用聚酰胺树脂从~(99)Mo中提取~(99)Tc~m
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摘要
固相分离材料是色层法从低比活度~(99)Mo料液中分离医用同位素~(99)Tc~m的关键。采用静态吸附和动态吸附淋洗实验,研究了聚酰胺树脂从~(99)Mo中吸附分离其衰变子体~(99)Tc~m的工艺,评价了其性能。结果表明:在NaOH浓度为3mol/L的钼酸钠溶液中,聚酰胺树脂能够在10s内选择性地吸附高锝酸根离子,并具有3.85mg/g的饱和吸附容量。2.0g装柱量的聚酰胺色层柱的漏穿体积约为70 mL,可用25 mL 3 mol/L NaOH溶液洗涤柱上残留的钼酸根离子,最后20mL水即可将吸附在聚酰胺色层柱上的锝淋洗下来。本研究为开发基于色层法的全自动~(99)Mo/~(99)Tc~m发生器装置提供了一种新型钼锝固相分离材料,其提取锝的淋洗效率为98%,洗脱液中钼的残留为0.6mg/L。
Solid extraction reagent is the key of separating medical isotope ~(99)Tc~m from low specific activity ~(99)Mo solution using chromatography.The static adsorption and dynamic adsorption-elution experiments have been conducted to study the process and performance of polyamide resin separation ~(99)Tc~mfrom its mother nuclide ~(99)Mo.The results show that:polyamide resin can selectively adsorb pertechnetate ions in 10 s,and with 3.85 mg/g saturated adsorption capacity in 3 mol/L NaOH solution.The breakthrough volume of 2.0 g polyamide chromatographic column is about 70 mL,and permolybdate ion remaining on column can be washed by 25 mL 3 mol/L NaOH solution.At last 20 mL water can be used for eluting technetium adsorbed on the polyamide chromatographic column.The research shows that:a novel solid extraction reagent for separation molybdenum and technetium has been developed for automatic ~(99)Mo/~(99)Tc~m generator.The yield of separation technetium is 98%,and residualconcentration of molybdenum is 0.6 mg/L in eluate.
Solid extraction reagent is the key of separating medical isotope ~(99)Tc~m from low specific activity ~(99)Mo solution using chromatography.The static adsorption and dynamic adsorption-elution experiments have been conducted to study the process and performance of polyamide resin separation ~(99)Tc~mfrom its mother nuclide ~(99)Mo.The results show that:polyamide resin can selectively adsorb pertechnetate ions in 10 s,and with 3.85 mg/g saturated adsorption capacity in 3 mol/L NaOH solution.The breakthrough volume of 2.0 g polyamide chromatographic column is about 70 mL,and permolybdate ion remaining on column can be washed by 25 mL 3 mol/L NaOH solution.At last 20 mL water can be used for eluting technetium adsorbed on the polyamide chromatographic column.The research shows that:a novel solid extraction reagent for separation molybdenum and technetium has been developed for automatic ~(99)Mo/~(99)Tc~m generator.The yield of separation technetium is 98%,and residualconcentration of molybdenum is 0.6 mg/L in eluate.
引文
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[14]Suzuki T,Fujii Y,Wu Y,et al.Adsorption behavior ofⅦgroup elements on tertiary pyridine resin in hydrochloric acid solution[J].J Radioanal Nucl Chem,2009,282(2):641-644.
[15]李树昌,赵建为.细菌浸出液中微量钼的测定[J].云南冶金,2001,30(6):49-50.
[2]汪勇先.关于保障我国同位素供应安全的考虑[J].核技术,2013,36(3):44-47.
[3]Jun B J,Tanimoto M,Kimura A.Feasibility study on mass production of(n,γ)99 Mo[J].JAEAResearch,2010,46:36-37.
[4]Tachimori S,Nakamura H,Amano H.Diffusion of Tc-99min neutron irradiated molybdenum trioxide and its application to separation[J].J Nucl Sci Technol,1971,8(6):295-301.
[5]Chakravarty R,Dash A,Venkatesh M.A novel electrochemical technique for the production of clinical grade Tc using(n,γ)Mo[J].Nucl Med Biol,2010,37(1):21.
[6]Bigott H M,Laforest R,Liu X D,et al.Advances in the production,processing and micro-PET image quality of technetium-94m[J].Nucl Med Biol,2006,33:923-933.
[7]Chattopadhyay S,Das S S,Das M K,et al.Recovery of 99mTc from Na2[99 Mo]MoO4solution obtained from reactor-produced(n,γ)99 Mo using a tiny Dowex-1column in tandem with a small alumina column[J].Appl Radiat Isotopes,2008,66(12):1814-1817.
[8]Rogers R D,Bond A H,Zhang J H,et al.New technetium-99m generator technologies utilizing polyethylene glycol-based aqueous biphasic systems[J].Sep Sci Technol,1997,32(1-4):867-882.
[9]Spear S K,Griffin S T,And J G H,et al.Radiopharmaceutical and hydrometallurgical separations of perrhenate using aqueous biphasic systems and the analogous aqueous biphasic extraction chromatographic resins[J].Indust Engin Chem Res,2000,39(9):3173-3180.
[10]Morley T J,Dodd M,Gagnon K,et al.An automated module for the separation and purification of cyclotron-produced 99mTcO-4[J].Nucl Med Biol,2012,39(4):551-559.
[11]阳国桂,胡骥.用活性碳纤维从99 Mo中提取99 Tc m[J].核化学与放射化学.DOI:10.7538/hhx.2018.YX.2017009.
[12]Bennett M E,Stepinski D,Dan D V,et al.Removal of Tc from neutron-capture 99 Mo using Eichrom’s ABEC resin[C]∥Mo-99 2015topical meeting on molybdenum-99technological development.Boston,Massachusetts,US.2015.
[13]Andersson J D,Gagnon K,Wilson J S,et al.Separation of molybdenum and technetium[R].American Institute of Physics,2012:233-238.
[14]Suzuki T,Fujii Y,Wu Y,et al.Adsorption behavior ofⅦgroup elements on tertiary pyridine resin in hydrochloric acid solution[J].J Radioanal Nucl Chem,2009,282(2):641-644.
[15]李树昌,赵建为.细菌浸出液中微量钼的测定[J].云南冶金,2001,30(6):49-50.