艾灸董氏奇穴配合微波治疗慢性盆腔炎疗效及对血清IL-2、TNF-?的影响
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摘要
目的观察艾灸董氏奇穴配合微波治疗慢性盆腔炎疗效及对血清IL-2、TNF-?的影响。方法将慢性盆腔炎患者随机分为观察组和对照组,每组30例。观察组予艾灸董氏奇穴配合微波治疗,对照组予微波治疗,两组均治疗3周。比较两组临床疗效及治疗前后血清IL-2和TNF-?表达的变化。结果两组患者治疗后症状、体征均改善,血清IL-2表达均升高,TNF-?表达均降低,差异有统计学意义(P<0.05);观察组治疗后症状、体征及血清IL-2和TNF-?改善幅度大于对照组,差异有统计学意义(P<0.05)。结论艾灸董氏奇穴配合微波治疗慢性盆腔炎具有较好的疗效,能调整血清IL-2和TNF-?的水平。
Objective To observe the therapeutic efficacy of moxibustion at Dong's extraordinary points plus microwave in treating chronic pelvic inflammatory disease and its effect on serum interleukin(IL)-2 and tumor necrosis factor(TNF)-α. Method The recruited patients with chronic pelvic inflammatory disease were randomized into an observation group and a control group, with 30 cases in each group. The observation group was intervened by moxibustion at Dong's extraordinary points plus microwave, while the control group was given microwave alone. The two groups were both treated for 3 weeks. The clinical efficacies were compared between the two groups, as well as the changes in the expressions of IL-2 and TNF-α in serum after the treatment. Result After the treatment, the symptoms and signs were improved, the expression of serum IL-2 increased and the expression of TNF-α decreased in both groups, and the differences were statistically significant(P<0.05); the improvements in the symptoms, signs, and the levels of serum IL-2 and TNF-α in the observation group were more significant than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Moxibustion at Dong's extraordinary points plus microwave can produce a satisfactory efficacy for chronic pelvic inflammatory disease, and it can regulate the serum levels of IL-2 and TNF-α.
Objective To observe the therapeutic efficacy of moxibustion at Dong's extraordinary points plus microwave in treating chronic pelvic inflammatory disease and its effect on serum interleukin(IL)-2 and tumor necrosis factor(TNF)-α. Method The recruited patients with chronic pelvic inflammatory disease were randomized into an observation group and a control group, with 30 cases in each group. The observation group was intervened by moxibustion at Dong's extraordinary points plus microwave, while the control group was given microwave alone. The two groups were both treated for 3 weeks. The clinical efficacies were compared between the two groups, as well as the changes in the expressions of IL-2 and TNF-α in serum after the treatment. Result After the treatment, the symptoms and signs were improved, the expression of serum IL-2 increased and the expression of TNF-α decreased in both groups, and the differences were statistically significant(P<0.05); the improvements in the symptoms, signs, and the levels of serum IL-2 and TNF-α in the observation group were more significant than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Moxibustion at Dong's extraordinary points plus microwave can produce a satisfactory efficacy for chronic pelvic inflammatory disease, and it can regulate the serum levels of IL-2 and TNF-α.
引文
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[23]王桂勤.中药直肠滴入联合微波治疗慢性盆腔炎40例疗效观察[J].湖南中医杂志,2016,32(9):66-67.
[24]王莉,吕耀凤,姚丽娟.慢性盆腔炎患者促炎因子与抗炎因子的关系[J].中国妇幼保健,2012,27(33):5292-5294.
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[26]农贤刚,程卫萍.艾灸配合川芎嗪治疗寒湿凝滞型慢性盆腔炎疗效及对CRP、IL-6和TNF-a的影响[J].中国中医基础医学杂志,2017,23(3):387-389.
[27]任艳青,苏红宁,冯梅梅,等.坤舒康颗粒对大鼠慢性盆腔炎的治疗作用及对子宫FGF-2、IGF-1 mRNA表达的影响[J].中药药理与临床,2017,33(3):152-155.
[28]张立双,杨丰文,张俊华,等.桂枝茯苓胶囊/丸治疗慢性盆腔炎性疾病临床随机对照试验的系统评价[J].中国中药杂志,2017,42(8):1500-1509.
[29]黄菊青.慢性盆腔炎应用清热活血消癥类中药灌肠配合微波治疗的临床疗效观察[J].中华中医药学刊,2014,32(8):2041-2042.
[30]厉恩施.温经祛湿汤配合脐灸治疗寒湿凝滞型盆腔炎性疾病后遗症的临床研究[D].山东中医药大学硕士论文,2016:23-26.
[2]McQueenDB,BernardiLA.Chronicendometritisin women with recurrent early pregnancy loss and/or fetal demise[J]. Fertil Steril, 2014,101(4):1026-1030.
[3]GreydanusDE,DodichC.Pelvicinflammatorydisease intheadolescent:apoignant,perplexing,potentially preventable problem for patients and physicians[J]. Curr Opin Pediatr, 2015,27(1):92-99.
[4]李世蓉,张三元.盆腔炎性疾病发病机制的现代研究[J].中国妇幼保健,2011,26(27):4298-4301.
[5]GradisonM.Pelvicinflammatorydisease[J].AmFam Physician, 2012,85(8):791-796.
[6]曹泽毅.中华妇产科学[M].北京:人民卫生出版社,2014:102-132.
[7]DuarteR,FuhrichD,RossJD.Areviewofantibiotic therapyforpelvicinflammatorydisease[J].IntJ Antimicrob Agents, 2015,46(3):272-277.
[8]王玲,许丽华.中医药治疗慢性盆腔炎的临床研究进展[J].临床合理用药杂志,2017,10(25):170-171.
[9]郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:122-130.
[10]张玉珍.中医妇科学[M].第7版,北京:中国中医药出版社,2007:317-322.
[11] Chen KJ. Blood stasis syndrome and its treatment with activatingbloodcirculationtoremovebloodstasis therapy[J]. Chin. J. Integr. Med, 2012,18(12):891-896.
[12]余曙光,唐勇,尹海燕,等.艾灸刺激穴位局部感受的生物学基础[J].世界中医药,2013,8(8):867-870.
[13]陈丽,周月希,张娟.艾灸治疗妇科疾病的研究进展[J].湖北中医药大学学报,2017,19(3):118-121.
[14]王音,于燕.灸法治疗慢性盆腔炎研究概况[J].实用中医药杂志,2017,33(5):596-598.
[15]杨维杰.董氏奇穴针灸学[M].北京:中医古籍出版社,2002:17-25.
[16]江瑜,张小珊.针刺董氏奇穴对慢性盆腔炎患者免疫功能的影响[J].中医药临床杂志,2015,27(1):61-62.
[17]张小珊,江瑜,冯麟,等.路绍祖运用奇穴结合十四经穴治疗慢性盆腔炎的疗效观察[J].时珍国医国药,2015,26(2):465-466.
[18]汤小敏,王丹,钟清玲,等.针刺董氏奇穴配合刺血疗法治疗原发性痛经的疗效观察[J].中华中医药杂志,2017,32(8):3852-3854.
[19]张立志,许能贵.十二经穴与董氏奇穴在大腿部位穴位分布及主治规律探析[J].辽宁中医杂志,2017,44(8):1728-1730.
[20]孙秀凤.痛经舒汤加减联合董氏奇穴常规穴针刺治疗痛经对症状评分及预后影响[J].河北医学,2017,23(5):848-851.
[21]文岚.温和灸与微波理疗对气滞血瘀症型慢性盆腔炎的治疗效果[J].医疗装备,2017,30(15):132-133.
[22]李莉.微波理疗配合中药内服加灌肠治疗慢性盆腔炎疗效观察[J].现代中西医结合杂志,2016,25(2):169-171.
[23]王桂勤.中药直肠滴入联合微波治疗慢性盆腔炎40例疗效观察[J].湖南中医杂志,2016,32(9):66-67.
[24]王莉,吕耀凤,姚丽娟.慢性盆腔炎患者促炎因子与抗炎因子的关系[J].中国妇幼保健,2012,27(33):5292-5294.
[25] Neziri AY, Bersinger NA, Andersen OK, et al. Correlation betweenalteredcentralpainprocessingandconcentrationofperitonealfluidinflammatorycytokinesin endometriosispatientswithchronicpelvicpain[J].Reg Anesth Pain Med, 2014,39(3):181-184.
[26]农贤刚,程卫萍.艾灸配合川芎嗪治疗寒湿凝滞型慢性盆腔炎疗效及对CRP、IL-6和TNF-a的影响[J].中国中医基础医学杂志,2017,23(3):387-389.
[27]任艳青,苏红宁,冯梅梅,等.坤舒康颗粒对大鼠慢性盆腔炎的治疗作用及对子宫FGF-2、IGF-1 mRNA表达的影响[J].中药药理与临床,2017,33(3):152-155.
[28]张立双,杨丰文,张俊华,等.桂枝茯苓胶囊/丸治疗慢性盆腔炎性疾病临床随机对照试验的系统评价[J].中国中药杂志,2017,42(8):1500-1509.
[29]黄菊青.慢性盆腔炎应用清热活血消癥类中药灌肠配合微波治疗的临床疗效观察[J].中华中医药学刊,2014,32(8):2041-2042.
[30]厉恩施.温经祛湿汤配合脐灸治疗寒湿凝滞型盆腔炎性疾病后遗症的临床研究[D].山东中医药大学硕士论文,2016:23-26.