柴胡疏肝散加减配合针灸对抑郁症疗效及相关指标的影响
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摘要
目的:研究与观察柴胡疏肝散加减配合针灸对抑郁症患者疗效及相关指标的影响。方法:选取2016年6月—2017年6月期间医院收治的120例抑郁症患者为研究对象,将其随机分为A组(柴胡疏肝散加减方组)、B组(针灸组)和C组(柴胡疏肝散加减配合针灸组)每组各40例。统计与比较3组患者的临床总有效率、治疗前后的血清细胞因子与神经递质表达水平。结果:C组的临床总有效率高于A组及B组,差异有统计学意义(P<0.05),治疗前3组患者的血清细胞因子与神经递质表达水平比较,差异无统计学意义(P>0.05),治疗后C组的血清细胞因子表达水平均低于A组及B组,血清神经递质表达水平均高于A组及B组,差异有统计学意义(P<0.05)。结论:柴胡疏肝散加减配合针灸对抑郁症患者的临床疗效较好,且对细胞因子及神经递质等疾病相关指标有较好的调节作用,因此在抑郁症患者中的应用价值较高。
Objective:To study and observe the effect of Modified Chaihu Shugan Powder combined with acupuncture in the patients with depression and influence for the related indexes. Methods:A total of 120 patients with depression in our hospital from June 2016 to June 2017 were selected for the research,and they were randomly divided into group A(modified Chaihu Shugan powder group),group B(acupuncture group)and group C(modified Chaihu Shugan powder combined with acupuncture group)with 40 cases in each group. Then the total effective rates,serum expression levels of cytokine and neurotransmitter before and after treatment of three groups were analyzed and compared. Results:The total effective rate of group C were higher than those of group A and group B and there were significant differences(P<0.05). The serum expression levels of cytokine and neurotransmitter of three groups before treatment were compared and there were no significant differences(P>0.05),and the serum expression levels of cytokine of group C after the treatment were lower than those of group A and group B. The serum expression levels of neurotransmitter were all higher than those of control group and there were significant differences(P<0.05). Conclusion:The clinical effect of Modified Chaihu Shugan Powder combined with acupuncture in the patients with depression is better,and it has better adjustment role for the cytokine and neurotransmitter and so its application value in the patients with depression is higher.
Objective:To study and observe the effect of Modified Chaihu Shugan Powder combined with acupuncture in the patients with depression and influence for the related indexes. Methods:A total of 120 patients with depression in our hospital from June 2016 to June 2017 were selected for the research,and they were randomly divided into group A(modified Chaihu Shugan powder group),group B(acupuncture group)and group C(modified Chaihu Shugan powder combined with acupuncture group)with 40 cases in each group. Then the total effective rates,serum expression levels of cytokine and neurotransmitter before and after treatment of three groups were analyzed and compared. Results:The total effective rate of group C were higher than those of group A and group B and there were significant differences(P<0.05). The serum expression levels of cytokine and neurotransmitter of three groups before treatment were compared and there were no significant differences(P>0.05),and the serum expression levels of cytokine of group C after the treatment were lower than those of group A and group B. The serum expression levels of neurotransmitter were all higher than those of control group and there were significant differences(P<0.05). Conclusion:The clinical effect of Modified Chaihu Shugan Powder combined with acupuncture in the patients with depression is better,and it has better adjustment role for the cytokine and neurotransmitter and so its application value in the patients with depression is higher.
引文
[1] 姜睿,郭忠伟,毛稚霞,等.柴胡疏肝散加减对脑梗死后抑郁患者血清细胞因子影响及临床疗效研究[J]. 辽宁中医杂志,2017,44(5):985-988.
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[4] 赵岳,李永祥,凌铿,等.柴胡疏肝散联合氟西汀对产后抑郁症患者IL-6、IL-1β、TNF-α的影响及其疗效[J]. 中国生化药物杂志,2016,36(4):127-129.
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[7] 李丽丽,周静,王宏国,等.柴郁地仙方对围绝经期抑郁症模型大鼠行为学及神经递质的影响[J]. 上海中医药大学学报,2017,31(1):69-72.
[8] 许二平,苗明三,尚立芝.基于抑郁症细胞因子、神经-内分泌发病机制的中医药治疗新进展[J]. 河南中医,2017,37(2):233-237.
[9] 何军,毕斌,罗洁,等.首发重度抑郁症患者不同亚类T淋巴细胞产生主要细胞因子水平的研究[J]. 中国现代医学杂志,2016,26(17):112-115.
[10] Steiner AJ,Recacho J,Vanle B,et al.Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study[J]. J Clin Psychiatry,2017,78(7):897-903.
[11] Undurraga J,Baldessarini RJ.Tricyclic and selective serotonin-reuptake-inhibitor antidepressants compared with placebo in randomized trials for acute major depression[J]. J Psychopharmacol,2017,31(12):1624-1625.
[12] 徐丽丽,张兰,马秀云,等.抑郁症神经内分泌及细胞因子的研究进展[J]. 中国医学创新,2016,13(34):138-141.
[13] 孟宪琦,王俊丽.奥氮平联合草酸艾司西酞普兰对抑郁症患者神经功能相关因子及细胞因子的影响[J]. 河北医学,2017,23(9):1540-1543.
[14] 徐英妹,黄文华,陈炜.柴胡疏肝散联合针灸治疗原发性抑郁症疗效观察[J]. 辽宁中医杂志,2016,43(12):2590-2592.
[15] 王国民,杨开仁,周波,等.帕罗西汀联合小剂量奥氮平对抑郁障碍患者血清神经递质及神经电生理指标的影响[J]. 中国医刊,2017,52(5):78-80.
[16] 徐爱军,刘昊,田艳霞,等.柴胡疏肝散对抑郁症大鼠行为学和海马神经元凋亡及自噬的影响[J]. 吉林大学学报:医学版,2014,40(4):801-804.
[17] 王红霞.加减柴胡疏肝散联合西药治疗抑郁症的疗效[J]. 光明中医,2017,32(1):107-108.
[18] 黄伟波,曾远强.柴胡疏肝散联合氟西汀治疗脑卒中后抑郁疗效观察[J]. 中医药导报,2015,21(13):79-81.
[2] 刘朝阳.柴胡疏肝散加减联合阿米替林治疗抑郁症的疗效分析及安全性评价[J]. 四川中医,2015,33(7):81-83.
[3] 梁友云,马纯.柴胡疏肝散加针灸配合三级康复治疗脑卒中后抑郁的疗效观察[J]. 四川中医,2015,33(7):115-117.
[4] 赵岳,李永祥,凌铿,等.柴胡疏肝散联合氟西汀对产后抑郁症患者IL-6、IL-1β、TNF-α的影响及其疗效[J]. 中国生化药物杂志,2016,36(4):127-129.
[5] Hedayati SS,Gregg LP,Carmody T,et al.Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial[J]. JAMA,2017,318(19):1876-1890.
[6] 于亚青,王林林,王静静,等.柴胡疏肝散醇提物对抑郁模型小鼠的抗抑郁作用[J]. 神经药理学报,2014,4(5):8-14.
[7] 李丽丽,周静,王宏国,等.柴郁地仙方对围绝经期抑郁症模型大鼠行为学及神经递质的影响[J]. 上海中医药大学学报,2017,31(1):69-72.
[8] 许二平,苗明三,尚立芝.基于抑郁症细胞因子、神经-内分泌发病机制的中医药治疗新进展[J]. 河南中医,2017,37(2):233-237.
[9] 何军,毕斌,罗洁,等.首发重度抑郁症患者不同亚类T淋巴细胞产生主要细胞因子水平的研究[J]. 中国现代医学杂志,2016,26(17):112-115.
[10] Steiner AJ,Recacho J,Vanle B,et al.Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study[J]. J Clin Psychiatry,2017,78(7):897-903.
[11] Undurraga J,Baldessarini RJ.Tricyclic and selective serotonin-reuptake-inhibitor antidepressants compared with placebo in randomized trials for acute major depression[J]. J Psychopharmacol,2017,31(12):1624-1625.
[12] 徐丽丽,张兰,马秀云,等.抑郁症神经内分泌及细胞因子的研究进展[J]. 中国医学创新,2016,13(34):138-141.
[13] 孟宪琦,王俊丽.奥氮平联合草酸艾司西酞普兰对抑郁症患者神经功能相关因子及细胞因子的影响[J]. 河北医学,2017,23(9):1540-1543.
[14] 徐英妹,黄文华,陈炜.柴胡疏肝散联合针灸治疗原发性抑郁症疗效观察[J]. 辽宁中医杂志,2016,43(12):2590-2592.
[15] 王国民,杨开仁,周波,等.帕罗西汀联合小剂量奥氮平对抑郁障碍患者血清神经递质及神经电生理指标的影响[J]. 中国医刊,2017,52(5):78-80.
[16] 徐爱军,刘昊,田艳霞,等.柴胡疏肝散对抑郁症大鼠行为学和海马神经元凋亡及自噬的影响[J]. 吉林大学学报:医学版,2014,40(4):801-804.
[17] 王红霞.加减柴胡疏肝散联合西药治疗抑郁症的疗效[J]. 光明中医,2017,32(1):107-108.
[18] 黄伟波,曾远强.柴胡疏肝散联合氟西汀治疗脑卒中后抑郁疗效观察[J]. 中医药导报,2015,21(13):79-81.