骨密度与25羟维生素D水平在婴幼儿佝偻病早期诊断中的应用
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摘要
目的探析骨密度与25羟维生素D水平在婴幼儿佝偻病早期诊断中的应用效果。方法回顾性分析2017年6月～2018年6月在我院接受治疗的58例婴幼儿佝偻病患儿的数据资料,并作为观察组,另选取同期于我院接受健康体检的58例健康婴幼儿作为本次研究的对照组,两组研究对象均行骨密度、25羟维生素D水平测定,对两组的测定结果进行比较。结果与健康婴幼儿的骨密度Z值、25羟维生素D水平相比,观察组患儿的骨密度Z值、25羟维生素D水平相对较低,两组比较差异有统计学意义(P <0.05);早产儿佝偻病发生率高于足月儿,差异有统计学意义(P <0.05)。结论骨密度、25羟维生素D均可作为筛查诊断婴幼儿佝偻病的主要参考指标,可为疾病的早期鉴别诊断提供科学依据。25羟维生素D检测需要一定的设备和技术,在基层医院仍然很难大面积推广,相对而言,超声骨密度操作更加简单且具备无创性,可在各级医院进行推广使用。
Objective To investigate the application effect of bone mineral density and 25 hydroxy vitamin D level on early diagnosis of infants with rickets. Methods Data of 58 infants with rickets who were treated in our hospital from June 2017 to June 2018 were retrospectively analyzed and they were set as the observation group.In addition,58 healthy infants who received physical examination in our hospital during the same period were selected as the control group in this study.Research objects in two groups underwent measurement of bone mineral density and25 hydroxy vitamin D level and results of the two groups were compared. Results Compared with the bone mineral density Z value and 25 hydroxy vitamin D level of healthy infants,the bone mineral density Z value and 25 hydroxy vitamin D level of children in the observation group were relatively low.The difference between the two groups was statistically significant(P < 0.05).The incidence of premature rickets was higher than that of full-term infants,and the difference was significant(P < 0.05). Conclusion Bone mineral density and 25 hydroxy vitamin D can be used as the main reference indicators for screening and diagnosis of infants with rickets,which can provide scientific basis for the early differential diagnosis of the disease.The 25 hydroxy vitamin D detection requires certain equipment and technology,which is still difficult to be widely promoted in primary hospitals.Comparatively,ultrasound bone mineral density operation is more simple and non-invasive,which can be widely used in hospitals at all levels.
Objective To investigate the application effect of bone mineral density and 25 hydroxy vitamin D level on early diagnosis of infants with rickets. Methods Data of 58 infants with rickets who were treated in our hospital from June 2017 to June 2018 were retrospectively analyzed and they were set as the observation group.In addition,58 healthy infants who received physical examination in our hospital during the same period were selected as the control group in this study.Research objects in two groups underwent measurement of bone mineral density and25 hydroxy vitamin D level and results of the two groups were compared. Results Compared with the bone mineral density Z value and 25 hydroxy vitamin D level of healthy infants,the bone mineral density Z value and 25 hydroxy vitamin D level of children in the observation group were relatively low.The difference between the two groups was statistically significant(P < 0.05).The incidence of premature rickets was higher than that of full-term infants,and the difference was significant(P < 0.05). Conclusion Bone mineral density and 25 hydroxy vitamin D can be used as the main reference indicators for screening and diagnosis of infants with rickets,which can provide scientific basis for the early differential diagnosis of the disease.The 25 hydroxy vitamin D detection requires certain equipment and technology,which is still difficult to be widely promoted in primary hospitals.Comparatively,ultrasound bone mineral density operation is more simple and non-invasive,which can be widely used in hospitals at all levels.
引文
[1]陈凤华.超声骨密度与25羟维生素D水平对婴幼儿佝偻病的诊断探讨[J].中国现代药物应用,2017,11(6):56-57.
[2]蔡闫闫,刘永春,朱玲玲,等.扬州城区婴幼儿血清25-羟维生素D与骨密度检测分析[J].实用临床医药杂志,2015,19(7):161-163.
[3]王全光.25羟维生素D3胰岛素样生长因子-Ⅰ及超声骨密度在佝偻病患儿中的意义[J].河北医学,2017,23(5):867-869.
[4]孙红燕,陈益明,王忠平,等.血清25-羟基维生素D_3水平对婴幼儿佝偻病的诊断意义[J].中国优生与遗传杂志,2015,12(10):123-125.
[5]周丽霞,邓红岩,侯江婷.婴幼儿佝偻病血清25-羟维生素D水平检测分析[J].现代诊断与治疗,2015,18(20):4715-4716.
[6]林晓燕,曾璐.血清25-羟维生素D对佝偻病诊断的意义[J].长春中医药大学学报,2016,32(4):823-825.
[7]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,9(5):21-24.
[8]魏秋实,陈镇秋,谭新,等.中国男性和女性血清25羟维生素D水平与年龄、性别和骨密度之间的关系[J].实用骨科杂志,2016,22(5):480.
[9]展磊,魏秋实.广州天河社区绝经后妇女血清25羟维生素D水平与骨密度的相关性分析[J].中国骨质疏松杂志,2017,23(9):1132-1135.
[10]李觅琼,邹映红,陈玉华,等.长风社区骨量异常女性患者25羟维生素D水平及骨密度状况[J].上海医药,2015,36(10):37-40.
[11]黄飞燕,罗雪.儿童血清25-羟维生素D水平与超声骨密度关系研究[J].西南军医,2016,18(1):9-12.
[12]李源斌,陆妹.早产儿血清25羟基维生素D_3水平与超声骨密度的相关性研究[J].中国当代医药,2017,24(13):106-108.
[13]陈小香,谭新,邓伟民.骨质疏松症患者骨密度与血清25羟维生素D的相关性研究[J].中国骨质疏松杂志,2017,23(7):851-855.
[14]郑晓东.中西医结合治疗甲状腺功能亢进症及对患者骨代谢指标和骨密度的影响[J].中国医药科学,2017,7(7):27-30.
[15]何小媚,罗裕旋,吴传安,等.儿童血钙联合化学发光法血清维生素D及骨碱性磷酸酶检测在佝偻病诊断中的应用价值[J].中国医药科学,2018,8(4):47-50.
[16]姜艳,谢桂芳,林丹桃,等.血清25羟维生素D水平和超声骨密度在诊断婴幼儿维生素D缺乏性佝偻病中的价值分析[J].沈阳医学院学报,2017,19(4):331-332.
[2]蔡闫闫,刘永春,朱玲玲,等.扬州城区婴幼儿血清25-羟维生素D与骨密度检测分析[J].实用临床医药杂志,2015,19(7):161-163.
[3]王全光.25羟维生素D3胰岛素样生长因子-Ⅰ及超声骨密度在佝偻病患儿中的意义[J].河北医学,2017,23(5):867-869.
[4]孙红燕,陈益明,王忠平,等.血清25-羟基维生素D_3水平对婴幼儿佝偻病的诊断意义[J].中国优生与遗传杂志,2015,12(10):123-125.
[5]周丽霞,邓红岩,侯江婷.婴幼儿佝偻病血清25-羟维生素D水平检测分析[J].现代诊断与治疗,2015,18(20):4715-4716.
[6]林晓燕,曾璐.血清25-羟维生素D对佝偻病诊断的意义[J].长春中医药大学学报,2016,32(4):823-825.
[7]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,9(5):21-24.
[8]魏秋实,陈镇秋,谭新,等.中国男性和女性血清25羟维生素D水平与年龄、性别和骨密度之间的关系[J].实用骨科杂志,2016,22(5):480.
[9]展磊,魏秋实.广州天河社区绝经后妇女血清25羟维生素D水平与骨密度的相关性分析[J].中国骨质疏松杂志,2017,23(9):1132-1135.
[10]李觅琼,邹映红,陈玉华,等.长风社区骨量异常女性患者25羟维生素D水平及骨密度状况[J].上海医药,2015,36(10):37-40.
[11]黄飞燕,罗雪.儿童血清25-羟维生素D水平与超声骨密度关系研究[J].西南军医,2016,18(1):9-12.
[12]李源斌,陆妹.早产儿血清25羟基维生素D_3水平与超声骨密度的相关性研究[J].中国当代医药,2017,24(13):106-108.
[13]陈小香,谭新,邓伟民.骨质疏松症患者骨密度与血清25羟维生素D的相关性研究[J].中国骨质疏松杂志,2017,23(7):851-855.
[14]郑晓东.中西医结合治疗甲状腺功能亢进症及对患者骨代谢指标和骨密度的影响[J].中国医药科学,2017,7(7):27-30.
[15]何小媚,罗裕旋,吴传安,等.儿童血钙联合化学发光法血清维生素D及骨碱性磷酸酶检测在佝偻病诊断中的应用价值[J].中国医药科学,2018,8(4):47-50.
[16]姜艳,谢桂芳,林丹桃,等.血清25羟维生素D水平和超声骨密度在诊断婴幼儿维生素D缺乏性佝偻病中的价值分析[J].沈阳医学院学报,2017,19(4):331-332.