药学服务对社区2型糖尿病患者用药安全性和有效性的影响研究
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摘要
目的:评价药学服务对于接受多药治疗的社区2型糖尿病患者用药安全性和有效性的影响。方法:设计一项随机、对照研究,对社区2型糖尿病患者提供社区药学服务,将合格患者随机分至研究组和对照组中,研究组患者接受规范化的抗糖尿病药相关药学服务,对照组患者接受普通生活方式教育。研究考察的主要指标为患者的血糖控制水平、用药偏差、服药依从性、药品不良事件及满意度。结果:研究组进入随访的患者有40例,对照组进入随访的患者有39例。实施药学服务后,研究组患者的糖化血红蛋白达标率、用药依从性明显高于对照组,药品不良事件的发生率明显低于对照组,监护过程中的满意度明显高于对照组,差异均有统计学意义(P<0.05)。结论:通过对社区2型糖尿病患者进行药学监护随访,可形成针对2型糖尿病患者的规范化社区药学服务工作模式,作为"家庭医师治疗团队"中药学知识和监护方面必要的补充,也可为社区药师参与到"家庭医生治疗团队"中提供可参照的工作模式。
OBJECTIVE: To evaluate the effects of pharmaceutical service on the safety and effectiveness of medication in patients with community type Ⅱ diabetes who received multi-drug therapy. METHODS: A randomized, controlled study was designed to provide community pharmaceutical services for patients with community type 2 diabetes, qualified patients were randomly divided into study group and control group, the study group received standardized antidiabetic drug-related pharmaceutical services, while the control group received normal lifestyle education. The main indicators of the study were the patient's blood-glucose control, medication bias, medication compliance, adverse drug events and satisfaction degree. RESULTS: 40 patients in study group and 39 patients in control group were enrolled into followed-up. After the implementation of the pharmaceutical service, the control rate of glycosylated hemoglobin and compliance rate of the study group were significantly higher than those of the control group, the incidence of adverse drug events was significantly lower than that of the control group, the satisfaction degree during monitoring was significantly higher than that of the control group, with statistically significant difference(P<0.05). CONCLUSIONS: Through the pharmaceutical monitoring and follow-up for patients with community type 2 diabetes, a standardized community pharmaceutical service model for patients with type 2 diabetes can be formed, which can be a necessary supplement to pharmaceutical knowledge and monitoring in the "family doctor team", and also provide a reference work mode for pharmacist participating in the "family doctor team".
OBJECTIVE: To evaluate the effects of pharmaceutical service on the safety and effectiveness of medication in patients with community type Ⅱ diabetes who received multi-drug therapy. METHODS: A randomized, controlled study was designed to provide community pharmaceutical services for patients with community type 2 diabetes, qualified patients were randomly divided into study group and control group, the study group received standardized antidiabetic drug-related pharmaceutical services, while the control group received normal lifestyle education. The main indicators of the study were the patient's blood-glucose control, medication bias, medication compliance, adverse drug events and satisfaction degree. RESULTS: 40 patients in study group and 39 patients in control group were enrolled into followed-up. After the implementation of the pharmaceutical service, the control rate of glycosylated hemoglobin and compliance rate of the study group were significantly higher than those of the control group, the incidence of adverse drug events was significantly lower than that of the control group, the satisfaction degree during monitoring was significantly higher than that of the control group, with statistically significant difference(P<0.05). CONCLUSIONS: Through the pharmaceutical monitoring and follow-up for patients with community type 2 diabetes, a standardized community pharmaceutical service model for patients with type 2 diabetes can be formed, which can be a necessary supplement to pharmaceutical knowledge and monitoring in the "family doctor team", and also provide a reference work mode for pharmacist participating in the "family doctor team".
引文
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[8] Lee H,Choi TK,Lee YB,et al.A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy[J].Nat Nanotechnol,2016,11(6):566-572.
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[11] 戴家强,戴国强.社区药学服务对2型糖尿病患者遵医行为和并发症的影响[J].中国初级卫生保健,2017,31(5):41-43.
[12] 钟俊珊,陈柳欢,李茂清等.2型糖尿病社区药学服务干预的效果评价[J].中国临床新医学,2017,10(3):264-267.
[13] 何立琦,方琦.社区药学服务干预联合多药控制治疗对2型糖尿病患者的影响[J].临床合理用药杂志,2017,10(3):96-97.
[14] 李桃园,张楠,杨啸白,等.北京市朝阳区南部医联体糖尿病用药风险防范模式探索[J].临床药物治疗杂志,2016,14(6):45-48.
[15] 高植明,陈煜初,赵玉珊等.社区药学服务模式探索[J].中国医院用药评价与分析,2016,16(7):982-985.
[16] 肖灿.社区药学指导在提高糖尿病患者用药依从性中的作用及意义[J].中国社区医师,2015,31(11):9-10.
[2] 杨薇.药学监护对糖尿病患者治疗依从性及其血糖控制的影响[J].抗感染药学,2018,15(10):1751-1754.
[3] 杜金土.2型糖尿病患者的临床药师药学监护及意义评析[J].中国处方药,2018,16(11):41-42.
[4] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013版)[J].中华内分泌代谢杂志,2014,30(10):893-942.
[5] Mozaffarian D.Dietary and Policy Priorities for Cardiovascular Disease,Diabetes,and Obesity:A Comprehensive Review[J].Circulation,2016,133(2):187-225.
[6] Lindsay RS,Mackin ST,Nelson SM.Gestational diabetes mellitus-right person,right treatment,right time?[J].BMC Med,2017,15(1):163.
[7] Qin ZY,Yan JH,Yang DZ,et al.Behavioral Analysis of Chinese Adult Patients with Type 1 Diabetes on Self-monitoring of Blood Glucose[J].Chin Med J(Engl),2017,130(1):39-44.
[8] Lee H,Choi TK,Lee YB,et al.A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy[J].Nat Nanotechnol,2016,11(6):566-572.
[9] 杨样新.药学干预对2型糖尿病患者用药依从性与药品不良反应的影响探析[J].药品评价,2018,15(22):29-30,43.
[10] 胡晓红.社区药师药学服务对糖尿病防治效果影响显著[J].世界最新医学信息文摘,2018,18(27):179-180.
[11] 戴家强,戴国强.社区药学服务对2型糖尿病患者遵医行为和并发症的影响[J].中国初级卫生保健,2017,31(5):41-43.
[12] 钟俊珊,陈柳欢,李茂清等.2型糖尿病社区药学服务干预的效果评价[J].中国临床新医学,2017,10(3):264-267.
[13] 何立琦,方琦.社区药学服务干预联合多药控制治疗对2型糖尿病患者的影响[J].临床合理用药杂志,2017,10(3):96-97.
[14] 李桃园,张楠,杨啸白,等.北京市朝阳区南部医联体糖尿病用药风险防范模式探索[J].临床药物治疗杂志,2016,14(6):45-48.
[15] 高植明,陈煜初,赵玉珊等.社区药学服务模式探索[J].中国医院用药评价与分析,2016,16(7):982-985.
[16] 肖灿.社区药学指导在提高糖尿病患者用药依从性中的作用及意义[J].中国社区医师,2015,31(11):9-10.