质子泵抑制剂联合伊托必利治疗胃食管反流病的效果观察
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摘要
目的:研究质子泵抑制剂与伊托必利联合疗法在胃食管反流病中的应用价值。方法:以2015年3月-2017年2月本院接诊的胃食管反流病患者100例为研究对象,按照随机数字表法将患者分成研究组和对照组,各50例。研究组施以质子泵抑制剂与伊托必利联合治疗,对照组施以质子泵抑制剂治疗。比较两组治疗后生活质量的改善情况、临床疗效、复发情况。结果:研究组的治疗总有效率为96.0%,高于对照组的84.0%,差异有统计学意义(P<0.05)。研究组治疗后的生活质量评分为(89.22±5.36)分,高于对照组的(80.14±4.97)分,差异有统计学意义(P<0.05)。研究组对治疗效果的满意度为98.0%,高于对照组的86.0%,差异有统计学意义(P<0.05)。研究组的复发率为3.0%,低于对照组的16.0%,差异有统计学意义(P<0.05)。结论:利用质子泵抑制剂和伊托必利对胃食管反流病患者进行联合治疗,可显著提高其病情控制的效果,改善生活质量,降低疾病复发率,建议临床推广和使用。
Objective:To study the application value of proton pump inhibitors combined with Itopride in gastroesophageal reflux disease.Method:A total of 100 patients with gastroesophageal reflux disease admitted to our hospital from March 2015 to February 2017 were selected as the research objects.According to the random number table method,the patients were divided into study group and control group,with 50 cases in each group.The study group was treated with proton pump inhibitors combined with Itopride,and the control group was treated with proton pump inhibitors.The improvement of quality of life,clinical efficacy and recurrence were compared between the two groups.Result:The total effective rate was 96.0% in the study group,higher than 84.0% in the control group,the difference was statistically significant(P<0.05).The quality of life score of the study group after treatment was(89.22±5.36)scores,better than(80.14±4.97)scores of the control group,the difference was statistically significant(P<0.05).The satisfaction degree of the treatment effect in the study group was 98.0%,higher than86.0% in the control group,the difference was statistically significant(P<0.05).The recurrence rate in the study group was 3.0%,lower than 16.0% in the control group,the difference was statistically significant(P<0.05)Conclusion:Combined treatment with proton pump inhibitors and Itopride for patients with gastroesophageal reflux disease can significantly improve the effect of disease control,improve the quality of life and reduce the recurrence rate of the disease,and it is recommended to be clinically popularized and used.
Objective:To study the application value of proton pump inhibitors combined with Itopride in gastroesophageal reflux disease.Method:A total of 100 patients with gastroesophageal reflux disease admitted to our hospital from March 2015 to February 2017 were selected as the research objects.According to the random number table method,the patients were divided into study group and control group,with 50 cases in each group.The study group was treated with proton pump inhibitors combined with Itopride,and the control group was treated with proton pump inhibitors.The improvement of quality of life,clinical efficacy and recurrence were compared between the two groups.Result:The total effective rate was 96.0% in the study group,higher than 84.0% in the control group,the difference was statistically significant(P<0.05).The quality of life score of the study group after treatment was(89.22±5.36)scores,better than(80.14±4.97)scores of the control group,the difference was statistically significant(P<0.05).The satisfaction degree of the treatment effect in the study group was 98.0%,higher than86.0% in the control group,the difference was statistically significant(P<0.05).The recurrence rate in the study group was 3.0%,lower than 16.0% in the control group,the difference was statistically significant(P<0.05)Conclusion:Combined treatment with proton pump inhibitors and Itopride for patients with gastroesophageal reflux disease can significantly improve the effect of disease control,improve the quality of life and reduce the recurrence rate of the disease,and it is recommended to be clinically popularized and used.
引文
[1]马晓光,高保华,吴方雄,等.质子泵抑制剂联合依托必利对胃食管反流病的疗效评价[J].胃肠病学和肝病学杂志,2013,22(11):1110-1113.
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[3]刘凡理,陈波蓓,陈小燕,等.埃索美拉唑联合伊托必利治疗咽喉反流性疾病及食管动力学分析[J].中国耳鼻咽喉头颈外科,2015,(9):445-448.
[4]张颖慧,李良平.伊托必利联合艾司奥美拉唑镁治疗食管运动功能障碍致胃食管反流病的临床观察[J].中国药房,2017,28(35):4974-4977.
[5]钟媚,张冰,李秀媚,等.氟哌噻吨美利曲辛联合促胃动力药治疗非糜烂性胃食管反流病伴抑郁患者临床效果分析[J].中国医药,2016,11(1):58-62.
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[8]毛东东,李会娜.联用埃索美拉唑和伊托必利治疗非糜烂性胃食管反流病的临床效果[J].当代医药论丛,2017,15(13):127-128.
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[10]郭沁,高峰.联用兰索拉唑和盐酸伊托必利对特殊症状的胃食管反流病患者进行治疗的效果分析[J].当代医药论丛,2015,13(18):210-211.
[11]易丹,戴华.兰索拉唑和伊托必利分散片联合用药对胃食管反流病的临床分析[J].现代医药卫生,2014,30(10):1544-1545.
[12]芦玲,陈玉龙,卢艳如,等.常规治疗及抗抑郁焦虑治疗在河南籍老年反流性食管病中疗效的性别差异[J].中国实用医刊,2014,41(6):37-38.
[13]尹小宁,姜春萌.黛力新联合埃索美拉唑、伊托必利治疗老年RGERD的临床疗效观察[J].世界最新医学信息文摘(电子版),2013(19):181.
[14]李勇.半夏泻心汤联合腹针治疗胃食管反流病的临床疗效观察[J].当代医学,2016,22(3):150-151.
[15]白雪冰,邓碧珠,楼红玲,等.旋覆代赭汤加减联合泮托拉唑治疗胃食管反流病临床效果观察[J].广西医学,2017,39(3):354-356.
[16]Vega K J,Langford-Legg T,Palacio C,et al.Females without reflux symptoms or gastroesophageal reflux disease have less distal esophageal acid exposure than males without reflux symptoms or gastroesophageal reflux disease[J].Diseases of the Esophagus:Official Journal of the International Society for Diseases of the Esophagus,2013,26(3):246-249.
[17]Langner C,Wolf E M,Plieschnegger W,et al.Multilayered epithelium at the gastroesophageal junction is a marker of gastroesophageal reflux disease:Data from a prospective Central European multicenter study(histo GERD trial)[J].Virchows Archiv:An International Journal of Pathology,2014,464(4):409-417.
[18]VanMeer S,Bogte A,Siersema P D,et al.Long-term follow up in patients with gastroesophageal reflux disease with specific emphasis on reflux symptoms,use of anti-reflux medication and anti-reflux surgery outcome:A retrospective study[J].Scandinavian Journal of Gastroenterology,2013,48(11):1242-1248.
[19]史长山.康复新与雷贝拉唑、伊托必利联合方案治疗胃食管反流病的临床疗效观察[J].航空航天医学杂志,2016,27(2):222-223.
[20]梁华荣,余伟,刘飞雄,等.雷贝拉唑联合伊托必利治疗胃食管反流病疗效观察[J].中华临床医师杂志(电子版),2011,5(24):7402-7404.
[2]牛春燕,汪雯,李雷,等.质子泵抑制剂联合伊托必利治疗胃食管反流病18个月疗效观察[J].胃肠病学和肝病学杂志,2013,22(8):744-748.
[3]刘凡理,陈波蓓,陈小燕,等.埃索美拉唑联合伊托必利治疗咽喉反流性疾病及食管动力学分析[J].中国耳鼻咽喉头颈外科,2015,(9):445-448.
[4]张颖慧,李良平.伊托必利联合艾司奥美拉唑镁治疗食管运动功能障碍致胃食管反流病的临床观察[J].中国药房,2017,28(35):4974-4977.
[5]钟媚,张冰,李秀媚,等.氟哌噻吨美利曲辛联合促胃动力药治疗非糜烂性胃食管反流病伴抑郁患者临床效果分析[J].中国医药,2016,11(1):58-62.
[6]张国华.抗焦虑联合兰索拉唑、伊托必利治疗难治性胃食管反流病临床疗效观察[J].临床消化病杂志,2010,22(3):179-180.
[7]秦波.伊托必利与埃索美拉唑联用治疗反流性食管炎的疗效分析[J].海峡药学,2013,25(2):178-180.
[8]毛东东,李会娜.联用埃索美拉唑和伊托必利治疗非糜烂性胃食管反流病的临床效果[J].当代医药论丛,2017,15(13):127-128.
[9]Koch O O,Spaun G,Antoniou S A,et al.Endoscopic grading of the gastroesophageal flap valve is correlated with reflux activity and can predict the size of the esophageal hiatus in patients with gastroesophageal reflux disease[J].Surgical Endoscopy,2013,27(12):4590-4595.
[10]郭沁,高峰.联用兰索拉唑和盐酸伊托必利对特殊症状的胃食管反流病患者进行治疗的效果分析[J].当代医药论丛,2015,13(18):210-211.
[11]易丹,戴华.兰索拉唑和伊托必利分散片联合用药对胃食管反流病的临床分析[J].现代医药卫生,2014,30(10):1544-1545.
[12]芦玲,陈玉龙,卢艳如,等.常规治疗及抗抑郁焦虑治疗在河南籍老年反流性食管病中疗效的性别差异[J].中国实用医刊,2014,41(6):37-38.
[13]尹小宁,姜春萌.黛力新联合埃索美拉唑、伊托必利治疗老年RGERD的临床疗效观察[J].世界最新医学信息文摘(电子版),2013(19):181.
[14]李勇.半夏泻心汤联合腹针治疗胃食管反流病的临床疗效观察[J].当代医学,2016,22(3):150-151.
[15]白雪冰,邓碧珠,楼红玲,等.旋覆代赭汤加减联合泮托拉唑治疗胃食管反流病临床效果观察[J].广西医学,2017,39(3):354-356.
[16]Vega K J,Langford-Legg T,Palacio C,et al.Females without reflux symptoms or gastroesophageal reflux disease have less distal esophageal acid exposure than males without reflux symptoms or gastroesophageal reflux disease[J].Diseases of the Esophagus:Official Journal of the International Society for Diseases of the Esophagus,2013,26(3):246-249.
[17]Langner C,Wolf E M,Plieschnegger W,et al.Multilayered epithelium at the gastroesophageal junction is a marker of gastroesophageal reflux disease:Data from a prospective Central European multicenter study(histo GERD trial)[J].Virchows Archiv:An International Journal of Pathology,2014,464(4):409-417.
[18]VanMeer S,Bogte A,Siersema P D,et al.Long-term follow up in patients with gastroesophageal reflux disease with specific emphasis on reflux symptoms,use of anti-reflux medication and anti-reflux surgery outcome:A retrospective study[J].Scandinavian Journal of Gastroenterology,2013,48(11):1242-1248.
[19]史长山.康复新与雷贝拉唑、伊托必利联合方案治疗胃食管反流病的临床疗效观察[J].航空航天医学杂志,2016,27(2):222-223.
[20]梁华荣,余伟,刘飞雄,等.雷贝拉唑联合伊托必利治疗胃食管反流病疗效观察[J].中华临床医师杂志(电子版),2011,5(24):7402-7404.