甲基苯丙胺成瘾生物标志物及其检测技术进展
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摘要
甲基苯丙胺(methamphetamine,MA)是一种具有精神兴奋作用的苯丙胺类兴奋剂(amphetamine-type stimulants,ATS),具有极强的耐受性和成瘾性,并且具有复吸率高,易获得以及躯体戒断症状不明显等特点。近年来,由于MA成瘾者的人数逐年上升,从分子生物学角度探究MA成瘾生物标志物的研究也在增加,并且出现了很多新的检测技术,综述这些候选生物标志物及其检测技术将有助于MA临床诊断及探究MA成瘾机制。
Methamphetamine(MA),which has the effect of mental excitement,is one of amphetamine-type stimulants(ATS). It has very strong tolerance and addiction,with high relapse rate,easy access,unconspicuous physical withdrawal symptoms and other characteristics. Because the number of MA addicts is gradually rising in recent years,the research of MA addiction biomakers from the aspect of molecular biology is also increasing and many new detection technologies have appeared. Summarizing these biomarkers and their detection technologies is benefit to MA's diagnostic technique and helps to discover MA's addictive mechanisms.
Methamphetamine(MA),which has the effect of mental excitement,is one of amphetamine-type stimulants(ATS). It has very strong tolerance and addiction,with high relapse rate,easy access,unconspicuous physical withdrawal symptoms and other characteristics. Because the number of MA addicts is gradually rising in recent years,the research of MA addiction biomakers from the aspect of molecular biology is also increasing and many new detection technologies have appeared. Summarizing these biomarkers and their detection technologies is benefit to MA's diagnostic technique and helps to discover MA's addictive mechanisms.
引文
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[14]李汉成,李婵,周玉婷.微小RNA-181a-5p在甲基苯丙胺依赖大鼠血清外泌体中的表达及生物信息学分析[J].中国临床药理学杂志,2018,34(1):45-48.
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[21]蒙国懿,何繁漪,隋念含. RGS4和D2受体信号通路相关分子在甲基苯丙胺依赖CPP大鼠纹状体的表达变化[J].中国临床药理学与治疗学,2017,22(12):1377-1381.
[22]潘俭. miR-219a-5p在甲基苯丙胺成瘾中的作用[D].宁波:宁波大学,2017.
[23]马艳君,邱云亮.利用基因芯片技术筛选汉族人群甲基苯丙胺依赖相关基因的初步研究[J].毒理学杂志,2017,31(1):25-29.
[24]李继印,刘青青,任国印.甲基苯丙胺检测方法的研究进展[J].河南科技大学学报(医学版),2016,34(3):236-240.
[2] BRENSILVER M,HEINZERLING KG,SHOPTAW S. Pharmacotherapy of amphetamine-type stimulant dependence:an update[J]. Drug Alcohol Rev,2013,32(5):449-460.
[3] FAN YL,CHEN DM,YU JR. Trends in biomarker research and application[J]. Chemistry of Life,2013,33(3):344-351.
[4]刘溪,代振凤,蒲小平.甲基苯丙胺成瘾机制进展[J].中国新药杂志,2017,26(21):2541-2545.
[5] SZUMLINSKI KK,LOMINAC KD,CAMPBELL RR,et al.Methamphetamine addiction vulnerability:the glutamate, the bad,and the ugly[J]. Biol Psychiat,2017,11(81):959-970.
[6]岳庆伟,朱德晓,吴金涛.甲基苯丙胺对中脑边缘投射多巴胺神经元自发动作电位频率和I_h电流的影响[J].山东大学学报(医版),2014,52(5):10-14.
[7] SHI WL,ZHAO X,LIU ZM,et al. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction[J]. Neurosci Lett,2012,525(1):23-28.
[8] LEHMANN S,KIELIBA T,BEIKE J,et al. Determination of 74new psychoactive substances in serum using automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B,2017,1064:124-138.
[9]吴明健,王玫,张高勤.甲基苯丙胺依赖大鼠血清代谢组学研究[J].中国药物依赖性杂志,2013,22(6):419-422.
[10]程洁,蒋雷,环飞.甲基苯丙胺对大鼠小胶质细胞的损伤及炎性相关基因表达的影响[J].南京医科大学学报(自然科学版),2017,37(9):1131-1135.
[11] RIFKIN RA,MOSS SJ,SLESINGER PA. G protein-gated potassium channels:a link to drug addiction[J]. Trends Pharm Sci,2017,38(4):378-392.
[12]程洁,蒋雷,钱文溢.甲基苯丙胺暴露对神经病理性蛋白APP及p-tau表达的影响[J].南京医科大学学报(自然科学版),2017,37(12):1548-1552.
[13]何永旺,李娟,周一卿. miRNAs在甲基苯丙胺成瘾中的作用研究进展[J].中国药理学通报,2017,33(8):1056-1060.
[14]李汉成,李婵,周玉婷.微小RNA-181a-5p在甲基苯丙胺依赖大鼠血清外泌体中的表达及生物信息学分析[J].中国临床药理学杂志,2018,34(1):45-48.
[15]郝柳,罗涛,董慧茜,等.嵌合蛋白-2基因启动子区甲基化改变可能与甲基苯丙胺成瘾有关[J].上海精神医学,2017,29(6):358-364.
[16] HUANG MC,LAI YC,LIN SK,et al. Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence[J]. The Am J Drug Alcohol Abuse,2018,44(3):395-402.
[17] IAMJAN SA,THANOI S,WATIKTINKORN P,et al. Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis[J]. J Psychopharmacol,2018,32(3):309-315.
[18] SU H,TAO J,ZHANG J. An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers[J].Neurosci Lett,2014,582(582):16-20.
[19] MYCHASIUK R,MUHAMMAD A,ILNYTSKYY S. Persistent gene expression changes in NAc,Mpfc,and OFC associated with previous nicotine or amphetamine exposure[J]. Behav Brain Res,2013,256(1):655-661.
[20] CADET JL,BRANNOCK C,KRASNOVA IN,et al. Genomewide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence[J]. Mol Psychiatr,2017,22(8):1196-1204.
[21]蒙国懿,何繁漪,隋念含. RGS4和D2受体信号通路相关分子在甲基苯丙胺依赖CPP大鼠纹状体的表达变化[J].中国临床药理学与治疗学,2017,22(12):1377-1381.
[22]潘俭. miR-219a-5p在甲基苯丙胺成瘾中的作用[D].宁波:宁波大学,2017.
[23]马艳君,邱云亮.利用基因芯片技术筛选汉族人群甲基苯丙胺依赖相关基因的初步研究[J].毒理学杂志,2017,31(1):25-29.
[24]李继印,刘青青,任国印.甲基苯丙胺检测方法的研究进展[J].河南科技大学学报(医学版),2016,34(3):236-240.