成骨细胞对造血的调控及传统药物在该调控中的作用研究进展
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摘要
目的:对成骨细胞对造血的调控及传统药物在该调控中的作用研究进展进行综述。方法:查阅国内外相关文献,从成骨细胞的起源及其特性、成骨细胞在造血功能活动中的作用、以及传统药物在成骨细胞造血调控中的干预作用研究进展进行总结、分析。结果:成骨细胞是体内造血诱导微环境的重要成分,可表达多种黏附分子将造血干细胞锚定于造血龛中并影响其功能;可分泌多种造血调节因子促进造血细胞增殖、生长;可影响干细胞的动员和移植后归巢;在一些造血系统疾病时,伴有成骨细胞数目及功能异常。传统药物经成骨细胞调节造血研究较少,作用肯定。结论:以成骨细胞为靶点,研究传统药物的造血调节作用,值得关注。
Objective: To review the progress of hematopoietic regulation of osteoblasts and the role of traditional medicine in the regulation. Method: Relevant literatures at home and abroad were reviewed. The origin and characteristics of osteoblasts, the role of osteoblasts in hematopoietic activity, and the intervention of traditional medicine in the regulation of osteoblasts hematopoiesis were summarized and analyzed. Result: Osteoblasts are important components of hematopoietic inductive microenvironment in vivo. This cell express various kinds of adhesion molecules to anchor hematopoietic stem cell into hematopoietic niches and affect their functions, promote the proliferation and the growth of hematopoietic cell, secrete many hematopoietic regulating factors as well as affect the stem cell's mobilization and homing after transplantation. The number and function of osteoblasts are abnormal in some hematopoietic diseases. Although there is little research on the effect of traditional medicine on hematopoiesis regulation by osteoblasts, the effect is positive. Conclusion: It is worthy to study the function of osteoblast in the hematopoiesis regulating of traditional medicine.
Objective: To review the progress of hematopoietic regulation of osteoblasts and the role of traditional medicine in the regulation. Method: Relevant literatures at home and abroad were reviewed. The origin and characteristics of osteoblasts, the role of osteoblasts in hematopoietic activity, and the intervention of traditional medicine in the regulation of osteoblasts hematopoiesis were summarized and analyzed. Result: Osteoblasts are important components of hematopoietic inductive microenvironment in vivo. This cell express various kinds of adhesion molecules to anchor hematopoietic stem cell into hematopoietic niches and affect their functions, promote the proliferation and the growth of hematopoietic cell, secrete many hematopoietic regulating factors as well as affect the stem cell's mobilization and homing after transplantation. The number and function of osteoblasts are abnormal in some hematopoietic diseases. Although there is little research on the effect of traditional medicine on hematopoiesis regulation by osteoblasts, the effect is positive. Conclusion: It is worthy to study the function of osteoblast in the hematopoiesis regulating of traditional medicine.
引文
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[19]Liersch R,Gerss J,Schliemann C,et al.Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients[J].Blood,2012,119(22):5215.
[20]Y Zhao,D Wu,C Fei,et al.Down-regulation of Dicer1promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome[J].Haematologica,2015,100(2):194.
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[23]马杰,史明霞,李炳宗,等.放射损伤对小鼠骨髓间充质干细胞成骨潜能及造血干细胞龛位的影响[J].西安交通大学学报(医学版),2009,30(3):295.
[24]尹利明,赵燕娜,杜文喜,等.人参总皂苷增强成骨分化的间充质干细胞促造血作用研究[J].中国药理学通报,2015,31(1):45.
[2]Zhang J,Niu C,Ye L,et al.Identification of the hematopoietic stem cell niche and control of the niche size[J].Nature,2003,425(6960):836.
[3]Calvi LM,Adams GB,Weibrecht KW,et al.Osteoblastic cells regulate the hematopoietic stem cell niche[J].Nature,2003,425(6960):841.
[4]Visnjic D,Kalajzic Z,Rowe DW,et al.Hematopoiesis is severely altered in mice with an induced osteoblast deficiency[J].Blood,2004,103(9):3258.
[5]Taichman R S.Blood and bone:two tissues whose fates are inter twinedto create the hematopoietic stem-cell niche[J].Blood,2005,105:2631.
[6]Arai F.Regulation of hematopoiesis by the osteoblastic niche[J].Clin Calcium,2005,15(7):73.
[7]Jung Y,Wang J,Havens A,et al.Cell-to-cell contact is critical for the survival of hematopoietic progenitor cells on osteoblasts[J].Cyto-kine,2005,32(3):155.
[8]Hosokawa K,Arai F,Yoshihara H,et al.Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells[J].Blood,2010,116(4):554.
[9]黄晓兵,刘霆,孟文彤,等.骨髓间充质干细胞分化的成骨细胞支持脐血造血干祖细胞的研究[J].中国实验血液学杂志,2006,14(3):552.
[10]赵国峰,宋克东,刘天庆,等.低氧条件下微囊化成骨细胞调控造血干/祖细胞扩增的研究[J].高校化学工程学报,2009,23(4):623.
[11]Malaval L,Aubin JE.Biphasic effects of leukemia inhibitory factor on osteoblastic differentiation[J].Journal of Cellular Biochemistry,2001,36:63.
[12]Nelissen JM,Torensma R,Pluyter M,et al.Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS[J].Exp Hematol,2000,28(4):422.
[13]Arai F,Yoshihara H,Hosokawa K,et al.Niche regulation of hematopoietic stem cells in the endosteum[J].Annals of the New York Academy of Sciences,2009,1176(1):36.
[14]Rankin EB,Wu C,Khatri R,et al.The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO[J].Cell,2012,149(1):63.
[15]Semerad CL.G-CSF potently inhibits osteoblast activity and CXCL12 m RNA expression in the bone marrow[J].Blood,2005,106(9):3020.
[16]Katayama Y.Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow[J].Cell,2006,124(2):407.
[17]Aysegul OS,Miranda B.Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells[J].Cell Adhesion&Migration,2012,6(1):39.
[18]Frisch BJ,Ashton JM,Xing L,et al.Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia[J].Blood,2012,119(2):540.
[19]Liersch R,Gerss J,Schliemann C,et al.Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients[J].Blood,2012,119(22):5215.
[20]Y Zhao,D Wu,C Fei,et al.Down-regulation of Dicer1promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome[J].Haematologica,2015,100(2):194.
[21]Borojevic R,Roela RA,Rodarte RS,et al.Bone marrow stroma in childhood myelodysplastic syndrome:composition,ability to sustain hematopoiesis in vitro,and altered gene expression[J].Leuk Res,2004,28(8):831.
[22]Sophia R,Balderman LM.Biology of Marrow Failure Syndromes:Role of Microenvironment and Niches[J].Hematology Am Soc Hematol Educ Program,2014,2014(1):71.
[23]马杰,史明霞,李炳宗,等.放射损伤对小鼠骨髓间充质干细胞成骨潜能及造血干细胞龛位的影响[J].西安交通大学学报(医学版),2009,30(3):295.
[24]尹利明,赵燕娜,杜文喜,等.人参总皂苷增强成骨分化的间充质干细胞促造血作用研究[J].中国药理学通报,2015,31(1):45.