龙胆属环烯醚萜类化学成分研究进展
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摘要
龙胆属Gentiana L.是龙胆科(Gentianaceae)中最大的属。该属植物中含有大量具有药理活性的化学成分,尤其富含环烯醚萜类成分,这类成分具有较好的保肝、抗炎解热、抗病毒等药理作用。对龙胆属植物中环烯醚萜类化学成分进行了分类综述,以期为龙胆属化学成分研究及药用资源的开发与利用提供参考。
Gentiana L. is the largest genera in Gentianaceae. Plants in Gentiana L. contain a lot of chemical constituents with pharmacological activities, especially iridoids. Iridoids has good hepatoprotective, anti-inflammatory, antipyretic, antiviral, and other pharmacological effects. This article summarizes the research progress of iridoids in plants from Gentiana L., which provide references for the studies of chemical constituents in Gentiana L. and the exploitation of medicinal resources.
Gentiana L. is the largest genera in Gentianaceae. Plants in Gentiana L. contain a lot of chemical constituents with pharmacological activities, especially iridoids. Iridoids has good hepatoprotective, anti-inflammatory, antipyretic, antiviral, and other pharmacological effects. This article summarizes the research progress of iridoids in plants from Gentiana L., which provide references for the studies of chemical constituents in Gentiana L. and the exploitation of medicinal resources.
引文
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[21]Amakura Y,Yoshimura M,Morimoto S,et al.Chromatographic evaluation and characterization of components of Gentian root extract used as food additives[J].Chem Pharm Bull,2016,64(1):78-82.
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[24]Garcia J,Mpondo E M,Kaouadji M.Kingiside and derivative from Gentiana pyrenaica[J].Phytochemistry,1990,29(10):3353-3355.
[25]Liu Q,Chou G X,Wang Z T.New iridoid and secoiridoid glucosides from the roots of Gentiana manshurica[J].Helv Chim Acta,2012,95(7):1094-1101.
[26]Mpondo E M,Garcia J.Iridoids from Gentiana verna[J].Phytochemistry,1989,28(9):2503-2504.
[27]Garcia J,Mpondo E M,Nardin R.Loganin and a new iridoid glucoside from Gentiana pyrenaica[J].J Nat Prod,2004,52(2):423-425.
[28]Pan Y,Shen T,Zhang J,et al.Simultaneous determination of six index constituents and comparative analysis of four ethnomedicines from genus Gentiana,using a UPLC-UV-MS method[J].Biomed Chromatogr,2015,29(1):87-96.
[29]Garcia J,Chulia A J.Loganin and new iridoid glucosides in Gentiana pedicellata[J].Planta Med,1986,81(4):327-329.
[30]Mpondo E M,Garcia J.Two iridoid glucosides from Gentiana verna[J].Phytochemistry,1990,29(2):643-644.
[31]Kusakari K,Fukuhara T,Motoyama A,et al.The corrected structure of depressoside,an antioxidative iridoid glucoside extracted from the flowers of Gentianaurnula Harry Sm[J].Nat Prod Res,2015,30(8):954-959.
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[34]Do T,Popov S,Marekov N,et al.Iridoids from gentianaceae plants growing in bulgaria[J].Planta Med,1987,53(6):580.
[35]Chulia A J,Kaouadji M.Depressoside,Nouvel Irido?de Isole de Gentiana depressa[J].J Nat Prod,1985,48(1):54-58.
[36]刘艳红,李兴从.秦艽中的环烯醚萜甙成分[J].植物分类与资源学报,1994(1):85-89.
[37]Wu Q,Liu X,Shi Y.Chemical components from Gentiana aristata[J].Chem Biodiv,2007,4(2):254-275.
[38]Zhang J S,Tian Z X,Lou Z C.Simultaneous determination of 5 bitter secoiridoid glucosides in 9Chinese Gentiana species used as the Chinese drug“Long Dan”by high performance liquid chromatography[J].Acta Pharm Sin,1991,26(11):864-870.
[39]Mihailovic V,Matic S,Mi?ic D,et al.Chemical composition,antioxidant and antigenotoic activities of different fractions of Gentiana asclepladeal roots extract[J].Excli J,2013,12(3):807-823.
[40]Yang A M,Li H,Liu J L,et al.Chemical constituents of Gentiana algida[J].Chem Nat Compd,2013,49(4):755-756.
[41]?al??,I,Rüegger H,Chun Z,et al.Secoiridoid glucosides isolated from Gentiana gelida[J].Planta Medica,1990,56(4):406-409.
[42]段朝辉,石宝俊,吴立宏,等.长梗秦艽的化学成分[J].中国天然药物,2007,5(6):417-420.
[43]Rojas A,Bah M,Isela Rojas J,et al.Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea[J].Planta Medica,2000,66(8):765-767.
[44]Pan Y,Zhang J,Shen T,et al.Investigation of chemical diversity in different parts and origins of ethnomedicine Gentiana rigescens,Franch using targeted metabolite profiling and multivariate statistical analysis[J].BiomedChromatogr,2015,30(2):232-240.
[45]Takeda Y,Masuda T,Honda G,et al.Secoiridoid glycosides from Gentiana olivieri[J].Chem Pharm Bull,1999,47(9):1338-1340.
[46]Kakuda R,Iijima T,Yaoita Y,et al.Secoiridoid glycosides from Gentiana scabra[J].J Nat Prod,2001,68(5):751-753.
[47]Mpondo M E,Chulia A J.6′-O-β-D-Glucosyl gentiopicroside:A new secoiridoid from Gentiana asclepiadea[J].Planta Med,1988,54(2):185-186.
[48]张莉,党军,梅丽娟,等.藏药麻花秦艽化学成分研究[J].中药材,2016,39(1):103-106.
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