细胞凋亡在激素性股骨头坏死发病机制中的研究进展
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摘要
目的:总结激素性股骨头坏死发病机制中细胞凋亡的研究进展,为临床上预防和治疗此病提供思路和理论依据。方法:对近十年来激素性股骨头坏死的文献做分析,归纳,总结。结果:激素性股骨头坏死的组织中存在大量凋亡细胞。激素性股骨头坏死相关的凋亡基因主要包括Bcl-2家族、p53基因、Caspase家族、Fas受体、一氧化氮等。结论:激素可以通过抑制bcl-2的表达、上调p53基因、调控Caspase家族、激活一氧化氮合酶诱导骨细胞凋亡,从而导致股骨头坏死。
引文
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[20]Ye T,Cao P,Qi J,et al.Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats[J].Plos One,2017,12(10):e0186 012.
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[24]刘伟.骨保护素通过Fas/FasL死亡受体通路诱导破骨细胞及其前体细胞发生凋亡的研究[D].扬州:扬州大学,2016.
[25]Wang L,Liu S,Zhao Y,et al.Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass[J].Cell death and differentiation,2015,22(10):1654-1664.
[26]Almeida M,Han L,Martin-Millan M,et al.Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids[J].Journal of Biological Chemistry,2007,282(37):37.
[27]Wang J,Kalhor A,Lu S,et al.iNOS expression and osteocyte apoptosis in idiopathic,non-traumatic osteonecrosis[J].Acta Orthopaedica,2015,86(1):134-141.
[28]Basso N,Heersche JN.Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes[J].Bone,2006,39(4):807.
[29]Joshua J,Kalyanaraman H,Marathe N,et al.Nitric oxide as a mediator of estrogen effects in osteocytes[J].Vitamins&Hormones,2014(96):247-263.
[30]王志美.雌激素及chOPG对鸡胚BMSCs诱导的成骨细胞增殖、凋亡、细胞周期以及BGP与ColⅠmRNA表达的影响[D].南京:南京农业大学,2010.
[31]Tomkinson A,Gevers EF,Wit JM,et al.The role of estrogen in the control of rat osteocyte apoptosis[J].Journal of Bone&Mineral Research,1998,13(8):1243.
[32]Rolvien T,Krause M,Jeschke A,et al.Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone[J].Bone,2017(103):78-87.
[33]Atsushi H,Alison C,Gordon D,et al.Chk2 Is a Tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated(ATM)-dependent and an ATM-independent manner[J].Molecular&Cellular Biology,2002,22(18):6521-6532.
[34]Wang Z,Guo J.Mechanical induction of BMP-7 in osteocyte blocks glucocorticoid-induced apoptosis through PI3K/AKT/GSK3-βpathway[J].Cell Biochemistry&Biophysics,2013,67(2):567-574.
[2]Weinstein RS,Chen JR,Powers CC,et al.Promotion of osteocl astsurvival and an-tagonism of bisphosphonateind ucedosteo-clast apoptosisbyg lucocorticoids[J].J Clin Invest,2002,109(8):1041-1048.
[3]Kamiya N,Shafer S,Oxendine I.Acute BMP2 upregulation following induction of ischemic osteonecrosis in immature femoral head[J].Bone,2013,23(1):529-531.
[4]Li H,Qian W,Weng X.Glucocorticoid receptor and sequential P53 acti-vation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells[J].PLos One,2012,29(37):303-306.
[5]宋奕,丁道芳,李玲慧,等.细胞凋亡在激素性股骨头坏死机制中的研究进展[J].中国矫形外科杂志,2013,21(21):2163-2165.
[6]张锐东,张澜,毛洪刚.激素性股骨头坏死模型中凋亡相关因子的表达[J].中国组织工程研究,2013,17(7):1189-1195.
[7]Zhang H,Zhou F,Pan Z.11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids[J].Biochem Biophys Res Commun,2017,490(4):1399-1406.
[8]王伟,刘利英,王坤正,等.激素性股骨头坏死模型的建立及其发病机理的探讨[J].西安交通大学学报:医学版,2007(5):544-547.
[9]贾岩波,刘万林,任逸众.激素性股骨头坏死发病机制中细胞凋亡的研究进展[J].中国组织工程研究,2012,16(13):2444-2450.
[10]Moriishi T,Fukuyama R,Miyazaki T,et al.Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength[J].Journal of Bone&Mineral Research,2016,31(7):1366-1380.
[11]余华.p53蛋白基因在酒精性股骨头缺血性坏死患者血液中表达及其致骨细胞凋亡机制研究[J].解剖学研究,2017,39(2):136-139.
[12]Huang S W,Chang SH,Mu SW,et al.Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line[J].Journal of Dermatological Science,2016,81(3):182-191.
[13]骆旭东,郭坤亮,安洪,等.酒精性股骨细胞凋亡及其p53等基因的表达[J].中国公共卫生,2004(10):61-62
[14]Trichilis A,Wroblewski J.Expression of p53 and hsp70 in relation to apoptosis during Meckel's cartilage development in the mouse[J].Anatomy&Embryology,1997,196(2):107.
[15]Guo KL.Effects of endogenous glucocorticoid(GC)on the expression of p53 and Bcl-2 proteins in osteocyte apoptosis in avascular necrosis of the femoral head induced by alcoholism[J].Liquor-Making Science&Technology,2009,183(9):55-57.
[16]弓娟琴,陈志强,李文忠,等.Fas介导的凋亡与Caspase家族[J].国外医学:肿瘤学分册,2001,27(5):279-280.
[17]王宇锋,陈超,杨春,等.6-姜烯酚诱导人结直肠癌细胞凋亡及Bax、BCL2、Caspase-3和PARP1表达的影响[J].现代食品科技,2017(11):1-9.
[18]Jang JY,Min JH,Chae YH,et al.Reactive oxygen species play a critical role in collagen-induced platelet activation via SHp-2 oxidation[J].Antioxidants&Redox Signaling,2014,20(16):2528-2540.
[19]Jia YB,Jiang DM,Ren YZ,et al.Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at early stage of steroid-induced femoral head necrosis[J].Molecular Medicine Reports,2017,15(4):1585-1592.
[20]Ye T,Cao P,Qi J,et al.Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats[J].Plos One,2017,12(10):e0186 012.
[21]Davis HM,Pacheco-Costa R,Atkinson EG,et al.Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging[J].Aging Cell,2017,16(3):551.
[22]Kennedy OD,Lendhey M,Mauer P,et al.Microdamage induced by in vivo reference point indentation in mice is repaired by osteocyte-apoptosis mediated remodeling[J].Bone,2017(95):192-198.
[23]Kogianni G,Mann V,Ebetino F,et al.Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis[J].Life Sciences,2004,75(24):2879.
[24]刘伟.骨保护素通过Fas/FasL死亡受体通路诱导破骨细胞及其前体细胞发生凋亡的研究[D].扬州:扬州大学,2016.
[25]Wang L,Liu S,Zhao Y,et al.Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass[J].Cell death and differentiation,2015,22(10):1654-1664.
[26]Almeida M,Han L,Martin-Millan M,et al.Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids[J].Journal of Biological Chemistry,2007,282(37):37.
[27]Wang J,Kalhor A,Lu S,et al.iNOS expression and osteocyte apoptosis in idiopathic,non-traumatic osteonecrosis[J].Acta Orthopaedica,2015,86(1):134-141.
[28]Basso N,Heersche JN.Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes[J].Bone,2006,39(4):807.
[29]Joshua J,Kalyanaraman H,Marathe N,et al.Nitric oxide as a mediator of estrogen effects in osteocytes[J].Vitamins&Hormones,2014(96):247-263.
[30]王志美.雌激素及chOPG对鸡胚BMSCs诱导的成骨细胞增殖、凋亡、细胞周期以及BGP与ColⅠmRNA表达的影响[D].南京:南京农业大学,2010.
[31]Tomkinson A,Gevers EF,Wit JM,et al.The role of estrogen in the control of rat osteocyte apoptosis[J].Journal of Bone&Mineral Research,1998,13(8):1243.
[32]Rolvien T,Krause M,Jeschke A,et al.Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone[J].Bone,2017(103):78-87.
[33]Atsushi H,Alison C,Gordon D,et al.Chk2 Is a Tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated(ATM)-dependent and an ATM-independent manner[J].Molecular&Cellular Biology,2002,22(18):6521-6532.
[34]Wang Z,Guo J.Mechanical induction of BMP-7 in osteocyte blocks glucocorticoid-induced apoptosis through PI3K/AKT/GSK3-βpathway[J].Cell Biochemistry&Biophysics,2013,67(2):567-574.