摘要
Pegvaliase-pqpz(商品名Palynziq)是由美国BioMarin制药公司研发的一种新型酶疗药物,是首个苯丙氨酸解氨酶法治疗成年患者苯丙酮尿症的药物。2018-05-24,美国食品和药品监督管理局(FDA)批准pegvaliase-pqpz用于成年苯丙酮尿症患者的治疗。本文对pegvaliase-pqpz的作用机制、药代动力学、药物相互作用、临床评价和安全性等进行综述。
Pegvaliase-pqpz( trade name Palynziq) is a new type of enzymatic drug developed by BioMarin Pharmaceuticals( USA),which is the first phenylalanine ammonia-lyase to treat phenylketonuria in adult patients. On May 24 2018,the US Food and Drug Administration( FDA)approved pegvaliase-pqpz for the treatment of adult patients with phenylketonuria. In this paper,the mechanism,pharmacokinetics,drug interaction,clinical evaluation,and safety of pegvaliase-pqpz were reviewed.
引文
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