通窍鼻炎丸治疗慢性鼻窦炎疗效及ECP、TIgE、hs-CRP等因子影响研究
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摘要
目的:分析通窍鼻炎丸治疗慢性鼻窦炎对患者体内炎症因子、血清和鼻腔嗜酸性粒细胞阳离子蛋白(ECP)水平的影响。方法:慢性鼻窦炎患者102例,根据治疗方法不同分为对照组和观察组。对照组患者采用克拉霉素治疗,观察组患者采用克拉霉素+通窍鼻炎丸治疗,分析两组患者治疗后的临床疗效。结果:治疗前,两组患者临床症状积分比较无统计学差异(P>0.05)。治疗后,观察组患者鼻塞、嗅觉减退、流涕、头痛及面部胀痛积分低于对照组(P<0.05)。治疗前,两组患者IL-1β、hs-CRP、TNF-α、IL-8水平比较无统计学差异(P>0.05)。治疗后,观察组患者IL-1β、hs-CRP、TNF-α、IL-8水平低于对照组(P<0.05)。治疗前,两组患者血清ECP、TIgE、鼻腔ECP水平比较无统计学差异(P>0.05)。治疗后,观察组患者血清ECP、TIgE、鼻腔ECP水平低于对照组(P<0.05)。治疗1个月后,观察组患者复查鼻腔CT正常率74.51%,对照组正常率43.17%,观察组患者复查鼻腔CT结果优于对照组(P<0.05)。结论:通窍鼻炎丸辅助治疗慢性鼻窦炎疗效显著,可改善患者临床症状,降低患者体内血清炎症因子、血清和鼻腔ECP的表达水平。
Objective:To analyze the effect of Tongqiao Rhinitis Pill on the levels of inflammatory factors, eosinophil cationic protein(ECP) in serum and nasal cavity in patients with chronic sinusitis.Methods:102 patients with chronic sinusitis were divided into control group and observation group. The patients in the control group were treated with clarithromycin, and those in the observation group were treated with Tongqiao Biyan Pills. We analyzed the clinical effect of two groups after treatment.Results:Before treatment, there was no significant difference in the scores of clinical symptoms between the two groups(P>0.05). After treatment, the scores of nasal congestion, decreased smelling, runny, headache and facial distending pain in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the level of IL-8 between the two groups(P>0.05). After treatment, the level of IL-8 in the observation group was lower than that in the control group(P<0.05). Before treatment, the serum ECP,TIgE and nasal cavity ECP in the two groups were lower than those in the control group(P<0.05). There was no significant difference between the two groups(P>0.05). After treatment, the levels of ECP in the nasal cavity of the patients in the observation group were lower than those in the control group(P<0.05). After one month treatment, the level of ECP of the patients in the observation group was lower than that in the control group. The normal rate of nasal CT in the observation group was 74.51 and the normal rate in the control group was 43.17. The result of CT in the observation group was better than that in the control group(P<0.05).Conclusion:Tongqiao Biyan Pills have a remarkable curative effect on chronic sinusitis. It can improve the clinical symptoms and decrease the expression of serum inflammatory factors, serum and nasal ECP in patients with chronic sinusitis.
Objective:To analyze the effect of Tongqiao Rhinitis Pill on the levels of inflammatory factors, eosinophil cationic protein(ECP) in serum and nasal cavity in patients with chronic sinusitis.Methods:102 patients with chronic sinusitis were divided into control group and observation group. The patients in the control group were treated with clarithromycin, and those in the observation group were treated with Tongqiao Biyan Pills. We analyzed the clinical effect of two groups after treatment.Results:Before treatment, there was no significant difference in the scores of clinical symptoms between the two groups(P>0.05). After treatment, the scores of nasal congestion, decreased smelling, runny, headache and facial distending pain in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the level of IL-8 between the two groups(P>0.05). After treatment, the level of IL-8 in the observation group was lower than that in the control group(P<0.05). Before treatment, the serum ECP,TIgE and nasal cavity ECP in the two groups were lower than those in the control group(P<0.05). There was no significant difference between the two groups(P>0.05). After treatment, the levels of ECP in the nasal cavity of the patients in the observation group were lower than those in the control group(P<0.05). After one month treatment, the level of ECP of the patients in the observation group was lower than that in the control group. The normal rate of nasal CT in the observation group was 74.51 and the normal rate in the control group was 43.17. The result of CT in the observation group was better than that in the control group(P<0.05).Conclusion:Tongqiao Biyan Pills have a remarkable curative effect on chronic sinusitis. It can improve the clinical symptoms and decrease the expression of serum inflammatory factors, serum and nasal ECP in patients with chronic sinusitis.
引文
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[13] 薛萌,许必芳,韩瑞阳,等.鼻科常用药苍耳子新识新用[J].中医眼耳鼻喉杂志,2017,7(1):35-36.
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[15] 龚志龙,汪志坚.阿奇霉素联合布地奈德喷鼻对慢性鼻窦炎伴鼻息肉术后的疗效及对嗜酸性粒细胞的影响[J].实用中西医结合临床,2016,16(7):39-40.
[16] 阳玉萍,范宇琴,王燕,等.鼻部和咽部非变应性炎症对下气道高反应的影响[J].中华临床免疫和变态反应杂志,2016,10(4):320-324.
[17] 沙敏,李勇,李静,等.HGF与TGF-β1的平衡在慢性鼻窦炎组织重塑中的作用[J].中华全科医学,2017,15(4):663-666.
[18] 史凌改,刘军,王广科,等.鼻内镜手术患者感染的相关因素分析[J].中华医院感染学杂志,2017,27(12):2783-2785,2789.
[19] 林淑萍,代红磊,房宏伟,等.慢性鼻窦炎患者中变应性因素的临床研究[J].天津医科大学学报,2017,23(3):259-262.
[20] 刘学良,雷刚.鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎的临床观察[J].中国药房,2017,28(2):215-219.
[21] 叶艳.组胺受体拮抗剂联合白三烯受体拮抗剂治疗过敏性鼻炎的疗效观察[J].安徽医药,2017,21(11):2069-2073.
[22] 钱建娥,陶丹丹,黄超,等.皮下注射与舌下含服免疫疗法对儿童变应性鼻炎的疗效及安全性比较[J].中国中西医结合耳鼻咽喉科杂志,2017,25(3):196-199.
[2] 陈志伟,刘龙庆,高燕,等.鼻渊通窍颗粒对儿童慢性鼻窦炎鼻黏膜纤毛传输功能及炎性细胞因子的影响[J].实用临床医药杂志,2016,20(13):83-86.
[3] 冶娟,王菲.枸地氯雷他定联合鼻窦内窥镜手术治疗慢性鼻窦炎疗效及对患者血清TIgE、ECP和炎性因子的影响[J].中国内镜杂志,2017,23(2):21-25.
[4] 中华医学会耳鼻咽喉科学分会,《中华耳鼻咽喉科杂志》编辑委员会.慢性鼻-鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准[J].中华耳鼻咽喉科杂志,1998,33(17): 1334-1336.
[5] 郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:196.
[6] 刘业军,张承宏,刘建设,等.吡酮莫特治疗对慢性鼻窦炎患者外周T淋巴细胞亚群、NK细胞活性以及炎症因子的影响[J].海南医学院学报,2016,22(3):306-309,312.
[7] Hyera K,Yasuhiro T,Kunihiro N,et al.Invasive Fungal Sinusitis Involving the Orbital Apex in a Patient with Chronic Renal Failure[J].Neuro-ophthalmology,2015,39(4):183-186.
[8] 熊静,周振峰,吴婷,等.龙胆通窍丸对湿热型慢性鼻窦炎患者血清IL-6和IL-8水平的影响[J].中国中西医结合耳鼻咽喉科杂志,2017,25(4):241-243,249.
[9] 熊静,周振峰,吴婷,等.龙胆通窍丸对湿热型慢性鼻窦炎抗炎效应的临床研究[J].湖南中医药大学学报,2016,36(12):34-36.
[12] 李龙义,刘虹.刘虹主任医师辨治小儿腺样体肥大经验[J].浙江中医药大学学报,2017,41(8):696-698.
[10] 汪羽,孔旭辉,储九圣,等.慢性鼻-鼻窦炎患者鼻内镜术后口服鼻渊通窍颗粒效果观察[J].山东医药,2017,57(46):97-99.
[11] 刘昊斓,朱镇华.鼻渊舒丸治疗脾气虚弱型慢鼻渊的临床观察[J].湖南中医药大学学报,2017,37(2):185-187.
[13] 薛萌,许必芳,韩瑞阳,等.鼻科常用药苍耳子新识新用[J].中医眼耳鼻喉杂志,2017,7(1):35-36.
[14] Daramola OO,Lidder AK,Ramli R,et al.Patient Knowledge and Perception of Computed Tomography Scan in the Management of Chronic Rhinosinusitis Symptoms[J].The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery,2015,125(4):791-795.
[15] 龚志龙,汪志坚.阿奇霉素联合布地奈德喷鼻对慢性鼻窦炎伴鼻息肉术后的疗效及对嗜酸性粒细胞的影响[J].实用中西医结合临床,2016,16(7):39-40.
[16] 阳玉萍,范宇琴,王燕,等.鼻部和咽部非变应性炎症对下气道高反应的影响[J].中华临床免疫和变态反应杂志,2016,10(4):320-324.
[17] 沙敏,李勇,李静,等.HGF与TGF-β1的平衡在慢性鼻窦炎组织重塑中的作用[J].中华全科医学,2017,15(4):663-666.
[18] 史凌改,刘军,王广科,等.鼻内镜手术患者感染的相关因素分析[J].中华医院感染学杂志,2017,27(12):2783-2785,2789.
[19] 林淑萍,代红磊,房宏伟,等.慢性鼻窦炎患者中变应性因素的临床研究[J].天津医科大学学报,2017,23(3):259-262.
[20] 刘学良,雷刚.鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎的临床观察[J].中国药房,2017,28(2):215-219.
[21] 叶艳.组胺受体拮抗剂联合白三烯受体拮抗剂治疗过敏性鼻炎的疗效观察[J].安徽医药,2017,21(11):2069-2073.
[22] 钱建娥,陶丹丹,黄超,等.皮下注射与舌下含服免疫疗法对儿童变应性鼻炎的疗效及安全性比较[J].中国中西医结合耳鼻咽喉科杂志,2017,25(3):196-199.