来复汤加减治疗小儿神经母细胞瘤化疗后疲乏临床观察
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摘要
目的 :观察来复汤加减治疗小儿神经母细胞瘤化疗后疲乏的临床疗效。方法 :将60例患者随机分为治疗组及对照组各30例,治疗组在日常生活除正常作息外以来复汤治疗2周,对照组予以休息为主,并安慰剂治疗2周。以生活质量评分表、Piper疲乏量表、中医症状量表进行问卷调查,统计2组患者干预前后疲乏评分。结果 :治疗组治疗后的躯体功能、疲劳、总体生活质量评分均优于对照组(P<0.05)。2组治疗前疲乏症状程度比较,差异无统计学意义(P>0.05)。治疗后2组疲乏症状程度变化比较,差异有统计学意义(P<0.05)。治疗2周后,治疗组疲乏、多汗症状积分变化情况与治疗前比较,差异均有统计学意义(P<0.05);情绪低落、失眠症状积分较治疗前有所改善,但差异均无统计学意义(P>0.05);而对照组疲乏、情绪低落、失眠、多汗症状积分变化情况治疗前后比较,差异均无统计学意义(P>0.05)。结论:来复汤治疗小儿化疗后疲乏有显著疗效,从而可提高患者生存质量。
Objective: To observe the clinical curative effect of modified Laifu Decoction for the treatment of fatigue after chemotherapy in children with neuroblastoma. Methods: Sixty patients were randomly divided into treatment group and control group,30 cases in each group. Both groups led routine daily life. The treatment group was treated with modified Laifu Decoction and the control group received a placebo for 2 weeks. Quality of life scale, the Piper fatigue scale, and the Chinese medical symptom questionnaire were applied to record fatigue scores of both groups before and after intervention. Results: The scores of physical function, fatigue,and overall quality of life in the treatment group after treatment were superior to those in the control group(P < 0.05). The difference of fatigue symptoms degree between the 2 groups before treatment was not significant(P > 0.05), while the difference between the 2 groups after treatment was significant(P < 0.05). The scores of fatigue and sweating symptoms after treatment in the treatment group was improved, the difference being significant(P < 0.05 compared with before treatment). The scores of depression and insomnia symptoms after treatment in the treatment group was also improved, but the differences were insignificant(P >0.05 compared with before treatment). In the control group, the differences of the scores of fatigue, sweating and depression, insomnia symptoms before and after treatment were insignificant(P>0.05). Conclusion: There is a significant effect of Laifu Decoction is effective in treating fatigue after chemotherapy in children with neuroblastoma, and can improve the quality of life of the patients.
Objective: To observe the clinical curative effect of modified Laifu Decoction for the treatment of fatigue after chemotherapy in children with neuroblastoma. Methods: Sixty patients were randomly divided into treatment group and control group,30 cases in each group. Both groups led routine daily life. The treatment group was treated with modified Laifu Decoction and the control group received a placebo for 2 weeks. Quality of life scale, the Piper fatigue scale, and the Chinese medical symptom questionnaire were applied to record fatigue scores of both groups before and after intervention. Results: The scores of physical function, fatigue,and overall quality of life in the treatment group after treatment were superior to those in the control group(P < 0.05). The difference of fatigue symptoms degree between the 2 groups before treatment was not significant(P > 0.05), while the difference between the 2 groups after treatment was significant(P < 0.05). The scores of fatigue and sweating symptoms after treatment in the treatment group was improved, the difference being significant(P < 0.05 compared with before treatment). The scores of depression and insomnia symptoms after treatment in the treatment group was also improved, but the differences were insignificant(P >0.05 compared with before treatment). In the control group, the differences of the scores of fatigue, sweating and depression, insomnia symptoms before and after treatment were insignificant(P>0.05). Conclusion: There is a significant effect of Laifu Decoction is effective in treating fatigue after chemotherapy in children with neuroblastoma, and can improve the quality of life of the patients.
引文
[1]田海萍,杨永琴.神经母细胞瘤临床及病理分析[J].宁夏医学杂志,2014,36(5):449.
[2]张国锋,侯广军,耿宪杰,等.45例儿童神经母细胞瘤临床分析[J].中国实用医药,2014,9(21):8.
[3]中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[4]汤静燕,潘慈,陈静,等.45例儿童神经母细胞瘤预后因素分析[J].中华儿科杂志,2006,44(10):770-773.
[5]高晓宁,唐锁勤,林季.晚期儿童神经母细胞瘤的临床和预后分析[J].中国当代儿科杂志,2007,9(4):351-354.
[6]王晓戎,李平,吴志立.肿瘤化疗后中医症候学特征调查研究[J].山东中医杂志,2006,25(1):18.
[7]李可.李可老中医急危重症疑难病经验专辑[M].山西:山西科学技术出版社,2002:1.
[8]于淼,王晓先.山茱萸的药理作用研究进展[J].东南国防医药,2010,12(3):240.
[2]张国锋,侯广军,耿宪杰,等.45例儿童神经母细胞瘤临床分析[J].中国实用医药,2014,9(21):8.
[3]中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[4]汤静燕,潘慈,陈静,等.45例儿童神经母细胞瘤预后因素分析[J].中华儿科杂志,2006,44(10):770-773.
[5]高晓宁,唐锁勤,林季.晚期儿童神经母细胞瘤的临床和预后分析[J].中国当代儿科杂志,2007,9(4):351-354.
[6]王晓戎,李平,吴志立.肿瘤化疗后中医症候学特征调查研究[J].山东中医杂志,2006,25(1):18.
[7]李可.李可老中医急危重症疑难病经验专辑[M].山西:山西科学技术出版社,2002:1.
[8]于淼,王晓先.山茱萸的药理作用研究进展[J].东南国防医药,2010,12(3):240.