老年阻塞性睡眠呼吸暂停综合征与体质量指数、血压、血脂及血糖的相关性
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摘要
目的探讨老年阻塞性睡眠呼吸暂停综合征与患者的体质量指数、血压、血脂及血糖的相关性。方法将118例OSAS患者作为试验组,98例健康人作为对照组,比较2组患者的体质量指数、血压、血脂、血糖以及甘油三酯(TG)、血清胆固醇(TC)和C反应蛋白(CRP)等指标。结果试验组患者的MAP和BMI以及收缩压均显著高于对照组(P<0.05),而2组患者的舒张压、臀围及腰围则无显著差异(P>0.05)。2组患者的血清TC、HDL-C、LDL-C等均无显著差异(P>0.05),试验组患者的血清TG和血糖、Fig、CRP等水平则显著高于对照组(P<0.05),而CGRP则水平则显著低于对照组(P<0.05)。试验组患者的Sa O2<90%时间百分数、Sa O2<90%时间、低氧指数、低氧频数、呼吸紊乱次数等均显著高于对照组(P<0.05),而最低Sa O2则显著低于对照组(P<0.05)。试验组患者心血管疾病的发病率为80.5%,显著高于对照组的27.6%(P<0.01)。经Logistic回归分析显示,患者的低氧指数和CGRP水平、TG水平以及颈围等均与OSAS呈正相关关系(P<0.05)。结论老年OSAS和心血管疾病危险因素存在极为密切的关系。
Objective To investigate the correlation between obstructive sleep apnea syndrome( OSAS) and body mass index,blood pressure,blood lipid and blood glucose in elderly patients. Methods A total of 118 elderly male patients with OSAS were selected as experimental group,and 98 healthy people were selected as control group. The body mass index,blood pressure,blood lipid,blood glucose and triglycerides( TG),serum cholesterol( TC),tumor necrosis and c-reactive protein( CRP),and other indicators were compared. Results The MAP,BMI and systolic blood pressure in experimental group were significantly higher than those in control group( P < 0. 05),while there were no significant differences in diastolic blood pressure and hip and waist circumference( P >0. 05). There were no significant differences between the two groups in serum TC,HDL-C and LDL-C(P > 0. 05),the serum TG and blood glucose,Fig and CRP levels in experimental group were significantly higher than those in control group( P < 0. 05),and the CGRP level was significantly lower than the control group( P < 0. 05). In the experimental group,Sa O2< 90%,Sa O2< 90% the percentage of the time,oxygen index,hypoxia frequency,respiratory disturbance frequency were significantly higher than the control group(P < 0. 05),while the lowest Sa O2 was significantly lower than the control group(P < 0. 05). The incidence rate of cardiovascular disease in the experimental group was 80. 5%,which was significantly higher than 27. 6% in the control group(P < 0. 01). Logistic regression analysis showed that there was a positive correlation between OSAS index and CGRP level,TG level and neck circumference( P < 0. 05). Conclusion There is a close relationship between OSAS and cardiovascular disease risk factors in elderly patients.
Objective To investigate the correlation between obstructive sleep apnea syndrome( OSAS) and body mass index,blood pressure,blood lipid and blood glucose in elderly patients. Methods A total of 118 elderly male patients with OSAS were selected as experimental group,and 98 healthy people were selected as control group. The body mass index,blood pressure,blood lipid,blood glucose and triglycerides( TG),serum cholesterol( TC),tumor necrosis and c-reactive protein( CRP),and other indicators were compared. Results The MAP,BMI and systolic blood pressure in experimental group were significantly higher than those in control group( P < 0. 05),while there were no significant differences in diastolic blood pressure and hip and waist circumference( P >0. 05). There were no significant differences between the two groups in serum TC,HDL-C and LDL-C(P > 0. 05),the serum TG and blood glucose,Fig and CRP levels in experimental group were significantly higher than those in control group( P < 0. 05),and the CGRP level was significantly lower than the control group( P < 0. 05). In the experimental group,Sa O2< 90%,Sa O2< 90% the percentage of the time,oxygen index,hypoxia frequency,respiratory disturbance frequency were significantly higher than the control group(P < 0. 05),while the lowest Sa O2 was significantly lower than the control group(P < 0. 05). The incidence rate of cardiovascular disease in the experimental group was 80. 5%,which was significantly higher than 27. 6% in the control group(P < 0. 01). Logistic regression analysis showed that there was a positive correlation between OSAS index and CGRP level,TG level and neck circumference( P < 0. 05). Conclusion There is a close relationship between OSAS and cardiovascular disease risk factors in elderly patients.
引文
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[10]洪姣,王佳蕊,黄春琦,等.西兰花预防和治疗肿瘤研究的新进展[J].肿瘤药学,2014,(6):405-409.
[11]Smeijers L,Mostofsky E,Tofler G H,et al.Anxiety and anger immediately prior to myocardial infarction and long-term mortality:Characteristics of high-risk patients[J].J Psychosom Res,2017,93:19-27.
[12]柴珍峰.阻塞性睡眠呼吸暂停综合征与心血管疾病相关性研究进展[J].医学综述,2012,18(21):3658-3660.
[13]Cahill T J,Baddour L M,Habib G,et al.Challenges in Infective Endocarditis[J].J Am Coll Cardiol,2017,69(3):325-344.
[2]Farvid M S,Malekshah A F,Pourshams A,et al.Dietary Protein Sources and All-Cause and Cause-Specific Mortality:The Golestan Cohort Study in Iran[J].Am J Prev Med,2017,52(2):237-248.
[3]赵博,兰艳丽,马小川,等.老年男性阻塞性睡眠呼吸暂停与心血管疾病危险因素相关性分析[J].实用临床医药杂志,2015,19(15):165-166,171.
[4]Mao L,Nie B,Nie T,et al.Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model[J].Diabetes,2017,66(2):407-417.
[5]徐振媛,杜秀平,韩正祥,等.NRP-1的生物学特征及其在肿瘤发生发展中的作用[J].肿瘤药学,2014(2):97-102.
[6]Farvid M S,Malekshah A F,Pourshams A,et al.Dietary Protein Sources and All-Cause and Cause-Specific Mortality:The Golestan Cohort Study in Iran[J].Am J Prev Med,2017,52(2):237-248.
[7]李本玲.阻塞性睡眠呼吸暂停低通气综合征对血压的影响及护理干预[J].实用临床医药杂志,2012,16(18):56-58.
[8]Ranasinghe P,Mathangasinghe Y,Jayawardena R,et al.Prevalence and trends of metabolic syndrome among adults in the asia-pacific region:a systematic review[J].BMC Public Health,2017,17(1):101-7.
[9]Mao L,Nie B,Nie T,et al.Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model[J].Diabetes,2017,66(2):407-417.
[10]洪姣,王佳蕊,黄春琦,等.西兰花预防和治疗肿瘤研究的新进展[J].肿瘤药学,2014,(6):405-409.
[11]Smeijers L,Mostofsky E,Tofler G H,et al.Anxiety and anger immediately prior to myocardial infarction and long-term mortality:Characteristics of high-risk patients[J].J Psychosom Res,2017,93:19-27.
[12]柴珍峰.阻塞性睡眠呼吸暂停综合征与心血管疾病相关性研究进展[J].医学综述,2012,18(21):3658-3660.
[13]Cahill T J,Baddour L M,Habib G,et al.Challenges in Infective Endocarditis[J].J Am Coll Cardiol,2017,69(3):325-344.