荆花胃康胶丸联合三联疗法治疗消化性溃疡的疗效观察
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摘要
目的探讨分析荆花胃康胶丸联合三联疗法治疗消化性溃疡的临床疗效。方法选取2013年10月—2016年10月在天津市中医药研究院附属医院治疗的消化性溃疡患者96例,随机分成对照组和治疗组,每组各48例。对照组患者口服奥美拉唑镁肠溶片,20 mg/次,2次/d;同时口服阿莫西林胶囊,1 000 mg/次,2次/d,以及饭后口服克拉霉素片500 mg/次,2次/d。治疗组患者在对照组的基础上口服荆花胃康胶丸,160 mg/次,3次/d。两组患者均治疗14 d。评价治疗前后两组患者胃痛和胃镜疗效以及幽门螺杆菌(Hp)清除率。结果治疗后,对照组和治疗组胃痛疗效分别为81.25%和91.66%,两组比较差异具有统计学意义(P<0.05)。对照组和治疗组胃镜疗效分别为85.42%、89.58%,两组比较差异无统计学意义。治疗后,对照组Hp清除率31.25%,显著低于治疗组的83.33%,两组比较差异具有统计学意义(P<0.05)。结论荆花胃康胶丸治疗消化性溃疡效果确切,与三联疗法联合使用可增强根除Hp作用。
Objective To investigate the clinical effect of Jinhua Weikang Capsules Combined with triple therapy in treatment of peptic ulcer.Methods Patients(96 cases) with peptic ulcer in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from October 2013 to October 2016 were randomly divided into control and treatment groups,and each group had 48 cases.Patients in the control group were po administered with Omeprazole Magnesium Enteric-coated Tablets,20 mg/time,twice daily,and they were po administered with Amoxicillin Capsules at the same time,100 mg/time,twice daily,also po administered with Clarithromycin Tablets after meals,500 mg/time,twice daily.Patients in the treatment group were po administered with Jinhua Weikang Capsules on the basis of the control group,160 mg/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the stomachache efficacy,gastroscopic figures and Hp clearance rate in two groups before and after treatment were evaluated.Results After treatment,the stomachache efficacy in the control and treatment groups were 81.25% and 91.66%,respectively,and there were differences between two groups(P < 0.05).Gastroscopic figures in the control and treatment groups were 85.42% and 89.58%,respectively,and there were no difference between two groups.After treatment,the Hp clearance rate in the control group was 31.25%,which was significantly lower than 83.33% in the treatment group,with significant difference between two groups(P < 0.05).Conclusion Jinhua Weikang Capsules has significantly effect in treatment of peptic ulcer,which combined with triple therapy can increase Hp clearance rate.
Objective To investigate the clinical effect of Jinhua Weikang Capsules Combined with triple therapy in treatment of peptic ulcer.Methods Patients(96 cases) with peptic ulcer in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from October 2013 to October 2016 were randomly divided into control and treatment groups,and each group had 48 cases.Patients in the control group were po administered with Omeprazole Magnesium Enteric-coated Tablets,20 mg/time,twice daily,and they were po administered with Amoxicillin Capsules at the same time,100 mg/time,twice daily,also po administered with Clarithromycin Tablets after meals,500 mg/time,twice daily.Patients in the treatment group were po administered with Jinhua Weikang Capsules on the basis of the control group,160 mg/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the stomachache efficacy,gastroscopic figures and Hp clearance rate in two groups before and after treatment were evaluated.Results After treatment,the stomachache efficacy in the control and treatment groups were 81.25% and 91.66%,respectively,and there were differences between two groups(P < 0.05).Gastroscopic figures in the control and treatment groups were 85.42% and 89.58%,respectively,and there were no difference between two groups.After treatment,the Hp clearance rate in the control group was 31.25%,which was significantly lower than 83.33% in the treatment group,with significant difference between two groups(P < 0.05).Conclusion Jinhua Weikang Capsules has significantly effect in treatment of peptic ulcer,which combined with triple therapy can increase Hp clearance rate.
引文
[1]张丽贤,陈庆,姜慧卿.荆花胃康对糜烂性胃炎患者胃黏膜环氧合酶的影响[J].胃肠病学和肝病学杂志,2008,17(11):873-875.
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[10]中华医学会消化病学分会幽门螺杆菌学组/全国幽门螺杆菌研究协作组.第四次全国幽门螺杆菌感染处理共识报告[J].胃肠病学,2012,17(10):618-625
[11]董圣惠,刘生杰,王瑾,等.荆花胃康胶丸对阿司匹林致小鼠胃黏膜损伤的修复作用[J].中国新药杂志,2005,14(5):565-567.
[12]叶晖,李宁,于靖,等.荆花胃康胶丸对幽门螺杆菌感染小鼠胃黏膜核因子κBp65表达的影响[J].中国中医药信息杂志,2015,22(2):60-63.
[13]梁文郁,李超波,张学智,等.荆花胃康胶丸对溃疡大鼠胃黏膜NO,NOS和ET含量的影响[J].中国新药杂志,2006,15(16):1354-1356.
[14]张学智,杨国生,李宁,等.荆花胃康胶丸对胃溃疡大鼠黏膜组织表皮生长因子和碱性成纤维细胞生长因子含量的影响[J].中医杂志,2009,50(6):547-549.
[15]张万岱,胡伏莲,萧树东,等.中国自然人群幽门螺旋杆菌感染的流行病学调查[J].现代消化及介入诊疗,2010,15(5):265-270.
[2]朱国琴,施瑞华,沈健,等.荆花胃康胶丸对大鼠胃黏膜的保护机制[J].世界华人消化杂志,2007,15(5):505-508.
[3]谢振家,黄美星.荆花胃康胶丸对实验性胃溃疡及幽门螺杆菌的抑制作用[J].中国新药杂志,2001,10(3):221-223.
[4]朱文锋.中医内科疾病诊疗常规:国家标准应用[M].长沙:湖南科学技术出版社,1999.
[5]唐琳.黄启阳.杨云生.消化性溃疡的检查方法及诊断标准[J].医学与哲学,2010,31(10):16-18.
[6]中华中医药学会脾胃病分会.消化性溃疡中医诊疗共识意见[J].中医杂志,2010,51(10):941-944.
[7]孙明,王蔚文,等.临床疾病诊断与疗效判断标准[M].北京:科学技术文献出版社,2010.
[8]杜红飞.中西医结合治疗胃溃疡50例[J].山西中医,2010,26(11):22.
[9]张声生,赵鲁卿.消化性溃疡的中医辨证分型与治疗[J].现代消化及介入诊疗,2011,16(4):252-255.
[10]中华医学会消化病学分会幽门螺杆菌学组/全国幽门螺杆菌研究协作组.第四次全国幽门螺杆菌感染处理共识报告[J].胃肠病学,2012,17(10):618-625
[11]董圣惠,刘生杰,王瑾,等.荆花胃康胶丸对阿司匹林致小鼠胃黏膜损伤的修复作用[J].中国新药杂志,2005,14(5):565-567.
[12]叶晖,李宁,于靖,等.荆花胃康胶丸对幽门螺杆菌感染小鼠胃黏膜核因子κBp65表达的影响[J].中国中医药信息杂志,2015,22(2):60-63.
[13]梁文郁,李超波,张学智,等.荆花胃康胶丸对溃疡大鼠胃黏膜NO,NOS和ET含量的影响[J].中国新药杂志,2006,15(16):1354-1356.
[14]张学智,杨国生,李宁,等.荆花胃康胶丸对胃溃疡大鼠黏膜组织表皮生长因子和碱性成纤维细胞生长因子含量的影响[J].中医杂志,2009,50(6):547-549.
[15]张万岱,胡伏莲,萧树东,等.中国自然人群幽门螺旋杆菌感染的流行病学调查[J].现代消化及介入诊疗,2010,15(5):265-270.