控癌战重在六个整合
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摘要
鉴于癌症是机体"内乱"所致(癌细胞来自正常细胞),异于传染病的外敌入侵,因此"抗癌战"宜改为"控癌战"。控癌战需要强调六个整合,即消灭战略与改造战略的整合,单兵作战与综合治疗的整合,战役速决与战略持久的整合,被动治疗与主动参与的整合,高精尖新与多快好省的整合,以及洋为中用与中国思维的整合。
Cancer is an internal disorder, as cancer cells come from normal cells, unlike infectious diseases. Therefore, "War on Cancer" should be renamed as "Cancer Control War". Cancer Control War would need to emphasize on six integrations: integration of elimination and transformation strategies, integration of individual combat and comprehensive treatment, integration of quick decision in battle and lasting strategy, integration of passive treatment and active participation, integration of advanced technology and efficient, economical results, and integration of foreign service and Chinese mindset.
Cancer is an internal disorder, as cancer cells come from normal cells, unlike infectious diseases. Therefore, "War on Cancer" should be renamed as "Cancer Control War". Cancer Control War would need to emphasize on six integrations: integration of elimination and transformation strategies, integration of individual combat and comprehensive treatment, integration of quick decision in battle and lasting strategy, integration of passive treatment and active participation, integration of advanced technology and efficient, economical results, and integration of foreign service and Chinese mindset.
引文
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[2]Early Breast Cancer Trialists'Collaborative Group(EBCTCG).Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer:meta-analysis of individual patient data from ten randomised trials[J].Lancet Oncol,2018,19(1):27-39.
[3]Zappasodi R,Merghoub T,Wolchok JD.Emerging concepts for immune checkpoint blockade-based combination therapies[J].Cancer Cell,2018,33(4):581-598.
[4]Rankin EB,Giaccia AJ.Hypoxic control of metastasis[J].Science,2016,352(6282):175-180.
[5]Barton MK.Daily aspirin may reduce mortality from prostate cancer with risk of high recurrence[J].CA Cancer J Clin,2015,65(2):83-84.
[6]Wang WQ,Liu L,Sun HC,et al.TanshinoneⅡA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization[J].J Hematol Oncol,2012,(5):69-80.
[7]Boilly B,Faulkner S,Jobling P,et al.Nerve dependence:from regeneration to cancer[J].Cancer Cell,2017,31(3):342-354.
[8]Renz BW,Takahashi R,Tanaka T,et al.β2 Adrenergic-neurotrophin feed forward loop promotes pancreatic cancer[J].Cancer Cell,2018,33(1):75-90.
[9]Benemei S,Geppetti P,De Giorgi V.Improving the propranolol treatment of melanoma-reply[J].JAMA Oncol,2018,4(7):1013-1014.
[10]Nyquist MD,Nelson PS.Anti-depressant therapy brightens the outlook for prostate cancer bone metastases[J].Cancer Cell,2017,31(3):303-305.
[11]Spitzer MH,Carmi Y,Reticker-Flynn NE,et al.Systemic immunity is required for effective cancer immunotherapy[J].Cell,2017,168(3):487-502.
[12]June CH,Warshauer JT,Bluestone JA.Is autoimmunity the Achilles'heel of cancer immunotherapy[J]?Nat Med,2017,23(5):540-547.
[13]Derks MGM,Blok EJ,Seynaeve C,et al.Adjuvant tamoxifen and exemestane in women with postmenopausal early breast cancer(TEAM):10-year follow-up of a multicentre,open-label,randomised,phase 3trial[J].Lancet Oncol,2017,18(9):1211-1220.
[14]Geiger R,Rieckmann JC,Wolf T,et al.L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity[J].Cell,2016,167(3):829-842.
[15]Maddocks ODK,Athineos D,Cheung EC,et al.Modulating the therapeutic response of tumours to dietary serine and glycine starvation[J].Nature,2017,544(7650):372-376.
[16]Corbet C,Feron O.Tumour acidosis:from the passenger to the driver's seat[J].Nat Rev Cancer,2017,17(10):577-593.
[17]Roerink SF,Sasaki N,Lee-Six H,et al.Intra-tumour diversification in colorectal cancer at the single-cell level[J].Nature,2018,556(7702):457-462.
[18]Boshuizen J,Koopman LA,Krijgsman O,et al.Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors[J].Nat Med,2018,24(2):203-212.
[19]Kleppe M,Koche R,Zou L,et al.Dual Targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms[J].Cancer Cell,2018,33(1):29-43.
[20]Kagoya Y,Tanaka S,Guo T,et al.A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects[J].Nat Med,2018,24(3):352-359.
[21]Zhang QB,Zhang BH,Zhang KZ,et al.Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in nude mice model:with reference to nervous system[J].Oncogene,2015:1-10.doi:10.1038/onc.2015.484
[22]Zhang QB,Meng XT,Jia QA,et al.Herbal compound Songyou Yin and moderate swimming suppress growth and metastasis of liver cancer by enhancing immune function[J].Integr Cancer Ther,2015:1-8.DOI:10.1177/1534735415622011
[23]Yan YQ,Jiang W,Liu L,et al.Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome[J].Cell,2015,160(1-2):62-73.
[24]Ben-Shaanan TL,Schiller M,Azulay-Debby H,et al.Modulation of antitumor immunity by the brain's reward system[J].Nat Commun,2018,9(1):2723.
[25]McGranahan N,Swanton C.Cancer evolution constrained by the immune microenvironment[J].Cell,2017,170(5):825-827.
[26]Koelwyn GJ,Quail DF,Zhang X,et al.Exercise-dependent regulation of the tumour microenvironment[J].Nat Rev Cancer,2017,17(10):620-632.
[27]Ribas A,Wolchok JD.Cancer immunotherapy using checkpoint blockade[J].Science,2018,359(6382):1350-1355.
[28]Chen Q,Shu C,Laurence AD,et al.Effect of huaier granule on recurrence after curative resection of HCC:a multicentre,randomised clinical trial[J].Gut,2018,67(11):2006-2016.