含氨鲁米特的DTPA双酰胺配体的合成与表征
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摘要
以二乙三胺五乙酸(DTPA)、醋酸酐和氨鲁米特为原料,合成了一个含氨鲁米特的DTPA双酰胺配体二乙三胺-N,N″-(二乙酰氨鲁米特)-N,N′,N″-三乙酸(L),并用红外光谱、核磁共振氢谱、核磁共振碳谱、高分辨质谱对配体的组成和结构进行了表征。
A DTPA bisamide ligand containing aminoglutethimide,diethylenetriamine-N,N″-bis(acetyl-aminoglutethimide)-N,N′,N″-triacetic acid(L)was synthesized by using diethylene triamine pentaacetic acid(DTPA),acetic anhydride,and aminoglutethimide as raw materials.And its structure was characterized by FTIR,~1HNMR,~(13)CNMR and HRMS(ESI-MS).
A DTPA bisamide ligand containing aminoglutethimide,diethylenetriamine-N,N″-bis(acetyl-aminoglutethimide)-N,N′,N″-triacetic acid(L)was synthesized by using diethylene triamine pentaacetic acid(DTPA),acetic anhydride,and aminoglutethimide as raw materials.And its structure was characterized by FTIR,~1HNMR,~(13)CNMR and HRMS(ESI-MS).
引文
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[2]WEN Y,DONG H Q,LI Y,et al.Nano-assembly of bovine serum albumin driven by rare-earth-ion(Gd)biomineralization for highly efficient photodynamic therapy and tumor imaging[J].Journal of Materials Chemistry B,2016,4:743-751.
[3]李倩,韩林,鄢国平,等.含磺胺嘧啶基团的葡聚糖钆配合物的研究[J].高分子学报,2014(2):263-269.
[4]HUANG J Z,LIAO K,WANG G,et al.Exploitation of the sizeexclusion effect of reversed-phase high performance liquid chromatography for the direct analysis of diethylene triamine pentaacetic acid in therapeutic monoclonal antibody formulations[J].Journal of Chromatography A,2016,1455:140-146.
[5]SOUR A,JENNI S,ORTI-SUAREZ A,et al.Four gadolinium(Ⅲ)complexes appended to a porphyrin:a water-soluble molecular theranostic agent with remarkable relaxivity suited for MRI tracking of the photosensitizer[J].Inorganic Chemistry,2016,55(9):4545-4554.
[6]NI D L,SHEN Z W,ZHANG J W,et al.Integrating anatomic and functional dual-mode magnetic resonance imaging:design and applicability of a bifunctional contrast agent[J].ACS Nano,2016,10(3):3783-3790.
[7]SUN L,LI X,WEI X L,et al.Stimuli-responsive biodegradable hyperbranched polymer-gadolinium conjugates as efficient and biocompatible nanoscale magnetic resonance imaging contrast agents[J].ACS Applied Materials&Interfaces,2016,8(16):10499-10512.
[8]KIM H R,YOU D G,PARK S J,et al.MRI monitoring of tumorselective anticancer drug delivery with stable thermosensitive liposomes triggered by high-intensity focused ultrasound[J].Molecular Pharmaceutics,2016,13(5):1528-1539.
[9]张定娃,刘庆奎,吴道伟,等.二乙三胺-N,N″-二(乙酰异烟肼)-N,N′,N″-三乙酸及其中性稀土配合物的合成、表征、驰豫性能研究[J].井冈山大学学报(自然科学版),2010,31(1):40-44.
[10]刘瑞清,梁爽,江存,等.温度和pH敏感高分子含钆核磁共振成像造影剂的合成及性能[J].高等学校化学学报,2016,37(1):155-160.
[11]袁泽利,吴庆,杨兴变,等.新型含均三唑席夫碱型大环化合物的合成及其抗菌活性[J].有机化学,2011,31(10):1698-1702.
[12]郝志峰,吴雅红,汪朝阳,等.酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能[J].高等学校化学学报,2012,33(4):663667.