子午时辰开穴法低频电配合药物治疗原发性高血压疗效观察
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摘要
目的观察子午时辰开穴法低频电治疗配合口服厄贝沙坦片治疗原发性高血压的临床疗效。方法将90例原发性高血压患者随机分为治疗组、对照1组和对照2组,每组30例。对照1组给予子午时辰开穴法低频电治疗,对照2组给予口服厄贝沙坦片治疗,治疗组给予子午时辰开穴法低频电治疗配合口服厄贝沙坦片治疗。观察3组治疗前后血压与心率指标、昼夜节律变化、各项血脂水平(总胆固醇、甘油三酯、低密度脂蛋白胆固醇)及心功能相关指标(CO、SV、LVEF、E/A)的变化情况,并比较3组临床疗效。结果治疗组总有效率为93.3%,对照1组为73.3%,对照2组为70.0%,治疗组总有效率与对照1组和对照2组比较,差异均具有统计学意义(P<0.05)。3组治疗后收缩压、舒张压、昼夜节律变化、各项血脂水平及心功能相关指标与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后收缩压、舒张压、昼夜节律变化、各项血脂水平及心功能相关指标与对照1组和对照2组比较,差异均具有统计学意义(P<0.05)。结论子午时辰开穴法低频电治疗配合口服厄贝沙坦片治疗原发性高血压,可有效持续降压,促进昼夜节律恢复,改善患者血脂水平,改善心功能指标,从而提高临床疗效。
Objective To observe the clinical efficacy of midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets in treating essential hypertension.Method Ninety patients with essential hypertension were randomized into a treatment group, control group 1 and control group 2, with 30 cases in each group. Control group 1 was given midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation; control group 2 was given oral administration of irbesartan tablets;the treatment group received midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets. Before and after treatment, the blood pressure, heart rate,circadian rhythm, blood lipids(total cholesterol, triglyceride, low density lipoprotein cholesterol), and heart function indexes(CO, SV, LVEF, E/A) in the three groups were observed, and the clinical efficacies were compared. Result The total effective rate was 93.3% in the treatment group, versus 73.3% in control group 1 and 70.0% in control group 2,and the rate in the treatment group was significantly different from that in control group 1 and control group 2(P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure, circadian rhythm, blood lipid levels and heart function indexes all changed significantly in the three groups(P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure, circadian rhythm, blood lipid levels and heart function indexes in the treatment group were significantly different from those in control group 1 and control group 2(P<0.05). Conclusion Using midnightnoon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets can persistently down-regulate blood pressure, help restore the circadian rhythm, improve blood lipids and heart function, thereby enhancing the clinical efficacy in treating essential hypertension.
Objective To observe the clinical efficacy of midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets in treating essential hypertension.Method Ninety patients with essential hypertension were randomized into a treatment group, control group 1 and control group 2, with 30 cases in each group. Control group 1 was given midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation; control group 2 was given oral administration of irbesartan tablets;the treatment group received midnight-noon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets. Before and after treatment, the blood pressure, heart rate,circadian rhythm, blood lipids(total cholesterol, triglyceride, low density lipoprotein cholesterol), and heart function indexes(CO, SV, LVEF, E/A) in the three groups were observed, and the clinical efficacies were compared. Result The total effective rate was 93.3% in the treatment group, versus 73.3% in control group 1 and 70.0% in control group 2,and the rate in the treatment group was significantly different from that in control group 1 and control group 2(P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure, circadian rhythm, blood lipid levels and heart function indexes all changed significantly in the three groups(P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure, circadian rhythm, blood lipid levels and heart function indexes in the treatment group were significantly different from those in control group 1 and control group 2(P<0.05). Conclusion Using midnightnoon time-based acupoint-opening needling with low-frequency electrical stimulation plus oral administration of irbesartan tablets can persistently down-regulate blood pressure, help restore the circadian rhythm, improve blood lipids and heart function, thereby enhancing the clinical efficacy in treating essential hypertension.
引文
[1]富路.关于高血压治疗的客观评价[J].中华老年心脑血管病杂志,2015,17(2):113-114.
[2]Patnaik M,Pati P,Swain SN,et al.Aldosterone synthase C-344T,angiotensinⅡtype 1 receptor A1166C and 11-?hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha,India[J].J Genet,2014,93(3):799-808.
[3]庞英华.中医外治法治疗原发性高血压的研究进展[J].世界中医药,2014,9(6):817-819,823.
[4]黄震华.世界卫生组织和国际高血压联盟颁布新的高血压治疗指南[J].中国新药与临床杂志,1999,18(3):63.
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[6]Schiffrin EL.Inflammation,immunity and development of essential hypertension[J].J Hypertens,2014,32(2):228-229.
[7]Levi-Marpillat N,Macquin-Mavier I,Tropeano AI,et al.Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension[J].Hypertens Res,2014,37(6):585-590.
[8]杨大赋,杨颖,沈元良,等.中西医结合治疗对原发性高血压患者血压及生存质量改善的临床观察[J].辽宁中医杂志,2014,41(4):753-755.
[9]翟亚川,东方.中西医结合治疗老年原发性高血压合并高脂血症的临床观察[J].实用临床医药杂志,2014,18(16):150-152,155.
[10]张友生.夜间高血压对原发性高血压患者心功能及肾功能的影响研究[J].实用心脑肺血管病杂志,2015,23(8):22-24,42.
[11]郝鹏,朱玮玮,罗鸿宇,等.原发性高血压患者血脂水平与血压变异性的相关研究[J].四川医学,2015,36(5):628-631.
[12]贾一平,赵仙先,吴弘,等.原发性高血压患者血压昼夜节律与靶器官损害的关系研究[J].现代生物医学进展,2017,17(3):473-475,535.
[13]赵瑛,黄璞,华小黎,等.厄贝沙坦与依那普利治疗原发性高血压的系统评价[J].中国药师,2015,18(7):1154-1159.
[14]蔡东向,王明辉.厄贝沙坦与不同降压药物联合治疗原发性高血压的疗效与药物临床观察[J].中国医药导刊,2014,16(1):131-132.
[15]金茫茫.高血压病患者穴位治疗的依从性及其对疗效的影响[J].解放军护理杂志,2014,31(19):20-22.
[16]张立娟,王康锋,王平,等.针灸治疗原发性高血压取穴现状分析[J].长春中医药大学学报,2015,31(1):102-104.
[17]李实,卢玉彬,张磊,等.子午流注低频开穴法联合厄贝沙坦治疗原发性高血压临床疗效分析[J].医学综述,2016,22(3):620-622.
[18]卢玉彬,李实,张敦憨,等.子午流注低频开穴法联合口服降压药及健康宣教对原发性高血压疗效观察[J].针灸临床杂志,2016,32(6):21-23.
[2]Patnaik M,Pati P,Swain SN,et al.Aldosterone synthase C-344T,angiotensinⅡtype 1 receptor A1166C and 11-?hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha,India[J].J Genet,2014,93(3):799-808.
[3]庞英华.中医外治法治疗原发性高血压的研究进展[J].世界中医药,2014,9(6):817-819,823.
[4]黄震华.世界卫生组织和国际高血压联盟颁布新的高血压治疗指南[J].中国新药与临床杂志,1999,18(3):63.
[5]郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:77-85.
[6]Schiffrin EL.Inflammation,immunity and development of essential hypertension[J].J Hypertens,2014,32(2):228-229.
[7]Levi-Marpillat N,Macquin-Mavier I,Tropeano AI,et al.Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension[J].Hypertens Res,2014,37(6):585-590.
[8]杨大赋,杨颖,沈元良,等.中西医结合治疗对原发性高血压患者血压及生存质量改善的临床观察[J].辽宁中医杂志,2014,41(4):753-755.
[9]翟亚川,东方.中西医结合治疗老年原发性高血压合并高脂血症的临床观察[J].实用临床医药杂志,2014,18(16):150-152,155.
[10]张友生.夜间高血压对原发性高血压患者心功能及肾功能的影响研究[J].实用心脑肺血管病杂志,2015,23(8):22-24,42.
[11]郝鹏,朱玮玮,罗鸿宇,等.原发性高血压患者血脂水平与血压变异性的相关研究[J].四川医学,2015,36(5):628-631.
[12]贾一平,赵仙先,吴弘,等.原发性高血压患者血压昼夜节律与靶器官损害的关系研究[J].现代生物医学进展,2017,17(3):473-475,535.
[13]赵瑛,黄璞,华小黎,等.厄贝沙坦与依那普利治疗原发性高血压的系统评价[J].中国药师,2015,18(7):1154-1159.
[14]蔡东向,王明辉.厄贝沙坦与不同降压药物联合治疗原发性高血压的疗效与药物临床观察[J].中国医药导刊,2014,16(1):131-132.
[15]金茫茫.高血压病患者穴位治疗的依从性及其对疗效的影响[J].解放军护理杂志,2014,31(19):20-22.
[16]张立娟,王康锋,王平,等.针灸治疗原发性高血压取穴现状分析[J].长春中医药大学学报,2015,31(1):102-104.
[17]李实,卢玉彬,张磊,等.子午流注低频开穴法联合厄贝沙坦治疗原发性高血压临床疗效分析[J].医学综述,2016,22(3):620-622.
[18]卢玉彬,李实,张敦憨,等.子午流注低频开穴法联合口服降压药及健康宣教对原发性高血压疗效观察[J].针灸临床杂志,2016,32(6):21-23.