甲状腺疾病与乳腺癌风险相关性研究进展
摘要
<正>乳腺癌是女性最常见的恶性肿瘤,而常见的甲状腺疾病,如甲状腺功能异常(包括甲状腺功能减退和亢进)、自身免疫性甲状腺疾病、地方性甲状腺肿、甲状腺良性肿瘤、甲状腺癌,在女性人群的患病率同样较高。甲状腺和乳腺均为下丘脑-垂体-腺体轴调节的激素依赖性靶器官,且两类疾病的发生、发展与机体内分泌的变化密切相关,因此很可能存
引文
1 S?gaard M,Farkas DK,Ehrenstein V,et al.Hypothyroidism and hyperthyroidism and breast cancer risk:a nationwide cohort study.Eur J Endocrinol,2016,174(4):409-414.
2 Tosovic A,Becker C,Bondeson AG,et al.Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to breast cancer risk.Int J Cancer,2012,131(9):2126-2133.
3 Tosovic A,Bondeson AG,Bondeson L,et al.Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women.Breast Cancer Res,2010,12(3):R33.
4 Brandt J,Borgquist S,Manjer J.Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to risk of different breast cancer subgroups:a Malm9 Diet and Cancer Study.Cancer Causes Control,2015,26(8):1093-1104.
5王亘,陈小松,毛艳,等.乳腺癌患者血清游离T4水平高于乳腺良性疾病患者.肿瘤,2014,34(4):366-369.
6 Fang Y,Yao L,Sun J,et al.Does thyroid dysfunction increase the risk of breast cancer?A systematic review and meta-analysis.JEndocrinol Invest,2017,40(10):1035-1047.
7 Kuijpens JL,Nyklíctek I,Louwman MW,et al.Hypothyroidism might be related to breast cancer in post-menopausal women.Thyroid,2005,15(11):1253-1259.
8高丽霞,张益枝,吴克雄,等.乳腺癌患者甲状腺功能的相关研究.现代肿瘤医学,2016,24(7):1071-1074.
9 Angelousi AG,Anagnostou VK,Stamatakos MK,et al.Mechanisms in endocrinology:primary HT and risk for breast cancer:a systematic review and meta-analysis.Eur J Endocrinol,2012,166(3):373-381.
10 Hardefeldt PJ,Eslick GD,Edirimanne S.Benign thyroid disease is associated with breast cancer:a meta-analysis.Breast Cancer Res Treat,2012,33(3):1169-1177.
11 Giustarini E,Pinchera A,Fierabracci P,et al.Thyroid autoimmunity in patients with malignant and benign breast diseases before surgery.Eur J Endocrinol,2006,154(5):645-649.
12 Prinzi N,Baldini E,Sorrenti S,et al.Prevalence of breast cancer in thyroid diseases:results of a cross-sectional study of 3,921 patients.Breast Cancer Res Treat,2014,144(3):683-688.
13 Muller I,Giani C,Zhang L,et al.Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?Int J Cancer,2014,134(7):1706-1714.
14 Fiore E,Giustarini E,Mammoli C,et al.Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer.J Endocrinol Invest,2007,30(9):734-738.
15 ?zmen T,Güllüoglu BM,Yegen C?,et al.Autoimmune thyroid disease and breast cancer prognosis.J Breast Health,2015,11(2):67-71.
16曾斌,刘瑛,沈方媛,等.自身免疫性甲状腺炎与乳腺癌关系的meta分析.中国现代医学杂志,2018,28(16):117-121.
17 Chiappa C,Rovera F,Rausei S,et al.Breast cancer and thyroid diseases:analysis of 867 consecutive cases.J Endocrinol Invest,2017,40(2):179-184.
18 Zbigniew S.Role of iodine in metabolism.Recent Pat Endocr Metab Immune Drug Discov,2017,10(2):123-126.
19 Smyth PP,Smith DF,Mc Dermott EW,et al.A direct relationship between thyroid enlargement and breast cancer.J Clin Endocrinol Metab,1996,81(3):937-941.
20 Venturi S.Is there a role for iodine in breast diseases?Breast,2001,10(5):379-382.
21 Eskin BA,Grotkowski CE,Connolly CP,et al.Different tissue responses for iodine and iodide in rat thyroid and mammary glands.Biol Trace Elem Res,1995,49(1):9-19.
22 Soriano O,Delgado G,Anguiano B,et al.Antineoplastic effect of iodine and iodide in dimethylbenz[a]anthracene-induced mammary tumors:association between lactoperoxidase and estrogen-adduct production.Endocr Relat Cancer,2011,18(4):529-539.
23 Yamamoto I,Maruyama H,Moriguchi M.The effect of dietary seaweeds on 7,12-dimethyl-benz[a]anthracene-induced mammary tumorigenesis in rats.Cancer Lett,1987,35(2):109-118.
24 Stoddard FR 2nd,Brooks AD,Eskin BA,et al.Iodine alters gene expression in the MCF7 breast cancer cell line:evidence for an antiestrogen effect of iodine.Int J Med Sci,2008,5(4):189-196.
25 Nio Y,Iguchi C,Itakura M,et al.High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders.Anticancer Res,2009,29(5):1607-1610.
26 Carhill AA,Litofsky DR,Ross DS,et al.Long-term outcomes following therapy in differentiated thyroid carcinoma:NTCTCSregistry analysis 1987-2012.J Clin Endocrinol Metab,2015,100(9):3270-3279.
27 Vigneri R,Malandrino P,Vigneri P.The changing epidemiology of thyroid cancer:why is incidence increasing?Curr Opin Oncol,2015,27(1):1-7.
28 Subramanian S,Goldstein DP,Parlea L,et al.Second primary malignancy risk in thyroid cancer survivors:a systematic review and meta-analysis.Thyroid,2007,17(12):1277-1288.
29 Keegan THM,Bleyer A,Rosenberg AS,et al.Second primary malignant neoplasms and survival in adolescent and young adult cancer survivors.JAMA Oncol,2017,3(11):1554-1557.
30 Chalstrey LJ,Benjamin B.High incidence of breast cancer in thyroid cancer patients.Br J Cancer,1966,20(4):670-675.
31 Verkooijen RB,Smit JW,Romijn JA,et al.The incidence of second primary tumors in thyroid cancer patients is increased,but not related to treatment of thyroid cancer.Eur J Endocrinol,2006,155(6):801-806.
32 Chen AY,Levy L,Goepfert H,et al.The development of breast carcinoma in women with thyroid carcinoma.Cancer,2001,92(2):225-231.
33 Li CI,Rossing MA,Voigt LF,et al.Multiple primary breast and thyroid cancers:role of age at diagnosis and cancer treatments(United States).Cancer Causes Control,2000,11(9):805-811.
34 Travis LB,Demark Wahnefried W,et al.Aetiology,genetics and prevention of secondary neoplasms in adult cancer survivors.Nat Rev Clin Oncol,2013,10(5):289-301.
35 Nielsen SM,White MG,Hong S,et al.The breast-thyroid cancer link:a systematic review and meta-analysis.Cancer Epidemiol Biomarkers Prev,2016,25(2):231-238.
36 Charalampoudis P,Agrogiannis G,Kontzoglou K,et al.Thyroid hormone receptor alpha(TRa)tissue expression in ductal invasive breast cancer:a study combining quantitative immunohistochemistry with digital slide image analysis.Eur J Surg Oncol,2017,43(8):1428-1432.
37 Ditsch N,Toth B,Himsl I,et al.Thyroid hormone receptor(TR)alpha and TR beta expression in breast cancer.Histol Histopathol,2013,28(2):227-237.
38 Jerzak KJ,Cockburn J,Pond GR,et al.Thyroid hormone receptorαin breast cancer:prognostic and therapeutic implications.Breast Cancer Res Treat,2015,149(1):293-301.
39 Saraiva PP,Figueiredo NB,Padovani CR,et al.Profile of thyroid hormones in breast cancer patients.Braz J Med Biol Res,2005,38(5):761-765.
40 Hall LC,Salazar EP,Kane SR,et al.Effects of thyroid hormones on human breast cancer cell proliferation.J Steroid Biochem Mol Biol,2008,109(1-2):57-66.
41 Conde I,Paniagua R,Zamora J,et al.Influence of thyroid hormone receptors on breast cancer cell proliferation.Ann Oncol,2006,17(1):60-64.
42李英,李宗龙.乳腺癌组织甲状腺激素受体β1表达及其临床意义.山东医药,2017,57(40):84-86.
43张洋洋,彭效祥,孙艳丽,等.甲状腺激素受体βΔ对大鼠乳腺癌SHZ-88细胞增殖及凋亡的影响.肿瘤防治研究,2016,43(12):1018-1022.
44 Haugen BR,Alexander EK,Bible KC,et al.2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.Thyroid,2016,26(1):1-133.
45 Sawka AM,Thabane L,Parlea L,et al.Second primary malignancy risk after radioactive iodine treatment for thyroid cancer:a systematic review and meta-analysis.Thyroid,2009,19(5):451-457.
46 Hall P,Holm LE,Lundell G,et al.Cancer risks in thyroid cancer patients.Br J Cancer,1991,64(1):159-163.
47 Zhang Y,Liang J,Li H,et al.Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer:a systematic review and meta-analysis.Nucl Med Commun,2016,37(2):110-115.
48 Lin CY,Lin CL,Huang WS,et al.Risk of breast cancer in patients with thyroid cancer receiving or not receiving 131I treatment:a nationwide population-based cohort study.J Nucl Med,2016,57(5):685-690.
49 Sun LM,Lin CL,Liang JA,et al.Radiotherapy did not increase thyroid cancer risk among women with breast cancer:a nationwide population-based cohort study.Int J Cancer,2015,137(12):2896-2903.
50 Ahn HY,Min HS,Yeo Y,et al.Radioactive iodine therapy did not significantly increase the incidence and recurrence of subsequent breast cancer.J Clin Endocrinol Metab,2015,100(9):3486-3493.
51 Guigon CJ,Kim DW,Willingham MC,et al.Mutation of thyroid hormone receptor-βin mice predisposes to the development of mammary tumors.Oncogene,2011,30(30):3381-3390.
52 Ling Y,Ling X,Fan L,et al.Mutation analysis underlying the downregulation of the thyroid hormone receptorβ1 gene in the Chinese breast cancer population.Onco Targets Ther,2015,16(8):2967-2972.
53 Pal T,Vogl FD,Chappuis PO,et al.Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer:a hospital-based study.J Clin Endocrinol Metab,2001,86(11):5307-5312.
54张岷,姚永强,方红,等.乳腺癌易感基因1在家族性甲状腺癌中的表达及临床意义.中华内分泌外科杂志,2017,11(6):513-516.
55 Siolek M,Cybulski C,Gasior-Perczak D,et al.CHEK2 mutations and the risk of papillary thyroid cancer.Int J Cancer,2015,137(3):548-552.
56 Pal T,Hamel N,Vesprini D,et al.Double primary cancers of the breast and thyroid in women:molecular analysis and genetic implications.Fam Cancer,2001,1(1):17-24.
2 Tosovic A,Becker C,Bondeson AG,et al.Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to breast cancer risk.Int J Cancer,2012,131(9):2126-2133.
3 Tosovic A,Bondeson AG,Bondeson L,et al.Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women.Breast Cancer Res,2010,12(3):R33.
4 Brandt J,Borgquist S,Manjer J.Prospectively measured thyroid hormones and thyroid peroxidase antibodies in relation to risk of different breast cancer subgroups:a Malm9 Diet and Cancer Study.Cancer Causes Control,2015,26(8):1093-1104.
5王亘,陈小松,毛艳,等.乳腺癌患者血清游离T4水平高于乳腺良性疾病患者.肿瘤,2014,34(4):366-369.
6 Fang Y,Yao L,Sun J,et al.Does thyroid dysfunction increase the risk of breast cancer?A systematic review and meta-analysis.JEndocrinol Invest,2017,40(10):1035-1047.
7 Kuijpens JL,Nyklíctek I,Louwman MW,et al.Hypothyroidism might be related to breast cancer in post-menopausal women.Thyroid,2005,15(11):1253-1259.
8高丽霞,张益枝,吴克雄,等.乳腺癌患者甲状腺功能的相关研究.现代肿瘤医学,2016,24(7):1071-1074.
9 Angelousi AG,Anagnostou VK,Stamatakos MK,et al.Mechanisms in endocrinology:primary HT and risk for breast cancer:a systematic review and meta-analysis.Eur J Endocrinol,2012,166(3):373-381.
10 Hardefeldt PJ,Eslick GD,Edirimanne S.Benign thyroid disease is associated with breast cancer:a meta-analysis.Breast Cancer Res Treat,2012,33(3):1169-1177.
11 Giustarini E,Pinchera A,Fierabracci P,et al.Thyroid autoimmunity in patients with malignant and benign breast diseases before surgery.Eur J Endocrinol,2006,154(5):645-649.
12 Prinzi N,Baldini E,Sorrenti S,et al.Prevalence of breast cancer in thyroid diseases:results of a cross-sectional study of 3,921 patients.Breast Cancer Res Treat,2014,144(3):683-688.
13 Muller I,Giani C,Zhang L,et al.Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?Int J Cancer,2014,134(7):1706-1714.
14 Fiore E,Giustarini E,Mammoli C,et al.Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer.J Endocrinol Invest,2007,30(9):734-738.
15 ?zmen T,Güllüoglu BM,Yegen C?,et al.Autoimmune thyroid disease and breast cancer prognosis.J Breast Health,2015,11(2):67-71.
16曾斌,刘瑛,沈方媛,等.自身免疫性甲状腺炎与乳腺癌关系的meta分析.中国现代医学杂志,2018,28(16):117-121.
17 Chiappa C,Rovera F,Rausei S,et al.Breast cancer and thyroid diseases:analysis of 867 consecutive cases.J Endocrinol Invest,2017,40(2):179-184.
18 Zbigniew S.Role of iodine in metabolism.Recent Pat Endocr Metab Immune Drug Discov,2017,10(2):123-126.
19 Smyth PP,Smith DF,Mc Dermott EW,et al.A direct relationship between thyroid enlargement and breast cancer.J Clin Endocrinol Metab,1996,81(3):937-941.
20 Venturi S.Is there a role for iodine in breast diseases?Breast,2001,10(5):379-382.
21 Eskin BA,Grotkowski CE,Connolly CP,et al.Different tissue responses for iodine and iodide in rat thyroid and mammary glands.Biol Trace Elem Res,1995,49(1):9-19.
22 Soriano O,Delgado G,Anguiano B,et al.Antineoplastic effect of iodine and iodide in dimethylbenz[a]anthracene-induced mammary tumors:association between lactoperoxidase and estrogen-adduct production.Endocr Relat Cancer,2011,18(4):529-539.
23 Yamamoto I,Maruyama H,Moriguchi M.The effect of dietary seaweeds on 7,12-dimethyl-benz[a]anthracene-induced mammary tumorigenesis in rats.Cancer Lett,1987,35(2):109-118.
24 Stoddard FR 2nd,Brooks AD,Eskin BA,et al.Iodine alters gene expression in the MCF7 breast cancer cell line:evidence for an antiestrogen effect of iodine.Int J Med Sci,2008,5(4):189-196.
25 Nio Y,Iguchi C,Itakura M,et al.High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders.Anticancer Res,2009,29(5):1607-1610.
26 Carhill AA,Litofsky DR,Ross DS,et al.Long-term outcomes following therapy in differentiated thyroid carcinoma:NTCTCSregistry analysis 1987-2012.J Clin Endocrinol Metab,2015,100(9):3270-3279.
27 Vigneri R,Malandrino P,Vigneri P.The changing epidemiology of thyroid cancer:why is incidence increasing?Curr Opin Oncol,2015,27(1):1-7.
28 Subramanian S,Goldstein DP,Parlea L,et al.Second primary malignancy risk in thyroid cancer survivors:a systematic review and meta-analysis.Thyroid,2007,17(12):1277-1288.
29 Keegan THM,Bleyer A,Rosenberg AS,et al.Second primary malignant neoplasms and survival in adolescent and young adult cancer survivors.JAMA Oncol,2017,3(11):1554-1557.
30 Chalstrey LJ,Benjamin B.High incidence of breast cancer in thyroid cancer patients.Br J Cancer,1966,20(4):670-675.
31 Verkooijen RB,Smit JW,Romijn JA,et al.The incidence of second primary tumors in thyroid cancer patients is increased,but not related to treatment of thyroid cancer.Eur J Endocrinol,2006,155(6):801-806.
32 Chen AY,Levy L,Goepfert H,et al.The development of breast carcinoma in women with thyroid carcinoma.Cancer,2001,92(2):225-231.
33 Li CI,Rossing MA,Voigt LF,et al.Multiple primary breast and thyroid cancers:role of age at diagnosis and cancer treatments(United States).Cancer Causes Control,2000,11(9):805-811.
34 Travis LB,Demark Wahnefried W,et al.Aetiology,genetics and prevention of secondary neoplasms in adult cancer survivors.Nat Rev Clin Oncol,2013,10(5):289-301.
35 Nielsen SM,White MG,Hong S,et al.The breast-thyroid cancer link:a systematic review and meta-analysis.Cancer Epidemiol Biomarkers Prev,2016,25(2):231-238.
36 Charalampoudis P,Agrogiannis G,Kontzoglou K,et al.Thyroid hormone receptor alpha(TRa)tissue expression in ductal invasive breast cancer:a study combining quantitative immunohistochemistry with digital slide image analysis.Eur J Surg Oncol,2017,43(8):1428-1432.
37 Ditsch N,Toth B,Himsl I,et al.Thyroid hormone receptor(TR)alpha and TR beta expression in breast cancer.Histol Histopathol,2013,28(2):227-237.
38 Jerzak KJ,Cockburn J,Pond GR,et al.Thyroid hormone receptorαin breast cancer:prognostic and therapeutic implications.Breast Cancer Res Treat,2015,149(1):293-301.
39 Saraiva PP,Figueiredo NB,Padovani CR,et al.Profile of thyroid hormones in breast cancer patients.Braz J Med Biol Res,2005,38(5):761-765.
40 Hall LC,Salazar EP,Kane SR,et al.Effects of thyroid hormones on human breast cancer cell proliferation.J Steroid Biochem Mol Biol,2008,109(1-2):57-66.
41 Conde I,Paniagua R,Zamora J,et al.Influence of thyroid hormone receptors on breast cancer cell proliferation.Ann Oncol,2006,17(1):60-64.
42李英,李宗龙.乳腺癌组织甲状腺激素受体β1表达及其临床意义.山东医药,2017,57(40):84-86.
43张洋洋,彭效祥,孙艳丽,等.甲状腺激素受体βΔ对大鼠乳腺癌SHZ-88细胞增殖及凋亡的影响.肿瘤防治研究,2016,43(12):1018-1022.
44 Haugen BR,Alexander EK,Bible KC,et al.2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.Thyroid,2016,26(1):1-133.
45 Sawka AM,Thabane L,Parlea L,et al.Second primary malignancy risk after radioactive iodine treatment for thyroid cancer:a systematic review and meta-analysis.Thyroid,2009,19(5):451-457.
46 Hall P,Holm LE,Lundell G,et al.Cancer risks in thyroid cancer patients.Br J Cancer,1991,64(1):159-163.
47 Zhang Y,Liang J,Li H,et al.Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer:a systematic review and meta-analysis.Nucl Med Commun,2016,37(2):110-115.
48 Lin CY,Lin CL,Huang WS,et al.Risk of breast cancer in patients with thyroid cancer receiving or not receiving 131I treatment:a nationwide population-based cohort study.J Nucl Med,2016,57(5):685-690.
49 Sun LM,Lin CL,Liang JA,et al.Radiotherapy did not increase thyroid cancer risk among women with breast cancer:a nationwide population-based cohort study.Int J Cancer,2015,137(12):2896-2903.
50 Ahn HY,Min HS,Yeo Y,et al.Radioactive iodine therapy did not significantly increase the incidence and recurrence of subsequent breast cancer.J Clin Endocrinol Metab,2015,100(9):3486-3493.
51 Guigon CJ,Kim DW,Willingham MC,et al.Mutation of thyroid hormone receptor-βin mice predisposes to the development of mammary tumors.Oncogene,2011,30(30):3381-3390.
52 Ling Y,Ling X,Fan L,et al.Mutation analysis underlying the downregulation of the thyroid hormone receptorβ1 gene in the Chinese breast cancer population.Onco Targets Ther,2015,16(8):2967-2972.
53 Pal T,Vogl FD,Chappuis PO,et al.Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer:a hospital-based study.J Clin Endocrinol Metab,2001,86(11):5307-5312.
54张岷,姚永强,方红,等.乳腺癌易感基因1在家族性甲状腺癌中的表达及临床意义.中华内分泌外科杂志,2017,11(6):513-516.
55 Siolek M,Cybulski C,Gasior-Perczak D,et al.CHEK2 mutations and the risk of papillary thyroid cancer.Int J Cancer,2015,137(3):548-552.
56 Pal T,Hamel N,Vesprini D,et al.Double primary cancers of the breast and thyroid in women:molecular analysis and genetic implications.Fam Cancer,2001,1(1):17-24.