清胰汤治疗急性胰腺炎随机对照试验的Meta分析
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摘要
目的:客观评价清胰汤联合常规西医治疗急性胰腺炎的有效应和安全性。方法:计算机检索PubMed、Embase、Cochrane Library、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方(Wan Fang)和维普(VIP)数据库,手工补充检索相关的重要会议集和过刊资料,由2名研究者单独筛选文献、提取资料。用软件RevMan5.3和stata14作Meta分析。结果:共纳入的37篇RCTs,共纳入3 165例急性胰腺炎患者。Meta分析结果:1)清胰汤联合常规西医治疗急性清胰汤在提高有效率方面优于单纯使用西医常规治疗(RR=1.13,95%CI[1.09,1.17],Z=6.59,P<0.00001);2)清胰汤联合常规西医治疗能够明显降低急性胰腺炎患者的病死率和住院时间(RR=0.36,95%CI[0.24,0.53],P<0.00001;MD=-5.52,95%CI[-6.20,-4.84],Z=15.93,P<0.00001);3)平均住院时间的亚组SAP的合并效应量MD_(SAP)=-5.99,亚组MAP的合并效应量MD_(MAP)=-5.05,MD_(SAP)>MDMAP,因此清胰汤联合常规西医治疗在缩短住院时间方面对重症胰腺炎患者的效果更明显。结论:基于目前的证据,清胰汤联合常规西医治疗急性胰腺炎能够明显提高有效率,降低病死率,缩短住院时间,且对重症急性胰腺炎的效果更佳,但需要更多高质量的证据进一步验证本结论。
Objective: To evaluate the efficacy and safety of Qingyi Decoction combined with conventional western medicine in the treatment of acute pancreatitis.Methods: We searched PubMed,Embase,Cochrane Library,CBM,CNKI,Wan Fang) and VIP database,Manual Supplement retrieval important meeting set and Backissues related,by 2 researchers independently screened literature extracted data.Meta analysis with software RevMan5.3 and stata14.Results: A total of 37 RCTs were included in the study,including a total of 3165 patients with acute pancreatitis.Meta analysis results: 1) Qingyi Decoction Combined with conventional western medicine in the treatment of acute Qingyi Decoction in improving the efficiency is better than the simple use of conventional western medicine treatment( RR = 1.13,95% CI[1.09,1.17],Z = 6.59,P < 0.00001).2) the Qing Yi Decoction Combined with routine western medicine treatment can significantly reduce the mortality of patients with acute pancreatitis and the rate of hospitalization time( RR = 0.36.95% CI[0.24,0.53],P < 0.00001; MD =-5.52,95% CI[-6.20,-4.84],Z = 15.93,P < 0.00001).3) the combined effect of the amount of MD_(SAP) =-5.99 subgroup SAP the average hospitalization time,the combined effect of the amount of MD_(MAP) =-5.05 subgroup MAP,MD_(SAP) > MD_(MAP),so Qingyi decoction combined with conventional western medicine in the treatment of severe acute pancreatitis and shorten the hospitalization time with the more obvious effect.Conclusion: Based on current evidence,Qingyi Decoction Combined with conventional western medicine in the treatment of acute pancreatitis can significantly improve the efficiency,reduce the mortality,shorten the hospitalization time,and better effect on severe acute pancreatitis,but need more high quality evidence to further validate this conclusion.
Objective: To evaluate the efficacy and safety of Qingyi Decoction combined with conventional western medicine in the treatment of acute pancreatitis.Methods: We searched PubMed,Embase,Cochrane Library,CBM,CNKI,Wan Fang) and VIP database,Manual Supplement retrieval important meeting set and Backissues related,by 2 researchers independently screened literature extracted data.Meta analysis with software RevMan5.3 and stata14.Results: A total of 37 RCTs were included in the study,including a total of 3165 patients with acute pancreatitis.Meta analysis results: 1) Qingyi Decoction Combined with conventional western medicine in the treatment of acute Qingyi Decoction in improving the efficiency is better than the simple use of conventional western medicine treatment( RR = 1.13,95% CI[1.09,1.17],Z = 6.59,P < 0.00001).2) the Qing Yi Decoction Combined with routine western medicine treatment can significantly reduce the mortality of patients with acute pancreatitis and the rate of hospitalization time( RR = 0.36.95% CI[0.24,0.53],P < 0.00001; MD =-5.52,95% CI[-6.20,-4.84],Z = 15.93,P < 0.00001).3) the combined effect of the amount of MD_(SAP) =-5.99 subgroup SAP the average hospitalization time,the combined effect of the amount of MD_(MAP) =-5.05 subgroup MAP,MD_(SAP) > MD_(MAP),so Qingyi decoction combined with conventional western medicine in the treatment of severe acute pancreatitis and shorten the hospitalization time with the more obvious effect.Conclusion: Based on current evidence,Qingyi Decoction Combined with conventional western medicine in the treatment of acute pancreatitis can significantly improve the efficiency,reduce the mortality,shorten the hospitalization time,and better effect on severe acute pancreatitis,but need more high quality evidence to further validate this conclusion.
引文
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