T_1-T_2双模式磁共振造影剂的设计及应用
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摘要
核磁共振成像作为一种无侵入的早期诊断方式早已在临床上得到了非常广泛的应用,其成像方式分为弛豫加权和扩散加权,其中弛豫加权又分为T_1加权成像和T_2加权成像。为了增强MR图像对比度,可通过引入造影剂,根据其增强类型可以分为阳性的T_1造影剂和阴性的T_2造影剂。虽然两种造影剂各有其优点,但是也存在着一些不足,因此一种全新的T_1-T_2双模态造影剂应运而生。T_1-T_2双模态造影剂的优势就在于可以利用同一台仪器,实现MRI成像在时间和空间上的精确匹配。本文系统地总结了T_1-T_2双模态造影剂的设计思路和其化学合成方法,并对其生物医学应用作了介绍。
Magnetic resonance imaging(MRI) has been used in the clinic widely as an early noninvasive diagnosis technique. According to the theory of MRI, three imaging modes exist, namely, T_1-weighted imaging, T_2-weighted imaging and diffusion weighted imaging. Accordingly, there are two types of exogenous MRI contrast agents, namely T_1 contrast agent and T_2 contrast agent, for improvement in contrast in MR images. Either T_1 or T_2 contrast agents has its own advantages and disadvantages, respectively. Recently, a kind of new contrast agents, T_1-T_2 dual-modal contrast agent, has been designed, which can be used on one machine with an accurate match of spatial and temporal imaging parameters. This article reviews the progress of design and chemical synthesis methods of T_1-T_2 dual-mode contrast agents, and also introduces their biomedical applications.
Magnetic resonance imaging(MRI) has been used in the clinic widely as an early noninvasive diagnosis technique. According to the theory of MRI, three imaging modes exist, namely, T_1-weighted imaging, T_2-weighted imaging and diffusion weighted imaging. Accordingly, there are two types of exogenous MRI contrast agents, namely T_1 contrast agent and T_2 contrast agent, for improvement in contrast in MR images. Either T_1 or T_2 contrast agents has its own advantages and disadvantages, respectively. Recently, a kind of new contrast agents, T_1-T_2 dual-modal contrast agent, has been designed, which can be used on one machine with an accurate match of spatial and temporal imaging parameters. This article reviews the progress of design and chemical synthesis methods of T_1-T_2 dual-mode contrast agents, and also introduces their biomedical applications.
引文
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