莫沙必利联合艾迪注射液对结直肠癌术后患者胃肠功能的改善研究
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摘要
目的:探讨莫沙必利联合艾迪注射液对结直肠癌术后患者胃肠功能的改善作用。方法:选取本院收治的结直肠癌术患者88例。按照随机数字表法将其分为对照组和观察组,各44例。两组均给予常规干预措施,对照组予莫沙必利口服治疗,观察组在对照组基础上给予艾迪注射液静脉滴注,两组连续干预12周。比较两组胃肠动力恢复情况、临床疗效、生活质量评分。结果:观察组排气、排便及肠鸣音恢复时间均显著短于对照组,比较差异均有统计学意义(P<0.01);观察组总有效率为93.18%,高于对照组的75.00%(P<0.05);治疗后,两组躯体功能、角色功能、认知功能、情绪功能及社会功能评分均高于治疗前,且观察组均高于对照组,比较差异均有统计学意义(P<0.01)。结论:莫沙必利联合艾迪注射液可促进结直肠癌术后患者胃肠功能的改善,提高临床疗效,改善患者生活质量。
Objective:To investigate improvement role of Mosapride combined with Addie Injection on gastrointestinal function post colorectal cancer operation.Method:A total of 88 patients with colorectal cancer treated in our hospital were selected.According to the random number table method,they were divided into control group and observation group,44 cases in each group.They were given routine intervention measures,the control group was given oral Mosapride treatment,while observation group was given intravenous drip of Aidi Injection on the basis of control group.They were given continuous intervention for 12 weeks.The recovery of gastrointestinal motility,clinical efficacy and quality of life scores between two groups were compared.Result:The exhaust time,defecation time and recovery time of bowel sounds in observation group were significantly shorter than those of control group(P<0.01).The total effective rate was 93.18% in observation group,which was higher than75.00% in control group(P<0.05).After treatment,the scores of physical function,role function,cognitive function,emotional function and social function of two groups were higher than those of before treatment,and observation group were higher than those of control group,the differences were statistically significant(P<0.01).Conclusion:Mosapride combined with Addie Injection can improve gastrointestinal function post colorectal cancer operation,increase the efficacy,and improve the quality.
Objective:To investigate improvement role of Mosapride combined with Addie Injection on gastrointestinal function post colorectal cancer operation.Method:A total of 88 patients with colorectal cancer treated in our hospital were selected.According to the random number table method,they were divided into control group and observation group,44 cases in each group.They were given routine intervention measures,the control group was given oral Mosapride treatment,while observation group was given intravenous drip of Aidi Injection on the basis of control group.They were given continuous intervention for 12 weeks.The recovery of gastrointestinal motility,clinical efficacy and quality of life scores between two groups were compared.Result:The exhaust time,defecation time and recovery time of bowel sounds in observation group were significantly shorter than those of control group(P<0.01).The total effective rate was 93.18% in observation group,which was higher than75.00% in control group(P<0.05).After treatment,the scores of physical function,role function,cognitive function,emotional function and social function of two groups were higher than those of before treatment,and observation group were higher than those of control group,the differences were statistically significant(P<0.01).Conclusion:Mosapride combined with Addie Injection can improve gastrointestinal function post colorectal cancer operation,increase the efficacy,and improve the quality.
引文
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[5]李博萍,庞宏威,贺毅洁,等.中医针药联合治疗结直肠癌患者术后胃肠功能障碍的疗效观察[J].现代生物医学进展,2017,17(12):2310-2313.
[6]王建明,何毅,袁彩霞,等.莫沙必利联合氟西汀治疗结直肠癌患者术后胃肠功能障碍临床疗效[J].中国现代应用药学,2018,35(4):582-585.
[7]吕遐智.艾迪注射液联合化疗方案治疗晚期结直肠癌的效果[J].中国医药导报,2017,14(17):146-149.
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[13]刘刚,徐艳松,赵波,等.维生素B1穴位注射对结直肠癌术后患者胃肠功能恢复的影响[J].结直肠肛门外科,2014,20(6):428-429.
[14]马宁,李国栋.FTS理念下早期肠内营养在结直肠癌手术患者治疗中的临床观察[J].南京医科大学学报(自然科学版),2018,38(4):505-508,513.
[15]仇伊尔,骆洋,秦绍岚,等.围手术期厚朴排气合剂在腹腔镜结直肠癌快速康复中疗效的随机对照研究[J].胃肠病学,2018,23(3):148-151.
[16]魏晨晨,伏杭江,陆彬彬,等.枸橼酸莫沙必利预防芬太尼透皮贴剂引起的癌痛患者恶心呕吐的疗效观察[J].中国医药科学,2017,7(24):24-26.
[17]张仕林.艾迪注射液辅助奥沙利铂联合替吉奥治疗晚期结直肠癌的临床观察[J].中国药房,2015,26(36):5075-5077.
[18]李竹梅,李双梅,张喜丽,等.精细化护理干预对结直肠癌患者术后胃肠功能的影响[J].河南科技大学学报(医学版),2016,34(3):233-235.
[19]孟琼,万崇华,罗家洪.癌症患者生命质量测定量表EORTCQLQ-C30的应用[J].中国行为医学科学,2005,14(3):273-274.
[20]刘景,徐晶.老年晚期结直肠癌患者化疗联合使用艾迪注射液的效果研究[J].药品评价,2017,14(18):59-61.
[2]郭小萌,杨秀娟.舒芬太尼和羟考酮对腹腔镜下结直肠癌根治术患者免疫功能的影响[J].中国医学创新,2018,15(8):119-124.
[3]刘芳芳.结直肠癌免疫治疗的研究及前景展望[J].世界华人消化杂志,2018,23(28):4464-4472.
[4]韩远峰,孙颖,叶志红.枳术丸汤剂结合针刺疗法对结直肠癌术后胃肠功能的影响[J].中国民族民间医药,2016,25(21):100-102.
[5]李博萍,庞宏威,贺毅洁,等.中医针药联合治疗结直肠癌患者术后胃肠功能障碍的疗效观察[J].现代生物医学进展,2017,17(12):2310-2313.
[6]王建明,何毅,袁彩霞,等.莫沙必利联合氟西汀治疗结直肠癌患者术后胃肠功能障碍临床疗效[J].中国现代应用药学,2018,35(4):582-585.
[7]吕遐智.艾迪注射液联合化疗方案治疗晚期结直肠癌的效果[J].中国医药导报,2017,14(17):146-149.
[8]中华人民共和国卫生和计划生育委员会医政医管局,中华医学会肿瘤学分会.中国结直肠癌诊疗规范(2015版)[J].中华消化外科杂志,2015,14(10):783-799.
[9]卫生部医政司.结直肠癌诊疗规范(2010年版)[J].中国医学前沿杂志,2011,3(6):130-146.
[10]万崇华,陈明清,张灿珍,等.癌症患者生命质量测定量表E-ORTC QLQ-C30中文版评介[J].实用肿瘤杂志,2005,20(4):353-355.
[11]Longstreth G F,Thompson W G,Chey W D,et al.Functional bowel disorders[J].Gastroenterology,2006,130(5):1480-1491.
[12]林毅,王振飞,王智健,等.华蟾素片联合XELOX方案对结直肠癌术后化疗的临床观察[J].中国中医药现代远程教育,2017,15(22):107-109.
[13]刘刚,徐艳松,赵波,等.维生素B1穴位注射对结直肠癌术后患者胃肠功能恢复的影响[J].结直肠肛门外科,2014,20(6):428-429.
[14]马宁,李国栋.FTS理念下早期肠内营养在结直肠癌手术患者治疗中的临床观察[J].南京医科大学学报(自然科学版),2018,38(4):505-508,513.
[15]仇伊尔,骆洋,秦绍岚,等.围手术期厚朴排气合剂在腹腔镜结直肠癌快速康复中疗效的随机对照研究[J].胃肠病学,2018,23(3):148-151.
[16]魏晨晨,伏杭江,陆彬彬,等.枸橼酸莫沙必利预防芬太尼透皮贴剂引起的癌痛患者恶心呕吐的疗效观察[J].中国医药科学,2017,7(24):24-26.
[17]张仕林.艾迪注射液辅助奥沙利铂联合替吉奥治疗晚期结直肠癌的临床观察[J].中国药房,2015,26(36):5075-5077.
[18]李竹梅,李双梅,张喜丽,等.精细化护理干预对结直肠癌患者术后胃肠功能的影响[J].河南科技大学学报(医学版),2016,34(3):233-235.
[19]孟琼,万崇华,罗家洪.癌症患者生命质量测定量表EORTCQLQ-C30的应用[J].中国行为医学科学,2005,14(3):273-274.
[20]刘景,徐晶.老年晚期结直肠癌患者化疗联合使用艾迪注射液的效果研究[J].药品评价,2017,14(18):59-61.