口腔鳞状上皮细胞癌中Borealin的表达及其意义
摘要
目的探讨Borealin在口腔鳞状上皮细胞癌(oral squamous cell carcinoma, OSCC)中的表达及与Ki-67增殖指数的关系。方法采用免疫组化LSAB法检测20例正常口腔黏膜组织和111例手术切除OSCC组织中Borealin及Ki-67的表达,分析其与OSCC临床病理特征的关系。结果 Borealin在OSCC中高表达(52/111),在正常口腔黏膜中低表达(0/20),差异有统计学意义(P<0.01);Borealin在OSCC中的表达与肿瘤分化程度、淋巴结转移密切相关(P<0.05);Borealin与Ki-67的表达具有相关性(P<0.01)。结论 Borealin表达对判断OSCC的增殖、转移及恶性程度有重要意义,有望成为OSCC新的诊断标志物和治疗靶点。
引文
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[14] 张前军,卢光琇.Borealin及CPC相关基因在胚胎干细胞畸变过程中的表达差异[J].激光生物学报,2012,21(1):12-15.
[15] 李世灵,蔡扬,于燕妮,成元华.口腔癌及癌前病变中PLK1蛋白表达及其意义[J].临床与实验病理学杂志,2010,26(1):108-111.
[2] Kademani D,Bell R B,Schmidt B L,et al.Oral and maxillofacial surgeons treating oral cancer:a preliminary report from the American association of oral and maxillofacial surgeons task force on oral cancer[J].J Oral Maxillofac Surg,2008,66(10):2151-2157.
[3] Carmena M,Wheelock M,Funabiki H,et al.The chromo-somal passenger complex (CPC):from easy rider to the godfather of mitosis[J].Nat Rev Mol Cell Biol,2012,13(12):789-803.
[4] Ruchaud S,Carmena M,Earnshaw W C.The chromosomal passenger complex:one for all and all for one[J].Cell,2007,131(2):230-231.
[5] van der Horst A,Lens S M.Cell division:control of the chromosomal passenger complex in time and space[J].Chromosoma,2014,123(1-2):25-42.
[6] Ruchaud S,Carmena M,Earnshaw W C.Chromosomal passengers:conducting cell division[J].Nat Rev Mol Cell Biol,2007,8(10):798-812.
[7] van der Waal M S,Hengeveld R C,van der Horst A,Lens S M.Cell division control by the chromosomal passenger complex[J].Exp Cell Res,2012,318(12):1407-1420.
[8] Gasmann R,Garvalho A,Henzing A J,et al.Borealin:a novel chromosomal passenger required for stability of the bipolar mitotic spindle[J].J Cell Biol,2004,166(2):179-191.
[9] Chang J L,Chen T H,Wang C F,et al.Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer[J].Exp Cell Res,2006,312(7):962-973.
[10] Hayama S,Daigo Y,Yamabuki T,et al.Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis[J].Cancer Res,2007,67(9):4113-4122.
[11] Wang Y,Zhao Z,Bao X P,et al.Borealin/Dasra B is overexpressed in colorectal cancers and contributes to proliferation of cancer cells[J].Med Oncol,2014,31(11):248.
[12] Li L,Li D,Tian F,et al.Hepatic loss of Borealin impairs postnatal liver development,regeneration,and hepatocarcinogenesis[J].J Biol Chem,2016,291(40):21137-21147.
[13] Zhang Q,Lin G,Gu Y,et al.Borealin is differentially expressed in ES cells and is essential for the early development of embryonic cells[J].Mol Biol Rep,2009,36(3):603-609.
[14] 张前军,卢光琇.Borealin及CPC相关基因在胚胎干细胞畸变过程中的表达差异[J].激光生物学报,2012,21(1):12-15.
[15] 李世灵,蔡扬,于燕妮,成元华.口腔癌及癌前病变中PLK1蛋白表达及其意义[J].临床与实验病理学杂志,2010,26(1):108-111.