
[19]Cesar M,Christian L.The voltage-gated sodium channel:Amajor target of marineneurotoxins[J].Toxicon,2014,84:85-94.
[20]Reboreda A,Lago J,Chapela M J,et al.Decrease of marine toxin content in bivalves by industrial processes[J].Toxicon,2014,55(2):235-243.
[21]Jing Liu,Fen Wei,Ying Lu,et al.Production level of tetrodotoxin in Aeromonas is associated with the copy number of a plasmid[J].toxicon,2015,101:27-34.
[22]Medcof J C,Leim A H,Needler A B,et al.Paralytic shellfish poisoning on the Canadian Atlantic coast[J].Bull Fish,1947,75:1-32.
[23]Moore R E,Scheuer P J.Palytoxin:a new marine toxin from a coelenterate[J].Science,1971,172:495-498.
[24]Ciminiello P,Aversano C,Fattorusso E,et al.Putative palytoxin and its new analogue,ovatoxin-a,in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak.[J]Mass Spectrom,2008,19,111-120.
[25]EFSA(European Food Safety Authority).Scientific opinion on marine bio-toxins in shell fish palytoxin group[J].EFSA J2009,7:1-38.
[26]Dai QY.Conus snail species in China[M]//Liang SP,Zhang Y.Animal Peptide Toxins of China.Beijing:Science Press,2016:385-390.
[27]Aligizaki K,Katikou P,Milandri A,et al.Occurrence of palytoxin group toxins in seafood and future strategies to complement the present state of the art[J],Toxicon.2011,57,390-399.
[28]戴秋云.芋螺毒素的毒理学和药理学研究[J].中国药理学与毒理学杂志,2016,30(12):1397-1404.
[29]Reboreda A,Lago J,Chapela M J,et al.Decrease of marine toxin content in bivalves by industrial processes[J].Toxicon,2010,55(2):235-243.
[30]毛丹卉,解万翠,杨锡红,等.贝类中PSP毒素的脱出方法研究进展[J]食品工业科技,2015,36(4):391-396.
[31]王广和,华元渝,朱永祥,等.暗纹东方去毒技术研究[J].动物医学防治,2004,20(11):662-664.
[32]Bricelj V M,Shumway S E.Paralytic shellfish toxins in bivalve molluscs:occurrence,transfer kinetics,and Biotrans formation[J].Reviews in Fisheries Science,1998,6(4):315-383.
[33]位正鹏,步营,于玲,等.电离辐射对腹泻性贝毒和麻痹性贝毒降解的研究[J].水产科技情报,2010,37(3):139-143.
[34]Jiangbing Qiu,Hua Fan,Ting Liu,et al.Application of activated carbon to accelerate detoxification of paralytic shell fish toxins from mussels Mytilus galloprovincialis and scallops Chlamys farreri.[J].Ecotoxicology and Environmental Safety,2018(148):402-409.
[35]Ali Fakhri,Mahsa Naji.Degradation photocatalysis of tetrodotoxin as a poison by gold doped Pd O nanoparticles supported on reduced graphene oxide nanocomposites and evaluation of its antibacterial activity[J].Photochemistry and Photobiology 2017:167:58-63.
[36]Yin Kuo Chao,MinHsiao Hung.Preparation of iodine doped titanium dioxide to photodegrade aqueous bisphenol A under visible light[J].Process Safety and Environmental Protection,2015,95:265-270.
[37]Cheng Wang,Jiaxiang Zhu,Xiangyang Wu,et al.Photocatalytic degradation of bisphenol A and dye by grapheneoxide/Ag3PO4 composite under visible light irradiation[J].Ceramics International,2013,40:8061-8070.
[38]毛羽扬,蒋云升,周忠民,等.河豚鱼的去毒方法与去毒后风味调整的研究[J].食品科学,2006,23(10):121-123.
[39]张松山,哈益明.麻痹性贝类毒素控制与降解技术研究[D].北京:中国农业科学院,2015.
[40]Ciminiello P,Aversano C,Fattorusso E,et al.Putative palytoxin and its new analogue,ovatoxin-a,in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak[J].Mass Spectrom,2008,19,111-120.
[41]96/77/EC:Commission Decision of 18 January 1996establishing the conditions for the harvesting and processing of certain bivalve molluscs coming from areas where the paralytic shellfish poison level exceeds the limit laid down by Council Directive 91/492/EEC[J].Official Journal of European Communities,1996,15(1):46-47.
[42]Newcombe G,Nicholson B.Treatment options for the saxitoxin class of cyanotoxins[J].Water Science and Technology:Water supply,2002,5(2):271-275.
[43]贾晋斌,舒静,彭锐,等.酒曲生物转化降解河豚毒素的初步研究[J]中国医药生物技术,2013,8(4):269-273.
[44]藤井建夫,森真由美.水産加工品のいろいろ「ふぐ肉·卵巣糠漬け」[OL].http://nrifs.fra.affrc.go.jp/kakou/souran/ransounukaduke/.
[45]Sugawara A,Imamura T,Aso S,et al.Change of paralyticshellfish poison by the marinebacteria living in the intestine of the Japanesesurf clam,Pseudocardium sybillae,and the brown sole,Pleuronectes herensteini[J].Scientific Reports of the Hokkaido Fisheries Experimental Station,1997,50(3):35-42.
[46]Donovan C J,Ku J C,Quilliam M A,et al.Bacterial degradation of paralytic shellfish toxins[J].Toxicon,2008,52(1):91-100.
[47]Mari Vasama,Himanshu Kumar,Seppo Salminen.Removal of paralytic shellfish toxins by probiotic lactic acid bacteria[J].Toxins 2014,6,2127-2136.
[48]Zou Z Y,He Z F,Li H J,et al.In vitro removal of deoxynivalenol and t-2 toxin by lactic acid bacteria[J].Food Sci Biotechnol,2012,21,1677-1683.
[49]Elsanhoty R M,Ramadan M F,El-Goherym S S,et al.Ability of selected microorganisms for removing aflatoxins in vitro and fate of aflatoxins in dontaminated wheat during baladi bread baking[J].Food Control,2013,33,287-292.
[50]Andrinolo D,Gomes P,Fraga S,et al.Transport of the organic cations gonyautoxin 2/3 epimers,a paralytic shellfish poison toxin,through the human and rat intestinal epitheliums[J].Toxicon,2002,40,1389-1397.
[51]Sullivan J J,Iwaoka W T,Liston J.Enzymatic transformation of PSP toxins in the littleneck clam(Protothaca staminea)[J].Biochem Biophys,1983,114:465-472.
[52]Oshima Y.Harmful Marine Algal Blooms:Chemical and enzymatic transformation of paralytic shell fish toxins in marine organisms[M].Paris:Lavoisier Intercept,1995:475-480.
[53]Yuko Cho,Noriyuki Ogawa,Miyako Takahashi,et al.Purification and characterization of paralytic shell fish toxintransforming enzyme,sulfocarbamoylase I,from the Japanese bivalve Peronidia venulosa[J].Biochimicaet Biophysica Acta2008,1784(9):1277-1285.