摘要
A组链球菌是(GAS)一种常见的革兰阳性病原菌,人是其唯一自然宿主。GAS感染人体后可导致一系列感染性疾病,还可引起一些自身免疫性疾病,严重危害人体健康,同时也给社会带来巨大的经济负担。目前,GAS对青霉素仍然敏感,但对其他抗生素的耐药率不断增加。预防GAS感染最好的方法是研制安全、有效的疫苗。GAS疫苗的研究已经持续了近百年,但迄今还没有商品化的疫苗研制出来。现在有多种疫苗正处于不同的研发阶段之中,该文就GAS疫苗的研究进展进行概述。
Group A streptococcus(GAS) is a common gram-positive pathogenic bacterium.Human is the only natural host of GAS.GAS infection can lead to a wide spectrum of infectious diseases and several autoimmune diseases,which seriously damages human health and brings significant economic burden to the society.Currently,GAS is still sensitive to penicillin,but it yields increasing resistance to other antibiotics.The best strategy to prevent GAS infection is to develop a safe and effective vaccine.Even though investigated for almost 100 years,no commercial vaccine for GAS has been developed worldwide.Multiple types of vaccine candidates are being investigated in different stages.In this paper,recent research progress on GAS vaccine was reviewed.
引文
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