1407例酒精依赖住院患者抗菌药物应用调查与分析
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摘要
目的:了解新乡医学院第二附属医院(以下简称"我院")酒精依赖住院患者抗菌药物的使用情况,促进临床合理用药。方法:回顾性调取2015年1月—2017年6月我院1 407例酒精依赖出院患者的病历资料,对患者住院期间抗菌药物的使用情况进行统计与分析。结果:1 407例患者中,使用抗菌药物者216例,抗菌药物使用率为15.35%;伴发震颤谵妄或(和)癫痫患者抗菌药物使用率明显高于未伴发震颤谵妄或(和)癫痫患者。216例使用抗菌药物的患者中,治疗用药191例(占88.43%),预防用药25例(占11.57%);单一用药116例(占53.70%),二联应用99例(占45.83%),三联用药1例(占0.46%);35例进行了细菌培养,标本送检率为16.20%。结论:我院酒精依赖住院患者抗菌药物使用在预防用药、联合用药等方面存在不合理,应加强抗菌药物应用的培训与管理,提高合理用药水平。
OBJECTIVE: To investigate the application status of antibiotics in inpatients with alcohol dependence from the Second Affiliated Hospital of Xinxiang Medical University( hereinafter referred to as"our hospital"),so as to promote the rational application of antibiotics in clinic. METHODS: Medical records of 1 407 patients with alcohol dependence were retrospectively collected from Jan. 2015 to Jun. 2017,and statistical analysis was conducted on the application status of antibiotics in inpatients. RESULTS: Of the 1 407 patients,216 patients used antibiotics,and the application rate was 15. 35%. The application rate of antibiotics in patients complicated with delirium tremens or( and) epilepsy was significantly higher than that of patients without delirium tremens or( and) epilepsy. Of the 216 patients with antibiotics,191 cases( 88. 43%) were therapeutic medication,25 cases( 11. 57%) were preventive medication; 116 cases( 53. 70%) were single medication,99 cases( 45. 83%) were double medication and 1 cases( 0. 46%) was three-drug medication. There were 35 cases had bacterial culture,with bacterial examination rate of16. 20%. CONCLUSIONS: There are still some irrational phenomenon in application of antibiotics in preventive medication and drug combination for inpatients with alcohol dependence,it is necessary to strengthen the train and management of application of antibiotics,so as to improve the level of rational drug application.
OBJECTIVE: To investigate the application status of antibiotics in inpatients with alcohol dependence from the Second Affiliated Hospital of Xinxiang Medical University( hereinafter referred to as"our hospital"),so as to promote the rational application of antibiotics in clinic. METHODS: Medical records of 1 407 patients with alcohol dependence were retrospectively collected from Jan. 2015 to Jun. 2017,and statistical analysis was conducted on the application status of antibiotics in inpatients. RESULTS: Of the 1 407 patients,216 patients used antibiotics,and the application rate was 15. 35%. The application rate of antibiotics in patients complicated with delirium tremens or( and) epilepsy was significantly higher than that of patients without delirium tremens or( and) epilepsy. Of the 216 patients with antibiotics,191 cases( 88. 43%) were therapeutic medication,25 cases( 11. 57%) were preventive medication; 116 cases( 53. 70%) were single medication,99 cases( 45. 83%) were double medication and 1 cases( 0. 46%) was three-drug medication. There were 35 cases had bacterial culture,with bacterial examination rate of16. 20%. CONCLUSIONS: There are still some irrational phenomenon in application of antibiotics in preventive medication and drug combination for inpatients with alcohol dependence,it is necessary to strengthen the train and management of application of antibiotics,so as to improve the level of rational drug application.
引文
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[14]蔡柏蔷,李龙芸.协和呼吸病学[M].北京:中国协和医科大学出版社,2004:606.
[15]中华医学会呼吸病学分会.中国成人社区获得性肺炎诊断和治疗指南:2016年版[J].中华结核和呼吸杂志,2016,39(4):253-279.
[2]李晓霞.23例戒酒硫样反应临床分析[J].当代医学,2012,18(21):39-40.
[3]孙红岩,司继刚.药物双硫仑样反应预防和治疗进展[J].中国药物评价,2014,31(2):96-98.
[4]郝伟.酒精相关障碍的诊断与治疗指南[M].北京:人民卫生出版社,2014:131-136.
[5]王桂英,李宁宁,郭卜豪.酒精所致震颤谵妄相关因素研究[J].中国民康医学,2014,26(7):10-11.
[6]王海明.酒精戒断震颤谵妄状态合并肺部感染临床资料分析[J].临床心身疾病杂志,2016,22(3):130-131.
[7]胡晓华,刘修军,徐汉明.慢性酒精中毒酒戒断的震颤谵妄发作危险因素探析[J].中国神经精神疾病杂志,2006,32(5):407-411.
[8]常小龙,谭梦姗,郁金泰,等.抗癫痫药的致死性不良反应[J].中华神经科杂志,2015,48(12):1102-1105.
[9]原亚文,李仓霞.癫痫持续状态并发吸入性肺炎的特点[J].检验医学与临床,2011,8(24):3064-3065.
[10]李焕芬,朱利芳,褚留杰.精神病医院住院患者抗菌药物使用情况调查分析[J].中国药物警戒,2016,13(9):567-569.
[11]张英杰,张丹,邹吉敏.精神病院患者医院感染调查分析[J].中华医院感染学杂志,2015,25(5):1073-1075.
[12]曲红艳,钟家旺,甘红梅,等.酒精戒断综合征患者医院内肺部感染的原因分析与预防[J].中国疗养医学,2015,24(9):991-992.
[13]陈孝平,汪建平.外科学[M].8版.北京:人民卫生出版社,2013:136.
[14]蔡柏蔷,李龙芸.协和呼吸病学[M].北京:中国协和医科大学出版社,2004:606.
[15]中华医学会呼吸病学分会.中国成人社区获得性肺炎诊断和治疗指南:2016年版[J].中华结核和呼吸杂志,2016,39(4):253-279.