香杞平脂咀嚼片的降脂作用
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摘要
本文探讨香杞平脂咀嚼片对高脂血症模型小鼠体重、血脂以及肝功能的影响。选取雄性ICR小鼠60只,随机平均分为6组:正常组(生理盐水),模型组(生理盐水),辛伐他汀组(5 mg/kg),香杞平脂咀嚼片高(2 g/kg)、中(1 g/kg)、低剂量组(0.5 g/kg),除正常组饲喂普通饲料外,其余各组采用饲喂高糖高脂饲料进行造模,实验期间采取经口灌胃给药方式,在6周后测定各项实验指标。此造模方法得到的高脂血症模型对小鼠体重影响不大,而香杞平脂咀嚼片组与模型组相比较能够降低高脂血症小鼠血清中的总胆固醇、低密度脂蛋白、谷草转氨酶和谷丙转氨酶,其最大降幅为28.85%、37.90%、25.08%和42.09%,并且可以升高高密度脂蛋白,最大升幅为73.70%。结果表明香杞平脂咀嚼片具有降血脂和保护肝脏的作用,且此效应在高剂量(2 g/kg)时最为明显。
The effects of Xiang Qi lower blood lipids chewable tablet on body weight, blood lipids and liver function in hyperlipidemia model mice were investigated in this work. Sixty male Institute of Cancer Research mouse were randomly divided into 6 groups: normal group(normal saline), model group(normal saline), simvastatin-positive group(5 mg/kg), and Xiang Qi lower blood lipids chewable tablet high dose(2 g/kg), medium dose(1 g/kg) and low dose(0.5 g/kg) groups. The normal group was fed with normal feed, and the other groups were fed high-sugar and high-fat feed. Oral administration during the experiment, and various experimental indicators were measured after 6 weeks. The hyperlipidemia model obtained with this modeling method has little effect on the body weight of mouse. Compared with model group, total cholesterol, low-density lipoprotein, aspartate aminotransferase and alanine aminotransferase of the hyperlipidemia mouse serum of decreased Xiang Qi lower blood lipids chewable tablet groups with the largest reduce rates of 28.85%, 37.90%, 25.08% and 42.09%, while high-density lipoprotein increased with the highest growing rate of 73.70%. The results demonstrated that Xiang Qi lower blood lipids chewable tablet has the function of hypolipidemicing and protecting liver, and this effect is most obvious in high dose(2 g/kg).
The effects of Xiang Qi lower blood lipids chewable tablet on body weight, blood lipids and liver function in hyperlipidemia model mice were investigated in this work. Sixty male Institute of Cancer Research mouse were randomly divided into 6 groups: normal group(normal saline), model group(normal saline), simvastatin-positive group(5 mg/kg), and Xiang Qi lower blood lipids chewable tablet high dose(2 g/kg), medium dose(1 g/kg) and low dose(0.5 g/kg) groups. The normal group was fed with normal feed, and the other groups were fed high-sugar and high-fat feed. Oral administration during the experiment, and various experimental indicators were measured after 6 weeks. The hyperlipidemia model obtained with this modeling method has little effect on the body weight of mouse. Compared with model group, total cholesterol, low-density lipoprotein, aspartate aminotransferase and alanine aminotransferase of the hyperlipidemia mouse serum of decreased Xiang Qi lower blood lipids chewable tablet groups with the largest reduce rates of 28.85%, 37.90%, 25.08% and 42.09%, while high-density lipoprotein increased with the highest growing rate of 73.70%. The results demonstrated that Xiang Qi lower blood lipids chewable tablet has the function of hypolipidemicing and protecting liver, and this effect is most obvious in high dose(2 g/kg).
引文
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[10]孙国栋,毛新民,李琳琳,等.胡芦巴乙醇提取物对酒精性脂肪肝大鼠的作用[J].中南药学,2014,12(9):867-870SUN Guo-dong,MAO Xin-min,LI Lin-lin,et al.Effect of ethanol extract of Fenugreek on alcoholic fatty liver rats[J].Central South Pharmacy,2014,12(9):867-870
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[12]卢芙蓉,杨胜兰,沈霖,等.葫芦巴提取物对营养性肥胖大鼠糖脂的调节效应[J].世界华人消化杂志,2012,20(30):2902-2906LU Fu-rong,YANG Sheng-lan,SHEN Lin,et al.Therapeutic effect of trigonella Foenum-graecum L.total saponins on diet-induced obesity in rats[J].World Chinese Journal of Digestology,2012,20(30):2902-2906
[13]饶颖竹,陈蓉,莫锦坚,肖桂元.仙人掌对小鼠实验性高脂血症的降脂作用[J].中国康复医学杂志,2004,19(7):523-525RAO Ying-zhu,CHEN Rong,MO Jin-jian,et al.Effects of Opuntia dillenii on reducing serum lipid in experimental hyerlipidemia rats[J].Chinese Journal of Rehabilitation Medicine,2004,19(7):523-525
[14]韦唯.沙棘-枸杞保健品对血脂调节功能及其毒性研究[D].内蒙古农业大学,2013WEI Wei.Study on Hippophae rhamnoides L.and Lyceum barbarum L.dietary supplement of blood lipid regulating function and toxicity[D].Inner Mongolia Agricultural University,2013
[15]黄培池,王娟.枸杞多糖对小白鼠肝损伤的保护作用研究[J].海峡药学,2009,21(10):29-31HUANG Pei-chi,WANG Juan.The protective effects of LBPextraction on acute liver Injury caused by CCl4[J].Strait Pharmaceutical Journal,2009,21(10):29-31
[16]杨小舟,黄卫,曾富华,等.仙人掌多糖对高脂血症大鼠体内抗氧化作用的研究[J].时珍国医国药,2009,20(10):2440-2442YANG Xiao-zhou,HUANG Wei,ZENG Fu-hua,et al.Apreliminary study on antioxidative effects of polysaccharides from Opuntia dillenii haw.in hyperlipidemi[J].Lishizhen Medicine and Materia Medica Research,2009,20(10):2440-2442
[17]姜海,姜国志,陈钟,等.姜黄提取物联合阿托伐他汀钙对高脂血症小鼠降血脂作用的研究[J].中国临床药理学与治疗学,2017,22(1):48-51JIANG Hai,JIANG Guo-zhi,CHEN Zhong,et al.Study on the effect of turmeric extract combined with atorvastatin calcium on hypolipidemic in hyperlipidemia mice[J].Chin JClin Pharm Therap,2017,22(1):48-51
[18]江云丽.降血脂西药研究进展[J].临床合理用药杂志,2017,10(32):176-178JIANG Yun-li.Research progress in blood-lowering western medicine[J].Chinese Journal of Clinical Rational Drug Use,2017,10(32):176-178
[19]龚海荣,李向平,梁思宇.贝特类调脂药物研究进展[J].中南药学,2011,9(7):539-542GONG Hai-rong,LI Xiang-ping,LIANG Si-yu.Research progress in fibrate-lowering drugs[J].Central South Pharmacy,2011,9(7):539-542
[20]江文文.胆汁酸螯合剂类降血脂药研究进展[J].中国民康医学,2015,27(11):67-69JIANG Wen-wen.Research progress of blood lipid-lowering drugs for bile acid sequestrants[J].Medical Journal of Chinese People`s Health,2015,27(11):67-69
[21]Kem M C.Serum aminotransferase concentration as evidence of hepatocellular damage[J].The Lancet,2000,355(204):591-592
[22]赵水平.美国胆固醇教育计划成人治疗组第三次报告要点[J].中国医药导刊,2001,3(5):317-319ZHAO Shui-ping.The third report of the adult treatment group of the American cholesterol education program[J].Chinese Journal of Medicinal Guide,2001,3(5):317-319
[2]国家卫生和计划生育委员会疾病预防控制局.中国居民营养与慢性病状况报告(2015年)[M].北京:人民卫生出版社,2015National Institute of Health and Family Planning Disease Prevention and Control.Report on the status of nutrition and chronic diseases among Chinese residents(2015)[M].Beijing:People's Medical Publishing House,2015
[3]郭改会,张沛然.高脂血症的诊断及治疗[J].中国临床医生杂志,2012,40(3):20-23GUO Gai-hui,ZHANG Pei-ran.Diagnosis and treatment of hyperlipidemia[J].Chinese Journal of Clinicians,2012,40(3):20-23
[4]赵水平.赵水平血脂学研修全集[M].长沙:中南大学出版社,2014ZHAO Shui-ping.Zhao Shuiping’s complete works of blood lipids training[M].Changsha:Central South University Press,2014
[5]Motohiro S,Norihiro F,Fujiko M,et al.Subclinical carotid atherosclerosis and triglycerides predict the incidence of chronic kidney disease in the Japanese general population:results from the Kyushu and Okinawa population study(KOPS)[J].Atherosclerosis,2015,238(2):207-212
[6]刘悦,毕齐,刘向荣.高血压,糖尿病,高脂血症对老年脑梗死患者颈动脉粥样硬化的作用[J].实用老年医学,2016,30(1):58-60LIU Yue,BI Qi,LIU Xiang-rong.Effect of hypertension,diabetes and hyperlipidemia on carotid atherosclerosis in elderly patients with cerebral infarction[J].Practical Geriatrics,2016,30(1):58-60
[7]衣艳君.枸杞降血脂作用的实验研究[J].首都师范大学学报(自然科学版),2000,4:68-70YI Yan-jun.Experimental study on the effect of blood stasis on blood stasis[J].Journal of Capital Normal University(Natural Science Edition),2000,4:68-70
[8]罗川,张万年.仙人掌降血脂作用的研究进展[J].食品科技,2009,34(5):60-63LUO Chuan,ZHANG Wan-nian.A review of studied about the chemotrophy and lipd-lowering activities of Opuntia Dillenii[J].Food Science and Technology,2009,34(5):60-63
[9]李春艳,成小松,崔美芝,等.仙人掌粉对大鼠血脂的调节作用及其机制的探讨[J].中国中药杂志,2005,9:694-696LI Chun-yan,CHENG Xiao-song,CUI Mei-zhi,et al.The regulation of cactus powder on blood lipids in rats and its mechanism[J].Chinese Journal of Chinese Materia Medicine,2005,9:694-696
[10]孙国栋,毛新民,李琳琳,等.胡芦巴乙醇提取物对酒精性脂肪肝大鼠的作用[J].中南药学,2014,12(9):867-870SUN Guo-dong,MAO Xin-min,LI Lin-lin,et al.Effect of ethanol extract of Fenugreek on alcoholic fatty liver rats[J].Central South Pharmacy,2014,12(9):867-870
[11]宋艳华.浅析检查血脂的意义及血脂低的危害[J].医学信息(中旬刊),2010,5(12):3586-3587SONG Yan-hua.Analysis of the significance of checking blood lipids and the harm of low blood lipids[J].Medical Information(Mid-term publication),2010,5(12):3586-3587
[12]卢芙蓉,杨胜兰,沈霖,等.葫芦巴提取物对营养性肥胖大鼠糖脂的调节效应[J].世界华人消化杂志,2012,20(30):2902-2906LU Fu-rong,YANG Sheng-lan,SHEN Lin,et al.Therapeutic effect of trigonella Foenum-graecum L.total saponins on diet-induced obesity in rats[J].World Chinese Journal of Digestology,2012,20(30):2902-2906
[13]饶颖竹,陈蓉,莫锦坚,肖桂元.仙人掌对小鼠实验性高脂血症的降脂作用[J].中国康复医学杂志,2004,19(7):523-525RAO Ying-zhu,CHEN Rong,MO Jin-jian,et al.Effects of Opuntia dillenii on reducing serum lipid in experimental hyerlipidemia rats[J].Chinese Journal of Rehabilitation Medicine,2004,19(7):523-525
[14]韦唯.沙棘-枸杞保健品对血脂调节功能及其毒性研究[D].内蒙古农业大学,2013WEI Wei.Study on Hippophae rhamnoides L.and Lyceum barbarum L.dietary supplement of blood lipid regulating function and toxicity[D].Inner Mongolia Agricultural University,2013
[15]黄培池,王娟.枸杞多糖对小白鼠肝损伤的保护作用研究[J].海峡药学,2009,21(10):29-31HUANG Pei-chi,WANG Juan.The protective effects of LBPextraction on acute liver Injury caused by CCl4[J].Strait Pharmaceutical Journal,2009,21(10):29-31
[16]杨小舟,黄卫,曾富华,等.仙人掌多糖对高脂血症大鼠体内抗氧化作用的研究[J].时珍国医国药,2009,20(10):2440-2442YANG Xiao-zhou,HUANG Wei,ZENG Fu-hua,et al.Apreliminary study on antioxidative effects of polysaccharides from Opuntia dillenii haw.in hyperlipidemi[J].Lishizhen Medicine and Materia Medica Research,2009,20(10):2440-2442
[17]姜海,姜国志,陈钟,等.姜黄提取物联合阿托伐他汀钙对高脂血症小鼠降血脂作用的研究[J].中国临床药理学与治疗学,2017,22(1):48-51JIANG Hai,JIANG Guo-zhi,CHEN Zhong,et al.Study on the effect of turmeric extract combined with atorvastatin calcium on hypolipidemic in hyperlipidemia mice[J].Chin JClin Pharm Therap,2017,22(1):48-51
[18]江云丽.降血脂西药研究进展[J].临床合理用药杂志,2017,10(32):176-178JIANG Yun-li.Research progress in blood-lowering western medicine[J].Chinese Journal of Clinical Rational Drug Use,2017,10(32):176-178
[19]龚海荣,李向平,梁思宇.贝特类调脂药物研究进展[J].中南药学,2011,9(7):539-542GONG Hai-rong,LI Xiang-ping,LIANG Si-yu.Research progress in fibrate-lowering drugs[J].Central South Pharmacy,2011,9(7):539-542
[20]江文文.胆汁酸螯合剂类降血脂药研究进展[J].中国民康医学,2015,27(11):67-69JIANG Wen-wen.Research progress of blood lipid-lowering drugs for bile acid sequestrants[J].Medical Journal of Chinese People`s Health,2015,27(11):67-69
[21]Kem M C.Serum aminotransferase concentration as evidence of hepatocellular damage[J].The Lancet,2000,355(204):591-592
[22]赵水平.美国胆固醇教育计划成人治疗组第三次报告要点[J].中国医药导刊,2001,3(5):317-319ZHAO Shui-ping.The third report of the adult treatment group of the American cholesterol education program[J].Chinese Journal of Medicinal Guide,2001,3(5):317-319