沙丁胺醇对小儿支气管哮喘急性期疗效分析
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摘要
目的探讨沙丁胺醇雾化吸入治疗小儿支气管哮喘急性发作效果。方法选取我院2017年1月—2018年12月收治132例支气管哮喘急性发作患儿作为研究对象。计算机随机将其等分成对照组与观察组,每组各66例。对照组患儿接受小儿化痰止咳颗粒治疗,观察组患儿在对照组治疗基础上,接受沙丁胺醇雾化吸入治疗。比较两组患儿临床疗效、肺功能、体征消失时间。结果观察组患儿临床总有效率高于对照组,差异具有统计学意义(P <0.05)。治疗前,两组患儿肺功能各项指标比较,差异无统计学意义(P> 0.05)。治疗后,两组患儿FEV1、FEF50%、PEF、FVC较治疗前升高,其中观察组患儿FEV1、FEF50%、PEF、FVC水平高于对照组,差异具有统计学意义(P <0.05)。观察组患儿咳嗽消失时间、哮鸣音消失时间、呼吸困难消失时间短于对照组,差异具有统计学意义(P <0.05)。结论沙丁胺醇雾化吸入是治疗小儿支气管哮喘急性发作期的有效方法,能显著提高临床疗效,促使肺功能恢复,加快症状改善。
Objective To investigate the effect of salbutamol aerosol inhalation in children with acute exacerbation of bronchial asthma.Methods 132 children with acute attack of bronchial asthma were treated in our hospital from January 2017 to December 2018. The computer randomly divided them into control group and observation group, 66 cases in each group. The children in the control group were treated with Xiaoer Huatan Zhike Granule. The children in the observation group received salbutamol aerosol inhalation therapy on the basis of the treatment in the control group. The clinical efficacy, pulmonary function and disappearance time of signs were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group, with statistical significance(P < 0.05). Before treatment, there was no significant difference in lung function between the two groups(P > 0.05). After treatment, the levels of FEV1, FEF50%, PEF and FVC in the two groups were higher than those before treatment. The levels of FEV1, FEF50%, PEF and FVC in the observation group were higher than those in the control group(P < 0.05). The cough disappearance time, wheezing disappearance time and dyspnea disappearance time of the observation group were shorter than those of the control group, the difference was statistically significant(P < 0.05). Conclusion The application of the salbutamol aerosol inhalation can effectively ameliorate the pulmonary function and the clinical symptoms of children with acute exacerbation of bronchial asthma.
Objective To investigate the effect of salbutamol aerosol inhalation in children with acute exacerbation of bronchial asthma.Methods 132 children with acute attack of bronchial asthma were treated in our hospital from January 2017 to December 2018. The computer randomly divided them into control group and observation group, 66 cases in each group. The children in the control group were treated with Xiaoer Huatan Zhike Granule. The children in the observation group received salbutamol aerosol inhalation therapy on the basis of the treatment in the control group. The clinical efficacy, pulmonary function and disappearance time of signs were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group, with statistical significance(P < 0.05). Before treatment, there was no significant difference in lung function between the two groups(P > 0.05). After treatment, the levels of FEV1, FEF50%, PEF and FVC in the two groups were higher than those before treatment. The levels of FEV1, FEF50%, PEF and FVC in the observation group were higher than those in the control group(P < 0.05). The cough disappearance time, wheezing disappearance time and dyspnea disappearance time of the observation group were shorter than those of the control group, the difference was statistically significant(P < 0.05). Conclusion The application of the salbutamol aerosol inhalation can effectively ameliorate the pulmonary function and the clinical symptoms of children with acute exacerbation of bronchial asthma.
引文
[1]刘丽芬.雾化吸入布地奈德与沙丁胺醇治疗支气管哮喘急性发作对HMGB1的影响及治疗效果评价[J].临床肺科杂志,2016,21(5):805-808.
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[9]陈祥瑞,简国江,张晓霞.硫酸沙丁胺醇联合布地奈德雾化治疗小儿哮喘的临床效果及相关机制分析[J].中国妇幼保健,2018,15(20):1402-1405.
[10]吴乾东.沙丁胺醇联合硫酸特布他林雾化吸入治疗小儿支气管哮喘的临床疗效观察[J].实用心脑肺血管病杂志,2017,12(3):150-152.
[11]吕瑞珠.小儿支气管哮喘应用药物联合雾化吸入治疗的临床研究[J].中国医药导刊,2017,25(7):1456-1459.
[12]王平.沙丁胺醇联合布地奈德雾化吸入治疗老年支气管哮喘急性发作的临床疗效及安全性[J].实用心脑肺血管病杂志,2017,25(5):144-146.
[13]张云,张晓,黄治华.雾化吸入对小儿哮喘调节性T细胞及气道炎症的治疗效果[J].河北医药,2016,38(19):2942-2944.
[2]羊礼荣,顾倩,杨晓光,等.硫酸镁联合硫酸沙丁胺醇雾化吸入治疗小儿重度支气管哮喘急性发作的临床观察[J].中国药房,2016,27(23):3252-3254.
[3]何聪华,谢少玲,张国祥,等.布地奈德联合沙丁胺醇雾化吸入治疗小儿毛细支气管炎122例[J].医药导报,2016,35(z1):145-148.
[4]王扬帆.沙丁胺醇与异丙托溴铵雾化吸入治疗小儿毛细支气管炎的临床效果和症状缓解情况观察[J].河北医药,2016,38(15):2393-2394.
[5]彭林强,马春利,薛满,等.不同剂量沙丁胺醇雾化吸入对支气管哮喘患儿肺功能及心率的影响[J].实用临床医药杂志,2016,20(13):175-177.
[6]杨兰.布地奈德和沙丁胺醇联合雾化吸入治疗COPD急性发作期患者的临床疗效[J].实用临床医药杂志,2016,20(7):1347-1349.
[7]吴乾东.沙丁胺醇联合硫酸特布他林雾化吸入治疗小儿支气管哮喘的临床疗效观察[J].实用心脑肺血管病杂志,2017,16(3):150-152.
[8]王平.沙丁胺醇联合布地奈德雾化吸入治疗老年支气管哮喘急性发作的临床疗效及安全性[J].实用心脑肺血管病杂志,2017,14(5):144-146.
[9]陈祥瑞,简国江,张晓霞.硫酸沙丁胺醇联合布地奈德雾化治疗小儿哮喘的临床效果及相关机制分析[J].中国妇幼保健,2018,15(20):1402-1405.
[10]吴乾东.沙丁胺醇联合硫酸特布他林雾化吸入治疗小儿支气管哮喘的临床疗效观察[J].实用心脑肺血管病杂志,2017,12(3):150-152.
[11]吕瑞珠.小儿支气管哮喘应用药物联合雾化吸入治疗的临床研究[J].中国医药导刊,2017,25(7):1456-1459.
[12]王平.沙丁胺醇联合布地奈德雾化吸入治疗老年支气管哮喘急性发作的临床疗效及安全性[J].实用心脑肺血管病杂志,2017,25(5):144-146.
[13]张云,张晓,黄治华.雾化吸入对小儿哮喘调节性T细胞及气道炎症的治疗效果[J].河北医药,2016,38(19):2942-2944.