盐酸曲美他嗪治疗冠心病稳定型心绞痛的临床治疗疗效探析
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摘要
目的分析研讨盐酸曲美他嗪治疗冠心病稳定型心绞痛的临床疗效。方法 80例冠心病稳定型心绞痛患者,采用随机数字法分为研究组与对照组,每组40例。对照组接受常规治疗,研究组接受盐酸曲美他嗪治疗,观察两组治疗效果并对比。结果治疗后,研究组总有效率为95.00%,明显高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗后,研究组最大ST段压低(STmax)、ST段压低总和(∑ST)、ST段压低总导联数(NST)、心绞痛持续时间、心绞痛发作频率均明显优于对照组,差异具有统计学意义(t=3.3019、3.4181、2.0105、2.0336、3.0939,P<0.05)。结论临床治疗冠心病稳定型心绞痛疾病可考虑给予盐酸曲美他嗪,其疗效突出,可使患者心绞痛持续时间和发作频率均得到降低,心电图恢复正常,应用性高。
Objective To analyze and discuss the clinical efficacy of trimetazidine hydrochloride in the treatment of stable angina pectoris of coronary heart disease. Methods A total of 80 patients with stable angina pectoris of coronary heart disease were divided by random number method into research group and control group, with 40 cases in each group. The control group received conventional therapy, and the research group received trimetazidine hydrochloride for treatment. The treatment condition in two groups was observed and compared. Results After treatment, the research group had obviously higher total effective rate as 95.00% than 77.50% in the control group, and the difference was statistically significant(P<0.05). after treatment, the research group had obviously better maximum ST segment depression(STmax), ST segment depression sum(∑ST), ST segment depression total lead(NST), duration of angina pectoris, and frequency of angina pectoris than the control group, and their difference was statistically significant(t=3.3019, 3.4181, 2.0105, 2.0336, 3.0939, P<0.05). Conclusion Trimetazidine hydrochloride provides excellent efficacy in treating stable angina pectoris of coronary heart disease can reduce duration of the angina pectoris and the frequency of attack, and the electrocardiogram can be restored to normal. So it has high application.
Objective To analyze and discuss the clinical efficacy of trimetazidine hydrochloride in the treatment of stable angina pectoris of coronary heart disease. Methods A total of 80 patients with stable angina pectoris of coronary heart disease were divided by random number method into research group and control group, with 40 cases in each group. The control group received conventional therapy, and the research group received trimetazidine hydrochloride for treatment. The treatment condition in two groups was observed and compared. Results After treatment, the research group had obviously higher total effective rate as 95.00% than 77.50% in the control group, and the difference was statistically significant(P<0.05). after treatment, the research group had obviously better maximum ST segment depression(STmax), ST segment depression sum(∑ST), ST segment depression total lead(NST), duration of angina pectoris, and frequency of angina pectoris than the control group, and their difference was statistically significant(t=3.3019, 3.4181, 2.0105, 2.0336, 3.0939, P<0.05). Conclusion Trimetazidine hydrochloride provides excellent efficacy in treating stable angina pectoris of coronary heart disease can reduce duration of the angina pectoris and the frequency of attack, and the electrocardiogram can be restored to normal. So it has high application.
引文
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[4]陈亚静,陈亚青,肖暖,等.冠心舒通胶囊联合盐酸曲美他嗪对不稳定型心绞痛病人IL6、NTpro BNP的影响.中西医结合心脑血管病杂志,2016,14(21):2484-2486.
[5]梁华添.盐酸曲美他嗪片辅助治疗心绞痛的临床效果及对IL6与BNP水平的影响.现代诊断与治疗,2016,27(18):3476-3477.
[6]来路生.盐酸曲美他嗪对社区冠心病稳定劳力型心绞痛的疗效分析.临床医学研究与实践,2016,1(10):56.
[7]贾彬彬,缪金龙,张玉杰,等.丹参川芎嗪注射液合盐酸曲美他嗪对冠脉慢血流的临床研究.甘肃科技纵横,2017,46(2):96-98.
[8]蒋建光,李本玲,丁志坚,等.曲美他嗪改善原发性扩张性心肌病患者心功能和运动耐量的临床研究.实用临床医药杂志,2016,20(17):133-134.
[9]辛振杰,周智文,叶玲,等.三参胶囊联合盐酸曲美他嗪常规治疗冠心病不稳定心绞痛的临床观察.中国现代药物应用,2016,10(18):266-267.
[10]崔春便,程华,王敬,等.盐酸曲美他嗪对冠心病心绞痛患者白细胞介素-6C反应蛋白N-末端脑钠肽原的影响.山西医药杂志,2016,45(9):1069-1072.
[2]马颖娟.益心通脉颗粒治疗冠心病稳定型心绞痛87例疗效观察.中国社区医师,2012,28(31):13.
[3]陈德生,史大卓.名医谈冠心病心绞痛的防治.中外女性健康(月刊),2012(8):7.
[4]陈亚静,陈亚青,肖暖,等.冠心舒通胶囊联合盐酸曲美他嗪对不稳定型心绞痛病人IL6、NTpro BNP的影响.中西医结合心脑血管病杂志,2016,14(21):2484-2486.
[5]梁华添.盐酸曲美他嗪片辅助治疗心绞痛的临床效果及对IL6与BNP水平的影响.现代诊断与治疗,2016,27(18):3476-3477.
[6]来路生.盐酸曲美他嗪对社区冠心病稳定劳力型心绞痛的疗效分析.临床医学研究与实践,2016,1(10):56.
[7]贾彬彬,缪金龙,张玉杰,等.丹参川芎嗪注射液合盐酸曲美他嗪对冠脉慢血流的临床研究.甘肃科技纵横,2017,46(2):96-98.
[8]蒋建光,李本玲,丁志坚,等.曲美他嗪改善原发性扩张性心肌病患者心功能和运动耐量的临床研究.实用临床医药杂志,2016,20(17):133-134.
[9]辛振杰,周智文,叶玲,等.三参胶囊联合盐酸曲美他嗪常规治疗冠心病不稳定心绞痛的临床观察.中国现代药物应用,2016,10(18):266-267.
[10]崔春便,程华,王敬,等.盐酸曲美他嗪对冠心病心绞痛患者白细胞介素-6C反应蛋白N-末端脑钠肽原的影响.山西医药杂志,2016,45(9):1069-1072.