康复新联合碘甘油佐治儿童急性化脓性扁桃体炎的疗效及对炎症介质的影响观察
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摘要
目的观察康复新联合碘甘油对急性化脓性扁桃体炎患儿血清炎症介质降钙素原(PCT)、C-反应蛋白(CRP)、白介素-6(IL-6)表达水平的影响及疗效。方法将250例急性化脓性扁桃体炎住院患儿采用随机数字表法分为观察组和对照组,每组125例。两组患儿均以抗感染、退热及营养支持等常规治疗。观察组在常规治疗基础上加用康复新联合碘甘油。检测两组患儿治疗前和治疗后第3天血清PCT、CRP、IL-6的表达水平变化,并比较两组临床疗效。结果治疗后第3天,两组患儿血清PCT、CRP、IL-6表达水平均有不同幅度下降,但观察组下降幅度较对照组更明显(P <0. 05)。观察组痊愈75例,显效40例,无效10例。对照组痊愈40例,显效35例,无效50例。观察组疗效优于对照组(P <0. 01)。结论康复新联合碘甘油佐治儿童急性化脓性扁桃体炎具有较好的疗效,可降低血清PCT、CRP、IL-6表达水平。
Objective To observe the treatment of Kangfuxin combined with iodine glycerol in children with acute suppurative tonsillitis and its effects on inflammatory mediators including inflammatory medium serum procalcitonin( PCT),C-reactive protein( CRP) and interleukin-6( IL-6). Methods Two hundred and fifty hospitalized children with acute suppurative tonsillitis were divided into observation group and control group according to the principle of random allocation,with 125 cases in each group. All the children were treated with anti infection,abatement of fever and nutritional support and other conventional treatments. The observation group was treated with Kangfuxin combined with iodine glycerol. The levels of serum PCT,CRP and IL-6 were observed before and 3 days after treatment in the two groups. The clinical efficacy was compared between the two groups. Results The levels of serum PCT,CRP and IL-6 were decreased in the two groups after treatment. The decreases of the observation group were more obvious than those of the control group( P < 0. 05). In the observation group,75 cases were cured,40 cases markedly effective and 10 cases ineffective. In the control group,40 cases were cured,35 cases markedly effective and 50 cases ineffective. The curative effect of the observation group was better than that of the control group( P < 0. 01). Conclusion Kangfuxin combined with iodine glycerol has good curative effect in treatment of children's acute suppurative tonsillitis. It can reduce the serum levels of PCT,CRP and IL-6.
Objective To observe the treatment of Kangfuxin combined with iodine glycerol in children with acute suppurative tonsillitis and its effects on inflammatory mediators including inflammatory medium serum procalcitonin( PCT),C-reactive protein( CRP) and interleukin-6( IL-6). Methods Two hundred and fifty hospitalized children with acute suppurative tonsillitis were divided into observation group and control group according to the principle of random allocation,with 125 cases in each group. All the children were treated with anti infection,abatement of fever and nutritional support and other conventional treatments. The observation group was treated with Kangfuxin combined with iodine glycerol. The levels of serum PCT,CRP and IL-6 were observed before and 3 days after treatment in the two groups. The clinical efficacy was compared between the two groups. Results The levels of serum PCT,CRP and IL-6 were decreased in the two groups after treatment. The decreases of the observation group were more obvious than those of the control group( P < 0. 05). In the observation group,75 cases were cured,40 cases markedly effective and 10 cases ineffective. In the control group,40 cases were cured,35 cases markedly effective and 50 cases ineffective. The curative effect of the observation group was better than that of the control group( P < 0. 01). Conclusion Kangfuxin combined with iodine glycerol has good curative effect in treatment of children's acute suppurative tonsillitis. It can reduce the serum levels of PCT,CRP and IL-6.
引文
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3 刘华香,岳峰,吴涛.降钙素原超敏C反应蛋白及白细胞检测在肺部细菌感染中的诊断价值[J].中国临床新医学,2015,8(2):137-139.
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6 赵军,赵静,刘爱霞,等.降钙素原和白介素-6在感染性疾病病原体诊断中的联合检测价值[J].中华实验和临床病毒学杂志,2014,28(5):380-382.
7 乔小宁,曹红利.康复新液治疗疱疹性口腔炎疗效观察[J].现代中西医结合杂志,2010,19(5):542-543.
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9 俞秀英.康复新液雾化吸入佐治小儿急性化脓性扁桃体炎60例疗效观察[J].浙江中医杂志,2017,52(3):203.
10 王永午.现代儿科药物治疗学[M].北京:人民军医出版社,1998:374.
11 何解生.碘甘油的临床新用途[J].中国药师,2004,7(9):733-735.
2 欧阳学认,刘华,许华.喜炎平注射液治疗小儿急性化脓性扁桃体炎的临床研究[J].广州中医药大学学报,2017,34(4):492-495.
3 刘华香,岳峰,吴涛.降钙素原超敏C反应蛋白及白细胞检测在肺部细菌感染中的诊断价值[J].中国临床新医学,2015,8(2):137-139.
4 罗建华,肖汉龙,王军.复方甘草酸苷联合枸地氯雷他定治疗慢性荨麻疹[J].实验医药杂志,2011,28(8):697.
5 张晓慧,李光韬,张卓莉. C反应蛋白与超敏C反应蛋白的检测及其临床意义[J].中华临床免疫和变态反应杂志,2011,5(1):74-79.
6 赵军,赵静,刘爱霞,等.降钙素原和白介素-6在感染性疾病病原体诊断中的联合检测价值[J].中华实验和临床病毒学杂志,2014,28(5):380-382.
7 乔小宁,曹红利.康复新液治疗疱疹性口腔炎疗效观察[J].现代中西医结合杂志,2010,19(5):542-543.
8 林小苑.康复新液治疗小儿急性化脓性扁桃体炎疗效观察[J].中医临床研究,2014,24(6):90-91.
9 俞秀英.康复新液雾化吸入佐治小儿急性化脓性扁桃体炎60例疗效观察[J].浙江中医杂志,2017,52(3):203.
10 王永午.现代儿科药物治疗学[M].北京:人民军医出版社,1998:374.
11 何解生.碘甘油的临床新用途[J].中国药师,2004,7(9):733-735.