基于双源CT灌注成像对正常颅脑血流动力学的定量研究
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摘要
目的探讨双源CT灌注成像在正常人群中脑血流动力学定量研究中的价值,并测量其灌注参数的正常范围。方法收集无颅脑疾病的健康志愿者30例,行颅脑CT灌注扫描,利用灌注软件测得灰质(额颞顶叶)及白质(侧脑室前后角旁)、豆状核、尾状核、内囊及丘脑的CBV、CBF、MTT和TTP,并进行统计分析。结果 1、正常成人脑灰质CBF及CBV最高,MTT及TTP最长,白质CBF及CBV最低,豆状核及尾状核MTT及TTP最短;2、额叶、颞叶及顶叶CBV、CBF、TTP比较均无统计学差异(P>0.05),仅MTT有统计学差异(P<0.05);侧脑室前、后角旁CBV、CBF、MTT比较均无统计学差异(P>0.05),侧脑室前、后角旁TTP比较有统计学差异(P<0.05);3、左右侧脑室后角旁CBF比较有统计学差异(P<0.05),余左右半球各参数均无明显统计学差异(P>0.05)。结论双源CT灌注成像可以反映正常人群脑血流动力学变化,且测得了正常成人颅脑灌注参数正常值范围,为将来进一步开展CT灌注检查及相关研究提供理论基础。
Objective To investigate the value of dual source CT perfusion imaging in the quantitative study of cerebral hemodynamics in normal population and to measure the normal range of perfusion parameters.Methods A total of 30 healthy volunteers with no craniocerebral disease were collected and the CT perfusion scan was performed.The CBV、CBF、MTT and TTP of gray matter(frontal/temporal/parietal) and white matter(lateral front/back corner),cerebral blood volume,lentiform nucleus,caudate nucleus,thalamus and internal capsule was measured by perfusion software,and the statistical analysis was carried out.Results 1 The CBF and CBV of cerebral gray matter in normal adults were the highest,and MTT and TTP were the longest,the CBF and CBV of the white matter were the lowest,the MTT and TTP of the lentiform nucleus and caudate nucleus were the shortest.2 There was no significant difference in CBV,CBF,TTP between the frontal,temporal and parietal lobes(P>0.05),while there was statistically significant difference in MTT(P<0.05).There was no significant difference in CBV,CBF,MTT between the anterior and posterior lateral ventricles of the lateral ventricle(P>0.05),while there was statistically significant in TTP(P<0.05).3 There was a statistically significant difference between the left and right lateral ventricle CBF(P<0.05),and there was no significant difference in the other parameters of the left and right hemispheres(P<0.05).Conclusion Dual source CT perfusion imaging can reflect the cerebral hemodynamic changes in the normal population,and measured normal adult brain perfusion parameters of the normal reference range,to provide a theoretical basis for the further research of CT perfusion imaging and related research.
Objective To investigate the value of dual source CT perfusion imaging in the quantitative study of cerebral hemodynamics in normal population and to measure the normal range of perfusion parameters.Methods A total of 30 healthy volunteers with no craniocerebral disease were collected and the CT perfusion scan was performed.The CBV、CBF、MTT and TTP of gray matter(frontal/temporal/parietal) and white matter(lateral front/back corner),cerebral blood volume,lentiform nucleus,caudate nucleus,thalamus and internal capsule was measured by perfusion software,and the statistical analysis was carried out.Results 1 The CBF and CBV of cerebral gray matter in normal adults were the highest,and MTT and TTP were the longest,the CBF and CBV of the white matter were the lowest,the MTT and TTP of the lentiform nucleus and caudate nucleus were the shortest.2 There was no significant difference in CBV,CBF,TTP between the frontal,temporal and parietal lobes(P>0.05),while there was statistically significant difference in MTT(P<0.05).There was no significant difference in CBV,CBF,MTT between the anterior and posterior lateral ventricles of the lateral ventricle(P>0.05),while there was statistically significant in TTP(P<0.05).3 There was a statistically significant difference between the left and right lateral ventricle CBF(P<0.05),and there was no significant difference in the other parameters of the left and right hemispheres(P<0.05).Conclusion Dual source CT perfusion imaging can reflect the cerebral hemodynamic changes in the normal population,and measured normal adult brain perfusion parameters of the normal reference range,to provide a theoretical basis for the further research of CT perfusion imaging and related research.
引文
[1]季立标,王德杭.脑CT灌注成像对比剂注射速率与剂量实验研究[D].南京:南京医科大学,2016.
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[4]李乾露,杨德雨,刘波,等.脑供血侧枝循环的影像学评估[J].中国卒中杂志,2015,10(2):175-180.
[5]罗沛霖,李龙,周毅方,等.不同管电流对正常颅脑CT灌注参数和辐射剂量的影响[J].临床放射学杂志,2012,31(2):277-282.
[6]韩晓红,李晓鹏,李培,等.大脑中动脉M1段的显微解剖与血管造影对照观测及临床意义[J].中国临床解剖学杂志,2012,3(2):154-157.
[7]魏建强,李健,马剑,等.CT和MRI在脑血管疾病中的诊断有效性及效果观察[J].中国CT和MRI杂志,2016,14(7):18-20.
[2]崔若棣,易明岗.CT灌注与MR灌注加权成像评价烟雾病血管重建术对烟雾病患者短期脑血流的影响[J].中国CT和MRI杂志,2015,13(11):10-12.
[3]高培毅.脑梗死前期脑局部低灌注成像的CT灌注成像表现及分期[J].中华放射学杂志,2008,3(2):115-116.
[4]李乾露,杨德雨,刘波,等.脑供血侧枝循环的影像学评估[J].中国卒中杂志,2015,10(2):175-180.
[5]罗沛霖,李龙,周毅方,等.不同管电流对正常颅脑CT灌注参数和辐射剂量的影响[J].临床放射学杂志,2012,31(2):277-282.
[6]韩晓红,李晓鹏,李培,等.大脑中动脉M1段的显微解剖与血管造影对照观测及临床意义[J].中国临床解剖学杂志,2012,3(2):154-157.
[7]魏建强,李健,马剑,等.CT和MRI在脑血管疾病中的诊断有效性及效果观察[J].中国CT和MRI杂志,2016,14(7):18-20.