半夏白术天麻汤联合前列地尔注射液治疗脑缺血的临床研究
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摘要
目的:探讨半夏白术天麻汤联合前列地尔注射液对脑缺血患者的临床治疗效果。方法:将80例脑缺血患者随机分为对照组和观察组各40例,对照组给予前列地尔治疗,观察组给予半夏白术天麻汤联合前列地尔治疗。治疗结束后评估两组的临床治疗效果,并观察两组患者在治疗前后相关指标的变化情况。结果:观察组患者治疗后其总有效率(92.5%)及其显效比例(72.5%)明显高于对照组总有效率(70%)及显效比例(47.5%),两者之间的差异具有统计学意义(P<0.05);与对照组相比,观察组治疗后短暂性脑缺血发作(transient iscehemic atacks,TIA)发作停止时间明显优于对照组,两者之间的差异具有统计学意义(P<0.05);治疗后观察组TIA患者疾病转归情况与对照组相比,其差异具有明显的统计学意义(P<0.01);治疗后观察组NO检测值高于对照组(P<0.05),ET检测值低于对照组(P<0.05);治疗后两组TIA患者不良反应情况相比,其差异未见统计学意义(P>0.05)。结论:半夏白术天麻汤联合前列地尔注射液治疗TIA患者其临治疗效果显著,安全性高,值得临床推广及应用。
Objective: To investigate the clinical effect of Banxia Baizhu Tianma Decoction combined with alprostadil injection on cerebral ischemia. Methods: Eighty patients with cerebral ischemia were randomly divided into control group and observation group with 40 cases in each. The control group was treated with alprostadil. The observation group was treated with Banxia Baizhu Tianma Decoction combined with alprostadil. After treatment, the clinical treatment effects of the two groups were evaluated, and the changes of related indicators before and after treatment were observed. Results: The total effective rate(92.5%) and effective rate(72.5%) in the observation group were significantly higher than those in the control group(70%,47.5%). The difference between the two groups was significant(P<0.05). Compared with the control group, the duration of TIA attack after treatment in the observation group was significantly better than that of the control groupand the difference between the two groups was statistically significant(P<0.05).The observation group's TIA recovery after treatmentwas statistically significant compared with that of the control group(P<0.01). After treatment, NO was higher in the observation group than that in the control group(P<0.05), and the ET value was lower in the observation group than that in the control group(P<0.05). There was no statistically significant difference in the adverse reactions between TIA patients after treatment(P>0.05). Conclusion: The combination of Banxia Baizhu Tianma Decoction and alprostadil injection has significant clinical safety and efficacy in the treatment of TIA patients, which is worthy of clinical promotion and application.
Objective: To investigate the clinical effect of Banxia Baizhu Tianma Decoction combined with alprostadil injection on cerebral ischemia. Methods: Eighty patients with cerebral ischemia were randomly divided into control group and observation group with 40 cases in each. The control group was treated with alprostadil. The observation group was treated with Banxia Baizhu Tianma Decoction combined with alprostadil. After treatment, the clinical treatment effects of the two groups were evaluated, and the changes of related indicators before and after treatment were observed. Results: The total effective rate(92.5%) and effective rate(72.5%) in the observation group were significantly higher than those in the control group(70%,47.5%). The difference between the two groups was significant(P<0.05). Compared with the control group, the duration of TIA attack after treatment in the observation group was significantly better than that of the control groupand the difference between the two groups was statistically significant(P<0.05).The observation group's TIA recovery after treatmentwas statistically significant compared with that of the control group(P<0.01). After treatment, NO was higher in the observation group than that in the control group(P<0.05), and the ET value was lower in the observation group than that in the control group(P<0.05). There was no statistically significant difference in the adverse reactions between TIA patients after treatment(P>0.05). Conclusion: The combination of Banxia Baizhu Tianma Decoction and alprostadil injection has significant clinical safety and efficacy in the treatment of TIA patients, which is worthy of clinical promotion and application.
引文
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[13] 苏淑娟, 李朝健, 林任, 等. 中医辨证治疗脑梗死恢复期疗效分析[J]. 中华中医药学刊, 2018, 36(2): 489-491.
[14] 倪金迪, 李响, 刘梅, 等. 脑卒中及短暂性脑缺血发作的二级预防指南核心内容(2014年AHA/ASA版) [J]. 中国临床神经科学, 2015, 48(1): 65-73.
[15] 彭子壮, 卢晶晶, 蔡海荣, 等. 短暂性脑缺血发作危险因素与中医体质的相关性研究[J]. 中西医结合心脑血管病杂志, 2018, 16(3): 280-283.
[16] 袁咏梅. 半夏白术天麻汤辅助治疗短暂性脑缺血发作疗效分析[J].吉林中药, 2013, 33(9):919.
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[18] Zeng X, Zhang S, Zhang L, et al. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro[J]. Planta Med, 2016, 72(15): 1359-1365.
[19] 文平. 80例腔隙性脑梗死性眩晕临床疗效观察[J]. 光明中医, 2016, 31(8): 1111-1112.
[20] 张继程,李金花. 天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作的疗效[J]. 医药前沿, 2016, 6(1): 197-198.
[21] 杨树萍, 侯志东, 王永. 天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作疗效观察[J]. 医药前沿, 2016, 22(2): 42-43.
[2] Johnston DC, Hill MD. The patient with transient cerebral ischemia: a golden opportunity for stroke prevention[J]. CMAJ, 2017, 170(7): 1134-1137.
[3] Wang R, Wu X, Liang J, et al.Intra-artery infusion of recombinant human erythropoietin reduces blood-brain barrier disruption in rats following cerebral ischemia and reperfusion[J]. Int J Neurosci, 2015, 125(9): 693-702.
[4] Ding W, Zhou L, Liu W, et al.Opposite effects of the gap junction blocker octanol on focal cerebral ischemia occluded for different durations[J]. Mol Med Rep,2017, 9(6): 2485-2490.
[5] Chen X, Bi H, Zhang M, et al.Research of Sleep Disorders in Patients with Acute Cerebral Infarction[J]. J Stroke Cerebrovasc Dis,2015, 24(11):2508-2513.
[6] Okamura K, Tsubokawa T, Johshita H, et al.Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperiycemia[J]. Neurol Res, 2014, 36(1):65-69.
[8] 李春, 黄波, 韦朝阳. 短暂性脑缺血发作病因研究进展[J].解放军预防医学杂志, 2018, 36(2): 279-282.
[9] 薛保国. 中医干预治疗短暂性脑缺血发作的研究进展[J]. 实用中医内科杂志, 2012, 17: 103-104.
[10] 中华神经科学会, 中华神经外科学会. 各类脑血管疾病诊断要点[J]. 中华神经科杂志, 1996, 29 (6): 379-380.
[11] 黄小龙, 王玮. 补气通滞方对短暂性脑缺血发作气虚血滞型患者的安全性及有效性分析[J]. 中华中医药学刊, 2016, 34(9): 2032-2034.
[12] 顾玉宝, 刘敬霞, 王枫, 等. 中医药治疗脑梗死的临床研究进展[J]. 中华中医药学刊, 2017, 35(2): 303-306.
[13] 苏淑娟, 李朝健, 林任, 等. 中医辨证治疗脑梗死恢复期疗效分析[J]. 中华中医药学刊, 2018, 36(2): 489-491.
[14] 倪金迪, 李响, 刘梅, 等. 脑卒中及短暂性脑缺血发作的二级预防指南核心内容(2014年AHA/ASA版) [J]. 中国临床神经科学, 2015, 48(1): 65-73.
[15] 彭子壮, 卢晶晶, 蔡海荣, 等. 短暂性脑缺血发作危险因素与中医体质的相关性研究[J]. 中西医结合心脑血管病杂志, 2018, 16(3): 280-283.
[16] 袁咏梅. 半夏白术天麻汤辅助治疗短暂性脑缺血发作疗效分析[J].吉林中药, 2013, 33(9):919.
[17] 中华中医药学会. 中医内科常见病诊疗指南[S]. 北京: 中国中医药出版社, 2008: 253-254.
[18] Zeng X, Zhang S, Zhang L, et al. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro[J]. Planta Med, 2016, 72(15): 1359-1365.
[19] 文平. 80例腔隙性脑梗死性眩晕临床疗效观察[J]. 光明中医, 2016, 31(8): 1111-1112.
[20] 张继程,李金花. 天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作的疗效[J]. 医药前沿, 2016, 6(1): 197-198.
[21] 杨树萍, 侯志东, 王永. 天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作疗效观察[J]. 医药前沿, 2016, 22(2): 42-43.