促红细胞生成素对体外循环下心脏外科手术器官功能影响的研究进展
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摘要
体外循环(cardiopulmonary bypass,CPB)是心脏外科手术时维持患者机体重要器官血液供应的一种手段。由于人工管道与机体血液成分接触以及在此期间的器官缺血再灌注损伤等原因,CPB会造成患者术后重要器官损伤。研究表明:促红细胞生成素(erythropoietin,EPO)除治疗贫血外,还可以通过多种途径对重要脏器功能产生影响。
Cardiopulmonary bypass(CPB) is a method to maintain the blood supply of important organs during cardiac surgery. Because of the contact between artificial conduit and blood component and the injury of organ ischemia reperfusion during this period, CPB will cause important organ injury after operation. In addition to treating anemia, erythropoietin(EPO) can affect the function of important organs in many ways.
Cardiopulmonary bypass(CPB) is a method to maintain the blood supply of important organs during cardiac surgery. Because of the contact between artificial conduit and blood component and the injury of organ ischemia reperfusion during this period, CPB will cause important organ injury after operation. In addition to treating anemia, erythropoietin(EPO) can affect the function of important organs in many ways.
引文
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2.Dreher M,Glatz AC,Kennedy A,et al.A single-center analysis of methylprednisolone use during pediatric cardiopulmonary bypass[J].JExtra Corpor Technol,2015,47(3):155-159.
3.Kim JE,Song SW,Kim JY,et al.Effect of a single bolus of erythropoietin on renoprotection in patients undergoing thoracic aortic surgery with moderate hypothermic circulatory arrest[J].Ann Thorac Surg,2016101(2):690-696.
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7.Sugita J,Fujiu K.Systemic inflammatory stress response during cardiac surgery[J].Int Heart J,2018,59(3):457-459.
8.Xiong Y,Yao H,Cheng Y,et al.Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice[J]Biochem Biophys Res Commun,2018,506(3):578-584.
9.Adamik B,Kübler A,Gozdzik A.Prolonged cardiopulmonary bypass is a risk factor for intestinal ischaemic damage and endotoxaemia[J]Heart Lung Circ,2017,26(7):717-723.
10.Miljus N,Massih B,Weis MA,et al.Neuroprotection and endocytosis:erythropoietin receptors in insect nervous systems[J].J Neurochem2017,141(1):63-74.
11.Zhang C,Yang C,Zhu T.From erythropoietin to its peptide derivatives:smaller but stronger[J].Curr Protein Pept Sci,2017,18(12):1191-1194.
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13.Joyeux-Faure M,Durand M,Bedague D,et al.Evaluation of the effect of one large dose of erythropoietin against cardiac and cerebral ischemic injury occurring during cardiac surgery with cardiopulmonary bypass:a randomized double-blind placebo-controlled pilot study[J].Fundam Clin Pharmacol,2012,26(6):761-770.
14.Danielson M,Reinsfelt B,Westerlind A,et al.Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery-a randomized trial[J].J Neuroinflamm,2018,15(1):283
15.Liu X,Zhang T,Xia W,et al.Recombinant human erythropoietin pretreatment al lev iates renal glomer ular injur y induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation[J].JThorac Cardiov Sur,2013,146(3):681-687.
16.Oh SW,Chin HJ,Dong WC,et al.Erythropoietin improves long-term outcomes in patients with acute kidney injury after coronary artery bypass grafting[J].J Korean Med Sci,2012,27(5):506-511.
17.Kim JH,Shim JK,Song JW,et al.Effect of erythropoietin on the incidence of acute kidney injury following complex valvular heart surgery:a double blind,randomized clinical trial of efficacy and safety[J].Crit Care,2013,17(5):R254.
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19.Heitrich M,García DM,Stoyanoff TR,et al.Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R,VEGF and VEGF-R2 modulation[J].Biomed Pharmacother2016,82:606-613.
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22.Liu Y,Lu J,Wang X,et al.Erythropoietin-derived peptide protects against acute lung injury after rat traumatic brain injury[J].Cell Physiol Biochem,2017,41(5):2037-2044.
23.He Q,Zhao X,Bi S,et al.Pretreatment with erythropoietin attenuates lung ischemia/reperfusion injury via toll-like receptor-4/nuclear factor-κB(TLR4/NF-κB)pathway[J].Med Sci Monit,2018,24:1251-1257.
24.Otsmane A,Kacimi G,Adane S,et al.Clinico-epidemiological profile and redox imbalance of lung cancer patients in Algeria[J].J Med Life2018,11(3):210-217.
25.Xu D,Perez RE,Ekekezie II,et al.Epidermal growth factor-like domain7 protects endothelial cells from hyperoxia-induced cell death[J].Am JPhysiol Lung Cell Mol Physiol,2008,294(1):L17.
26.Cui H,He J,Chen H,et al.Erythropoietin attenuates hyperoxiainduced lung injury by upregulating epidermal growth factor-like domain 7 in newborn rats[J].Biomed Rep,2017,6(1):32-38.
27.KimákováP,Solár P,SolárováZ,et al.Erythropoietin and its angiogenic activity[J].Int J Mol Sci,2017,18(7):E1519.
28.Heitrich M,García DM,Stoyanoff TR,et al.Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R,VEGF and VEGF-R2 modulation[J].Biomed Pharmacother2016,82:606-613.
29.肖锦雯,李龙虎,洪炳哲,等.促红细胞生成素缓释明胶水凝胶微球治疗小鼠下肢缺血的效果及机制[J].中华心血管病杂志2016,44(6):524-529.XIAO Jinwen,LI Longhu,HONG Bingzhe,et al.Therapeutic effects and related mechanisms of erythropoietin sustained-release gelatin hydrogel microspheres on a murine model of hindlimb ischemia[J]Chinese Journal of Cardiology,2016,44(6):524-529.
30.Caprara C,Britschgi C,Samardzija M,et al.The erythropoietin receptor is not required for the development,function,and aging of rods and cells in the retinal periphery[J].Mol Vis,2014,20(5):307-324.
31.Teramo KA,Klemetti MM,Widness JA.Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs[J].Pediatr Res,2018.[Epub ahead of print].
32.Nangaku M.Tissue protection by erythropoietin:new findings in a moving field[J].Kidney Int,2013,84(3):427-429.
33.Krapf R,Hulter HN.Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents(ESA)[J].Clin J Am Soc Nephrol,2009,4(2):470-480.
2.Dreher M,Glatz AC,Kennedy A,et al.A single-center analysis of methylprednisolone use during pediatric cardiopulmonary bypass[J].JExtra Corpor Technol,2015,47(3):155-159.
3.Kim JE,Song SW,Kim JY,et al.Effect of a single bolus of erythropoietin on renoprotection in patients undergoing thoracic aortic surgery with moderate hypothermic circulatory arrest[J].Ann Thorac Surg,2016101(2):690-696.
4.Skitek M,Jerin A.Proenkefalin A and protachykinin in ischemic neurological complications after cardiac surgery[J].Med Glas(Zenica)2016,13(1):8-13.
5.Zhang Y,Chen W,Wu Y.Renoprotection and mechanisms of erythropoietin and its derivatives helix B surface peptide in kidney injuries[J].Curr Protein Pept Sci,2017,18(12):1183-1190.
6.Graham EM,Atz AM,Mchugh KE,et al.Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates:results from a randomized trial[J].J Thorac Cardiov Sur2014,147(3):902-908.
7.Sugita J,Fujiu K.Systemic inflammatory stress response during cardiac surgery[J].Int Heart J,2018,59(3):457-459.
8.Xiong Y,Yao H,Cheng Y,et al.Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice[J]Biochem Biophys Res Commun,2018,506(3):578-584.
9.Adamik B,Kübler A,Gozdzik A.Prolonged cardiopulmonary bypass is a risk factor for intestinal ischaemic damage and endotoxaemia[J]Heart Lung Circ,2017,26(7):717-723.
10.Miljus N,Massih B,Weis MA,et al.Neuroprotection and endocytosis:erythropoietin receptors in insect nervous systems[J].J Neurochem2017,141(1):63-74.
11.Zhang C,Yang C,Zhu T.From erythropoietin to its peptide derivatives:smaller but stronger[J].Curr Protein Pept Sci,2017,18(12):1191-1194.
12.Mocini D,Muso P,Guendouz E,et al.Endogenous erythropoietin and a single bolus of 40,000 IU of epoetin alpha do not protect the heart from ischaemia-reperfusion injury during extracorporeal circulation for cardiac surgery[J].Perfusion,2008,23(3):187-192.
13.Joyeux-Faure M,Durand M,Bedague D,et al.Evaluation of the effect of one large dose of erythropoietin against cardiac and cerebral ischemic injury occurring during cardiac surgery with cardiopulmonary bypass:a randomized double-blind placebo-controlled pilot study[J].Fundam Clin Pharmacol,2012,26(6):761-770.
14.Danielson M,Reinsfelt B,Westerlind A,et al.Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery-a randomized trial[J].J Neuroinflamm,2018,15(1):283
15.Liu X,Zhang T,Xia W,et al.Recombinant human erythropoietin pretreatment al lev iates renal glomer ular injur y induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation[J].JThorac Cardiov Sur,2013,146(3):681-687.
16.Oh SW,Chin HJ,Dong WC,et al.Erythropoietin improves long-term outcomes in patients with acute kidney injury after coronary artery bypass grafting[J].J Korean Med Sci,2012,27(5):506-511.
17.Kim JH,Shim JK,Song JW,et al.Effect of erythropoietin on the incidence of acute kidney injury following complex valvular heart surgery:a double blind,randomized clinical trial of efficacy and safety[J].Crit Care,2013,17(5):R254.
18.Tie HT,Luo MZ,Lin D,et al.Erythropoietin administration for prevention of cardiac surgery-associated acute kidney injury:a metaanalysis of randomized controlled trials[J].Eur J Cardiothorac Surg2015,48(1):32-39.
19.Heitrich M,García DM,Stoyanoff TR,et al.Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R,VEGF and VEGF-R2 modulation[J].Biomed Pharmacother2016,82:606-613.
20.Gammella E,Leuenberger C,Gassmann M,et al.Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells[J].Am JPhysiol Lung Cell Mol Physiol,2013,304(4):L230-L239.
21.Bakan V,Kuruta?EB,??ral?k H,et al.Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma-induced pulmonary contusion[J].Ulus Travma Acil Cerrahi Derg,2016,22(4):322-327.
22.Liu Y,Lu J,Wang X,et al.Erythropoietin-derived peptide protects against acute lung injury after rat traumatic brain injury[J].Cell Physiol Biochem,2017,41(5):2037-2044.
23.He Q,Zhao X,Bi S,et al.Pretreatment with erythropoietin attenuates lung ischemia/reperfusion injury via toll-like receptor-4/nuclear factor-κB(TLR4/NF-κB)pathway[J].Med Sci Monit,2018,24:1251-1257.
24.Otsmane A,Kacimi G,Adane S,et al.Clinico-epidemiological profile and redox imbalance of lung cancer patients in Algeria[J].J Med Life2018,11(3):210-217.
25.Xu D,Perez RE,Ekekezie II,et al.Epidermal growth factor-like domain7 protects endothelial cells from hyperoxia-induced cell death[J].Am JPhysiol Lung Cell Mol Physiol,2008,294(1):L17.
26.Cui H,He J,Chen H,et al.Erythropoietin attenuates hyperoxiainduced lung injury by upregulating epidermal growth factor-like domain 7 in newborn rats[J].Biomed Rep,2017,6(1):32-38.
27.KimákováP,Solár P,SolárováZ,et al.Erythropoietin and its angiogenic activity[J].Int J Mol Sci,2017,18(7):E1519.
28.Heitrich M,García DM,Stoyanoff TR,et al.Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R,VEGF and VEGF-R2 modulation[J].Biomed Pharmacother2016,82:606-613.
29.肖锦雯,李龙虎,洪炳哲,等.促红细胞生成素缓释明胶水凝胶微球治疗小鼠下肢缺血的效果及机制[J].中华心血管病杂志2016,44(6):524-529.XIAO Jinwen,LI Longhu,HONG Bingzhe,et al.Therapeutic effects and related mechanisms of erythropoietin sustained-release gelatin hydrogel microspheres on a murine model of hindlimb ischemia[J]Chinese Journal of Cardiology,2016,44(6):524-529.
30.Caprara C,Britschgi C,Samardzija M,et al.The erythropoietin receptor is not required for the development,function,and aging of rods and cells in the retinal periphery[J].Mol Vis,2014,20(5):307-324.
31.Teramo KA,Klemetti MM,Widness JA.Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs[J].Pediatr Res,2018.[Epub ahead of print].
32.Nangaku M.Tissue protection by erythropoietin:new findings in a moving field[J].Kidney Int,2013,84(3):427-429.
33.Krapf R,Hulter HN.Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents(ESA)[J].Clin J Am Soc Nephrol,2009,4(2):470-480.