IGF-1、IGF-1结合蛋白3在运动防治肥胖、糖尿病和心血管疾病中的作用
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摘要
运动防治肥胖、糖尿病和心血管疾病,改善其紊乱的糖脂代谢,但其机制仍未完全阐明。胰岛素类生长因子1(IGF-1)和IGF-1结合蛋白3(IGFBP-3)的水平在肥胖及其相关疾病如2型糖尿病、心血管疾病等的发生、发展和严重程度上的重要作用受到越来越多的关注。运动防治肥胖及其相关疾病的机制,部分与运动增加血清IGF-1、降低IGFBP-3水平和提高IGF-1活性(IGF-1/IGFBP-3摩尔比)有关。本文综述了IGF-1、IGFBP-3与肥胖、糖尿病和心血管疾病的相关性,及其在运动防治上述疾病中的作用及可能机制。
引文
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5 Puche JE,Castilla-Cortazar I.Human conditions of insulinlike growth factor-I(IGF-I)deficiency.J Transl Med,2012,10:224.
6 Berryman DE,Glad CA,List EO,et al.The GH/IGF-1 axis in obesity:pathophysiology and therapeutic considerations.Nat Rev Endocrinol,2013,9:346~356.
7 Gatti R,De Palo EF,Antonelli G,et al.IGF-I/IGFBP system:metabolism outline and physical exercise.J Endocrinol Invest,2012,35:699~707.
8 Savastano S,Di Somma C,Barrea L,et al.The complex relationship between obesity and the somatropic axis:the long and winding road.Growth Horm IGF Res,2014,24:221 ~226.
9 Redd MJ,Hoffman JR,Gepner Y,et al.The effect of HMB ingestion on the IGF-I and IGF binding protein response to high intensity military training.Growth Horm IGF Res,2017,32:55~59.
10 Ranke MB.Insulin-like growth factor binding-protein-3(IGFBP-3).Best Pract Res Clin Endocrinol Metab,2015,29:701~711.
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12 Liang S,Hu Y,Liu C,et al.Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents:a cross-sectional study.Lipids Health Dis,2016,15:112.
13 Miyake H,Kanazawa I,Sugimoto T.Decreased serum insulin-like growth factor-I level is associated with the increased mortality in type 2 diabetes mellitus.Endocr J,2016,63:811~818.
14 Lam CS,Chen MH,Lacey SM,et al.Circulating insulinlike growth factor-1 and its binding protein-3:metabolic and genetic correlates in the community.Arterioscler Thromb Vasc Biol,2010,30:1479~1484.
15 冯晓琪,马泽兵,罗强,等.血清胰岛素样生长因子1与心血管疾病及运动的关系.辽宁体育科技,2014,36:48 ~50.
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18 Ben Ounis O,Elloumi M,Zouhal H,et al.Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children.Ann Nutr Metab,2010,56:260~266.
19 Mason C,Xiao L,Duggan C,et al.Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women:a randomized controlled trial.Cancer Epidemiol Biomarkers Prev,2013,22:1457~1463.
20 Bjersing JL,Larsson A,Palstam A,et al.Benefits of resistance exercise in lean women with fibromyalgia:involvement of IGF-1 and leptin.BMC Musculoskelet Disord,2017,18:106.
21 Mohajeri Tehrani MR,Tajvidi M,Kahrizi S,et al.Does endurance training affect IGF-1/IGFBP-3 and insulin sensitivity in patients with type 2 diabetes?J Sports Med Phys Fitness,2015,55:1004~1012.
22 Annibalini G,Lucertini F,Agostini D,et al.Concurrent aerobic and resistance training has anti-inflammatory effects and increases both plasma and leukocyte levels of IGF-1 in late middle-aged type 2 diabetic patients.Oxid Med Cell Longev,2017,2017:3937842.
23 Brunke MW,Frye CW,Levine CB,et al.Insulin-like growth factor-1 and selected insulin-like growth factor binding protein concentrations during an ultramarathon sled dog race.Scientific World Journal,2016,2016:5686372.
24 Vestergaard PF,Vendelbo MH,Pedersen SB,et al.GH signaling in skeletal muscle and adipose tissue in healthy human subjects:impact of gender and age.Eur J Endocrinol,2014,171:623~631.
25 Romualdo MC,Nobrega FJ,Escrivao MA.Insulin resistance in obese children and adolescents.J Pediatr(Rio J),2014,90:600~607.
26 张醇,梁华平.胰岛素样生长因子及其与炎症关系的研究进展.感染、炎症、修复,2012,13:241~244.
27 Park HS,Ju UI,Park JW,et al.PPARgamma neddylation essential for adipogenesis is a potential target for treating obesity.Cell Death Differ,2016,23:1296~1311.
28 Ruffino JS,Davies NA,Morris K,et al.Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females:a putative role for PPARgamma.Eur J Appl Physiol,2016,116:1671~1682.
29 Kim JC.The effect of exercise training combined with PPARgamma agonist on skeletal muscle glucose uptake and insulin sensitivity in induced diabetic obese Zucker rats.J Exerc Nutrition Biochem,2016,20:42~50.
2 Mc Cormack SE,Mc Carthy MA,Harrington SG,et al.Effects of exercise and lifestyle modification on fitness,insulin resistance,skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents.Pediatr Obes,2014,9:281~291.
3 Mohamad MI,Khater MS.Evaluation of insulin like growth factor-1(IGF-1)level and its impact on muscle and bone mineral density in frail elderly male.Arch Gerontol Geriatr,2015,60:124~127.
4 Yang CW,Li TC,Li CI,et al.Insulinlike growth factor-1and its binding protein-3 polymorphisms predict circulating IGF-1 level and appendicular skeletal muscle mass in Chinese elderly.J Am Med Dir Assoc,2015,16:365~370.
5 Puche JE,Castilla-Cortazar I.Human conditions of insulinlike growth factor-I(IGF-I)deficiency.J Transl Med,2012,10:224.
6 Berryman DE,Glad CA,List EO,et al.The GH/IGF-1 axis in obesity:pathophysiology and therapeutic considerations.Nat Rev Endocrinol,2013,9:346~356.
7 Gatti R,De Palo EF,Antonelli G,et al.IGF-I/IGFBP system:metabolism outline and physical exercise.J Endocrinol Invest,2012,35:699~707.
8 Savastano S,Di Somma C,Barrea L,et al.The complex relationship between obesity and the somatropic axis:the long and winding road.Growth Horm IGF Res,2014,24:221 ~226.
9 Redd MJ,Hoffman JR,Gepner Y,et al.The effect of HMB ingestion on the IGF-I and IGF binding protein response to high intensity military training.Growth Horm IGF Res,2017,32:55~59.
10 Ranke MB.Insulin-like growth factor binding-protein-3(IGFBP-3).Best Pract Res Clin Endocrinol Metab,2015,29:701~711.
11 Aguirre GA,De Ita JR,de la Garza RG,et al.Insulinlike growth factor-1 deficiency and metabolic syndrome.J Transl Med,2016,14:3.
12 Liang S,Hu Y,Liu C,et al.Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents:a cross-sectional study.Lipids Health Dis,2016,15:112.
13 Miyake H,Kanazawa I,Sugimoto T.Decreased serum insulin-like growth factor-I level is associated with the increased mortality in type 2 diabetes mellitus.Endocr J,2016,63:811~818.
14 Lam CS,Chen MH,Lacey SM,et al.Circulating insulinlike growth factor-1 and its binding protein-3:metabolic and genetic correlates in the community.Arterioscler Thromb Vasc Biol,2010,30:1479~1484.
15 冯晓琪,马泽兵,罗强,等.血清胰岛素样生长因子1与心血管疾病及运动的关系.辽宁体育科技,2014,36:48 ~50.
16 Majorczyk M,Smolag D.Effect of physical activity on IGF-1 and IGFBP levels in the context of civilization diseases prevention.Rocz Panstw Zakl Hig,2016,67:105~111.
17 Nguyen KH,Yao XH,Moulik S,et al.Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretion.Endocrinology,2011,152:2184~2196.
18 Ben Ounis O,Elloumi M,Zouhal H,et al.Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children.Ann Nutr Metab,2010,56:260~266.
19 Mason C,Xiao L,Duggan C,et al.Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women:a randomized controlled trial.Cancer Epidemiol Biomarkers Prev,2013,22:1457~1463.
20 Bjersing JL,Larsson A,Palstam A,et al.Benefits of resistance exercise in lean women with fibromyalgia:involvement of IGF-1 and leptin.BMC Musculoskelet Disord,2017,18:106.
21 Mohajeri Tehrani MR,Tajvidi M,Kahrizi S,et al.Does endurance training affect IGF-1/IGFBP-3 and insulin sensitivity in patients with type 2 diabetes?J Sports Med Phys Fitness,2015,55:1004~1012.
22 Annibalini G,Lucertini F,Agostini D,et al.Concurrent aerobic and resistance training has anti-inflammatory effects and increases both plasma and leukocyte levels of IGF-1 in late middle-aged type 2 diabetic patients.Oxid Med Cell Longev,2017,2017:3937842.
23 Brunke MW,Frye CW,Levine CB,et al.Insulin-like growth factor-1 and selected insulin-like growth factor binding protein concentrations during an ultramarathon sled dog race.Scientific World Journal,2016,2016:5686372.
24 Vestergaard PF,Vendelbo MH,Pedersen SB,et al.GH signaling in skeletal muscle and adipose tissue in healthy human subjects:impact of gender and age.Eur J Endocrinol,2014,171:623~631.
25 Romualdo MC,Nobrega FJ,Escrivao MA.Insulin resistance in obese children and adolescents.J Pediatr(Rio J),2014,90:600~607.
26 张醇,梁华平.胰岛素样生长因子及其与炎症关系的研究进展.感染、炎症、修复,2012,13:241~244.
27 Park HS,Ju UI,Park JW,et al.PPARgamma neddylation essential for adipogenesis is a potential target for treating obesity.Cell Death Differ,2016,23:1296~1311.
28 Ruffino JS,Davies NA,Morris K,et al.Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females:a putative role for PPARgamma.Eur J Appl Physiol,2016,116:1671~1682.
29 Kim JC.The effect of exercise training combined with PPARgamma agonist on skeletal muscle glucose uptake and insulin sensitivity in induced diabetic obese Zucker rats.J Exerc Nutrition Biochem,2016,20:42~50.