2009—2015年浙江省台州市肾综合征出血热监测研究
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摘要
目的了解浙江省台州市2009 2015年肾综合征出血热(HFRS)的发病趋势及鼠类种群密度和携带汉坦病毒情况。方法病例资料来源于中国疾病监测信息系统,捕鼠采用夜夹法,鼠携带病毒检测采用免疫荧光法,鼠血清抗体检测采用酶联免疫吸附试验(ELISA)法。结果 2009 2015年台州市HFRS报告发病数为702例,年均报告发病率为1.68/10万。发病主要分布在天台县、三门县和临海市,占发病总数的70.94%;人群以农民为主,占81.34%,发病率与鼠密度存在显著的相关性(r=0.963,P=0.001);7年间监测点捕获鼠类11种1 425只,总鼠密度为3.91%,鼠平均带病毒率为3.72%,带病毒鼠种为黑线姬鼠50只,褐家鼠3只,其他鼠种未检出。结论台州市HFRS疫情维持在较低的水平,黑线姬鼠是主要的传染源及宿主,疫区仍为黑线姬鼠为主的混合型疫区。加强鼠间疫情监测对本病防控具有重要指导意义。
Objective To understand the incidence trend of hemorrhagic fever with renal syndrome( HFRS) and density and hantavirus carriage of rats in Taizhou,Zhejiang province,from 2009 to 2015. Methods The incidence data of HFRS were collected from national disease surveillance information system. Rats were captured by using traps. Hantavirus was detected using immunofluorescence assay and hantavirus antibodies were detected by using ELISA. Results From 2009 to 2015,a total of 702 HFRS cases were reported in Taizhou and the incidence rate was 1. 68/100 000. M ost cases occurred in Tiantai,Sanmen and Linhai counties,accounting for 70. 94% of total cases. About 81. 34% of cases were farmers. There was an obvious correlation between the incidence rate and the density of rats( r = 0. 963,P = 0. 001). A total of 1 425 rats in 11 species were captured from 2009 to 2015. The average density of rats was 3. 91% and the virus carriage rate was 3. 72%.Hantavirus was only detected in the samples from 50 Apodemus agrarius and 3 Rattus norvegicus. Conclusions The incidence of HFRS was lowin Taizhou. Apodemus agrarius was the major host animal in this mixed focus. It is necessary to strengthen the HFRS surveillance in Taizhou.
Objective To understand the incidence trend of hemorrhagic fever with renal syndrome( HFRS) and density and hantavirus carriage of rats in Taizhou,Zhejiang province,from 2009 to 2015. Methods The incidence data of HFRS were collected from national disease surveillance information system. Rats were captured by using traps. Hantavirus was detected using immunofluorescence assay and hantavirus antibodies were detected by using ELISA. Results From 2009 to 2015,a total of 702 HFRS cases were reported in Taizhou and the incidence rate was 1. 68/100 000. M ost cases occurred in Tiantai,Sanmen and Linhai counties,accounting for 70. 94% of total cases. About 81. 34% of cases were farmers. There was an obvious correlation between the incidence rate and the density of rats( r = 0. 963,P = 0. 001). A total of 1 425 rats in 11 species were captured from 2009 to 2015. The average density of rats was 3. 91% and the virus carriage rate was 3. 72%.Hantavirus was only detected in the samples from 50 Apodemus agrarius and 3 Rattus norvegicus. Conclusions The incidence of HFRS was lowin Taizhou. Apodemus agrarius was the major host animal in this mixed focus. It is necessary to strengthen the HFRS surveillance in Taizhou.
引文
[1]Ministry of Health Disease Control Division.Manual for prevention and control of hemorrhagic fever w ith renal syndrome[M].2nded.Beijing:The People's Medical Publishing House,1998.(in Chinese)卫生部疾病控制司《流行性出血热防治手册》编写组.流行性出血热防治手册[M].2版.北京:人民卫生出版社,1998.
[2]The Minister of Health of the People's Republic of China.National hemorrhagic fever w ith renal syndrome monitoring program(Trial)[S].Beijing:The M inister of Health of the People's Republic of China,2005.(in Chinese)中华人民共和国卫生部.全国肾综合征出血热监测方案(试行)[S].北京:卫生部,2005.
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[6]Wang Q,Li JD,Zhang QF,et al.Surveillance for hemorrhagic fever w ith renal syndrome in China,2014[J].Disease Surveillance,2016,31(3):192-199.(in Chinese)王芹,李建东,张全福,等.2014年全国肾综合征出血热监测总结和疫情分析[J].疾病监测,2016,31(3):192-199.
[7]Cui QR,Pang WL.Analysis on the surveillance results of hemorrhagic fever w ith renal syndrome in Tiantai country from2001 to 2003[J].Zhejiang Journal of Preventive Medicine,2005,17(6):16,21.(in Chinese)崔清荣,庞卫龙.天台县2001 2003年流行性出血热疫情分析[J].浙江预防医学,2005,17(6):16,21.
[8]Song G.Main achievements of prevention on epidemic hemorrhagic fever w ith renal syndrome in New China[J].Chinese Journal of Epidemiology,2000,21(5):378-382.(in Chinese)宋干.新中国流行性出血热防治研究的主要成就[J].中华流行病学杂志,2000,21(5):378-382.
[9]Zhang Z,Bo CR,Jiang X.Epidemiological analysis of hemorrhagic fever w ith renal syndrome in 2004 in Heilongjiang province[J].Disease Surveillance,2005,20(6):291-293.(in Chinese)张卓,柏春仁,姜欣.黑龙江省2004年肾综合征出血热流行情况分析[J].疾病监测,2005,20(6):291-293.
[10]Wang Q,Qu J,Zhang QF,et al.Surveillance for hemorrhagic fever w ith renal syndrome in China,2013[J].Disease Surveillance,2015,30(6):440-447.(in Chinese)王芹,曲靖,张全福,等.2013年全国肾综合征出血热疫情及监测分析[J].疾病监测,2015,30(6):440-447.
[11]Chen HX,Luo CW.Surveillance of hemorrhagic fever with renal syndrome and research on vaccine application[M].Hong Kong:Hong Kong Medical Press,2001:159-162.(in Chinese)陈化新,罗成旺.肾综合征出血热监测及疫苗应用研究[M].香港:香港医药出版社,2001:159-162.
[2]The Minister of Health of the People's Republic of China.National hemorrhagic fever w ith renal syndrome monitoring program(Trial)[S].Beijing:The M inister of Health of the People's Republic of China,2005.(in Chinese)中华人民共和国卫生部.全国肾综合征出血热监测方案(试行)[S].北京:卫生部,2005.
[3]Liu LC,Chen ZM,Cui QR,et al.Study and surveillance on hemorrhagic fever w ith renal syndrome in Taizhou city from 1984to 2005[J].Chinese Journal of Vector Biology and Control,2007,18(5):404-407.(in Chinese)刘令初,陈忠妙,崔清荣,等.1984 2005年台州市肾综合征出血热监测研究[J].中国媒介生物学及控制杂志,2007,18(5):404-407.
[4]Zhang ZX,Chen ZM,Cui QR,et al.Surveillance of hemorrhagic fever w ith renal syndrome(HFRS)in Taizhou city from 2000 to 2005[J].Disease Surveillance,2007,22(3):156-158.(in Chinese)张宗祥,陈忠妙,崔清荣,等.2000 2005年浙江省台州市肾综合征出血热监测研究[J].疾病监测,2007,22(3):156-158.
[5]Xie SY,Wang Z,Zhang L,et al.Analysis on the surveillance results of hemorrhagic fever w ith renal syndrome in Zhejiang province from 1996 to 2005[J].Disease Surveillance,2007,22(3):159-161.(in Chinese)谢淑云,王臻,张垒,等.1996 2005年浙江省肾综合征出血热监测结果分析[J].疾病监测,2007,22(3):159-161.
[6]Wang Q,Li JD,Zhang QF,et al.Surveillance for hemorrhagic fever w ith renal syndrome in China,2014[J].Disease Surveillance,2016,31(3):192-199.(in Chinese)王芹,李建东,张全福,等.2014年全国肾综合征出血热监测总结和疫情分析[J].疾病监测,2016,31(3):192-199.
[7]Cui QR,Pang WL.Analysis on the surveillance results of hemorrhagic fever w ith renal syndrome in Tiantai country from2001 to 2003[J].Zhejiang Journal of Preventive Medicine,2005,17(6):16,21.(in Chinese)崔清荣,庞卫龙.天台县2001 2003年流行性出血热疫情分析[J].浙江预防医学,2005,17(6):16,21.
[8]Song G.Main achievements of prevention on epidemic hemorrhagic fever w ith renal syndrome in New China[J].Chinese Journal of Epidemiology,2000,21(5):378-382.(in Chinese)宋干.新中国流行性出血热防治研究的主要成就[J].中华流行病学杂志,2000,21(5):378-382.
[9]Zhang Z,Bo CR,Jiang X.Epidemiological analysis of hemorrhagic fever w ith renal syndrome in 2004 in Heilongjiang province[J].Disease Surveillance,2005,20(6):291-293.(in Chinese)张卓,柏春仁,姜欣.黑龙江省2004年肾综合征出血热流行情况分析[J].疾病监测,2005,20(6):291-293.
[10]Wang Q,Qu J,Zhang QF,et al.Surveillance for hemorrhagic fever w ith renal syndrome in China,2013[J].Disease Surveillance,2015,30(6):440-447.(in Chinese)王芹,曲靖,张全福,等.2013年全国肾综合征出血热疫情及监测分析[J].疾病监测,2015,30(6):440-447.
[11]Chen HX,Luo CW.Surveillance of hemorrhagic fever with renal syndrome and research on vaccine application[M].Hong Kong:Hong Kong Medical Press,2001:159-162.(in Chinese)陈化新,罗成旺.肾综合征出血热监测及疫苗应用研究[M].香港:香港医药出版社,2001:159-162.