中药热奄包外敷配合桃仁红花煎口服治疗气滞血瘀型原发性痛经疗效观察
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摘要
目的观察中药热奄包热敷与桃仁红花煎中药汤剂口服对气滞血瘀性原发性痛经患者疗效的影响。方法将80例气滞血瘀性原发性痛经患者随机分为2组,对照组40例给予山莨菪碱注射液10 mg肌肉注射,每日1次,疼痛能耐受即停;观察组40例在对照组治疗基础上经前2 d开始给予中药热奄包与桃仁红花煎治疗,经期第2天即停。2组均持续治疗3个月经周期。观察2组患者治疗前与停药3个月经周期后腹痛时间与中医症状积分,并统计停药3个月经周期后腹痛程度及临床疗效。结果观察组患者治疗后的腹痛时间相比治疗前以及对照组明显缩短(P均<0.05),中医症状积分相比治疗前以及对照组明显降低(P均<0.05);观察组患者治疗后的痛经程度明显轻于对照组(P<0.05);观察组临床治疗总有效率明显高于对照组(P<0.05)。结论中药热奄包外敷与桃仁红花煎结合治疗能够有效改善原发性痛经患者的临床症状,减轻疼痛程度,缩短疼痛时间。
Objective It is to observe the effect of Reyanbao therapy combined with Taoren Honghua decoction on primary dysmenorrhea of Qi-stagnation and blood-stasis type. Methods Eighty patients with primary dysmenorrhea of qi stagnation and blood stasis type were randomly divided into two groups,the control group of 40 patients were given anisodamine injection 10 mg intramuscularly once daily for pain tolerance,the observation group of 40 cases were given Reyanbao therapy with traditional Chinese medicine by external application from 2 days before menstruation to the second day in menstruation based on the treatment in the control group. Both groups were continuly treated for 3 menstrual cycles. The abdominal pain time and TCM symptom scores before treatment and after 3 menstrual cycles of the patients in the two groups were observed,the degree of abdominal pain and clinical effect after 3 menstrual cycles were evaluated. Results The time of abdominal pain after treatment in the observation group was significantly shorter while symptom scores of TCM were significantly lower than that before treatment and in control group( P < 0. 05). After treatment,the degree of dysmenorrhea was significantly lower while the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group( P < 0. 05). Conclusion Reyanbao therapy combined with Taoren Honghua decoction can effectively improve the clinical symptoms,relieve abdominal pain and shorten the pain time in patients with primary dysmenorrhea.
Objective It is to observe the effect of Reyanbao therapy combined with Taoren Honghua decoction on primary dysmenorrhea of Qi-stagnation and blood-stasis type. Methods Eighty patients with primary dysmenorrhea of qi stagnation and blood stasis type were randomly divided into two groups,the control group of 40 patients were given anisodamine injection 10 mg intramuscularly once daily for pain tolerance,the observation group of 40 cases were given Reyanbao therapy with traditional Chinese medicine by external application from 2 days before menstruation to the second day in menstruation based on the treatment in the control group. Both groups were continuly treated for 3 menstrual cycles. The abdominal pain time and TCM symptom scores before treatment and after 3 menstrual cycles of the patients in the two groups were observed,the degree of abdominal pain and clinical effect after 3 menstrual cycles were evaluated. Results The time of abdominal pain after treatment in the observation group was significantly shorter while symptom scores of TCM were significantly lower than that before treatment and in control group( P < 0. 05). After treatment,the degree of dysmenorrhea was significantly lower while the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group( P < 0. 05). Conclusion Reyanbao therapy combined with Taoren Honghua decoction can effectively improve the clinical symptoms,relieve abdominal pain and shorten the pain time in patients with primary dysmenorrhea.
引文
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[14]杨文潮,王小平,白吉庆.丹参-红花配伍比例对血瘀证大鼠血流变学和血流动力学的影响[J].西北农林科技大学学报:自然科学版,2015,43(12):35-40
[15]范恺磊,蔡皓,刘晓,等.香附与艾叶对治疗原发性痛经作用机制的研究进展[J].中药新药与临床药理,2017,28(1):139-143
[16]俞茹云,过忆,林莉莉.NF-κB通路与川芎提取物抗脑缺血作用相关性研究[J].南京中医药大学学报,2017,33(1):74-77
[17]贺文彬,楚世峰,陈乃宏.丹参总酚酸对大鼠缺血性脑卒中后免疫抑制现象的改善作用[J].中国药理学与毒理学杂志,2015,29(3):391-397
[2]杨定芳.原发性痛经的中医治疗研究进展[J].云南中医中药杂志,2014,35(2):70-71
[3]张玉珍.中医妇科学[M].北京:中国中医药出版社,2002:124-127
[4]国家中医药管理局.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:77-85
[5]Iacovides S,Avidon I,Bentley A,et al.Reduced quality of life when experiencing menstrual pain in women with primary dysmenorrhea[J].Acta Obstet Gynecol Scand,2014,93(2):213-217
[6]梁雪迪,王文慧,王聪,等.女大学生原发性痛经现状及影响因素分析[J].齐鲁护理杂志,2017,23(2):43-45
[7]嵇波,任晓暄,赵雅芳,等.原发性痛经发病机制与防治研究述评[J].中国现代医学杂志,2008,18(13):1856-1858;1862
[8]胡年春,熊森林,刘四军.中药穴位贴敷法缓解女性学生原发性痛经的效果研究[J].广州中医药大学学报,2016,33(6):817-822
[9]佘延芬,孙立虹,杨继军,等.隔物灸对寒湿凝滞型原发性痛经患者经期血浆β-EP含量的影响[J].中国针灸,2008,28(10):719-721
[10]祝玲,温贤秀,谭君梅,等.改良中药热奄包法在寒凝血瘀型原发性痛经患者中的应用研究[J].中国计划生育和妇产科,2016,8(10):52-55
[11]王利然,李颜飞,贾元媛.温针灸配合中药热奄包治疗寒湿凝滞型痛经128例[J].中国民间疗法,2016,24(7):50-51
[12]李巧红.桃仁红花煎抗血小板聚集及改善血液流变实验研究[J].亚太传统医药,2016,12(9):14-15
[13]周蓓.桂枝桃仁及其配伍对抗凝血作用影响的研究[J].云南中医中药杂志,2014,35(1):62-63
[14]杨文潮,王小平,白吉庆.丹参-红花配伍比例对血瘀证大鼠血流变学和血流动力学的影响[J].西北农林科技大学学报:自然科学版,2015,43(12):35-40
[15]范恺磊,蔡皓,刘晓,等.香附与艾叶对治疗原发性痛经作用机制的研究进展[J].中药新药与临床药理,2017,28(1):139-143
[16]俞茹云,过忆,林莉莉.NF-κB通路与川芎提取物抗脑缺血作用相关性研究[J].南京中医药大学学报,2017,33(1):74-77
[17]贺文彬,楚世峰,陈乃宏.丹参总酚酸对大鼠缺血性脑卒中后免疫抑制现象的改善作用[J].中国药理学与毒理学杂志,2015,29(3):391-397