右丙亚胺治疗蒽环类药物诱发静脉炎2例
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摘要
目的观察右丙亚胺在治疗蒽环类药物诱发化疗性静脉炎中的安全性及有效性。方法65岁男性急性髓细胞白血病(M2a)患者静滴蒽环类药物后,左手背出现红肿、疼痛,先后给予硫酸镁外敷、芦荟外敷、土豆外敷,无效,后静脉注射右丙亚胺治疗(500mg,连续5d);38岁男性MDS转急性髓细胞白血病患者给予蒽环类药物后左手背出现红肿、疼痛,即静脉注射右丙亚胺治疗(500mg,连续5d)。临床随访(1个月)评定疗效。结果第1例应用右丙亚胺后4d疼痛减轻,7d红肿消退;第2例给予右丙亚胺治疗次日疼痛减轻,3d红肿消退。2例患者除局部留有轻度色素沉着外,手及前臂功能无影响。结论右丙亚胺治疗蒽环类药物诱发静脉炎行之有效,尽早应用,疗效更佳。
Objective The purpose of this study was to assess the efficiency and safety of the treatment of anthracyclines induced phlebitis with dexrazoxane.Methods The first case was a 65year-old male patient with acute myelogenous leukemia(M2a).His left back appeared redness swollen,and pain after giving anthracyclines.The successively external application with magnesium sulfate,aloe,and potatoes was ineffective,then dexrazoxane(500mg,5d)was given intravenously;The second case was a 38 yearold male patient with acute myelogenous leukemia transferred by MDS.His left back appeared redness,swollen,and pain after giving anthracyclines dexrazoxane(500mg,5d).The curative effect was evaluated by clinical follow-up(1month).Results After giving dexrazoxane intravenously,pain was relieved,and red faded,no side effects observed.Conclusion Giving dexrazoxane intravenously for phlebitis induced by anthracyclines,is an effective method.
Objective The purpose of this study was to assess the efficiency and safety of the treatment of anthracyclines induced phlebitis with dexrazoxane.Methods The first case was a 65year-old male patient with acute myelogenous leukemia(M2a).His left back appeared redness swollen,and pain after giving anthracyclines.The successively external application with magnesium sulfate,aloe,and potatoes was ineffective,then dexrazoxane(500mg,5d)was given intravenously;The second case was a 38 yearold male patient with acute myelogenous leukemia transferred by MDS.His left back appeared redness,swollen,and pain after giving anthracyclines dexrazoxane(500mg,5d).The curative effect was evaluated by clinical follow-up(1month).Results After giving dexrazoxane intravenously,pain was relieved,and red faded,no side effects observed.Conclusion Giving dexrazoxane intravenously for phlebitis induced by anthracyclines,is an effective method.
引文
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[2]王书杰,武永吉,沈悌.蒽环类药物的心脏毒性[J].医学研究杂志,2006,35(1):64.
[3]李小强.诺氟沙星葡萄糖注射液致局部静脉炎1例[J].西北药学杂志,2001,16(2):230.
[4]王林翀,申向英,李小怡,等.静滴甘露醇引起静脉炎的原因、预防和护理[J].西北药学杂志,2002,17(5):230.
[5]Jacobi U,Waibler E,Schulze P,et al.Release of doxorubicin in sweat:fitst step to induce the palmar-plantar erytrodysesthesia syndrome[J].European Society Med Oncol(ESMO),2005,16(7):1210-1211.
[6]Classen S,Olland S,Berger J M,et al.Structure of the topoisemerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187[J].Proc Natl Acad Sci,2003,100(19):10629-10634.
[7]Hasinoff B B.Dexrazoxane use in the prevention of anthracycline extravasation injury[J].Future Oncol,2006,2(1):15-20.