动物源性食品中氟喹诺酮类药物残留色谱质谱检测技术研究进展
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  • 英文篇名:Research Status on Chromatographic and Mass Spectrometry Analytical Methods for the Detection of Fluoroquinolones Residues in Animal Food
  • 作者:郭亚文 ; 卜晓娜 ; 刘楚 ; 王雅娟 ; 赵霞 ; 王波 ; 谢恺舟
  • 英文作者:GUO Ya-wen;BU Xiao-na;LIU Chu-jun;WANG Ya-juan;ZHAO Xia;WANG Bo;XIE Kai-zhou;College of Animal Science and Technology,Yangzhou University;Joint International Research Laboratory of Agriculture & Agri-Product Safety,Yangzhou University;
  • 关键词:氟喹诺酮类 ; 药物残留 ; 动物源性食品 ; 色谱和质谱检测技术
  • 英文关键词:fluoroquinolones;;drug residues;;animal foods;;chromatographic and mass spectrometry analytical methods
  • 中文刊名:ZSYY
  • 英文刊名:Chinese Journal of Veterinary Drug
  • 机构:扬州大学动物科学与技术学院;扬州大学教育部农业与农产品安全国际合作联合实验室;
  • 出版日期:2019-01-20
  • 出版单位:中国兽药杂志
  • 年:2019
  • 期:v.53
  • 基金:国家现代农业产业技术体系项目(CARS-41-G23);; 扬州大学高端人才支持计划资助(201801);; 江苏省农业科技自主创新基金项目(CX(18)3022)
  • 语种:中文;
  • 页:ZSYY201901022
  • 页数:13
  • CN:01
  • ISSN:11-2820/S
  • 分类号:69-81
摘要
兽药残留检测已成为保障全球动物源性食品安全技术手段的重要组成部分,色谱与质谱是兽药残留分析中最常用的检测方法。由于兽药各种类之间在理化性质、残留状态、限量要求等方面差异较大,导致在仪器分析环节存在一定的技术困难。综述动物源性食品中氟喹诺酮类药物残留色谱和质谱检测方法,指出各种方法的优缺点并对检测技术的发展进行展望,以期为氟喹诺酮类药物的残留检测提供技术支持和理论依据。
        Veterinary drug residue analysis has become an important component of global animal-origin foods safety,chromatography and mass spectrometry are the most commonly used methods for veterinary drug residue analysis. Because of the differences of physicochemical properties,residual station and limited quantity exist among the multiclass veterinary drugs,there are some technical difficulties in instrument analysis. To know more about the research development in this field,this review describes the chromatographic and mass spectrometry detection technology of fluoroquinolones residues in animal source food status,the characteristics of various methods are pointed out,and the development of detection technology is prospected,in order to provide certain references about fluoroquinolones residues in food detection.
引文
[1]张家禾,孟婷,周作红,等.动物性食品中氟喹诺酮类药物残留检测方法的研究进展[J].中国畜牧兽医,2014,41(5):262-266.Zhang J H,Meng T,Zhou Z H,et al. Research progress on detection method for fluoroquinolones residues in ebible animal products[J]. China animal husbandry and veterinary medicine,2014,41(5):262-266.
    [2]范维,高晓月,陈超,等.动物源性食品中喹诺酮类药物残留的检测[J].肉类研究,2017,31(4):36-42.Fan W,Gao X Y,Chen C,et al. Screening and confirmation of quinolones residues in animal-derived food[J]. Meat research,2017,34(4):36-42.
    [3]王勇,龚勇,卢明华.氟喹诺酮类药物残留检测方法的研究进展[J].中国畜牧兽医,2017,44(8):2509-2516.Wang Y,Gong Y,Lu M H. Research progress on detection methods of fluoroquinolones residues[J]. China animal husbandry and veterinary medicine,2017,44(8):2509-2516.
    [4]李琳,文学忠,钟雯,等.检测氟喹诺酮类药物残留对比与分析[J].农业与技术,2015,35(21):7-9.Li L,Wen X Z,Zhong W,et al. Comparison and analysis of the detection of fluoroquinolones residues[J]. Agriculture and technology,2015,35(21):7-9.
    [5]中华人民共和国农业部公告第235号.动物性食品中兽药最高残留限量[S].Bulletin 235th Ministry of Agriculture of the People's Republic of China. Maximum limit of veterinary drug residues in animal food[S].
    [6] Cho H J,Yi H,Cho S M,et al. Single-step extraction followed by LC for determination of(fluoro)quinolone drug residues in muscle,eggs, and milk[J]. Journal of separation science,2010,33(8):1034-1043.
    [7] Roybal J E,Pfenning A P,Turnipased S B,et al. Determination of four fluoroquinolones in milk by liquid chromatography[J].Journal of association of official analytical chemists international,1997,80(5):982-987.
    [8] Liu G Y,Wang N B,Li W,et al. Determination of fluo-roquinolone residues in penaeus japonicas by microwave-assisted extraction and ion-pair high performance liquid chromatography[J]. Journal of Liquid Chromatography and Related Technologies,2012,35:1270-1282.
    [9] Lv Y K,Jia C L,Zhang J Q,et al. Preparation and characterization of molecularly imprinted monolithic column for on-line solid-phase extraction coupled with HPLC for determination of the fluoroquinolone residues in honey samples[J]. Journal of liquid chromatography and related technologies,2013,36(2),249-260.
    [10] E Patyra,K Kwiatek. Determination of fluoroquinolones in animal feed by ion pair high-performance liquid chromatography with fluorescence detection[J]. Analytical letters,2017,7(50):1711-1720.
    [11] He X,Wang G N,Yang K,et al. Magnetic graphene dispersive solid phase extraction combining high performance liquid chromatography for determination of fluoroquinolones in foods[J]. Food chemistry,2016,221:1221-1226.
    [12] Yang K,Wang G N,Liu H Z,et al. Preparation of dual-template molecularly imprinted polymer coated stir bar based on computational simulation for detection of fluoroquinolones in meat[J].Journal of chromatography B,2017,1046:65-72.
    [13] SS Bozkurt,D Erdogan,M Antep,et al. Use of ionic liquid based chitosan as sorbent for preconcentration of fluoroquinolones in milk,egg,fish,bovine,and chicken meat samples by solid phase extraction prior to HPLC determination[J]. Journal of liquid chromatography and related technologies,2016,39(1):21-29.
    [14] C Vakh,M Alaboud,S Lebedinets,et al. An automated magnetic dispersive micro-solid phase extraction in a fluidized reactor for the determination of fluoroquinolones in baby food samples[J].Analytica Chimica Acta,2018,1001:59-69.
    [15] Mei M,Huang X. Determination of fluoroquinolones in environmental water and milk samples treated with stir cake sorptive extraction based on a boron-rich monolith[J]. Journal of Separation Science,2016,39(10):1908-1918.
    [16]陈小红,张顺喜,李少杰.液相色谱法检测鸡蛋中四种氟喹诺酮类药物残留前处理方法探讨[J].畜禽业,2017,10:19-20.Chen X H,Zhang S X,Li S J. Pretreatment of four Fluoroquinolones Residues in eggs by liquid chromatography[J]. Livestock and poultry industry,2017,10:19-20.
    [17]刘亚梅,闵盛.高效液相色谱法同时测定禽蛋中环丙沙星、达氟沙星和恩诺沙星的残留量[J].理化检验-化学分册,2016,152(3):305-307.Liu Y M,Min S. Simultaneous determination of the residues of ciprofloxacin,danofloxacin and enrofloxacin in eggs by HPLC[J]. Physical testing and chemical analysis part B,2016,152(3):305-307.
    [18]杨勇,罗奕,苏菊,等.高效液相色谱荧光检测器测定氟喹诺酮类药物残留方法的建立[J].中国农业科技导报,2016,18(2):176-181.Yang Y,Luo Y,Su J,et al. A method for determination of fluoroquinolone residues by HPLC with fluorescence detector[J]. Journal of agricultural science and technology,2016,18(2):176-181.
    [19]池永红,云雅光. SPE-HPLC检测动物源性食品中3种氟喹诺酮类药物残留[J].食品研究与开发,2015,36(20):152-155.Chi Y H,Yun Y G. Determination of three fluoroquinolones in animal-derived food by combining SPE with HPLC[J]. Food research and development,2015,36(20):152-155.
    [20]杨勇,姚天月,龚兴旺. HPLC-DAD法测定牛奶中6种氟喹诺酮类药物残留的研究[J].卫生职业教育,2017,35(17):97-99.Yang Y,Yao T Y,Gong X W. Determination of 6 fluoroquinolones residues in milk by HPLC-DAD[J]. Health vocational education,2017,35(17):97-99.
    [21]刘莉莉,罗雷,罗永煌.草鱼肌肉中诺氟沙星、恩诺沙星和环丙沙星的多残留检测[J].西南大学学报(自然科学报),2010,32(5):171-176.Liu L L,Luo L,Luo Y H. Detection of multiple residues in norfloxacin,enrofloxacin and ciprofloxacin in grass carp muscle[J].Journal of southwest university(natural science),2010,32(5):171-176.
    [22]杨长志,刘永,孟冰冰,等.动物源性食品中五种氟喹诺酮类药物残留量的同时测定[J].分析实验室,2008,27(9):82-85.Yang C Z,Liu Y,Meng B B,et al. Simultaneous determination of five fluoroquinolones residues in foodstuff of animal origin[J].Chinese journal of analysis laboratory,2008,27(9):82-85.
    [23]夏环,王妍,荆涛,等.分子印迹固相萃取-高效液相色谱法测定蜂蜜中三种氟喹诺酮类抗生素残留[J].分析科学学报,2012,28(3):297-302.Xia H,Wang Y,Jing T,et al. Determination of three fluoroquinolones antibiotics residue in honey using molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography[J]. Journal of analytical science,2012,28(3):297-302.
    [24]李佩佩,陈雪昌,张小军,等.高效液相色谱法检测水产品中氟喹诺酮类药物残留量方法的优化[J].中国渔业质量与标准,2012,2(2):84-88.Li P P,Chen X C,Zhang X J,et al. Optimization research on determination of fluoroquinolones residues in aquatic products by high performance liquid chromatography[J]. Chinese fishery quality and standards,2012,2(2):84-88.
    [25]王圣义,胡娟,张瑞延,等.高压液相色谱-荧光检测法测定蜂蜜中诺氟沙星、环丙沙星和恩诺沙星残留量[J].中国蜂业,2010,61(8):32-35.Wang S Y,Hu J,Zhang R Y,et al. Determination of norfloxacin,ciprofloxacin and enrofloxacin Residues in honey by high pressure liquid chromatography with fluorescence detection[J]. Apiculture of china,2010,61(8):32-35.
    [26]林玲,杨春亮,王明月,等.固相萃取-反相高效液相色谱法测定猪肉中4种氟喹诺酮类药物的残留量[J].分析仪器,2014,1:33-37.Lin L,Yang C L,Wang M Y,et al. Simultaneous determination of four fluoroquinolone residues in pork by SPE-RP-HPLC[J].Analysis instrument,2014,1:33-37.
    [27]程勇翔,夏曦,张鹏春,等.环境友好的HPLC方法检测鸡蛋中6种氟喹诺酮类药物残留[J].中国农业大学学报,2017,22(4):109-119.Chen Y X,Xia X,Zhang P C,et al. Development of environment-friendly HPLC method for simultaneous determination of six fluoroquinolones in eggs[J]. Journal of china agricultural university,2017,22(4):109-119.
    [28]李丹,张玉洁,孙志文,等.高效液相色谱法测定羊奶中五种氟喹诺酮类药物残留量的研究[J].中国兽药杂志,2016,50(1):31-35.Li D,Zhang Y J,Sun Z W,et al. Study on detection method quinolones residues in sheep milk by HPLC[J]. Chinese journal of veterinary drug,2016,50(1):31-35.
    [29]孙鹏,乔石,郭秀娟,等.离子液体分散液相微萃取-HPLC法测定液态奶中恩诺沙星和环丙沙星[J].药物分析杂志,2017,37(1):111-116.Sun P,Qiao S,Guo X J,et al. Determination of enrofloxacin and ciprofloxacin in liquid milk by ionic liquid-based dispersive liquid-phase microextraction coupled with HPLC[J]. Journal of pharmaceutical analysis,2017,37(1):111-116.
    [30]胡永萍,徐克功,余舒宁,等.高效液相色谱荧光法测定鸡肉及鸡蛋中4种喹诺酮类药物残留量的研究[J].畜牧与兽医,2017,49(11):47-51.Hu Y P,Xu K G,Yu S N,et al. Determination of four kinds of fluoroquinolone residues in the chicken or egg by high performance liquid chromatography with fluorescence[J]. Animal husbandry and veterinary medicine,2017,49(11):47-51.
    [31]徐尉力,聂稳,张凯丽,等.基于离子液体的基质固相分散萃取高效液相色谱法测定肌肉组织中的氟喹诺酮类抗生素[J].食品科学,2016,38(16):210-215.Xu W L,Nie W,Zhang K L,et al. Determination of Fluroquinolones in Muscle Samples by Ionic Liquid-based Matrix Solid Phase Dispersion Extraction coupled with High-Performance Liquid Chromatography[J]. Food science,2016,38(16):210-215.
    [32] J Aufartova,I Brabcova,Me Torres-Padron,et al. Determination of fluoroquinolones in fishes using microwave-assisted extraction combined with ultra-high performance liquid chromatography and fluorescence detection[J]. Journal of food composition and analysis,2017,56:140-146.
    [33] Sc Vardali,Vf Samanidou,Yp Kotzamanis. Rapid confirmatory method for the determination of danofloxacin and n-desmethyl danofloxacin in european seabass by UPLC-PDA[J]. Current analytical chemistry,2018,14(7):68-74.
    [34]赵芳,李研东,霍惠玲. UPLC法测定鸡蛋中氟喹诺酮类药物残留[J].今日畜牧兽医,2017:9-10.Zhao F,Li Y D,Huo H L. Determination of fluoroquinolone residues in eggs by UPLC[J]. Today animal husbandry and veterinary medicine,2017:9-10.
    [35]侯耀杰.超高效液色谱相法检测鸡蛋中氟喹诺酮类药物残留[J].家禽科学,2018,(1):11-13.Hou Y J. The determination of fluoroquinolones residues in egg by ultra performance liquid chromatography method[J]. Poultry science,2018,(1):11-13.
    [36]杨卫军,李曼,曹秀梅,等.超高效液相色谱法检测鸡肉中氟喹诺酮类药物残留[J].现代畜牧兽医学,2016,4:8-12.Yang W J,Li M,Cao X M,et al. Discussion on determination of fluoroquinolones residues in chicken by ultra-performance liquid chromatography[J]. Modern journal of animal husbandry and veterinary medicine,2016,4:8-12.
    [37]方益,严忠雍,喻亮,等.水产品中氟喹诺酮类药物残留的测定[J].安徽农业科学,2016,44(28):92-93.Fang Y,Yan Z Y,Yu L,et al. Determination of quinolones residues in aquatic products[J]. Journal of anhui agricultural sciences. 2016,44(28):92-93.
    [38]董艳峰,于静泉,张巍.超高效液相色谱法同时测定鸡肝中五种氟喹诺酮类药物残[J].中国兽药杂志,2010,44(6):5-8.Dong Y F,Yu J Q,Zhang W. Simultaneous determination of five fluoroquinolones residues in chicken liver by ultra performance liquid chromatography[J]. Chinese journal of veterinary drug,2010,44(6):5-8.
    [39]张玉洁,李倩,汪霞,等.高效液相色谱法检测多种动物组织中氟喹诺酮类药物残留量的研究[J].中国兽药杂志,2012,46(7):18-22.Zhang Y J,Li Q,Wang X,et al. Determination of fluoroquinolones in tissues of several animal by HPLC[J]. Chinese journal of veterinary drug,2012,46(7):18-22.
    [40]李宁,林小莉,董艳峰.优化超高效液相色谱法对鸡蛋中氟喹诺酮类药物残留的检[J].黑龙江农业科学,2014,(3):107-109.Li N,Lin X L,Dong Y F. Detection of quinolones residues in egg by UPLC method[J]. Heilongjiang agricultural sciences,2014,(3):107-109.
    [41] Kantiani L,Farr E M,Barcel D. Rapid residue analysis of fluoroquinolones in raw bovine milk by online solid phase extraction followed by liquid chromatography coupled to tandem mass spectrometry[J]. Journal of chromatography A,2011,1218(50):9019-9027.
    [42] Tang Y,Xu J,Chen L,et al. Rapid in vivo determination of fluoroquinolones in cultured puffer fish(Takifugu obscurus)muscle by solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry[J]. Talanta,2017,175:550-556.
    [43] Montesano C,Curini R,Sergi M,et al. Determination of marbofloxacin in plasma and synovial fluid by ultrafiltration followed by HPLC-MS/MS[J]. Journal of pharmaceutical and biomedical analysis,2016,123:31-36.
    [44] Johnston L,Mackay L,Croft M. Determination of quinolones and fluoroquinolones in fish tissue and seafood by high-performance liquid chromatography with electrospray ionisa-tion tandem mass spectrometric detection[J]. Journal of chromatography A,2002,982(1):97-109.
    [45] Barreto F,Ribeiro CBD,Hoff Rb,et al. Development and validation of a high-throughput method for determination of nine fluoroquinolones residues in muscle of different animal species by liquid chromatography coupled to tandem mass spectrometry with low temperature clean up[J]. Journal of chromatography A,2017,1521:131-139.
    [46] Chen L,Huang X. Sensitive monitoring of fluoroquinolones in milk and honey using multiple monolithic fiber solid-phase microextraction coupled to liquid chromatography tandem mass spectrometry[J]. Journal of agricultural and food chemistry,2016,64(45):86-84.
    [47] Sm Da,Rm Orlando,Af Faria. Electrical field assisted matrix solid phase dispersion as a powerful tool to improve the extraction efficiency and clean-up of fluoroquinolones in bovine milk[J].Journal of chromatography A,2016,1461:27-34.
    [48] Meng Z,Shi Z,LliangS,et al. Residues investigation of fluoroquinolones and sulphonamides and their metabolites in bovine milk by quantification and confirmation using ultra-performance liquid chromatography-tandem mass spectrometry[J]. Food chemistry,2015,174:597-605.
    [49]倪永付,朱莉萍,王勇,等.微波辅助萃取-液相色谱-串联质谱法检测猪肉中四种氟喹诺酮类药物残留[J].肉类工业,2012,9:42-44.Ni Y F,Zhu L P,Wang Y,et al. Determination of four fluoroquinolones residues in pork by LC-MS/MS using microwaveassisted extraction[J]. Meat industry,2012,9:42-44.
    [50]李婧妍,郭春锋,崔立辉,等.分散固相萃取法结合高效液相色谱-串联质谱法测定禽蛋中喹诺酮类兽药残留量[J].中国家禽,2016,38(14):31-35.Li J Y,Guo C F,Cui L H,et al. Determination of quinolones residues in eggs with dispersive solid phase extraction and high performance liquid chromatography tandem mass spectrometry[J]. China poultry,2016,38(14):31-35.
    [51]张中印,赵柳微,曹葳蕤,等. QuEChERS前处理方法结合高效液相色谱-串联质谱测定蜂蜜和蜂王浆中14种喹诺酮类药物残留[J].食品科学,2016,37(16):242-248.Zhang Z Y,Zhao L W,Cao W R,et al. Simultaneous determination of fluoroquinolone residues in honey and royal jelly by QuEChERS and high performance liquid chromatography-tandem mass spectrometry[J]. Food science,2016,37(16):242-248.
    [52]王威利,吴维煇,何绮霞,等.高效液相-串联质谱法同时检测鸡蛋中金刚烷胺与四种氟喹诺酮类药物残留的研究[J].中国家禽,2016,38(2):29-32.Wang W L,Wu W Y,He Q X,et al. Simultaneous determination of amantadine and four kinds of quinolones in eggs by high performance liquid chromatography with tandem mass spectrometry[J]. China poultry,2016,38(2):29-32.
    [53]黄优生,刘波平,朱筱玲,等.高效液相色谱-串联质谱法快速测定鱼肉中4种氟喹诺酮类药物残留[J].食品科学,2010,31(2):127-130.Huang Y S,Liu B P,Zhu Y L,et al. A rapid high-performance liquid chromatography-tandem mass spectrometric method for determination of 4 fhoroquinolones residues in fish meat[J].Food science,2010,31(2):127-130.
    [54]孙雷,朱馨乐,张骊,等.牛奶中七种氟喹诺酮类药物残留检测高效液相色谱-串联质谱法研究[J].中国兽药杂志,2008,42(11):16-19.Sun L,Zhu X L,Zhang L,et al. Determination of seven fluoroquinolones residues in milk by high performance liquid chromatography tandem mass spectrometry[J]. Chinese journal of veterinary drug,2008,42(11):16-19.
    [55]孙雷,朱馨乐,刘琪,等.猪肉组织中7种氟喹诺酮类药物残留检测高效液相色谱-串联质谱法研究[J].中国兽药杂志,2008,42(3):12-15.Sun L,Zhu X L,Liu Q,et al. Determination of seven fluoroquinolones in pig muscle by HPLC-MS/MS[J]. Chinese journal of veterinary drug,2008,42(3):12-15.
    [56]门婷婷,刘晨,刘珂飞. UPLC-MS/MS法测定鸡蛋、鸡肉中4种氟喹诺酮类药物残留[J].天津农业科学,2017,23(6):34-36.Men T T,Liu C,Liu K F. UPLC-MS/MS method for determination of four fluoroquinolones drug residues in eggs and chicken[J]. Tianjin agricultural sciences,2017,23(6):34-36.
    [57]徐芹,曲斌,朱志谦,等.超高效液相色谱-串联质谱快速测定生鲜牛乳中的氟喹诺酮类药物残留[J].畜牧与兽医,2014,46(9):19-22.Xu Q,Qu B,Zhu Z Q,et al. Rapid determination of fluoroquinolones residues in raw bovine milk by UPLC-MS/MS[J].Animal husbandry and veterinary medicine,2014,46(9):19-22.
    [58]郭伟,刘永,刘宁,等.超高效液相色谱-电喷雾串联质谱法同时分析鸡肉中7种氟喹诺酮类药物残留[J].色谱,2009,27(4):406-411.Guo W,Liu Y,Liu N,et al. Simultaneous analysis of 7 fluoroquinolone residues in chicken muscle by ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry[J]. Chinese journal of chromatography,2009,27(4)406-411.
    [59]孟哲,石志红,石运开,等.超高效液相色谱-高分辨四级杆飞行时间质谱法快速筛查乳制品中磺胺类与氟喹诺酮类药物[J].分析化学,2014,42(10):1493-1500.Meng Z,Shi Z H,Shi Y K,et al. Rapid screening of fluoroquinolones and sulfonamides in dairy products using ultra performance liquid chromatography coupled to high-resolution quadrupole time-of-flight mass spectrometry[J]. Chinese journal of analytical chemistry,2014,42(10):1493-4500.
    [60]杨艳菲,曹旭敏,李雪莲,等.分子印迹固相萃取-超高效液相色谱-串联质谱法测定鸡肉中9种氟喹诺酮药物残留[J].色谱,2016,34(11):1063-1069.Yang Y F,Cao X M,Li X L,et al. Determination of nine nuoroquinolone residues in chicken by ultra-performance liquid chromatography-tandem mass spectrometry coupled with molecularly imprinted solid phase extraction[J]. Chinese journal of chromatography,2016,34(11):1063-1069.
    [61]刘冬虹,吴玉銮,王斌,等.分散固相萃取-超高效液相色谱-串联质谱测定肉制品中5类药物残留[J].现代食品科技,2016,32(10):290-296.Liu D H,Wu Y L,Wang B,et al. Analysis of five types of veterinary drug residues in meat products by dispersive solid phase extraction-UPLC-MS/MS[J]. Modern food science and technology,2016,32(10):290-296.
    [62]杨盛茹,张恒业,张煌,等. UPLC-MS/MS检测鸡蛋中22种喹诺酮类药物残留方法的研究[J].现代食品科技,2007,33(8):262-268.Yang S R,Zhang H Y,Zhang H,et al. Simultaneous determination of twenty-two quinolone residues in eggs using ultra-performance liquid chromatography-tandem mass spectrometry[J]. Modern food science and technology,2007,33(8):262-268.
    [63]张颖颖,李莹莹.超高效液相色谱-串联质谱测定猪肉中16种喹诺酮药物残留量[J].肉类研究,2016,35(5):36-41.Zhang Y Y,Li Y Y. Determination of sixteen quinolones residues in pork by ultra-performance liquid chromatography-tandem mass spectrometry[J]. Meat research,2016,35(5):36-41.

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