维生素D与肥胖的研究进展
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摘要
维生素D作为一种脂溶性维生素,其骨骼外非经典作用越来越受到人们关注。越来越多的研究表明维生素D与糖尿病、肥胖、心血管疾病、肿瘤等疾病存在相关性。维生素D缺乏与肥胖的相关性为近年研究的热点,但相关机制仍未明确。本文就维生素D与肥胖二者之间的关系及其可能的相关机制进行综述。
As a fat-soluble vitamin, vitamin D has attracted more and more attention from its extraskeletal non-classical role. More and more studies have shown that vitamin D is associated with diseases such as diabetes, obesity, cardiovascular disease and cancer. The relationship between vitamin D deficiency and obesity is the research hotspot in recent years, but the related mechanisms are still unclear.This paper reviewed the relationship between vitamin D and obesity and its possible related mechanisms.
As a fat-soluble vitamin, vitamin D has attracted more and more attention from its extraskeletal non-classical role. More and more studies have shown that vitamin D is associated with diseases such as diabetes, obesity, cardiovascular disease and cancer. The relationship between vitamin D deficiency and obesity is the research hotspot in recent years, but the related mechanisms are still unclear.This paper reviewed the relationship between vitamin D and obesity and its possible related mechanisms.
引文
[1] Müller TD, Clemmensen C, Finan B, et al. Anti-obesity therapy:from rainbow pills to polyagonists[J]. Pharmacol Rev, 2018, 70(4):712-746.
[2] Bray GA, Heisel WE, Afshin A, et al. The science of obesity manage ment:an endocrine society scientific statement[J]. Endocr Rev,2018, 39(2):79-132.
[3] Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat:evidence for a storage site in the rat[J]. J Clin Invest, 1971, 50(3):679-687.
[4] Hossein-nezhad A, Holick MF. Vitamin D for health:a global perspective[J]. Mayo Clinic Proc, 2013, 88(7):720-755.
[5] Hypponen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities[J].Nutr Rev, 2018, 76(9):678-692.
[6] Sato M, Hiragun A. Demonstration of 1α, 25-dihydroxyvitamin D3receptor-like molecule in ST 13 and 3T3 L1 preadipocytes and its inhibitory effects on preadipocyte differentiation[J]. J Cell Physiol,1988, 135(3):545-550.
[7] Looker AC. Body fat and vitamin D status in black versus white women[J]. J Clin Endocrinol Metab, 2005, 90(2):635-640.
[8] Rafiq R, Walschot F, Lips P, et al. Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations[J]. Clin Nutr, 2018. DOI:10.1016/j.clnu.2018.12.018.
[9] Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis[J].Annu Rev Cell Dev Biol, 2000, 16:145-171.
[10] Kong J, Li YC. Molecular mechanism of 1, 25-dihydroxyvitamin D3inhibition of adipogenesis in 3T3-L1 cells[J]. Am J Physiol Endocrinol Metab, 2006, 290(5):E916-924.
[11] Sergeev IN. 1, 25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12[J].Biochem Biophys Res Commun, 2009, 384(1):18-21.
[12] Chang E, Kim Y. Vitamin D decreases adipocyte lipid storage and in creases NAD-SIRT1 pathway in 3T3-L1 adipocytes[J]. Nutr, 2016,32(6):702-708.
[13] CantóC, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 ac tivity[J].Nature, 2009, 458(7241):1056-1060.
[14] Marcotorchino J, Tourniaire F, Astier J, et al. Vitamin D pro tects against diet-induced obesity by enhancing fatty acid oxidation[J]. J Nutr Biochem, 2014, 25(10):1077-1083.
[15] Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D3supplementation on body fat mass in healthy overweight and obese women[J]. Nutr J, 2012, 11:78.
[16] Rosenblum JL, Castro VM, Moore CE, et al. Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults[J]. Am J Clin Nutr,2012, 95(1):101-108.
[17] Wamberg L, Kampmann U, Stodkilde-Jorgensen H, et al. Ef fects of vitamin D supplementation on body fat accumulation, in flammation,and metabolic risk factors in obese adults with low vitamin D levelsresults from a randomized trial[J]. Eur J Intern Med, 2013, 24(7):644-649.
[18] Szlagatys-Sidorkiewicz A, Brzeziński M, Jankowska A, et al. Longterm effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme(a double-blind placebo-controlled study)-rationale for the study design[J]. BMC Pediatr, 2017, 17(1):97.
[2] Bray GA, Heisel WE, Afshin A, et al. The science of obesity manage ment:an endocrine society scientific statement[J]. Endocr Rev,2018, 39(2):79-132.
[3] Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat:evidence for a storage site in the rat[J]. J Clin Invest, 1971, 50(3):679-687.
[4] Hossein-nezhad A, Holick MF. Vitamin D for health:a global perspective[J]. Mayo Clinic Proc, 2013, 88(7):720-755.
[5] Hypponen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities[J].Nutr Rev, 2018, 76(9):678-692.
[6] Sato M, Hiragun A. Demonstration of 1α, 25-dihydroxyvitamin D3receptor-like molecule in ST 13 and 3T3 L1 preadipocytes and its inhibitory effects on preadipocyte differentiation[J]. J Cell Physiol,1988, 135(3):545-550.
[7] Looker AC. Body fat and vitamin D status in black versus white women[J]. J Clin Endocrinol Metab, 2005, 90(2):635-640.
[8] Rafiq R, Walschot F, Lips P, et al. Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations[J]. Clin Nutr, 2018. DOI:10.1016/j.clnu.2018.12.018.
[9] Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis[J].Annu Rev Cell Dev Biol, 2000, 16:145-171.
[10] Kong J, Li YC. Molecular mechanism of 1, 25-dihydroxyvitamin D3inhibition of adipogenesis in 3T3-L1 cells[J]. Am J Physiol Endocrinol Metab, 2006, 290(5):E916-924.
[11] Sergeev IN. 1, 25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12[J].Biochem Biophys Res Commun, 2009, 384(1):18-21.
[12] Chang E, Kim Y. Vitamin D decreases adipocyte lipid storage and in creases NAD-SIRT1 pathway in 3T3-L1 adipocytes[J]. Nutr, 2016,32(6):702-708.
[13] CantóC, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 ac tivity[J].Nature, 2009, 458(7241):1056-1060.
[14] Marcotorchino J, Tourniaire F, Astier J, et al. Vitamin D pro tects against diet-induced obesity by enhancing fatty acid oxidation[J]. J Nutr Biochem, 2014, 25(10):1077-1083.
[15] Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D3supplementation on body fat mass in healthy overweight and obese women[J]. Nutr J, 2012, 11:78.
[16] Rosenblum JL, Castro VM, Moore CE, et al. Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults[J]. Am J Clin Nutr,2012, 95(1):101-108.
[17] Wamberg L, Kampmann U, Stodkilde-Jorgensen H, et al. Ef fects of vitamin D supplementation on body fat accumulation, in flammation,and metabolic risk factors in obese adults with low vitamin D levelsresults from a randomized trial[J]. Eur J Intern Med, 2013, 24(7):644-649.
[18] Szlagatys-Sidorkiewicz A, Brzeziński M, Jankowska A, et al. Longterm effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme(a double-blind placebo-controlled study)-rationale for the study design[J]. BMC Pediatr, 2017, 17(1):97.