子午流注开穴法联合中药对经前期综合征内分泌系统和睡眠质量的影响
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摘要
目的观察子午流注开穴法联合中药治疗经前期综合征(PMS)的临床疗效及对神经内分泌系统和睡眠质量的影响。方法将60例PMS患者随机分为观察组30例及对照组30例,对照组给予西医治疗,观察组在对照组治疗基础上给予子午流注开穴法+自拟中药治疗,2组均治疗3个月经周期。观察临床疗效,并记录2组治疗前后中医证候积分、神经内分泌系统和睡眠质量的变化情况。结果观察组治疗总有效率明显高于对照组(P<0.05);2组治疗后烦躁易怒、乳房胀痛、头痛、失眠多梦、性欲降低、小腹胀痛、胃脘胀痛、注意力不集中、总积分均显著降低(P均<0.05),观察组治疗后前5项及总积分均明显低于对照组(P均<0.05);2组治疗后卵泡期和黄体期血清性激素指标孕激素(P)、雌二醇(E_2)水平均显著升高(P均<0.05),泌乳素(PRL)水平显著降低(P均<0.05),且观察组治疗后的卵泡期和黄体期以上指标改善情况均优于对照组(P均<0.05)。2组治疗后匹斯堡睡眠质量指数(PSQI)中睡眠质量、入睡时间、睡眠效率、日间功能、睡眠时间、睡眠障碍、总分均显著降低(P均<0.05),观察组前4项和总分均显著低于对照组(P均<0.05)。结论子午流注开穴法联合中药治疗PMS的临床疗效显著,不仅能够减轻患者临床症状,还能够调节机体性激素分泌,改善睡眠质量,值得临床推荐。
Objective It is to observe the clinical efficacy of point selection by midday-midnight combined with traditional Chinese medicine in the treatment of premenstrual syndrome(PMS) and its effect on neuroendocrine system and sleep quality. Methods Sixty patients with PMS were randomly divided into observation group(30 cases) and control group(30 cases). The control group was treated with western medicine. The observation group was given acupuncture therapy of midnight-noon ebb-flow and self-made traditional Chinese medicine on the basis of the control group. Both groups were treated for 3 menstrual cycle. The clinical efficacy was observed, and the changes of TCM syndrome scores, neuroendocrine system and sleep quality before and after treatment were recorded. Results The total effective rate of the observation group was higher than that of the control group(P<0.05). After treatment, the scores of anxiety and irritability, breast pain, headache, insomnia and dreams, decreased libido, abdominal pain, stomach cramps, inattention, and total scores were significantly decreased in the two groups(P<0.05), the scores of the first 5 items and total scores in the observation group were lower than those in the control group(P<0.05). The levels of progesterone(P) and estradiol(E_2) in the follicular and luteal phase of the two groups were significantly increased after treatment, and the level of prolactin(PRL) was decreased(P<0.05), the improvements of these indexes in the follicular and luteal phase in the observation group were better than those in the control group(P<0.05). The scores of sleep quality, sleep latency, sleep efficiency, daytime function, sleep time, sleep dysfunction, and total score in PSQI after treatment were significantly decreased in the two groups(P<0.05), the scores of the first 4 items and total scores in the observation group were lower than those in the control group(P<0.05). Conclusion The clinical effect of point selection by midday-midnight combined with traditional Chinese medicine which can not only reduce the clinical symptoms of patients, but also regulate the secretion of sex hormones and improve the quality of sleep is significant in the treatment of PMS, it is worthy of clinical recommendation.
Objective It is to observe the clinical efficacy of point selection by midday-midnight combined with traditional Chinese medicine in the treatment of premenstrual syndrome(PMS) and its effect on neuroendocrine system and sleep quality. Methods Sixty patients with PMS were randomly divided into observation group(30 cases) and control group(30 cases). The control group was treated with western medicine. The observation group was given acupuncture therapy of midnight-noon ebb-flow and self-made traditional Chinese medicine on the basis of the control group. Both groups were treated for 3 menstrual cycle. The clinical efficacy was observed, and the changes of TCM syndrome scores, neuroendocrine system and sleep quality before and after treatment were recorded. Results The total effective rate of the observation group was higher than that of the control group(P<0.05). After treatment, the scores of anxiety and irritability, breast pain, headache, insomnia and dreams, decreased libido, abdominal pain, stomach cramps, inattention, and total scores were significantly decreased in the two groups(P<0.05), the scores of the first 5 items and total scores in the observation group were lower than those in the control group(P<0.05). The levels of progesterone(P) and estradiol(E_2) in the follicular and luteal phase of the two groups were significantly increased after treatment, and the level of prolactin(PRL) was decreased(P<0.05), the improvements of these indexes in the follicular and luteal phase in the observation group were better than those in the control group(P<0.05). The scores of sleep quality, sleep latency, sleep efficiency, daytime function, sleep time, sleep dysfunction, and total score in PSQI after treatment were significantly decreased in the two groups(P<0.05), the scores of the first 4 items and total scores in the observation group were lower than those in the control group(P<0.05). Conclusion The clinical effect of point selection by midday-midnight combined with traditional Chinese medicine which can not only reduce the clinical symptoms of patients, but also regulate the secretion of sex hormones and improve the quality of sleep is significant in the treatment of PMS, it is worthy of clinical recommendation.
引文
[1] 刘小菊,郭英慧,王海娟,等. 经前平颗粒治疗经前期综合征肝气逆证作用机制研究进展[J]. 辽宁中医杂志,2016,43(7):1542-1546
[2] 陈桂清. 维生素B6联合氟西汀治疗经前期综合征的临床研究[J/CD]. 中西医结合心血管病电子杂志,2017,5(36):81
[3] 连永祥. 柴胡加龙骨牡蛎汤治疗肝郁气滞型经前期综合征的临床研究[D]. 广州:广州中医药大学,2016:14-15
[4] 曹泽毅. 中华妇产科学[M]. 3版. 北京:人民卫生出版社,2014:203-204
[5] 国家中医药管理局. 中医病证诊断疗效标准[S]. 南京:南京大学出版社,1994:234
[6] 国家中医药管理局. 中药新药临床研究指导原则(试行)[S]. 北京:中国医药科技出版社,2002:198-199
[7] 陈昱文,曹泽标,周小青,等. 中医症状量化方法及其临床应用述评[J]. 湖南中医药大学学报,2016,36(3):82-86
[8] 路桃影,李艳,夏萍,等. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学,2014,43(3):260-263
[9] 龚水萍. 红花逍遥片治疗经前期综合征随机双盲双模拟、多中心临床研究[J/CD]. 实用妇科内分泌杂志:电子版,2017,4(16):54-58
[10] 孙晓玲,许丽绵,罗颂平,等. 经前平颗粒对经前期综合征肝气逆证患者的神经内分泌调节[J]. 时珍国医国药,2010,21(4):840-842
[11] 葛文娜. 香楝胶囊对经前期综合征肝气逆证大鼠血清激素水平的测定[J]. 中国保健营养,2017,27(22):11
[12] 张冬丽,张红霞,张洁. 坤泰胶囊对经前期综合征的临床疗效及对激素水平的影响[J]. 中药材,2016,39(11):2643-2645
[13] 杜素英. 谈经前期综合症与失眠[J]. 心理医生,2017,23(6):290-291
[14] 宋翠玲. 安神汤加减辨证治疗肝郁气滞型失眠的临床效果[J]. 中国保健营养,2016,26(14):270-271
[15] Jehan S,Auguste E,Hussain M,et al. Sleep and Premenstrual Syndrome[J]. J Sleep Med Disord,2016,3(5):1061-1065
[16] Ozisik Karaman HI,Tanriverdi G,Degirmenci Y. Subjective sleep quality in premenstrual syndrome[J]. Gynecol Endocrinol,2012,28(8):661-664
[17] 史宇航,邢翔宇,崔妍,等. 柴胡疏肝散配合耳穴治疗肝气郁滞型不寐30例疗效观察[J]. 中医临床研究,2015,7(19):68-69
[18] 张艺,谭桂云. 中药结合中医情志疗法治疗经前期综合征50例疗效观察[J]. 湖南中医杂志,2015,31(12):8-10
[19] 李宁,张莹. 子午流注开穴法治疗多囊卵巢综合征排卵障碍的疗效观察[J]. 北京中医药,2017,36(1):74-76
[20] 黄墩兵,谷诗浓,周凡萍,黄赛娥. 子午流注针法治疗原发性失眠的Meta分析[J]. 康复学报,2018,28(1):60-66
[21] 宋爱利. 子午流注针法临床研究进展[J]. 中华中医药杂志,2014,29(8):2551-2555
[2] 陈桂清. 维生素B6联合氟西汀治疗经前期综合征的临床研究[J/CD]. 中西医结合心血管病电子杂志,2017,5(36):81
[3] 连永祥. 柴胡加龙骨牡蛎汤治疗肝郁气滞型经前期综合征的临床研究[D]. 广州:广州中医药大学,2016:14-15
[4] 曹泽毅. 中华妇产科学[M]. 3版. 北京:人民卫生出版社,2014:203-204
[5] 国家中医药管理局. 中医病证诊断疗效标准[S]. 南京:南京大学出版社,1994:234
[6] 国家中医药管理局. 中药新药临床研究指导原则(试行)[S]. 北京:中国医药科技出版社,2002:198-199
[7] 陈昱文,曹泽标,周小青,等. 中医症状量化方法及其临床应用述评[J]. 湖南中医药大学学报,2016,36(3):82-86
[8] 路桃影,李艳,夏萍,等. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学,2014,43(3):260-263
[9] 龚水萍. 红花逍遥片治疗经前期综合征随机双盲双模拟、多中心临床研究[J/CD]. 实用妇科内分泌杂志:电子版,2017,4(16):54-58
[10] 孙晓玲,许丽绵,罗颂平,等. 经前平颗粒对经前期综合征肝气逆证患者的神经内分泌调节[J]. 时珍国医国药,2010,21(4):840-842
[11] 葛文娜. 香楝胶囊对经前期综合征肝气逆证大鼠血清激素水平的测定[J]. 中国保健营养,2017,27(22):11
[12] 张冬丽,张红霞,张洁. 坤泰胶囊对经前期综合征的临床疗效及对激素水平的影响[J]. 中药材,2016,39(11):2643-2645
[13] 杜素英. 谈经前期综合症与失眠[J]. 心理医生,2017,23(6):290-291
[14] 宋翠玲. 安神汤加减辨证治疗肝郁气滞型失眠的临床效果[J]. 中国保健营养,2016,26(14):270-271
[15] Jehan S,Auguste E,Hussain M,et al. Sleep and Premenstrual Syndrome[J]. J Sleep Med Disord,2016,3(5):1061-1065
[16] Ozisik Karaman HI,Tanriverdi G,Degirmenci Y. Subjective sleep quality in premenstrual syndrome[J]. Gynecol Endocrinol,2012,28(8):661-664
[17] 史宇航,邢翔宇,崔妍,等. 柴胡疏肝散配合耳穴治疗肝气郁滞型不寐30例疗效观察[J]. 中医临床研究,2015,7(19):68-69
[18] 张艺,谭桂云. 中药结合中医情志疗法治疗经前期综合征50例疗效观察[J]. 湖南中医杂志,2015,31(12):8-10
[19] 李宁,张莹. 子午流注开穴法治疗多囊卵巢综合征排卵障碍的疗效观察[J]. 北京中医药,2017,36(1):74-76
[20] 黄墩兵,谷诗浓,周凡萍,黄赛娥. 子午流注针法治疗原发性失眠的Meta分析[J]. 康复学报,2018,28(1):60-66
[21] 宋爱利. 子午流注针法临床研究进展[J]. 中华中医药杂志,2014,29(8):2551-2555