慢性乙肝合并脂肪肝发病机制研究进展
|
摘要
我国慢性HBV感染人群基数较大,近些年随着人们生活水平的提高及饮食结构改变,非酒精性脂肪肝的人群亦随之增加,但对慢乙肝合并脂肪肝的相关研究并不多。此文就国内外慢乙肝合并脂肪肝的发病机制研究做一综述。
The prevalence of chronic HBV infection in our country is relatively large. In recent years, with the improvement of people's living standard and the change of diet, the population of nonalcoholic fatty liver disease also increased, but related researches on chronic hepatitis B complicated with nonalcoholic fatty liver disease are not many. This article gave a review of domestic and foreign pathogenesis of chronic hepatitis b complicated with nonalcoholic fatty liver disease.
The prevalence of chronic HBV infection in our country is relatively large. In recent years, with the improvement of people's living standard and the change of diet, the population of nonalcoholic fatty liver disease also increased, but related researches on chronic hepatitis B complicated with nonalcoholic fatty liver disease are not many. This article gave a review of domestic and foreign pathogenesis of chronic hepatitis b complicated with nonalcoholic fatty liver disease.
引文
[1]徐志勇,陈婕,肖荣,等.乙型肝炎病毒YMDD变异与病毒数量和药物治疗时间的关系[J].微循环学杂志,2012(4):52-53,56,114.
[2]谢维宁,黄腊平,吴颖仪,等.补肾健脾方联合拉米夫定治疗慢乙肝YMDD变异36例[J].福建中医药,2016(4):13-15.
[3]Ashtari S,Pourhoseingholi MA,Zali MR.Nonalcoholfatty liver disease in Asia:Prevention andplanning[J].World J Hepatol.2015 Jul 8;7(13):1788-96.
[4]潘慧英.高职院校学生脂肪肝发病率情况调查[J].临床医药文献电子杂志,2015(3):568,570.
[5]Jar u觢ka P,Jani ko M,Kru觩liak P,et al.Hepatitis B virus infection in patients with metabolic syndrome:a complicated relationship.Results of a population based study[J].Eur J Intern Med.2014,25(3):286-91.
[6]Pais R,Rusu E,Ratziu V.The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease[J].Clin Liver Dis.2014,18(1):165-78.
[7]Salvatore Petta,Calogero Camma`,Vito Di Marco,et al.Hepatic steatosis and insulin resistance are associated with severe￠brosisin patients with chronic hepatitis caused by HBV or HCV infection[J].Liver international:official journal of the International Association for the Study of the Liver.2011,31(4):507-15.
[8]李彩东,陈锡莲,田鹏飞,等.慢性乙型肝炎患者外周血中T淋巴细胞亚群和CD4~+CD25~+调节性T淋巴细胞的表达水平与HBV DNA定量的相关分析[J].临床肝胆病杂志,2015(4):541-545.
[9]Shimizu Y.T cell immunopathogenesis and immunotherapeutic strategies for chronic hepatitis B virus infection[J].World J Gastroenterol.2012 May 28;18(20):2443-51.
[10]江宇泳,叶永安,刘遥.慢性乙型肝炎合并脂肪肝的临床特征[J].中国临床医生杂志,2015(2):32-35.
[11]陈娟,沈薇,程文会,等.乙型肝炎病毒X蛋白对Hep G2细胞脂代谢相关基因表达的影响[J].中华肝脏病杂志,2011,19(10):768-773.
[12]王荣荣.TGFβ1及TNF-α与慢性乙型肝炎合并非酒精性脂肪肝关系的研究[D].山西医科大学,2011.
[13]韩玉香,刘国旺,钱静,等.健肝降脂丸联合干扰素治疗慢性乙型肝炎合并非酒精性脂肪肝的疗效观察[J].天津医药,2014(6):610-612.
[14]何鼎淳,钟承彪,万碟云,等.乙肝病毒慢性感染与肝源性糖尿病发生的相关性研究[J].临床医学工程,2016,23(1):45-47.
[15]Wong VW,Wong GL,Chu WC,et al.Hepatitis B virus infection and fatty liver in the general population[J].J Hepatol.2012,56(3):533-40.
[16]李冰,赵中夫.慢性HBV感染与非酒精性脂肪肝关系研究进展[J].长治医学院学报,2015(1):70-72.
[17]Zheng RD,Xu CR,Jiang L,et a1.Predictors of hepatic steatosis in HBe Agnegative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis[J].Int J Med Sci.2010,7(5):272-7.
[18]李洪艳,梁军,刘学奎,等.非酒精性脂肪肝肝纤维化评分与脂肪肝及胰岛素抵抗的相关性研究[J].中华临床医师杂志(电子版),2013,7(17):40-44.
[19]宓余强,刘勇钢,徐亮,等.慢性乙型肝炎患者肝脂肪变与肝脏HBs Ag和HBc Ag的关系[J].中华消化杂志,2012,32(5):316-319.
[20]施军平.加强HBV感染合并肝脂肪变的基础研究[J].中华实验和临床病毒学杂志,2013,27(5):321.
[21]李知玉,何清,敖飞健,等.79例ALT正常慢性乙型肝炎合并脂肪肝患者的肝脏病理特点及其影响因素[J].中华实验和临床感染病杂志(电子版),2011,5(4):465-469.
[22]滕颖,侯伟.乙型肝炎合并脂肪肝的研究现状[J].国际检验医学杂志,2015(22):3297-3299.
[23]张诤,潘勤,段晓燕,等.慢性乙型肝炎病毒感染合并非酒精性脂肪性肝病动物模型的建立与鉴定[J].中华肝脏病杂志,2011,19(9):658-663.
[24]张要栋,徐尧江,宋伟泉,等.肝脂肪变性对慢性乙型肝炎患者拉米夫定治疗临床疗效的影响[J].中国医师杂志,2014,(z1):62-65.
[2]谢维宁,黄腊平,吴颖仪,等.补肾健脾方联合拉米夫定治疗慢乙肝YMDD变异36例[J].福建中医药,2016(4):13-15.
[3]Ashtari S,Pourhoseingholi MA,Zali MR.Nonalcoholfatty liver disease in Asia:Prevention andplanning[J].World J Hepatol.2015 Jul 8;7(13):1788-96.
[4]潘慧英.高职院校学生脂肪肝发病率情况调查[J].临床医药文献电子杂志,2015(3):568,570.
[5]Jar u觢ka P,Jani ko M,Kru觩liak P,et al.Hepatitis B virus infection in patients with metabolic syndrome:a complicated relationship.Results of a population based study[J].Eur J Intern Med.2014,25(3):286-91.
[6]Pais R,Rusu E,Ratziu V.The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease[J].Clin Liver Dis.2014,18(1):165-78.
[7]Salvatore Petta,Calogero Camma`,Vito Di Marco,et al.Hepatic steatosis and insulin resistance are associated with severe￠brosisin patients with chronic hepatitis caused by HBV or HCV infection[J].Liver international:official journal of the International Association for the Study of the Liver.2011,31(4):507-15.
[8]李彩东,陈锡莲,田鹏飞,等.慢性乙型肝炎患者外周血中T淋巴细胞亚群和CD4~+CD25~+调节性T淋巴细胞的表达水平与HBV DNA定量的相关分析[J].临床肝胆病杂志,2015(4):541-545.
[9]Shimizu Y.T cell immunopathogenesis and immunotherapeutic strategies for chronic hepatitis B virus infection[J].World J Gastroenterol.2012 May 28;18(20):2443-51.
[10]江宇泳,叶永安,刘遥.慢性乙型肝炎合并脂肪肝的临床特征[J].中国临床医生杂志,2015(2):32-35.
[11]陈娟,沈薇,程文会,等.乙型肝炎病毒X蛋白对Hep G2细胞脂代谢相关基因表达的影响[J].中华肝脏病杂志,2011,19(10):768-773.
[12]王荣荣.TGFβ1及TNF-α与慢性乙型肝炎合并非酒精性脂肪肝关系的研究[D].山西医科大学,2011.
[13]韩玉香,刘国旺,钱静,等.健肝降脂丸联合干扰素治疗慢性乙型肝炎合并非酒精性脂肪肝的疗效观察[J].天津医药,2014(6):610-612.
[14]何鼎淳,钟承彪,万碟云,等.乙肝病毒慢性感染与肝源性糖尿病发生的相关性研究[J].临床医学工程,2016,23(1):45-47.
[15]Wong VW,Wong GL,Chu WC,et al.Hepatitis B virus infection and fatty liver in the general population[J].J Hepatol.2012,56(3):533-40.
[16]李冰,赵中夫.慢性HBV感染与非酒精性脂肪肝关系研究进展[J].长治医学院学报,2015(1):70-72.
[17]Zheng RD,Xu CR,Jiang L,et a1.Predictors of hepatic steatosis in HBe Agnegative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis[J].Int J Med Sci.2010,7(5):272-7.
[18]李洪艳,梁军,刘学奎,等.非酒精性脂肪肝肝纤维化评分与脂肪肝及胰岛素抵抗的相关性研究[J].中华临床医师杂志(电子版),2013,7(17):40-44.
[19]宓余强,刘勇钢,徐亮,等.慢性乙型肝炎患者肝脂肪变与肝脏HBs Ag和HBc Ag的关系[J].中华消化杂志,2012,32(5):316-319.
[20]施军平.加强HBV感染合并肝脂肪变的基础研究[J].中华实验和临床病毒学杂志,2013,27(5):321.
[21]李知玉,何清,敖飞健,等.79例ALT正常慢性乙型肝炎合并脂肪肝患者的肝脏病理特点及其影响因素[J].中华实验和临床感染病杂志(电子版),2011,5(4):465-469.
[22]滕颖,侯伟.乙型肝炎合并脂肪肝的研究现状[J].国际检验医学杂志,2015(22):3297-3299.
[23]张诤,潘勤,段晓燕,等.慢性乙型肝炎病毒感染合并非酒精性脂肪性肝病动物模型的建立与鉴定[J].中华肝脏病杂志,2011,19(9):658-663.
[24]张要栋,徐尧江,宋伟泉,等.肝脂肪变性对慢性乙型肝炎患者拉米夫定治疗临床疗效的影响[J].中国医师杂志,2014,(z1):62-65.