手机控制型便携经颅直流电刺激器的设计与实现
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摘要
目的设计并实现一种手机控制型低功耗、便携式经颅直流电刺激器。方法采用恒流刺激电路通过场效应管,实现输出稳定可调的低强度直流电流;阻抗检测电路和过流保护电路增加刺激器的有效性和安全性。通过微控制器实现对刺激电路的控制和实时检测,通过智能手机安卓软件实现刺激器的参数设置和实际刺激信息的显示及保存。结果输出电流强度与精度、最大负载,控制模块的计时、设备连接、刺激信息采集与显示,都达到预期设计目标。结论实现了刺激器的移动终端控制,具有便携、低成本、低功耗的优点,可为进一步应用提供解决方案。
Objective To design and implement a low-power and portable transcranial direct current stimulator controlled by mobile phones.Methods The constant current stimulation circuit was realized by a field effect transistor, which could output stable and adjustable low-intensity direct current, and the impedance detection circuit and the over-current protection circuit increased the effectiveness and safety of the stimulator. The control and real-time detection of the stimulation circuit was realized through a microcontroller, and the parameters' settings of the stimulator and the display and preservation of the actual stimulus information were realized through the Android software on the smartphone.Results The output current strength and accuracy, maximum load, as well as the timing, device connection, stimulus information collection and display all achieved the expected goals.Conclusion The design realized the mobile control of the stimulator, with portability, low cost and low power consumption, providing a new solution for wider applications.
Objective To design and implement a low-power and portable transcranial direct current stimulator controlled by mobile phones.Methods The constant current stimulation circuit was realized by a field effect transistor, which could output stable and adjustable low-intensity direct current, and the impedance detection circuit and the over-current protection circuit increased the effectiveness and safety of the stimulator. The control and real-time detection of the stimulation circuit was realized through a microcontroller, and the parameters' settings of the stimulator and the display and preservation of the actual stimulus information were realized through the Android software on the smartphone.Results The output current strength and accuracy, maximum load, as well as the timing, device connection, stimulus information collection and display all achieved the expected goals.Conclusion The design realized the mobile control of the stimulator, with portability, low cost and low power consumption, providing a new solution for wider applications.
引文
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[17]刘艳,汪毅,贾雯杰,等.一种常见精密恒流源的改进与应用[J].电测与仪表, 2011, 48(4):93-96.
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[19]任保宏,徐科军. MSP430单片机原理与应用[M].北京:电子工业出版社, 2014.
[20]刘勇.基于MSP430F149的OLED显示系统的设计[J].电子技术与软件工程, 2013(21):177-179.
[21]田鑫,刘金涛,张凯临.基于MSP430和OLED通用显示系统设计[J].微计算机信息, 2010, 26(23):82-83.
[22]刘辉.基于蓝牙传输的Android手机心电、呼吸监护系统的设计[D].镇江:江苏大学, 2016.
[23]陈志崇,张祺.基于Android的蓝牙通信接口[J].电子世界, 2013(6):16-17.
[24]罗富财.基于Android平台的蓝牙通信系统的研究与实现[D].北京:华北电力大学, 2013.
[25]陈钰琨,马忠梅,曾礼. Android系统的蓝牙远程控制研究[J].单片机与嵌入式系统应用, 2015, 15(1):16-19.
[26] Bashar M R, Li Y, Wen P. Effects of local tissue conductivity on spherical and realistic head models[J]. Austr Phys Eng Sci Med, 2010,33(3):233-242.
[27] Dannhauer M, Lanfer B, Wolters C H, et al. Modeling of the human skull in EEG source analysis[J]. Human Brain Mapping, 2011, 32(9):1383-1399.
[2]宋昕,洪羽蓉,胡秋莹.阿尔兹海默病发病原因及机制的研究进展[J].临床和实验医学杂志,2015,14(10):871-873.
[3]吴春薇,谢瑛.经颅直流电刺激的研究进展[J].中国康复理论与实践,2015,21(2):171-175.
[4] Shin Y I, Foersterá, Nitsche M A. Transcranial direct current stimula‐tion(tDCS)-Application in neuropsychology[J]. Neuropsychologia,2015, 69(2):154-175.
[5] Kuo M F, Paulus W, Nitsche M A. Therapeutic effects of non-invasive brain stimulation with direct currents(tDCS)in neuropsychiatric diseas‐es[J]. Neuroimage, 2014, 85(2):948-960.
[6] Ferrucci R, Mameli F, Guidi I, et al. Transcranial direct current stimula‐tion improves recognition memory in Alzheimer disease[J]. Neurology,2016, 71(7):493-498.
[7] Marceglia S, Mrakicsposta S, Rosa M, et al. Transcranial direct current stimulation modulates cortical neuronal activity in Alzheimer's disease[J]. Front Neurosci, 2016, 10(83):134.
[8]雷幸幸,杜晓霞,宋鲁平.经颅直流电刺激在阿尔兹海默病中的应用进展[J].中国老年保健医学, 2018, 16(3):65-69.
[9]俞雪鸿.经颅直流电刺激仪的设计及动物实验研究[D].重庆:重庆大学, 2015.
[10] Nitsche M A, Bikson M. Extending the parameter range for tDCS:safety and tolerability of 4 mA stimulation[J]. Brain Stimulation, 2017,10(3):541-542.
[11]刘盼,刘世文.经颅直流电刺激的研究及应用[J].中国组织工程研究与临床康复, 2011, 15(39):7379-7383.
[12] Zhao H, Qiao L, Fan D, et al. Modulation of brain activity with non‐invasive transcranial direct current stimulation(tDCS):clinical applica‐tions and safety concerns[J]. Front Psychol, 2017, 8:1-17.
[13]关龙舟,魏云,李小俚.经颅电刺激:一项具有发展前景的脑刺激技术[J].中国医疗设备, 2015, 30(11):1-5.
[14]李天钢,马春排.生物医学测量与仪器:原理与设计[M].西安:西安交通大学出版社,2009.
[15]孙曦东,邢壮. MC34063 DC/DC转换控制电路测试方法概述[J].电子与封装, 2013, 13(5):9-11.
[16]陈沛丰.基于MC34063A的开关稳压电源设计及外围器件参数计算[J].机电工程技术, 2012, 41(5):90-94.
[17]刘艳,汪毅,贾雯杰,等.一种常见精密恒流源的改进与应用[J].电测与仪表, 2011, 48(4):93-96.
[18]田俊杰,董威,陈静,等.基于场效应管的恒流源设计[J].中国测试,2009, 35(1):118-121.
[19]任保宏,徐科军. MSP430单片机原理与应用[M].北京:电子工业出版社, 2014.
[20]刘勇.基于MSP430F149的OLED显示系统的设计[J].电子技术与软件工程, 2013(21):177-179.
[21]田鑫,刘金涛,张凯临.基于MSP430和OLED通用显示系统设计[J].微计算机信息, 2010, 26(23):82-83.
[22]刘辉.基于蓝牙传输的Android手机心电、呼吸监护系统的设计[D].镇江:江苏大学, 2016.
[23]陈志崇,张祺.基于Android的蓝牙通信接口[J].电子世界, 2013(6):16-17.
[24]罗富财.基于Android平台的蓝牙通信系统的研究与实现[D].北京:华北电力大学, 2013.
[25]陈钰琨,马忠梅,曾礼. Android系统的蓝牙远程控制研究[J].单片机与嵌入式系统应用, 2015, 15(1):16-19.
[26] Bashar M R, Li Y, Wen P. Effects of local tissue conductivity on spherical and realistic head models[J]. Austr Phys Eng Sci Med, 2010,33(3):233-242.
[27] Dannhauer M, Lanfer B, Wolters C H, et al. Modeling of the human skull in EEG source analysis[J]. Human Brain Mapping, 2011, 32(9):1383-1399.