绝经后女性冠心病患者中性粒细胞/淋巴细胞比值与冠状动脉病变程度的相关性研究
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摘要
目的:探讨绝经后女性冠心病患者的中性粒细胞/淋巴细胞比值(NLR)与冠状动脉(冠脉)病变程度的关系。方法:收集经冠脉造影确诊的女性冠心病患者226例,根据NLR值分为NLR低值组(110例)和NLR高值组(116例)。记录Gensini积分,探讨NLR与冠脉病变程度的关系。结果:与NLR低值组的Gensini积分(38.07±29.50)比较,NLR高值组Gensini积分(47.45±34.91)较高,差异有统计学意义(P<0.05)。运用双变量相关分析发现,Gensini积分与NLR呈正相关(r=0.206,P<0.05)。结论:与NLR低值组相比,NLR高值组的冠脉病变程度较严重,冠脉严重程度与NLR呈正相关。
Objective:To explore the relationship between neutrophil to lymphocyte ratio(NLR) and coronary artery lesions in postmenopausal female patients with coronary artery disease.Method:Data were collected from 226 female patients with coronary artery disease diagnosed by coronary angiography.According to NLR,the patients were divided into low-NLR group(n=110) and high-NLR group(n=116).Gensini scores were detected.The relationship Between NLR and severity of coronary artery lesions was studied.Result:Compared with the low-NLR group,Gensini scores were increased in the high-NLR group(38.07±29.50 vs 47.45±34.91,P<0.05).NLR were positively correlated with the Gensini scores in the low-NLR group and the high-NLR group(r=0.206,P<0.05).Conclusion:Compared with the low-NLR group,the degree of coronary artery lesions is more serious in the high-NLR group.NLR is correlated with the severity of coronary artery lesions.
Objective:To explore the relationship between neutrophil to lymphocyte ratio(NLR) and coronary artery lesions in postmenopausal female patients with coronary artery disease.Method:Data were collected from 226 female patients with coronary artery disease diagnosed by coronary angiography.According to NLR,the patients were divided into low-NLR group(n=110) and high-NLR group(n=116).Gensini scores were detected.The relationship Between NLR and severity of coronary artery lesions was studied.Result:Compared with the low-NLR group,Gensini scores were increased in the high-NLR group(38.07±29.50 vs 47.45±34.91,P<0.05).NLR were positively correlated with the Gensini scores in the low-NLR group and the high-NLR group(r=0.206,P<0.05).Conclusion:Compared with the low-NLR group,the degree of coronary artery lesions is more serious in the high-NLR group.NLR is correlated with the severity of coronary artery lesions.
引文
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[17] Ohira T,Folsom AR,Cushman M,et al.Reproductive history,hormone replacement,and incidence of venous thromboembolism:the longistudinal investigation of thromboembolism Etiology[J].Br Haematol,2010,149(4):606-612.
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[19] 李秋儒.围绝经期女性ST-T改变的临床分析56例[J].实用妇科内分泌电子杂志,2014,1(3):13-14.
[20] 董海秋,董梅,任法新.雌激素水平对绝经后女性急性心肌梗死发生的影响研究[J].临床心血管病杂志,2017,33(2):56-59.
[21] Azab B,Bhatt VR,Phookan J,et al.Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients[J].Ann Surg Oncol,2012,19(1):217-224.
[22] Shah N,Parikh V,Patel N,et al.Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction ofcoronary heart disease mortality:insights from the National Healthand Nutrition Examination Survey-Ⅲ[J].Int J Cardiol,2014,171(3):390-397.
[23] Bekler A,Erbag G,Sen H,et al.Predictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with non ST-elevated acute coronary syndrome[J].Pak J Med Sci,2015,31(1):159-163.
[24] 蔡莉娜,杨文博,强红丽,等.393例女性冠心病患者的临床特征及预后探讨[J].临床心血管病杂志,2018,34(9):876-879.
[2] 张秀连,孟军.性激素补充治疗与冠心病相关危险因素的研究[J].实用中西医结合临床,2016,16(3):86-89.
[3] Dosi R,Bhatt N,Shah P,et al.Cardiovascular disease and menopause[J].J Clin Diagn Res,2014,8(2):62-64.
[4] 尔璐,侯曜曜,张永亮,等.绝经前后女性冠心病患者HDL及LDL颗粒与冠状动脉病变程度的相关性研究[J].中国动脉硬化杂志,2017,25(8):823-829.
[5] Chen L,Li Q,Yang Z,et al.Osteocalcin,glucose metabolism,lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese[J].Diabet Med,2013,30(3):309-317.
[6] Bhat T,Teli S,Rijal J,et al.Neutrophil to lymphocyte ratio and cardiovascular diseases:a review [J].Expert Rev Cardiovasc Ther,2013,11(1):55-59.
[7] Torun S,Tunc BD,Suvak B,et al.Assessment of neutrophil-lymphocyte ratio in ulcerative colitis:a promising marker in predicting disease severity [J].Clin Res Hepatol Gastroenterol,2012,36(5):491-497.
[8] Acet H,Erta F,Akll MA,et al.Novel predictors of infarct related artery patency for ST-segment elevation myocardial infarction:platelet to lymphocyte ratio,uric acid,and neutrophil to lymphocyte ratio[J].Anatol J Cardiol,2015,15(8):648-656.
[9] Kurtul S,Sarli B,Baktir AO,et al.Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction[J].Int Heart J,2015,56(1):18-21.
[10] Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606-607.
[11] Meyer MR,Barton M.Estrogens and coronary artery disease:new clinicalperspectives[J].Adv Pharmacol,2016,77:307-360.
[12] Yan L,Cao X,Zeng S,et al.Associations of proteins relevant MAPK signaling pathway(p38MAPK-1,HIF-1 and HO-1) with coronary lesion characteristics and prognosis of peri-menopausal women[J].Lipids Health Dis,2016,15(1):187-187.
[13] Manson JE,Chlebowski RT,Stefanick ML,et al.Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women' s Health Initiativerandomized trials[J].JAMA,2013,310(13):1353-1368.
[14] Boardman HM,Hartley L,Eisinga A,et al.Hormone therapy for preventing cardiovascular disease in post-menopausal women[J].Cochrane Database Syst Rev,2015,10(3):CD002229.
[15] Vittinghoff E,Shlipak MG,Varosy PD,et al.Risk factors and secondary prevention in women wish heart disease:the heart with heart disease:the heart and estrogen/progestin replacement study[J].Ann Intern Med,2003,138(2):81-89.
[16] Hulley S,Furberg C,Barrett-Connor E,et al.Noncardiovascular disease outcomes during 6.8 years of hormone therapy:Heart and Estrogen/progestin Replacement Study follow-up(HERSⅡ)[J].JAMA,2002,288(1):58-66.
[17] Ohira T,Folsom AR,Cushman M,et al.Reproductive history,hormone replacement,and incidence of venous thromboembolism:the longistudinal investigation of thromboembolism Etiology[J].Br Haematol,2010,149(4):606-612.
[18] Rossouw JE,Anderson GL,Prentice RL,et al.Risk and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the women′s health initiative randomized controlled trial[J].JAMA,2002,288(3):321-333.
[19] 李秋儒.围绝经期女性ST-T改变的临床分析56例[J].实用妇科内分泌电子杂志,2014,1(3):13-14.
[20] 董海秋,董梅,任法新.雌激素水平对绝经后女性急性心肌梗死发生的影响研究[J].临床心血管病杂志,2017,33(2):56-59.
[21] Azab B,Bhatt VR,Phookan J,et al.Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients[J].Ann Surg Oncol,2012,19(1):217-224.
[22] Shah N,Parikh V,Patel N,et al.Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction ofcoronary heart disease mortality:insights from the National Healthand Nutrition Examination Survey-Ⅲ[J].Int J Cardiol,2014,171(3):390-397.
[23] Bekler A,Erbag G,Sen H,et al.Predictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with non ST-elevated acute coronary syndrome[J].Pak J Med Sci,2015,31(1):159-163.
[24] 蔡莉娜,杨文博,强红丽,等.393例女性冠心病患者的临床特征及预后探讨[J].临床心血管病杂志,2018,34(9):876-879.