有氧运动对毒品成瘾患者精神行为干预效果的Meta分析
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摘要
目的:有氧运动在毒品成瘾患者中的治疗效果目前还存在争议,对此,我们对相关文献进行了荟萃分析,评价有氧运动对毒品依赖患者的干预效果。方法:检索Pub Med、Web of Science、Medline,Central和中国期刊全文数据库(CNKI)、万方数据库,收集有氧运动对毒品依赖患者干预效果的随机对照试验,利用Rev Man5. 3软件进行统计处理。结果:共纳入文献12篇,Meta结果显示:有氧运动能够改善毒品成瘾者的抑郁症状评分(SMD=-1. 88,95%CI:-3. 08～-0. 68,P=0. 002);提高毒品成瘾者对毒品迁延戒断症状的控制(SMD=-1. 46,95%CI:-2. 63～-0. 29,P=0. 010);降低毒品成瘾者的焦虑状态(SMD=-0. 49,95%CI:-0. 67～-0. 30,P <0. 001);亚组分析表明,有氧运动对新型毒品组的抑郁、焦虑症状改善较传统毒品组具有统计学意义(P <0. 05)。结论:中等强度的有氧运动能够改善毒品成瘾者的抑郁、焦虑等症状。
Objective: The therapeutic effect of aerobic exercise on drug addicts is still controversy,we performed a meta-analysis to examine the effects of aerobic exercise on physical fitness and mental behavior in patients with drug dependence.Methods: PubMed,Web of Science,Medline,Central,CNKI and Wanfang databases were searched in this study. We collected the effect of aerobic exercise on drug dependence patients in a randomized controlled trial. RevMan5. 3. 0 software was used for statistical processing.Results: A total of 12 articles were included in the literature,Meta results display: Aerobic exercise can improve the depression status score of drug addicts( SMD =-1. 88,95% CI:-3. 08 ～-0. 68,P = 0. 002); Aerobic exercise can improve the control of drug addicts' drug withdrawal symptoms( SMD =-1. 27,95% CI:-1. 50 ～-1. 04,P = 0. 010); can reduce the anxiety state of drug addicts( SMD =-0. 49,95% CI:-0. 67 ～-0. 30,P < 0. 001); Subgroup analysis shows that: Aerobic exercise improved the depression and anxiety status of the new drug group compared with the traditional drug group( P < 0. 050).Conclusion: Moderate-intensity aerobic exercise can improve the mental behavioral symptoms of drug addicts.
Objective: The therapeutic effect of aerobic exercise on drug addicts is still controversy,we performed a meta-analysis to examine the effects of aerobic exercise on physical fitness and mental behavior in patients with drug dependence.Methods: PubMed,Web of Science,Medline,Central,CNKI and Wanfang databases were searched in this study. We collected the effect of aerobic exercise on drug dependence patients in a randomized controlled trial. RevMan5. 3. 0 software was used for statistical processing.Results: A total of 12 articles were included in the literature,Meta results display: Aerobic exercise can improve the depression status score of drug addicts( SMD =-1. 88,95% CI:-3. 08 ～-0. 68,P = 0. 002); Aerobic exercise can improve the control of drug addicts' drug withdrawal symptoms( SMD =-1. 27,95% CI:-1. 50 ～-1. 04,P = 0. 010); can reduce the anxiety state of drug addicts( SMD =-0. 49,95% CI:-0. 67 ～-0. 30,P < 0. 001); Subgroup analysis shows that: Aerobic exercise improved the depression and anxiety status of the new drug group compared with the traditional drug group( P < 0. 050).Conclusion: Moderate-intensity aerobic exercise can improve the mental behavioral symptoms of drug addicts.
引文
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[18]赵振虎,范文勇,李汉兴.有氧运动对戒毒康复人员康复效果的影响[J].中国药物滥用防治杂志,2017,23(2):89-98.
[19]王东石,朱婷.有氧运动对甲基苯丙胺类依赖者体适能、渴求度及情绪状态的影响[J].体育科学,2017,37(7):50-58.
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[23]Zhu D,Xu D,Dai GB,et al. Beneficial effects of Tai Chi for amphetamine-type stimulant dependence:a pilot study[J]. Am J Durg Alcohol Abuse,2016,42(4):469-478.
[24]Zhang SM,An SH,Zhao Y. Yoga effects on mood and quality of life in Chinese women undergoing heroin detoxification[J].Nurs Res,2013,62(4):260-268.
[25]Li M,Chen K,Mo ZX. Use of Qigong therapy in the detoxification of heroin addicts[J]. Altem Ther Health Med,2002,8(1):50-54.
[26]Dolezal BA,Chudzynski J,Storer TW,et al. Eight weeks of exercise training improves fitness measures in methamphetaminedependent individuals in residential treatment[J]. J Addict Med,2013,7(2):122-128.
[27]Rawson RA,Chudzynski J,Gonzales R,et al. The impact of exercise on depression and anxiety symptoms among abstinent methamphetamine dependent individuals in a residential treatment setting[J]. J Subst Abuse Treat,2015,57(10):36-40.
[28]David H,Thomson P,Lina TR. The World Health Report 2007-A safer future:Global public health security in the 21st century[M]. Geneva,Switzerland,World Health Organization,2007.
[29]Buchowski MS,Meade NN,Charboneau E,et al. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults[J]. PLo S One,2011,6(3):e17465. doi:10. 1371/journal. pone. 0017465.
[30] Zhang K, Zhang Q, Jiang H. Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients[J]. Psychiatry Res,2018,266(8):328-333.
[31]Rawson RA,Chudzynski J,Gonzales R,et al. The impact of exercise on depression and anxiety symptoms among abstinent methamphetamine-dependent individuals in a residential treatment setting[J]. J Subst Abuse Treat,2015,57(10):36-40.
[32]Nakajima M,al’Absi M. Predictors of risk for smoking relapse in men and women:a prospective examination[J]. Psychol Addict Behav,2012; 26(3):633-637.
[33]Greenfield SF,Brooks AJ,Gordon SM,et al. Substance abuse treatment entry,retention,and outcome in women:a review of the literature[J]. Drug Alcohol Depend,2007,86(1):1-21.
[34]Hiburn C,Nejtek VA,Underwood WA,et al. Is serum brain-derived neurotrophic factor related to craving for or use of alcohol,cocaine,or methamphetamine?[J]. Neuropsychiatr Dis Tteat,2011,7:357-364.
[35]Somkuwar SS,Staples MC,Fannon MJ. Evaluating exercise as a therapeutic intervention for methamphetamine addiction-like behavior[J]. Brain Plast,2015,1(1):63-81.
[36]Wang F,Lee EK,Wu T. The effects of tai chi on depression,anxiety,and psychological well-being:a systematic review and meta-analysis[J]. Int J Behav Med,2014,21(4):605-617.
[37]Mooney LJ,Cooper C,London ED,et al. Exercise for methamphetamine dependence:Rationale,design,and methodology[J].Contemp Clin Trials,2014,37(1):139-147.
[38] Robertson CL,Ishibashi K,Chudzynski J,et al. Effect of exercise training on striatal dopamine D2/D3receptors in methamphetamine users during behavioral[J]. Neuropsychopham Logy,2016,41(6):1629-1636.
[39]周成林,施大庆,李彬,等.有氧运动在药物滥用康复治疗中的应用[J].中国药物依赖性杂志,2014,23(6):407-411.
[40]Thompson WR,Gordon NF,Pescatello LS. ACSM’s guidelines for exercise testing and prescription[M]. American college of sports Medicine,Hubsta Ltd,2009.
[2]World Drug Report 2017,Vienna,2017.
[3]Chen YC,Chen CK,Wang LJ,et al. Predictors of relapse and dropout during a 12-week relapse prevention program for methamphetamine users[J]. J Psychoactive Drugs,2015,8(12):1-8.
[4]Courtney KE,Ray LA. Methamphetamine:an update on epidemiology,pharmacology,clinical phenomenology,and treatment literature[J]. Drug Alcohol Depend,2014,143:11-21.
[5]Lynch WJ,Peterson AB,Sanchez V,et al. Exercise as a novel treatment for drug addiction:A neurobiological and stagedependent hypothesis[J]. Neurosci Biobehav Rev,2013,37(8):1622-1644.
[6]王东石.有氧运动对药物依赖者的康复作用及其机制研究[D].上海体育学院,2015.
[7]Buchowski MS. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults[J]. PLo S One,2011,6(3):doi:10. 1371/journal. pone. 0017465.
[8] Zhang K,Zhang QY,Jiang HF,et al. Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients[J]. Psychiatry Res,2018,266(8):328-333.
[9]Linzette M,Jessica S,Wardah E,et al. Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety,depression,fitness and quality of life in adults with previous methamphetamine dependency:a systematic review[J]. Addict Sci Clin Pract,2018,13(4):doi. org/10. 1186/s13722-018-0106-4.
[10]Buchowski MS,Meade NN,Charboneau E,et al. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults[J]. Plos One,2011,6(3):e17465. Published online 2011 Mar 8. doi:10. 1371/journal.pone. 0017465.
[11]Vickers KS,Patten CA,Lewis BA,et al. Feasibility of an exercise counseling intervention for depressed women smokers[J].Nicotine Tob Res,2009,11:985-995.
[12]Elibero A,Janse VRK,Drobes DJ,et al. Acute effects of aerobic exercise and hatha yoga on craving to smoke[J]. Nicotine Tob Res,2011,13:1140-1148.
[13] Adad AR,Moore RA,Carroll D. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding:a meta-analysis[J]. Hepatology,2002,35(08):609-615.
[14]Higgins PT,Geeen S,Connor D. Cochrance Handbook of Systematic Reviews of Intervention. Ves-ion 5. 0[EB/OL].[2008-09-01]. http://www. cochrance-handbook. org.
[15]刘鸣,吴红梅,卫茂玲,等.系统评价、Meta分析--设计与实施办法[M].北京:人民卫生出版社,2017:99-101.
[16]黄赫,杨芬.运动疗法辅助治疗海洛因依赖临床观察[J].中国药物滥用预防杂志,2000,26(3):30-31.
[17]黄赫,杨芬,杨双石,等.有氧运动对海洛因依赖者康复的影响[J].中国理疗杂志,2000,23(5):267-270.
[18]赵振虎,范文勇,李汉兴.有氧运动对戒毒康复人员康复效果的影响[J].中国药物滥用防治杂志,2017,23(2):89-98.
[19]王东石,朱婷.有氧运动对甲基苯丙胺类依赖者体适能、渴求度及情绪状态的影响[J].体育科学,2017,37(7):50-58.
[20]Li DX,Zhuang XY,Zhang YP,et al. Effects of Tai Chi on the protracted abstinence syndrome:a time trial analysis[J]. Am J Chin Med,2013,41(1):43-57.
[21]Smelson D,Chen KW,Ziedonis D,et al. A pilot study of Qigong for reducing cocaine craving early in recovery[J]. J Altem Complement Med,2013,19(2):97-101.
[22]Zhu D,Dai GB,Xu X,et al. Long-term effects of Tai Chi intervention on sleep and mental health of female individuals with dependence on amphetamine-type stimulants[J]. Front Psychol,2018,20(9):1476. doi:10. 3389/fpsyg. 2018. 01476.
[23]Zhu D,Xu D,Dai GB,et al. Beneficial effects of Tai Chi for amphetamine-type stimulant dependence:a pilot study[J]. Am J Durg Alcohol Abuse,2016,42(4):469-478.
[24]Zhang SM,An SH,Zhao Y. Yoga effects on mood and quality of life in Chinese women undergoing heroin detoxification[J].Nurs Res,2013,62(4):260-268.
[25]Li M,Chen K,Mo ZX. Use of Qigong therapy in the detoxification of heroin addicts[J]. Altem Ther Health Med,2002,8(1):50-54.
[26]Dolezal BA,Chudzynski J,Storer TW,et al. Eight weeks of exercise training improves fitness measures in methamphetaminedependent individuals in residential treatment[J]. J Addict Med,2013,7(2):122-128.
[27]Rawson RA,Chudzynski J,Gonzales R,et al. The impact of exercise on depression and anxiety symptoms among abstinent methamphetamine dependent individuals in a residential treatment setting[J]. J Subst Abuse Treat,2015,57(10):36-40.
[28]David H,Thomson P,Lina TR. The World Health Report 2007-A safer future:Global public health security in the 21st century[M]. Geneva,Switzerland,World Health Organization,2007.
[29]Buchowski MS,Meade NN,Charboneau E,et al. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults[J]. PLo S One,2011,6(3):e17465. doi:10. 1371/journal. pone. 0017465.
[30] Zhang K, Zhang Q, Jiang H. Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients[J]. Psychiatry Res,2018,266(8):328-333.
[31]Rawson RA,Chudzynski J,Gonzales R,et al. The impact of exercise on depression and anxiety symptoms among abstinent methamphetamine-dependent individuals in a residential treatment setting[J]. J Subst Abuse Treat,2015,57(10):36-40.
[32]Nakajima M,al’Absi M. Predictors of risk for smoking relapse in men and women:a prospective examination[J]. Psychol Addict Behav,2012; 26(3):633-637.
[33]Greenfield SF,Brooks AJ,Gordon SM,et al. Substance abuse treatment entry,retention,and outcome in women:a review of the literature[J]. Drug Alcohol Depend,2007,86(1):1-21.
[34]Hiburn C,Nejtek VA,Underwood WA,et al. Is serum brain-derived neurotrophic factor related to craving for or use of alcohol,cocaine,or methamphetamine?[J]. Neuropsychiatr Dis Tteat,2011,7:357-364.
[35]Somkuwar SS,Staples MC,Fannon MJ. Evaluating exercise as a therapeutic intervention for methamphetamine addiction-like behavior[J]. Brain Plast,2015,1(1):63-81.
[36]Wang F,Lee EK,Wu T. The effects of tai chi on depression,anxiety,and psychological well-being:a systematic review and meta-analysis[J]. Int J Behav Med,2014,21(4):605-617.
[37]Mooney LJ,Cooper C,London ED,et al. Exercise for methamphetamine dependence:Rationale,design,and methodology[J].Contemp Clin Trials,2014,37(1):139-147.
[38] Robertson CL,Ishibashi K,Chudzynski J,et al. Effect of exercise training on striatal dopamine D2/D3receptors in methamphetamine users during behavioral[J]. Neuropsychopham Logy,2016,41(6):1629-1636.
[39]周成林,施大庆,李彬,等.有氧运动在药物滥用康复治疗中的应用[J].中国药物依赖性杂志,2014,23(6):407-411.
[40]Thompson WR,Gordon NF,Pescatello LS. ACSM’s guidelines for exercise testing and prescription[M]. American college of sports Medicine,Hubsta Ltd,2009.