丹参川芎嗪联合鼠神经生长因子治疗臂丛神经损伤临床研究
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摘要
目的探讨丹参川芎嗪联合鼠神经生长因子治疗臂丛神经损伤的临床疗效及安全性。方法选择医院2012年1月至2017年12月收治的臂丛神经损伤患者73例,按随机数字表法分为对照组(36例)和治疗组(37例)。对照组患者给予鼠神经生长因子治疗,治疗组患者在对照组治疗基础上联合丹参川芎嗪治疗,两组均连续治疗3个月。结果治疗组总有效率为81. 08%,优于对照组的69. 44%(χ~2=4. 423,P=0. 038);两组臂丛神经功能评分均明显高于治疗前,疼痛视觉模拟评分(VAS)均明显低于治疗前(P <0. 05),且治疗组明显优于对照组(P <0. 05);治疗组上肢自主生活能力的优良率为89. 19%,优于对照组的66. 67%(χ~2=5. 408,P=0. 020);两组治疗过程中均无严重不良反应发生。结论丹参川芎嗪联合鼠神经生长因子治疗臂丛神经损伤的临床疗效显著,可明显改善臂丛神经功能和上肢自主生活能力,减轻上肢疼痛,且安全性较高。
Objective To investigate the clinical effect and safety of salvia miltiorrhiza ligustrazine combined with rat nerve growth factor in the treatment of brachial plexus injury. Methods Totally 73 patients with brachial plexus injury admitted to our hospital from January 2012 to December 2017 were selected and divided into the control group( 36 cases) and the treatment group( 37 cases) according to the random number table method. The patients in the control group were treated with rat nerve growth factor, on this basis, the patients in the treatment group were treated with salvia miltiorrhiza ligustrazine. Both groups were treated for 3 months. Results The total effective rate of the treatment group was 81. 08%,which was better than 69. 44% of the control group( χ~2= 4. 423, P = 0. 038). The scores of brachial plexus nerve function in the two groups were significantly higher than those before treatment, and Visual Analogue Scale( VAS) scores in the two groups were significantly lower than those before treatment( P < 0. 05), and those in the treatment group were significantly better than those in the control group( P < 0. 05). The excellent and good rate of upper limb autonomous living ability in the treatment group was 89. 19%,which was better than 66. 67% in the control group( χ~2= 5. 408, P = 0. 020). There was no serious adverse reaction in the two groups. Conclusion Salvia miltiorrhiza ligustrazine combined with rat nerve growth factor is effective in the treatment of brachial plexus injury, which can significantly improve brachial plexus nerve function and upper limb autonomous living ability,alleviate upper limb pain,and it has high safety.
Objective To investigate the clinical effect and safety of salvia miltiorrhiza ligustrazine combined with rat nerve growth factor in the treatment of brachial plexus injury. Methods Totally 73 patients with brachial plexus injury admitted to our hospital from January 2012 to December 2017 were selected and divided into the control group( 36 cases) and the treatment group( 37 cases) according to the random number table method. The patients in the control group were treated with rat nerve growth factor, on this basis, the patients in the treatment group were treated with salvia miltiorrhiza ligustrazine. Both groups were treated for 3 months. Results The total effective rate of the treatment group was 81. 08%,which was better than 69. 44% of the control group( χ~2= 4. 423, P = 0. 038). The scores of brachial plexus nerve function in the two groups were significantly higher than those before treatment, and Visual Analogue Scale( VAS) scores in the two groups were significantly lower than those before treatment( P < 0. 05), and those in the treatment group were significantly better than those in the control group( P < 0. 05). The excellent and good rate of upper limb autonomous living ability in the treatment group was 89. 19%,which was better than 66. 67% in the control group( χ~2= 5. 408, P = 0. 020). There was no serious adverse reaction in the two groups. Conclusion Salvia miltiorrhiza ligustrazine combined with rat nerve growth factor is effective in the treatment of brachial plexus injury, which can significantly improve brachial plexus nerve function and upper limb autonomous living ability,alleviate upper limb pain,and it has high safety.
引文
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[14]万钧,杨晓炜,朱凌兰.丹参川芎嗪注射液对急性脑梗死患者神经功能缺损程度及日常生活能力的影响[J].时珍国医国药,2015,26(3):659-660.
[15]周黎,徐芝秀,吴永胜.鼠神经生长因子联合丹参川芎嗪治疗糖尿病周围神经病变的临床观察[J].中国中医药科技,2016,23(6):701-702.
[16]张玲.丹参川芎嗪注射液治疗对急性脑梗死患者神经功能缺损程度及日常生活能力的影响[J].中国处方药,2015,13(10):110-111.
[17]杨云春,刘庆,邓茹,等.鼠神经生长因子联合加巴喷丁治疗外周神经损伤后神经病理性疼痛[J].中国疼痛医学杂志,2012,18(6):360-362.
[18]赵婷.丹参川芎嗪注射液辅助治疗急性脑梗死对神经功能、血液流变学及炎性细胞因子的影响[J].中国合理用药探索,2017,14(6):1-5.
[2]李春雨,孙鸿斌,王悦书,等.臂丛神经损伤诊断及治疗新进展[J].吉林医学,2007,28(7):867-869.
[3]劳杰.臂丛神经损伤的治疗进展[J].实用医院临床杂志,2010,7(1):6-9.
[4]阮顺秋,黄琴,王琪,等.臂丛神经损伤患儿肌肉注射鼠神经生长因子操作要点及护理[J].临床医学工程,2014,21(11):1475-1476.
[5]郑晓春,丘春华,陈江湖.丹参川芎嗪注射液减轻大鼠坐骨神经缺血-再灌注损伤的作用[J].临床麻醉学杂志,2015,31(6):588-591.
[6]齐洪娜,孔繁托,王磊,等.丹参川芎嗪注射液联合神经节苷脂对急性重度一氧化碳中毒患者乳酸清除率及预后的影响[J].中国现代医学杂志,2016,26(19):89-93.
[7]顾玉东.臂丛神经损伤与疾病的诊治[M].上海:上海医科大学出版社,2001:31.
[8]窦祖林,敖丽娟.作业治疗学[M].北京:人民卫生出版社,2012:110.
[9]顾玉东,王澍寰,侍德.手外科学[M].上海:上海科学技术出版社,2002:539-540.
[10]朱新洪.临床神经外科学[M].北京:科学技术文献出版社,2007:103-105,388.
[11]于兑生.康复医学评价手册[M].北京:华夏出版社,1993:80.
[12]王亚军.臂丛神经损伤的临床诊治分析[J].中国医药指南,2017,15(11):52-53.
[13]施新革,夏永华,李爱国,等.小鼠神经生长因子治疗人急性脊髓损伤的疗效观察[J].军事医学,2011,35(2):142-144.
[14]万钧,杨晓炜,朱凌兰.丹参川芎嗪注射液对急性脑梗死患者神经功能缺损程度及日常生活能力的影响[J].时珍国医国药,2015,26(3):659-660.
[15]周黎,徐芝秀,吴永胜.鼠神经生长因子联合丹参川芎嗪治疗糖尿病周围神经病变的临床观察[J].中国中医药科技,2016,23(6):701-702.
[16]张玲.丹参川芎嗪注射液治疗对急性脑梗死患者神经功能缺损程度及日常生活能力的影响[J].中国处方药,2015,13(10):110-111.
[17]杨云春,刘庆,邓茹,等.鼠神经生长因子联合加巴喷丁治疗外周神经损伤后神经病理性疼痛[J].中国疼痛医学杂志,2012,18(6):360-362.
[18]赵婷.丹参川芎嗪注射液辅助治疗急性脑梗死对神经功能、血液流变学及炎性细胞因子的影响[J].中国合理用药探索,2017,14(6):1-5.